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Efficacy of HIPEC in Patients With Colorectal Cancer at High Risk of Peritoneal Carcinomatosis

Primary Purpose

Colorectal Cancer

Status
Recruiting
Phase
Phase 3
Locations
China
Study Type
Interventional
Intervention
Radical colectomy
HIPEC
Systemic chemotherapy
Sponsored by
Affiliated Cancer Hospital & Institute of Guangzhou Medical University
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Colorectal Cancer focused on measuring Colorectal cancer, Colectomy, Hyperthermic intraperitoneal chemotherapy, Peritoneal carcinomatosis

Eligibility Criteria

18 Years - 70 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Age between 18 and 70 years
  • Nonpregnant or breast-feeding women
  • ECOG status 0-1
  • Colorectal adenocarcinoma or mucinous adenocarcinoma;
  • Intraoperative confirmed cT4N0-2M0 Colorectal cancer (visual determination - according to AJCC 8th edition) without previous anti-cancer treatment and R0 resection could be achieved
  • Laboratory tests within 2 weeks before Randomization：Neutrophil ≥ 2.0 /mm3, , platelets ≥ 100,000/mm3, hemoglobin≥90g/l, Alanine transaminase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 ×ULN), total bilirubin(TBIL)≤ 1.5 × ULN, serum creatinine ≤ 1.5 ×ULN
  • Written informed consent

Exclusion Criteria:

  • Rectal cancer below peritoneal reflection
  • Concurrent with or have other cancer within the past 5 years ( except for skin basal cell carcinoma, or cervical carcinoma in situ, who have received radical treatment)
  • Severe abdominal infection or extensive fibrosis of peritoneal cavity that lead to impossible separation
  • Surgical procedures conversion(from robotic or laparoscopic surgery to laparotomy) or emergency surgery due to perforation or obstruction
  • Existence of distance metastasis during surgery (M1) or can not achieve R0 resection
  • Contraindiction of mitomycin c(chickenpox or shingles)
  • Poorly controlled respiratory or cardiac disease, severe hepatic or renal dysfunction,drug abuse or uncontrolled mental disease

Sites / Locations

  • Peking University People's Hospital
  • Beijing Hospital
  • Cancer Hospital Chinese Academy of Medical Sciences
  • Peking University Cancer Hospital & Institute
  • Chongqing Cancer Hospital
  • First Affiliated Hospital of Chongqing Medical University
  • Second Affiliated Hospital of Chongqing Medical University
  • The First People's Hospital of FoShan (Affiliated FoShan Hospital of Sun Yat-sen University)
  • Sun Yat-sen University Cancer Center
  • Guangdong Provincal people's Hospital
  • Affiliated Cancer Hospital & Institute of Guangzhou Medical UniversityRecruiting
  • Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
  • Nanfang Hospital of Southern Medical University
  • The First Affiliated Hospital, Sun Yat-sen University
  • The Six Affiliated Hospital,Sun Yat-sen University
  • JiangMen Central Hospital Affiliated JiangMen Hospital Of SUN YAT-SEN University
  • MeiZhou People's HospitalRecruiting
  • Affiliated Shantou Hospital of Sun Yat-sen University
  • Shenzhen Second People's Hospital
  • Zhongshan City People's Hospital
  • Zhuhai People's Hospital, Zhuhai hospital affiliated with Jinan University
  • People's hospital of guangxi zhuang autonomous region
  • The Affiliated Tumor Hospital of Guangxi Medical University
  • Hebei Medical University Fourth Hospital
  • Union Hospital,Tongji Medical College, Huazhong Uninersity of Science and TechnolgyRecruiting
  • Wuhan University Renmin Hospital
  • Zhongnan Hospital of Wuhan University
  • The Affiliated Hospital of Xuzhou Medical University
  • the First Affiliated Hospital of Nanchang University
  • Fudan University Shanghai Cancer Center
  • West China Hospital，Sichuan University
  • Sichuan Provincial People's HospitalRecruiting
  • The Third Peoples' Hospital of Chengdu
  • People'S Hospital of Deyang City
  • Leshan people's Hospital
  • The Affiliated hospital of southwest medical university
  • The Second Affiliated Hospital，Zhejiang University School of Medicine

