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Brentuximab Vedotin Plus Lenalidomide and Rituximab for the Treatment of Relapsed/Refractory DLBCL (ECHELON-3)

Primary Purpose

Diffuse Large B-cell Lymphoma

Status
Recruiting
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Brentuximab vedotin
Rituximab
Lenalidomide
Placebo
Sponsored by
Seagen Inc.
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Diffuse Large B-cell Lymphoma focused on measuring Seattle Genetics

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Participants with relapsed or refractory diffuse and transformed large B-cell lymphoma (R/R DLBCL). DLBCL and cell of origin (GCB versus non-GCB) will be histologically determined by local pathology assessment for the purposes of study eligibility and stratification.

  • Participants must have R/R disease following 2 or more lines of prior systemic therapy.

    • For participants with transformed DLBCL, at least the last systemic therapy used must have been for DLBCL

  • Participants must be HSCT or CAR-T ineligible according to the investigator and must meet at least one of the following criteria:

    1. One or more co-morbidities, including cardiac, pulmonary, renal or hepatic dysfunction that in the opinion of the Investigator make the participant medically unfit to received HSCT or CAR-T therapy
    2. Active disease following induction and salvage chemotherapy
    3. Inadequate stem cell mobilization (for HSCT)
    4. Relapse following prior HSCT or CAR-T
    5. Unable to receive CAR-T therapy due to financial, geographic, insurance, or manufacturing issues
  • Participants must have tumor tissue submitted to the central pathology lab. The tumor tissue submitted should be from the most recent biopsy that contains DLBCL.
  • An Eastern Cooperative Oncology Group (ECOG) performance status score of 0 to 2
  • Participants must have fluorodeoxyglucose (FDG)-avid disease by positron emission tomography (PET) and bidimensional measurable disease of at least 1.5 cm by computed tomography (CT), as assessed by the site radiologist within 28 days of Day 1.

Exclusion Criteria:

  • History of another malignancy within 2 years before the first dose of study drug or any evidence of residual disease from a previously diagnosed malignancy
  • History of progressive multifocal leukoencephalopathy (PML)
  • Active cerebral/meningeal disease related to the underlying malignancy. Participants with a history of cerebral/meningeal disease related to the underlying malignancy are allowed if prior CNS disease has been effectively treated and without progression for at least 3 months.
  • Any uncontrolled Grade 3 or higher (per NCI CTCAE version 5.0) viral, bacterial, or fungal infection within 2 weeks prior to the first dose of study drug. Routine antimicrobial prophylaxis is permitted
  • Chemotherapy, radiotherapy, biologics, and/or other antitumor treatment with immunotherapy that is not completed 3 weeks prior to first dose of study drug, unless underlying disease has progressed on treatment

  • Previous treatment with brentuximab vedotin or lenalidomide.

    • Previous treatment with other vedotin-based ADCs is permitted if the last dose is at least 6 months prior to Day 1.

  • Current therapy with immunosuppressive medications (including steroids), other systemic anti-neoplastic, or investigational agents

    a) Prednisone (or equivalent) ≤10 mg/day may be used for non-lymphomatous purposes

  • Documented history of a cerebral vascular event (stroke or transient ischemic attack), unstable angina, myocardial infarction, or cardiac symptoms consistent with New York Heart Association (NYHA) Class III-IV within 6 months prior to the first dose of study drugs
  • Congestive heart failure, Class III or IV, by the NYHA criteria
  • Grade 2 or higher peripheral sensory or motor neuropathy at baseline

