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Egg Consumption and Muscular Adaptations

Primary Purpose

Hypertrophy

Status
Completed
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
Whole egg and resistance training
Egg whites and resistance training
Sponsored by
Alexei Wong
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional basic science trial for Hypertrophy

Eligibility Criteria

18 Years - 30 Years (Adult)MaleAccepts Healthy Volunteers

Inclusion Criteria:

  • performing resistance training at least three times a week for 1 year prior to the start of the study
  • not taking any dietary supplements or medications for at least 1 year prior to the start of the study
  • no known medical issues
  • no alcohol consumption or smoking for at least 1 year prior to the start of the study
  • no egg allergy/sensitivity.

Exclusion Criteria:

  • non-willingness to continue nutritional or exercise protocols
  • participation in exercise other than the prescribed resistance training program
  • consumption of dietary supplement (other than egg) during the study period
  • Missing more than one resistance training session or post-exercise egg consumption throughout the study period

Sites / Locations

  • Marymount University

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Experimental

Arm Label

Whole egg consumption

Egg whites consumption

Arm Description

This arm involved whole egg consumption concomitant with 12 weeks of resistance training. Subject ingested three whole eggs per day immediately after resistance training.

This arm involved egg white consumption concomitant with 12 weeks of resistance training. Subject ingested an isonitrogenous quantity of six egg whites per day immediately after resistance training.

Outcomes

Primary Outcome Measures

Circulatory Myokines levels
Fasting blood samples were collected from the antecubital vein using standard procedures and then analized to establish concentration of myostatin, follistatin, FGF-2, TGF-β1 and ACVA.
Circulatory hormone levels
Fasting blood samples were collected from the antecubital vein using standard procedures and then analized to establish concentrations of testosterone, IGF-1, insulin and cortisol
Muscle mass
Skeletal muscle mass will be evaluated using computed tomography
Body fatness
Body fat will be evaluated using bioelectrical impedance

Secondary Outcome Measures

Muscular Strength
Using 1 repetition maximum

Full Information

First Posted
May 1, 2020
Last Updated
May 5, 2020
Sponsor
Alexei Wong
Collaborators
Tehran University
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1. Study Identification

Unique Protocol Identification Number
NCT04381390
Brief Title
Egg Consumption and Muscular Adaptations
Official Title
Comparison of Whole Eggs vs. Egg Whites Consumption on Regulatory Myokines, Muscular Strength, Hypertrophy, Power and Body Composition.
Study Type
Interventional

2. Study Status

Record Verification Date
May 2020
Overall Recruitment Status
Completed
Study Start Date
September 10, 2018 (Actual)
Primary Completion Date
October 2, 2019 (Actual)
Study Completion Date
October 2, 2019 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor-Investigator
Name of the Sponsor
Alexei Wong
Collaborators
Tehran University

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
Eggs may be a viable alternative to various types of supplemental proteins given its similar ratings on various measures of dietary protein quality. The investigators hypothesis is that whole eggs would create a greater improvement in skeletal regulatory markers, hormonal responses and body composition than egg white ingestion in resistance-trained men.
Detailed Description
The aim of this investigation was to compare the effects of whole egg versus egg white ingestion (daily and after training sessions) during 12 weeks of resistance training on skeletal muscle regulatory markers, hormonal responses and body composition in resistance-trained men. Specific aims of the study are to: To investigate the extent to which both whole egg and egg white ingestion will improve anabolic factors, fat free mass, fat mass and decrease catabolic markers after 12 weeks of resistance training in resistance-trained men.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Hypertrophy

7. Study Design

Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
Investigator
Allocation
Randomized
Enrollment
30 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Whole egg consumption
Arm Type
Experimental
Arm Description
This arm involved whole egg consumption concomitant with 12 weeks of resistance training. Subject ingested three whole eggs per day immediately after resistance training.
Arm Title
Egg whites consumption
Arm Type
Experimental
Arm Description
This arm involved egg white consumption concomitant with 12 weeks of resistance training. Subject ingested an isonitrogenous quantity of six egg whites per day immediately after resistance training.
Intervention Type
Dietary Supplement
Intervention Name(s)
Whole egg and resistance training
Intervention Description
This intervention consisted of whole egg consumption concomitant with 12 weeks of resistance training. Subject ingested three whole eggs per day immediately after resistance training.
Intervention Type
Dietary Supplement
Intervention Name(s)
Egg whites and resistance training
Intervention Description
This intervention consisted of egg white consumption concomitant with 12 weeks of resistance training. Subject ingested an isonitrogenous quantity of six egg whites per day immediately after resistance training.
Primary Outcome Measure Information:
Title
Circulatory Myokines levels
Description
Fasting blood samples were collected from the antecubital vein using standard procedures and then analized to establish concentration of myostatin, follistatin, FGF-2, TGF-β1 and ACVA.
Time Frame
12 weeks
Title
Circulatory hormone levels
Description
Fasting blood samples were collected from the antecubital vein using standard procedures and then analized to establish concentrations of testosterone, IGF-1, insulin and cortisol
Time Frame
12 weeks
Title
Muscle mass
Description
Skeletal muscle mass will be evaluated using computed tomography
Time Frame
12 weeks
Title
Body fatness
Description
Body fat will be evaluated using bioelectrical impedance
Time Frame
12 weeks
Secondary Outcome Measure Information:
Title
Muscular Strength
Description
Using 1 repetition maximum
Time Frame
12 weeks

10. Eligibility

Sex
Male
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
30 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: performing resistance training at least three times a week for 1 year prior to the start of the study not taking any dietary supplements or medications for at least 1 year prior to the start of the study no known medical issues no alcohol consumption or smoking for at least 1 year prior to the start of the study no egg allergy/sensitivity. Exclusion Criteria: non-willingness to continue nutritional or exercise protocols participation in exercise other than the prescribed resistance training program consumption of dietary supplement (other than egg) during the study period Missing more than one resistance training session or post-exercise egg consumption throughout the study period
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Alexei Wong
Organizational Affiliation
Marymount University
Official's Role
Principal Investigator
Facility Information:
Facility Name
Marymount University
City
Arlington
State/Province
Virginia
ZIP/Postal Code
22207
Country
United States

12. IPD Sharing Statement

Plan to Share IPD
No
Citations:
PubMed Identifier
33306586
Citation
Bagheri R, Hooshmand Moghadam B, Ashtary-Larky D, Forbes SC, Candow DG, Galpin AJ, Eskandari M, Kreider RB, Wong A. Whole Egg Vs. Egg White Ingestion During 12 weeks of Resistance Training in Trained Young Males: A Randomized Controlled Trial. J Strength Cond Res. 2021 Feb 1;35(2):411-419. doi: 10.1519/JSC.0000000000003922.
Results Reference
derived

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Egg Consumption and Muscular Adaptations

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