Arms of the Study

Arm 1

Arm 2

Arm Type

Active Comparator

Experimental

Arm Label

Matched control

HIPEC

Arm Description

Patients undergo radical resection of primary colorectal cancer and receive standard adjuvant systemic chemotherapy

Patients undergo radical resection of colorectal cancer and HIPEC simultaneously or within 2 days after primary tumor resection. Followed by standard adjuvant systemic chemotherapy

Outcomes

Primary Outcome Measures

Peritoneal recurrence free survival
Peritoneal recurrence free survival is calculated from the date of randomization to the date of record peritoneal recurrence(with or without other metastasis), ovarian metastasis, malignant ascites, or death from any cause, whichever occurred first.

Secondary Outcome Measures

Disease free survival
Disease free survival is calculated from randomization to to the date of a first relapse, the diagnosis of a secondary colorectal cancer after the initial diagnosis, or death from any cause, whichever occurred first.
Overall survival
Overall survival is calculated from randomization to death from any cause.
Liver metastatic rate
Liver metastatic rate is calculated from randomization to to the date of liver metastasis with or without other organ metastasis.
Number of participants with adverse events
Incidence of acute and late toxicity

Full Information

First Posted
April 8, 2020
Last Updated
June 15, 2020
Sponsor
Affiliated Cancer Hospital & Institute of Guangzhou Medical University
Collaborators
Nanfang Hospital, Southern Medical University, Sun Yat-sen University, Sixth Affiliated Hospital, Sun Yat-sen University, First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangdong Provincial People's Hospital, Meizhou People's Hospital, First People's Hospital of Foshan, Shantou Central Hospital, Jiangmen Central Hospital, Shenzhen Second People's Hospital, Zhongshan People's Hospital, Guangdong, China, ZhuHai Hospital, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing Hospital, Peking University Cancer Hospital & Institute, Peking University People's Hospital, Fudan University, The Second Affiliated Hospital of Chongqing Medical University, Chongqing University Cancer Hospital, First Affiliated Hospital of Chongqing Medical University, Second Affiliated Hospital, School of Medicine, Zhejiang University, Wuhan Union Hospital, China, Renmin Hospital of Wuhan University, Wuhan University, Sichuan Provincial People's Hospital, West China Hospital, The People's Hospital of Leshan, People's Hospital of Deyang City, Hebei Medical University Fourth Hospital, The First Affiliated Hospital of Nanchang University, The Affiliated Hospital Of Southwest Medical University, The Affiliated Hospital of Xuzhou Medical University, People's Hospital of Guangxi, The Third People's Hospital of Chengdu, The Affiliated Tumor Hospital of Guangxi Medical University
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1. Study Identification

Unique Protocol Identification Number
NCT04370925
Brief Title
Efficacy of HIPEC in Patients With Colorectal Cancer at High Risk of Peritoneal Carcinomatosis
Official Title
A Multicenter Prospective Randomized Controlled Clinical Trial of Hyperthermic Intraperitoneal Chemotherapy After Colectomy in Patients With Colorectal Cancer at High Risk of Peritoneal Carcinomatosis
Study Type
Interventional