Sites / Locations

  • Central Alabama ResearchRecruiting
  • Alabama Oncology
  • Arizona Oncology Associates, PC - NAHOA
  • The Oncology Institute of Hope & Innovation - California
  • University of California Davis
  • Lundquist Institute/Harbor-UCLA
  • Florida Cancer Specialists - South Region
  • Florida Cancer Specialists - North Region
  • Florida Cancer Specialists - East West Palm Beach, FL (SCRI)
  • Rush University Medical Center
  • Illinois Cancer Specialists
  • University of Maryland
  • Karmanos Cancer Institute / Wayne State University
  • Henry Ford Health System
  • Cancer and Hematology Centers of Western Michigan / Lemmen-Holton Cancer Pavilion
  • Ascension St John Hospital
  • Mayo Clinic Rochester
  • HCA Midwest Health Kansas City
  • Saint Louis University
  • Washington University in St LouisRecruiting
  • University of Nebraska Medical Center
  • MD Anderson Cancer Center at Cooper Health
  • Summit Medical Group
  • New York Cancer and Blood Specialists
  • Oncology Hematology CareRecruiting
  • University of Cincinnati Cancer Institute
  • Willamette Valley Cancer Institute and Research CenterRecruiting
  • Roper St. Francis HealthcareRecruiting
  • Medical University of South Carolina/Hollings Cancer Center
  • Saint Francis Hospital / Bon Secours - South Carolina
  • Prisma Health
  • University of Tennessee
  • Texas Oncology - Austin Midtown
  • Texas Oncology - San Antonio Medical Center
  • University of VirginiaRecruiting
  • Northwest Cancer Specialists, P.C.
  • Carbone Cancer Center / University of Wisconsin
  • Aurora Health Care, Inc
  • Royal Adelaide HospitalRecruiting
  • Central Coast Local Health District (Gosford and Wyong Hospitals)Recruiting
  • Royal Hobart HospitalRecruiting
  • Hollywood HaematologyRecruiting
  • Royal North Shore HospitalRecruiting
  • Ziekenhuis Netwerk Antwerpen Campus StuivenbergRecruiting
  • Universitair Ziekenhuis AntwerpenRecruiting
  • Universitair Ziekenhuis GentRecruiting
  • Hopital de JolimontRecruiting
  • Clinique Saint PierreRecruiting
  • AZ Delta - Campus WilgenstraatRecruiting
  • CHU UCL NamurRecruiting
  • H. Bliss Murphy Cancer Centre / Eastern Regional Health AuthorityRecruiting
  • Queen Elizabeth II Health Sciences CentreRecruiting
  • William Osler Health SciencesRecruiting
  • London Health Sciences Centre - Victoria HospitalRecruiting
  • Lakeridge Health - The R.S. McLaughlin Durham Regional Cancer Centre (MDRCC)Recruiting
  • University of Ottawa / Ottawa General HospitalRecruiting
  • CISSS de la Monteregie-CentreRecruiting
  • CIUSSS de L'Est de l'lle de Montreal / installation Hopital Maisonneuve-RosemontRecruiting
  • CIUSS NIM/Hopital du Sacre-Coeur de MontrealRecruiting
  • Fakultni nemocnice Hradec Kralove-oddeleni klinicke hematologieRecruiting
  • Fakultni Nemocnice Kralovske VinohradyRecruiting
  • Vseobecna fakultni nemocnice v PrazeRecruiting
  • Aalborg Universitetshospital
  • Aarhus University HospitalRecruiting
  • RigshospitaletRecruiting
  • Zealand University Hospital (Roskilde Sygehus)Recruiting
  • Center Hospitalier Universitaire d' AngersRecruiting
  • Centre de Lutte Contre le Cancer (CLCC) - Institut BergonieRecruiting
  • Centre Hospitalier Regional Universitaire (CHRU) Brest - Hopital Morvan
  • CHD Vendee, Site de La Roche-sur-Yon, Les Oudairies
  • Centre Hospitalier Metropole Savoie - ChamberyRecruiting
  • Centre Hospitalier Sud FrancilienRecruiting
  • Centre Hospitalier Universitaire (CHU) Dijon BourgogneRecruiting
  • Centre Hospitalier Universitaire de GrenobleRecruiting
  • Centre Hospitalier Le MansRecruiting
  • Centre Hospitalier Universitaire (CHU) De Limoges - Hopital DupuytrenRecruiting
  • Centre Leon Berard - Centre regional de lutte contre le cancer Rhone-AlpesRecruiting
  • Centre Hospitalier Regional Metz-Thionville, Hopital MercyRecruiting
  • Hopital Emile Muller
  • Centre Hospitalier Universitaire Nantes-Hotel Dieu
  • Centre de Lutte contre le Cancer (CLCC) - Centre Antoine LacassagneRecruiting
  • Centre Hospitalier de PerpignanRecruiting
  • CHU Bordeaux Hopital Haut-LevequeRecruiting
  • Centre Hospitalier Lyon SudRecruiting
  • Centre Henri Becquerel / Centre Regional de Lutte Contre le CancerRecruiting
  • Institut de Cancerologie Hematologie Universitaire de Saint Etienne (I.CHU.SE)Recruiting
