International ALLIANCE Study of Therapies to Prevent Progression of COVID-19
COVID19
About this trial
This is an interventional treatment trial for COVID19 focused on measuring COVID19, hydroxychloroquine, azithromycin, zinc, Vit-D3, B12, C
Eligibility Criteria
Inclusion Criteria:
- Age ≥ 18 years
- Provision of informed consent in writing, can be electronic
- Diagnosis of active COVID-19
Exclusion Criteria:
- Known G6PD deficiency
- Contra-indication to hydroxychloroquine, azithromycin or Vitamin C: allergy to study interventions, epilepsy, serious hearing or visual problems, history of severe depression, calcium oxalate stones, advanced liver disease, pregnancy or lactating
- Already receiving chloroquine, azithromycin, >3 grams Vitamin C daily or an experimental antiviral
- History of fever (e.g. night sweats, chills) and/or acute respiratory infection (e.g. cough, shortness of breath, sore throat) of more than 7 days' duration. Note, if study numbers not quickly reached, the investigators may decide to include those with symptoms of longer than 7 days
- Calculated creatinine clearance of < 30 mL/minute
- Baseline ECG showing: QTc ≥470 for males, QTc ≥480 for females
- Receipt of a drug known to increase QTc: quetiapine, amiodarone, sotalol
Sites / Locations
- National Institute of Integrative MedicineRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Vitamin C
Control
Participants will receive vitamin C in addition to active comparator treatment: Inpatients: IV Vitamin C (Sodium Ascorbate) 50mg/kg every 6hrs on day 1 followed by 100mg/kg every 6hrs (4x per day; 400mg/kg/day) for 7 days (average 28g/day; maximum dose of 50g/24hrs for those weighing more than 125kg). Can be converted to 1 gram three times per day PO on hospital discharge) Outpatients: Vitamin C Outpatient trial: 200mg/kg x1 IV, then 1 gram PO three times per day for 7 days; Plus Active Comparator treatment: Hydroxychloroquine Hydroxychloroquine 400mg (2x200mg) PO for 1 day, followed by 200mg PO per day for 6 days Azithromycin 500 mg PO on day 1 followed by 250 mg PO once daily for 4 days Zinc Citrate 30mg elemental zinc PO daily Vitamin D3 5,000iu PO daily for 14 days Vitamin B12 (Methylcobalamin) 500mcg PO daily for 14 days
Hydroxychloroquine Hydroxychloroquine 400mg (2x200mg) PO for 1 day, followed by 200mg PO per day for 6 days Azithromycin 500 mg PO on day 1 followed by 250 mg PO once daily for 4 days Zinc Citrate 30mg elemental zinc PO daily Vitamin D3 5,000iu PO daily for 14 days Vitamin B12 (Methylcobalamin) 500mcg PO daily for 14 days