2. Study Status

Record Verification Date
April 2020
Overall Recruitment Status
Recruiting
Study Start Date
June 4, 2020 (Actual)
Primary Completion Date
April 30, 2024 (Anticipated)
Study Completion Date
April 30, 2026 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Affiliated Cancer Hospital & Institute of Guangzhou Medical University
Collaborators
Nanfang Hospital, Southern Medical University, Sun Yat-sen University, Sixth Affiliated Hospital, Sun Yat-sen University, First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangdong Provincial People's Hospital, Meizhou People's Hospital, First People's Hospital of Foshan, Shantou Central Hospital, Jiangmen Central Hospital, Shenzhen Second People's Hospital, Zhongshan People's Hospital, Guangdong, China, ZhuHai Hospital, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing Hospital, Peking University Cancer Hospital & Institute, Peking University People's Hospital, Fudan University, The Second Affiliated Hospital of Chongqing Medical University, Chongqing University Cancer Hospital, First Affiliated Hospital of Chongqing Medical University, Second Affiliated Hospital, School of Medicine, Zhejiang University, Wuhan Union Hospital, China, Renmin Hospital of Wuhan University, Wuhan University, Sichuan Provincial People's Hospital, West China Hospital, The People's Hospital of Leshan, People's Hospital of Deyang City, Hebei Medical University Fourth Hospital, The First Affiliated Hospital of Nanchang University, The Affiliated Hospital Of Southwest Medical University, The Affiliated Hospital of Xuzhou Medical University, People's Hospital of Guangxi, The Third People's Hospital of Chengdu, The Affiliated Tumor Hospital of Guangxi Medical University

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The purpose of this study is to determine the efficacy of adjuvant HIPEC with Mitomycin C after colectomy in the treatment of colorectal cancer patients at high risk of peritoneal carcinomatosis.
Detailed Description
The effectiveness of cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) have been addressed for the treatment of peritoneal carcinomatosis in selected patients. However, prophylactic HIPEC in colorectal cancer patients at high risk of metachronous peritoneal metastases remained controversial. In this study, patients with colorectal cancer cT4N0-2M0(AJCC/UICC staging system 8th edition) and planed to undergo intentionally colectomy (laparotomy, laparoscopy，or robotic ) are randomized into HIPEC group and control group. In HIPEC group, closed HIPEC is performed with Mitomycin C(30mg/m2) at 43 °C for 90 minutes, simultaneously or within 2 days after colectomy and followed by systemic chemotherapy. For the patients in the control group, systemic chemotherapy were administered after colectomy. The primary endpoint is peritoneal recurrence-free survival (pRFS) rate. Secondary end points include overall survival (OS) rate, disease free survival (DFS) rate, liver metastatic rate, toxic effects, quality of life scores. All efficacy analyses are conducted in the intention-to-treat population, per-protocol population and pT4 subgroups due to pathologic tumor invasion can not be acquired before HIPEC. Safety analysis include only patients who receive their randomly assigned treatment.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Colorectal Cancer
Keywords
Colorectal cancer, Colectomy, Hyperthermic intraperitoneal chemotherapy, Peritoneal carcinomatosis

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
688 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Matched control
Arm Type
Active Comparator
Arm Description
Patients undergo radical resection of primary colorectal cancer and receive standard adjuvant systemic chemotherapy
Arm Title
HIPEC
Arm Type
Experimental
Arm Description
Patients undergo radical resection of colorectal cancer and HIPEC simultaneously or within 2 days after primary tumor resection. Followed by standard adjuvant systemic chemotherapy
Intervention Type
Procedure
Intervention Name(s)
Radical colectomy
Intervention Description
Patients undergo radical resection of the primary colorectal cancer(open or laparoscopic/robotic)
Intervention Type
Procedure
Intervention Name(s)
HIPEC
Intervention Description
HIPEC(simultaneously or within 2days after resection) with mitomycin c (30 mg/m2) at 43°C for 90 minutes.
Intervention Type
Drug
Intervention Name(s)
Systemic chemotherapy
Intervention Description
Systemic chemotherapy regimens: CapeOx and mFOLFOX6 are preferred for stage Ⅲ patients. CapeOx:oxaliplatin 130 mg/m2 IV d1 + capecitabine 1000mg/m2 po bid d1-14. Repeat every three weeks for eight cycles. mFOLFOX6:oxaliplatin 85 mg/m2 IV d1 + leucovorin calcium 400 mg/m2 IV d1 + 5-FU 400 mg/m2 IV bolus d1 + 5-FU 2400 mg/m2 continuous IV over 46-48 hours d1-2. Repeat every two weeks for twelve cycles. For stageⅡpatiens, regimens recommend by NCCN guide line(2019 v1) are acceptable.
Primary Outcome Measure Information:
Title
Peritoneal recurrence free survival
Description
Peritoneal recurrence free survival is calculated from the date of randomization to the date of record peritoneal recurrence(with or without other metastasis), ovarian metastasis, malignant ascites, or death from any cause, whichever occurred first.
Time Frame
3-year
Secondary Outcome Measure Information:
Title
Disease free survival
Description
Disease free survival is calculated from randomization to to the date of a first relapse, the diagnosis of a secondary colorectal cancer after the initial diagnosis, or death from any cause, whichever occurred first.
Time Frame
3-year
Title
Overall survival
Description
Overall survival is calculated from randomization to death from any cause.
Time Frame
5-year
Title
Liver metastatic rate
Description
Liver metastatic rate is calculated from randomization to to the date of liver metastasis with or without other organ metastasis.
Time Frame
3-year
Title
Number of participants with adverse events
Description
Incidence of acute and late toxicity
Time Frame
Up to 1 month after the last chemotherapy cycle