  • Centre Hospitalier Universitaire de Nancy - Hopital de BraboisRecruiting
  • Institut Gustave RoussyRecruiting
  • CHU Tours - Hopital BretonneauRecruiting
  • Hopital Saint-AntoineRecruiting
  • Medizinische Klinik & Poliklinik III (Bonn)nUniversitätsklinikum Bonn
  • Stadtisches Klinikum Brandenburg GmbH
  • Universitaetsklinikum Dusseldorf
  • Universitaetsklinikum Halle (Saale)
  • Centro di Riferimento Oncologico di AvianoRecruiting
  • IRCCS Istituto Tumori Giovanni Paolo IIRecruiting
  • Azienda Ospedaliero-Universitaria di Bologna Policlinico S. Orsola-MalpighiRecruiting
  • Azienda Ospedaliero Universitaria Careggi
  • Azienda Ospedaliera Universitaria San MartinoRecruiting
  • Azienda Ospedaliera Cardinale Giovanni PanicoRecruiting
  • IRCCS Ospedale San RaffaeleRecruiting
  • Istituto Europeo di OncologiaRecruiting
  • Azienda Ospedaliera Universitaria (AOU) Federico IIRecruiting
  • AOOR Villa Sofia Cervello - Presidio V. CervelloRecruiting
  • Azienda Ospedaliero Universitaria di ParmaRecruiting
  • IRCSS Policlinico San MatteoRecruiting
  • Universita degli Studi di Perugia Azienda Ospedaliera di Perugia (Ospedale Santa Maria della Misericordia)Recruiting
  • UO Ematologia RavennaRecruiting
  • AUSL della Romagna Ospedale InfermiRecruiting
  • Policlinico Universitario Agostino GemelliRecruiting
  • IRCCS Ospedale Casa Sollievo della SofferenzaRecruiting
  • Azienda Sanitaria Universitaria Giuliano IsontinaRecruiting
  • Fondazione IRCCS Ca' Granda Ospedale Maggiore PoliclinicoRecruiting
  • Dong-A University HospitalRecruiting
  • Pusan National University Hospital
  • Kosin University Gospel Hospital
  • Inje University Busan-Paik HospitalRecruiting
  • Keimyung University Dongsan Medical CenterRecruiting
  • National Cancer CenterRecruiting
  • Gachon University Gil Medical CenterRecruiting
  • Jeonbuk National University HospitalRecruiting
  • Severance Hospital, Yonsei University Health SystemRecruiting
  • Soon Chun Hyang University Hospital SeoulRecruiting
  • Asan Medical Center - OncologyRecruiting
  • Samsung Medical Center
  • Seoul Saint Mary's HospitalRecruiting
  • St. Vincent's Hospital, The Catholic University of KoreaRecruiting
  • Slingeland ziekenhuisRecruiting
  • Pratia Onkologia Katowice
  • Pratia MCM KrakowRecruiting
  • Warmian-Masurian Cancer Center of The Ministry of The Interior and Administraton's HospitalRecruiting
  • Pratia PoznanRecruiting
  • Nasz Lekarz Osrodek Badan Klinicznych
  • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut BadawczyRecruiting
  • Hospital Universitari Germans Trias i PujolRecruiting
  • Hospital del MarRecruiting
  • Hospital Universitari Vall d'HebronRecruiting
  • Hospital de la Santa Creu i Sant PauRecruiting
  • Hospital San Pedro de AlcantaraRecruiting
  • Institut Catala d'Oncologia - Hospital Duran i Reynals (ICO L'Hospitalet)Recruiting
  • Clinica Universidad de NavarraRecruiting
  • Hospital Universitario Infanta Leonor
  • Hospital Puerta de Hierro MajadahondaRecruiting
  • Hospital Universitario Fundacion Jimenez DiazRecruiting
  • Hospital Universitario 12 de OctubreRecruiting
  • Hospital Universitario La PazRecruiting
  • Hospital Regional Universitario de Malaga - Hospital General
  • Hospital Costa del SolRecruiting
  • Hospital Universitario Central de AsturiasRecruiting
  • Clinica Universidad de NavarraRecruiting
  • Complejo Hospitalario de NavarraRecruiting
  • Hospital Universitario Quironsalud MadridRecruiting
  • Hospital Clínico Universitario de SalamancaRecruiting
  • Universitatsspital BaselRecruiting
  • Kantonsspital Winterthur (KSW)Recruiting
  • Universitatsspital ZurichRecruiting
  • Chang Gung Memorial Hospital - KaohsiungRecruiting
  • China Medical University Hospital
  • Chang Gung Memorial Hospital - TaoyuanRecruiting
  • National Cheng-Kung University HospitalRecruiting
  • Chi Mei Hospital Liouying
  • National Taiwan University HospitalRecruiting
  • Taipei Veterans General HospitalRecruiting
  • East Sussex Healthcare NHS Trust
  • University Hospitals Birmingham NHS Foundation TrustRecruiting
  • St Bartholomew's HospitalRecruiting
  • Guy's and St Thomas' NHS FoundationRecruiting
  • The Royal Marsden HospitalRecruiting
  • Maidstone and Tunbridge Wells NHS TrustRecruiting
  • The Royal Marsden Hospital (Surrey)Recruiting
  • Singleton HospitalRecruiting