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
70 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Age between 18 and 70 years Nonpregnant or breast-feeding women ECOG status 0-1 Colorectal adenocarcinoma or mucinous adenocarcinoma; Intraoperative confirmed cT4N0-2M0 Colorectal cancer (visual determination - according to AJCC 8th edition) without previous anti-cancer treatment and R0 resection could be achieved Laboratory tests within 2 weeks before Randomization：Neutrophil ≥ 2.0 /mm3, , platelets ≥ 100,000/mm3, hemoglobin≥90g/l, Alanine transaminase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 ×ULN), total bilirubin(TBIL)≤ 1.5 × ULN, serum creatinine ≤ 1.5 ×ULN Written informed consent Exclusion Criteria: Rectal cancer below peritoneal reflection Concurrent with or have other cancer within the past 5 years ( except for skin basal cell carcinoma, or cervical carcinoma in situ, who have received radical treatment) Severe abdominal infection or extensive fibrosis of peritoneal cavity that lead to impossible separation Surgical procedures conversion(from robotic or laparoscopic surgery to laparotomy) or emergency surgery due to perforation or obstruction Existence of distance metastasis during surgery (M1) or can not achieve R0 resection Contraindiction of mitomycin c(chickenpox or shingles) Poorly controlled respiratory or cardiac disease, severe hepatic or renal dysfunction,drug abuse or uncontrolled mental disease
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Shuzhong Cui, MD
Phone
086-13802513800
Email
cuishuzhong@gzhmu.edu
First Name & Middle Initial & Last Name or Official Title & Degree
Tianpei Guan, MD
Phone
086-13660895051
Email
dr_guan@126.com
Facility Information:
Facility Name
Peking University People's Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100044
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bin Liang, MD
Phone
0086-136-8144-4694
Email
13681444694@163.com
First Name & Middle Initial & Last Name & Degree
Bin Liang, MD
First Name & Middle Initial & Last Name & Degree
Chao Wang, MD
Facility Name
Beijing Hospital
City
Beijing
State/Province
Beijing
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gang Zhao, MM
Phone
13910714396
Email
njg656@163.com
First Name & Middle Initial & Last Name & Degree
Gang Zhao, MM
First Name & Middle Initial & Last Name & Degree
Hua Yang, MM
Facility Name
Cancer Hospital Chinese Academy of Medical Sciences
City
Beijing
State/Province
Beijing
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xishan Wang, MD
Phone
086-13552367779
Email
Wxshan1208@126.com
First Name & Middle Initial & Last Name & Degree
Xishan Wang, MD
First Name & Middle Initial & Last Name & Degree
Wei Pei, MD
Facility Name
Peking University Cancer Hospital & Institute
City
Beijing
State/Province
Beijing
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Aiwen Wu, MD
Phone
086-13911577190
Email
wuaw@sina.com
First Name & Middle Initial & Last Name & Degree
Qiushi Dong, MM
First Name & Middle Initial & Last Name & Degree
Aiwen Wu, MD
Facility Name
Chongqing Cancer Hospital
City
Chongqing
State/Province
Chongqing
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hao Sun, MD
Phone
086-13508370438
Email
sunhao68@sina.com
First Name & Middle Initial & Last Name & Degree
Hao Sun, MD
First Name & Middle Initial & Last Name & Degree
Miao He, MD
Facility Name
First Affiliated Hospital of Chongqing Medical University
City
Chongqing
State/Province
Chongqing
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zhengqiang Wei, MD
Phone
086-13228675636
Email
384535713@qq.com
First Name & Middle Initial & Last Name & Degree
Zhengqiang Wei, MD
Facility Name
Second Affiliated Hospital of Chongqing Medical University
City
Chongqing
State/Province
Chongqing
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jijian Wang, MD
Phone
086-13908304080
Email
Wangjj1963@163.com
First Name & Middle Initial & Last Name & Degree
Jijian Wang, MD
Facility Name
The First People's Hospital of FoShan (Affiliated FoShan Hospital of Sun Yat-sen University)
City
Foshan
State/Province
Guangdong
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Longqing Cheng, MM
Phone
18038863563
Email
13702939022@139.com
First Name & Middle Initial & Last Name & Degree
Longqing Cheng, MM
First Name & Middle Initial & Last Name & Degree
Yan-an Gao, MM
Facility Name
Sun Yat-sen University Cancer Center
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510060
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zhizhong Pan, MD
Phone
086-13719388166
Email
panzz@sysucc.org.cn
First Name & Middle Initial & Last Name & Degree
Zhizhong Pan, MD
First Name & Middle Initial & Last Name & Degree
Fulong Wang, MD
Facility Name
Guangdong Provincal people's Hospital
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510080
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yong Li, MD
Phone
0086-138-2217-7479
Email
liyong@gdph.org.cn
First Name & Middle Initial & Last Name & Degree
M.M
First Name & Middle Initial & Last Name & Degree
Yong Li, MD
First Name & Middle Initial & Last Name & Degree
ZeJian Lv, MM
Facility Name
Affiliated Cancer Hospital & Institute of Guangzhou Medical University
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510095
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shuzhong Cui, MD
Phone
0086-138-0251-3800
Email
cuishuzhong@126.com
First Name & Middle Initial & Last Name & Degree
Tianpei Guan, MD
Phone
0086-136-6089-5051
Email
dr_guan@126.com
First Name & Middle Initial & Last Name & Degree
Shuzhong Cui, MD
First Name & Middle Initial & Last Name & Degree
Tianpei Guan, MD
Facility Name
Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510120
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Wei Wang, MD
Phone
0086-13922255515
Email
ww1640@yeah.net
First Name & Middle Initial & Last Name & Degree
Wei Wang, MD
First Name & Middle Initial & Last Name & Degree
WenJun Xiong, MD
Facility Name
Nanfang Hospital of Southern Medical University
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510515
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Haijun Deng, MD
Phone
0086-13189096629
Email
navyd999@163.com
First Name & Middle Initial & Last Name & Degree
Haijun Deng, MD
First Name & Middle Initial & Last Name & Degree
Kai Sun, MD
Facility Name
The First Affiliated Hospital, Sun Yat-sen University
City
Guangzhou
State/Province
Guangdong
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Chuangqi Chen, MD
Phone
086-13719334878
Email
2632864588@qq.com
First Name & Middle Initial & Last Name & Degree
Chuangqi Chen, MD
First Name & Middle Initial & Last Name & Degree
Jianhui Chen, MD
Facility Name
The Six Affiliated Hospital,Sun Yat-sen University
City
Guangzhou
State/Province
Guangdong
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Meijin Huang, MD
Phone
086-13924073322
Email
13924073322@139.com
First Name & Middle Initial & Last Name & Degree
Meijin Huang, MD
First Name & Middle Initial & Last Name & Degree
Wei Chen, MD
Facility Name
JiangMen Central Hospital Affiliated JiangMen Hospital Of SUN YAT-SEN University
City
Jiangmen
State/Province
Guangdong
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Chao Li, BD
Phone
13902888981
Email
Lichao8981@163.com
First Name & Middle Initial & Last Name & Degree
Chao Li, BD