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

Experimental Arm

Control Arm

Arm Description

Brentuximab vedotin + lenalidomide + rituximab

Placebo + lenalidomide + rituximab

Outcomes

Primary Outcome Measures

Overall survival (OS)
OS is defined as the time from the date of randomization to date of death due to any cause

Secondary Outcome Measures

Progression-free survival (PFS)
PFS is defined as the time from the date of randomization to the date of first documentation of progressive disease (PD) or death due to any cause, whichever occurs first. Assessment of PD will be performed by the investigator based on the Lugano Criteria for Response Assessment (Cheson 2014)
Objective response rate (ORR)
Proportion of participants with best response of complete response (CR) or partial response (PR) according to investigator assessment per the Lugano Criteria for Response Assessment (Cheson 2014).
Complete response (CR) rate
Proportion of participants with best response of CR according to investigator assessment per the Lugano Criteria for Response Assessment (Cheson 2014)
Duration of response (DOR)
Time from start of the first documentation of objective tumor response (CR or PR) to the first documentation of tumor progression by investigator assessment per the Lugano Criteria for Response Assessment (Cheson 2014) or death due to any cause, whichever occurs first.
Incidence of adverse events
Any untoward medical occurrence in a clinical investigational participant administered a medicinal product and which does not necessarily have a causal relationship with this treatment.
OS in CD30+ participants
Time from the date of randomization to date of death due to any cause.

Full Information

First Posted
May 21, 2020
Last Updated
October 23, 2023
Sponsor
Seagen Inc.
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1. Study Identification

Unique Protocol Identification Number
NCT04404283
Brief Title
Brentuximab Vedotin Plus Lenalidomide and Rituximab for the Treatment of Relapsed/Refractory DLBCL
Acronym
ECHELON-3
Official Title
A Randomized, Double-blind, Placebo-Controlled, Active-Comparator, Multicenter, Phase 3 Study of Brentuximab Vedotin or Placebo in Combination With Lenalidomide and Rituximab in Subjects With Relapsed or Refractory Diffuse Large B-cell Lymphoma (DLBCL)
Study Type
Interventional

2. Study Status

Record Verification Date
October 2023
Overall Recruitment Status
Recruiting
Study Start Date
August 20, 2020 (Actual)
Primary Completion Date
October 31, 2023 (Anticipated)
Study Completion Date
April 30, 2027 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Seagen Inc.

4. Oversight

Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
Participants in this study will have diffuse large B-cell lymphoma (DLBCL) that has come back or not gotten better with treatment. The trial will study whether brentuximab vedotin plus two drugs works better to treat this type of cancer than the two drugs alone. Participants will be randomly assigned to get either brentuximab vedotin or placebo. The placebo will look like brentuximab vedotin, but has no medicine in it. Since the study is "blinded," participants and their doctors will not know whether a participant gets brentuximab vedotin or placebo. All participants in the study will get rituximab and lenalidomide. These are drugs that can be used to treat DLBCL.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Diffuse Large B-cell Lymphoma
Keywords
Seattle Genetics

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigator
Allocation
Randomized
Enrollment
225 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Experimental Arm
Arm Type
Experimental
Arm Description
Brentuximab vedotin + lenalidomide + rituximab
Arm Title
Control Arm
Arm Type
Active Comparator
Arm Description
Placebo + lenalidomide + rituximab
Intervention Type
Drug
Intervention Name(s)
Brentuximab vedotin
Intervention Description
1.2 mg/kg administered into the vein (IV; intravenously) infusion every 3 weeks
Intervention Type
Drug
Intervention Name(s)
Rituximab
Intervention Description
375 mg/m^2 administered via intravenous infusion on Cycle 1 Day 1. 1400 mg injected under the skin (subcutaneous) permitted every 3 weeks from Cycle 2 Day 1 through end of treatment.
Intervention Type
Drug
Intervention Name(s)
Lenalidomide
Intervention Description
20 mg given by mouth (orally) daily
Intervention Type
Other
Intervention Name(s)
Placebo
Intervention Description
Administered via intravenous infusion every 3 weeks
Primary Outcome Measure Information:
Title
Overall survival (OS)
Description
OS is defined as the time from the date of randomization to date of death due to any cause
Time Frame
Approximately 2 years
Secondary Outcome Measure Information:
Title
Progression-free survival (PFS)
Description
PFS is defined as the time from the date of randomization to the date of first documentation of progressive disease (PD) or death due to any cause, whichever occurs first. Assessment of PD will be performed by the investigator based on the Lugano Criteria for Response Assessment (Cheson 2014)
Time Frame
Approximately 1 year
Title
Objective response rate (ORR)
Description
Proportion of participants with best response of complete response (CR) or partial response (PR) according to investigator assessment per the Lugano Criteria for Response Assessment (Cheson 2014).
Time Frame
Approximately 1 year
Title
Complete response (CR) rate
Description
Proportion of participants with best response of CR according to investigator assessment per the Lugano Criteria for Response Assessment (Cheson 2014)
Time Frame
Approximately 1 year
Title
Duration of response (DOR)
Description
Time from start of the first documentation of objective tumor response (CR or PR) to the first documentation of tumor progression by investigator assessment per the Lugano Criteria for Response Assessment (Cheson 2014) or death due to any cause, whichever occurs first.
Time Frame
Approximately 1 year
Title
Incidence of adverse events
Description
Any untoward medical occurrence in a clinical investigational participant administered a medicinal product and which does not necessarily have a causal relationship with this treatment.
Time Frame
Approximately 1 year
Title
OS in CD30+ participants
Description
Time from the date of randomization to date of death due to any cause.
Time Frame
Approximately 2 years