First Name & Middle Initial & Last Name & Degree
Wenchuan Jiang, MM
Facility Name
MeiZhou People's Hospital
City
Meizhou
State/Province
Guangdong
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zuguang Zuguang, MM
Phone
086-13502523063
Email
wuzg1913@163.com
First Name & Middle Initial & Last Name & Degree
Zuguang Zuguang, MM
First Name & Middle Initial & Last Name & Degree
Haijing Zeng, MM
Facility Name
Affiliated Shantou Hospital of Sun Yat-sen University
City
Shantou
State/Province
Guangdong
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xiaozhong Wang, MM
Phone
086-13809658922
Email
103776710@qq.com
First Name & Middle Initial & Last Name & Degree
Xiaozhong Wang, MM
First Name & Middle Initial & Last Name & Degree
Chufa Zheng, MM
Facility Name
Shenzhen Second People's Hospital
City
Shenzhen
State/Province
Guangdong
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Haitao Zhang, MM
Phone
13903025325
Email
www.13903025325.@163.com
First Name & Middle Initial & Last Name & Degree
Haitao Zhang, MM
First Name & Middle Initial & Last Name & Degree
Yuanzhi Tang, MM
Facility Name
Zhongshan City People's Hospital
City
Zhongshan
State/Province
Guangdong
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yao Wang, MD
Phone
18826006277
Email
tongjimc@126.com
First Name & Middle Initial & Last Name & Degree
Yao Wang, MD
First Name & Middle Initial & Last Name & Degree
Kai Li, MM
Facility Name
Zhuhai People's Hospital, Zhuhai hospital affiliated with Jinan University
City
Zhuhai
State/Province
Guangdong
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hui Liang, BD
Phone
086-13702760386
Email
zhlianghui@126.com
First Name & Middle Initial & Last Name & Degree
Hui Liang, BD
First Name & Middle Initial & Last Name & Degree
Yaoming Huang, MM
Facility Name
People's hospital of guangxi zhuang autonomous region
City
Nanning
State/Province
Guangxi Zhuang Autonomous Region
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Wei Mai, BS
Email
13977154858@139.com
First Name & Middle Initial & Last Name & Degree
Wei Mai, BS
First Name & Middle Initial & Last Name & Degree
Lei Li, MD
First Name & Middle Initial & Last Name & Degree
Xiaotong Wang, MD
Facility Name
The Affiliated Tumor Hospital of Guangxi Medical University
City
Nanning
State/Province
Guangxi Zhuang Autonomous Region
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jiansi Chen
First Name & Middle Initial & Last Name & Degree
Jiansi Chen
Facility Name
Hebei Medical University Fourth Hospital
City
Shijiazhuang
State/Province
Hebei
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bin Yu, MM
Phone
13832329699
Email
yubinli_68@163.com
First Name & Middle Initial & Last Name & Degree
Bin Yu, MM
First Name & Middle Initial & Last Name & Degree
Zhenya Zhang, MD
Facility Name
Union Hospital,Tongji Medical College, Huazhong Uninersity of Science and Technolgy
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
430030
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kaixiong Tao, MD
Phone
0086-135-0715-5452
Email
tao_kaixiong@163.com
First Name & Middle Initial & Last Name & Degree
Kaixiong Tao, MD
First Name & Middle Initial & Last Name & Degree
Chuanqing Wu, MD
Facility Name
Wuhan University Renmin Hospital
City
Wuhan
State/Province
Hubei
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yongbin Zheng, MD
Phone
086-13871189698
Email
13871189698@163.com
First Name & Middle Initial & Last Name & Degree
Yongbin Zheng, MD
First Name & Middle Initial & Last Name & Degree
Chao Yang, MD
Facility Name
Zhongnan Hospital of Wuhan University
City
Wuhan
State/Province
Hubei
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Congqing Jiang, MD