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Participants with relapsed or refractory diffuse and transformed large B-cell lymphoma (R/R DLBCL). DLBCL and cell of origin (GCB versus non-GCB) will be histologically determined by local pathology assessment for the purposes of study eligibility and stratification. Participants must have R/R disease following 2 or more lines of prior systemic therapy. For participants with transformed DLBCL, at least the last systemic therapy used must have been for DLBCL Participants must be HSCT or CAR-T ineligible according to the investigator and must meet at least one of the following criteria: One or more co-morbidities, including cardiac, pulmonary, renal or hepatic dysfunction that in the opinion of the Investigator make the participant medically unfit to received HSCT or CAR-T therapy Active disease following induction and salvage chemotherapy Inadequate stem cell mobilization (for HSCT) Relapse following prior HSCT or CAR-T Unable to receive CAR-T therapy due to financial, geographic, insurance, or manufacturing issues Participants must have tumor tissue submitted to the central pathology lab. The tumor tissue submitted should be from the most recent biopsy that contains DLBCL. An Eastern Cooperative Oncology Group (ECOG) performance status score of 0 to 2 Participants must have fluorodeoxyglucose (FDG)-avid disease by positron emission tomography (PET) and bidimensional measurable disease of at least 1.5 cm by computed tomography (CT), as assessed by the site radiologist within 28 days of Day 1. Exclusion Criteria: History of another malignancy within 2 years before the first dose of study drug or any evidence of residual disease from a previously diagnosed malignancy History of progressive multifocal leukoencephalopathy (PML) Active cerebral/meningeal disease related to the underlying malignancy. Participants with a history of cerebral/meningeal disease related to the underlying malignancy are allowed if prior CNS disease has been effectively treated and without progression for at least 3 months. Any uncontrolled Grade 3 or higher (per NCI CTCAE version 5.0) viral, bacterial, or fungal infection within 2 weeks prior to the first dose of study drug. Routine antimicrobial prophylaxis is permitted Chemotherapy, radiotherapy, biologics, and/or other antitumor treatment with immunotherapy that is not completed 3 weeks prior to first dose of study drug, unless underlying disease has progressed on treatment Previous treatment with brentuximab vedotin or lenalidomide. Previous treatment with other vedotin-based ADCs is permitted if the last dose is at least 6 months prior to Day 1. Current therapy with immunosuppressive medications (including steroids), other systemic anti-neoplastic, or investigational agents a) Prednisone (or equivalent) ≤10 mg/day may be used for non-lymphomatous purposes Documented history of a cerebral vascular event (stroke or transient ischemic attack), unstable angina, myocardial infarction, or cardiac symptoms consistent with New York Heart Association (NYHA) Class III-IV within 6 months prior to the first dose of study drugs Congestive heart failure, Class III or IV, by the NYHA criteria Grade 2 or higher peripheral sensory or motor neuropathy at baseline
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Seagen Trial Information Support
Phone
866-333-7436
Email
clinicaltrials@seagen.com
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Brandon Croft, PharmD
Organizational Affiliation
Seagen Inc.
Official's Role
Study Director
First Name & Middle Initial & Last Name & Degree
Evelyn Rustia, MD
Organizational Affiliation
Seagen Inc.
Official's Role
Study Director
Facility Information:
Facility Name
Central Alabama Research
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35209
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lorie Szymela
Phone
205-949-1907
Email
lszymela@centralalabamaresearch.com
First Name & Middle Initial & Last Name & Degree
Khaleel Ashraf
Facility Name
Alabama Oncology
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35223
Country
United States
Individual Site Status
Completed
Facility Name
Arizona Oncology Associates, PC - NAHOA
City
Goodyear
State/Province
Arizona
ZIP/Postal Code
85395
Country
United States
Individual Site Status
Completed
Facility Name
The Oncology Institute of Hope & Innovation - California
City
Riverside
State/Province
California
ZIP/Postal Code
92506
Country
United States
Individual Site Status
Completed
Facility Name
University of California Davis
City
Sacramento
State/Province
California
ZIP/Postal Code
95817
Country
United States
Individual Site Status
Completed
Facility Name
Lundquist Institute/Harbor-UCLA
City
Torrance
State/Province
California
ZIP/Postal Code
90502
Country
United States
Individual Site Status
Completed
Facility Name
Florida Cancer Specialists - South Region
City
Fort Myers
State/Province
Florida
ZIP/Postal Code
33901
Country
United States
Individual Site Status
Completed
Facility Name
Florida Cancer Specialists - North Region
City
Saint Petersburg
State/Province
Florida
ZIP/Postal Code
33705
Country
United States
Individual Site Status
Completed
Facility Name
Florida Cancer Specialists - East West Palm Beach, FL (SCRI)
City
West Palm Beach
State/Province
Florida
ZIP/Postal Code
33401
Country
United States
Individual Site Status
Completed
Facility Name
Rush University Medical Center
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Individual Site Status
Completed
Facility Name
Illinois Cancer Specialists
City
Niles
State/Province
Illinois
ZIP/Postal Code
60714
Country
United States
Individual Site Status
Completed
Facility Name
University of Maryland
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21201
Country
United States
Individual Site Status
Completed
Facility Name
Karmanos Cancer Institute / Wayne State University
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48201
Country
United States
Individual Site Status
Completed
Facility Name
Henry Ford Health System
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48202
Country
United States
Individual Site Status
Completed
Facility Name
Cancer and Hematology Centers of Western Michigan / Lemmen-Holton Cancer Pavilion
City
Grand Rapids
State/Province
Michigan
ZIP/Postal Code
49503
Country
United States
Individual Site Status
Completed
Facility Name
Ascension St John Hospital
City
Grosse Pointe Woods
State/Province
Michigan
ZIP/Postal Code
48236
Country
United States
Individual Site Status
Completed
Facility Name
Mayo Clinic Rochester
City
Rochester
State/Province
Minnesota
ZIP/Postal Code
55905
Country
United States
Individual Site Status
Completed
Facility Name
HCA Midwest Health Kansas City
City
Kansas City
State/Province
Missouri
ZIP/Postal Code
64132
Country
United States
Individual Site Status
Completed
Facility Name
Saint Louis University
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63103
Country
United States
Individual Site Status
Completed
Facility Name
Washington University in St Louis
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Molly Dubois
Phone
314-362-3515
Email
amalia@wustl.edu
First Name & Middle Initial & Last Name & Degree
Nancy Bartlett
Facility Name
University of Nebraska Medical Center
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68198-7680
Country
United States
Individual Site Status
Completed
Facility Name
MD Anderson Cancer Center at Cooper Health
City
Camden
State/Province
New Jersey
ZIP/Postal Code
08103
Country
United States
Individual Site Status
Completed
Facility Name
Summit Medical Group
City
Florham Park
State/Province
New Jersey
ZIP/Postal Code
07932
Country
United States
Individual Site Status
Completed
Facility Name
New York Cancer and Blood Specialists
City
Port Jefferson Station
State/Province
New York
ZIP/Postal Code
11776
Country
United States
Individual Site Status
Completed
Facility Name
Oncology Hematology Care
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45242
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Doug Hart
Phone
513-751-2273
Email
Douglas.Hart@usoncology.com
First Name & Middle Initial & Last Name & Degree
Ameet Patel
Facility Name
University of Cincinnati Cancer Institute
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45267
Country
United States
Individual Site Status
Completed
Facility Name
Willamette Valley Cancer Institute and Research Center
City
Eugene
State/Province
Oregon
ZIP/Postal Code
97401
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jeanne Schaffer
Phone
541-741-3451
Email
jeanne.schaffer@usoncology.com
First Name & Middle Initial & Last Name & Degree
Christopher A Yasenchak
Facility Name
Roper St. Francis Healthcare
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29414
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mishelle Beercheck
Phone
843-724-2053
Email
mishelle.beercheck@rsfh.com
First Name & Middle Initial & Last Name & Degree
James Orcutt
Facility Name
Medical University of South Carolina/Hollings Cancer Center
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29425
Country
United States
Individual Site Status
Completed
Facility Name
Saint Francis Hospital / Bon Secours - South Carolina
City
Greenville
State/Province
South Carolina
ZIP/Postal Code
29601
Country
United States
Individual Site Status
Completed
Facility Name
Prisma Health
City
Greenville
State/Province
South Carolina
ZIP/Postal Code
29615
Country
United States
Individual Site Status
Completed
Facility Name
University of Tennessee
City
Knoxville
State/Province
Tennessee
ZIP/Postal Code
37920
Country
United States
Individual Site Status
Completed
Facility Name
Texas Oncology - Austin Midtown
City
Austin
State/Province
Texas
ZIP/Postal Code
78731
Country
United States
Individual Site Status
Completed
Facility Name
Texas Oncology - San Antonio Medical Center
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78240
Country
United States
Individual Site Status
Completed
Facility Name
University of Virginia
City
Charlottesville
State/Province
Virginia
ZIP/Postal Code
22903
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Erica Stallard
Phone
434-243-2649
Email
ELG9R@hscmail.mcc.virginia.edu
First Name & Middle Initial & Last Name & Degree
Craig Portell
Facility Name
Northwest Cancer Specialists, P.C.
City
Vancouver
State/Province
Washington
ZIP/Postal Code
98684
Country
United States
Individual Site Status
Completed
Facility Name
Carbone Cancer Center / University of Wisconsin
City
Madison
State/Province
Wisconsin
ZIP/Postal Code
53792
Country
United States
Individual Site Status
Completed
Facility Name
Aurora Health Care, Inc
City
Wauwatosa
State/Province
Wisconsin
ZIP/Postal Code
53226
Country
United States
Individual Site Status
Completed
Facility Name
Royal Adelaide Hospital
City
Adelaide