Phone
086-18971525805
Email
wb002554@whu.edu.cn
First Name & Middle Initial & Last Name & Degree
Congqing Jiang, MD
First Name & Middle Initial & Last Name & Degree
Qun Qian, MD
Facility Name
The Affiliated Hospital of Xuzhou Medical University
City
Xuzhou
State/Province
Jiangsu
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jun Song, MD
Phone
15105200058
First Name & Middle Initial & Last Name & Degree
Jun Song, MD
First Name & Middle Initial & Last Name & Degree
Haixiao Fu, MM
Facility Name
the First Affiliated Hospital of Nanchang University
City
Nanchang
State/Province
Jiangxi
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zhigang Jie, MD
Phone
086-13707918042
Email
jiezg123@126.com
First Name & Middle Initial & Last Name & Degree
Zhigang Jie, MD
First Name & Middle Initial & Last Name & Degree
Tao Xiao, MD
Facility Name
Fudan University Shanghai Cancer Center
City
Shanghai
State/Province
Shanghai
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Guoxiang Cai, MD
Phone
086-18017312703
Email
gxcai@fudan.edu.cn
First Name & Middle Initial & Last Name & Degree
Guoxiang Cai, MD
First Name & Middle Initial & Last Name & Degree
Renjie Wang, MD
Facility Name
West China Hospital，Sichuan University
City
Chendu
State/Province
Sichuan
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ziqiang Wang, MD
Phone
086-18980602028
Email
wangzqzyh@163.com
First Name & Middle Initial & Last Name & Degree
Ziqiang Wang, MD
First Name & Middle Initial & Last Name & Degree
Xiangbing Deng, MD
Facility Name
Sichuan Provincial People's Hospital
City
Chengdu
State/Province
Sichuan
ZIP/Postal Code
610072
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Minghui Pang, MD
Phone
0086-134-0282-1952
Email
pangmh2000@163.com
First Name & Middle Initial & Last Name & Degree
Minghui Pang, MD
Facility Name
The Third Peoples' Hospital of Chengdu
City
Chengdu
State/Province
Sichuan
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yanjun Liu, MD
Email
365184541@qq.com
First Name & Middle Initial & Last Name & Degree
Yanjun Liu, MD
First Name & Middle Initial & Last Name & Degree
Yuanchuan Zhang, MD
Facility Name
People'S Hospital of Deyang City
City
Deyang
State/Province
Sichuan
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gang Mai, MD
Phone
086-15283831000
Email
1026823581@qq.com
First Name & Middle Initial & Last Name & Degree
Gang Mai, MD
First Name & Middle Initial & Last Name & Degree
Zhen Liu, MD
Facility Name
Leshan people's Hospital
City
Leshan
State/Province
Sichuan
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jian Wang, BD
Phone
086-13808138498
Email
Wjls1963@sina.com
First Name & Middle Initial & Last Name & Degree
Jian Wang, BD
Facility Name
The Affiliated hospital of southwest medical university
City
Luzhou
State/Province
Sichuan
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Liang Xu, MM
Phone
086-13708289307
Email
XUL1104@163.com
First Name & Middle Initial & Last Name & Degree
Liang Xu, MM
First Name & Middle Initial & Last Name & Degree
Hui Yao, MD
Facility Name
The Second Affiliated Hospital，Zhejiang University School of Medicine
City
Hangzhou
State/Province
Zhejiang
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kefeng Ding, MD
Phone
086-13906504783
Email
dingkefeng@zju.edu.cn
First Name & Middle Initial & Last Name & Degree
Kefeng Ding, MD
First Name & Middle Initial & Last Name & Degree
Lifeng Sun, MD

12. IPD Sharing Statement

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Efficacy of HIPEC in Patients With Colorectal Cancer at High Risk of Peritoneal Carcinomatosis

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