State/Province
Other
ZIP/Postal Code
5000
Country
Australia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Uwe Hahn, MD
Facility Name
Central Coast Local Health District (Gosford and Wyong Hospitals)
City
Gosford
State/Province
Other
ZIP/Postal Code
2250
Country
Australia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Cecily Forsyth, MD
Facility Name
Royal Hobart Hospital
City
Hobart
State/Province
Other
ZIP/Postal Code
7000
Country
Australia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sonali Sadawarte
Facility Name
Hollywood Haematology
City
Nedlands
State/Province
Other
ZIP/Postal Code
6009
Country
Australia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Chan Cheah, MD
Facility Name
Royal North Shore Hospital
City
Saint Leonards
State/Province
Other
ZIP/Postal Code
2065
Country
Australia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Luke Coyle, MD
Facility Name
Ziekenhuis Netwerk Antwerpen Campus Stuivenberg
City
Antwerpen
State/Province
Other
ZIP/Postal Code
2060
Country
Belgium
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
KaLung Wu, MD
Facility Name
Universitair Ziekenhuis Antwerpen
City
Edegem
State/Province
Other
ZIP/Postal Code
2650
Country
Belgium
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kirsten Saevels
Facility Name
Universitair Ziekenhuis Gent
City
Gent
State/Province
Other
ZIP/Postal Code
9000
Country
Belgium
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fritz Offner, MD
Facility Name
Hopital de Jolimont
City
La Louvière
State/Province
Other
ZIP/Postal Code
7100
Country
Belgium
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marie Christine Ngirabacu, MD
Facility Name
Clinique Saint Pierre
City
Ottignies
State/Province
Other
ZIP/Postal Code
1340
Country
Belgium
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Thierry Connerotte
Facility Name
AZ Delta - Campus Wilgenstraat
City
Roeselare
State/Province
Other
ZIP/Postal Code
8800
Country
Belgium
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dries Deeren
Facility Name
CHU UCL Namur
City
Yvoir
State/Province
Other
ZIP/Postal Code
5530
Country
Belgium
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marc Andre, MD
Facility Name
H. Bliss Murphy Cancer Centre / Eastern Regional Health Authority
City
St John's
State/Province
Newfoundland and Labrador
ZIP/Postal Code
A1B 3V6
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Neal Manning
Facility Name
Queen Elizabeth II Health Sciences Centre
City
Halifax
State/Province
Nova Scotia
ZIP/Postal Code
B3H 2Y9
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nick Forward
Facility Name
William Osler Health Sciences
City
East Brampton
State/Province
Ontario
ZIP/Postal Code
L6R 3J7
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Philip Kuruvilla
Facility Name
London Health Sciences Centre - Victoria Hospital
City
London
State/Province
Ontario
ZIP/Postal Code
N6A 5W9
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Selay Lam, MD
Facility Name
Lakeridge Health - The R.S. McLaughlin Durham Regional Cancer Centre (MDRCC)
City
Oshawa
State/Province
Ontario
ZIP/Postal Code
L1G 2B9
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Anthony Naassan
Facility Name
University of Ottawa / Ottawa General Hospital
City
Ottawa
State/Province
Ontario
ZIP/Postal Code
K1H 8L6
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David MacDonald
Facility Name
CISSS de la Monteregie-Centre
City
Greenfield Park
State/Province
Quebec
ZIP/Postal Code
J4V 2H1
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Melina Boutin
Facility Name
CIUSSS de L'Est de l'lle de Montreal / installation Hopital Maisonneuve-Rosemont
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H1T 2M4
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Isabelle Fleury, MD
Facility Name
CIUSS NIM/Hopital du Sacre-Coeur de Montreal
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H4J 1C5
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ines Chamakhi
Facility Name
Fakultni nemocnice Hradec Kralove-oddeleni klinicke hematologie
City
Hradec Kralove
State/Province
Other
ZIP/Postal Code
500 05
Country
Czechia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Belada
Facility Name
Fakultni Nemocnice Kralovske Vinohrady
City
Praha 10
State/Province
Other
ZIP/Postal Code
100 34
Country
Czechia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Heidi Mocikova
Facility Name
Vseobecna fakultni nemocnice v Praze
City
Praha 2
State/Province
Other
ZIP/Postal Code
128 08
Country
Czechia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marek Trneny
Facility Name
Aalborg Universitetshospital
City
Aalborg
State/Province
Other
ZIP/Postal Code
DK-9000
Country
Denmark
Individual Site Status
Completed
Facility Name
Aarhus University Hospital
City
Aarhus N
State/Province
Other
ZIP/Postal Code
8200
Country
Denmark
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Judit Meszaros Joergensen
Facility Name
Rigshospitalet
City
Copenhagen
State/Province
Other
ZIP/Postal Code
2100
Country
Denmark
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Anne Ortved Gang, MD
Facility Name
Zealand University Hospital (Roskilde Sygehus)
City
Roskilde
State/Province
Other
ZIP/Postal Code
4000
Country
Denmark
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Christian Bjorn Poulsen
Facility Name
Center Hospitalier Universitaire d' Angers
City
Angers Cedex 9
State/Province
Other
ZIP/Postal Code
49933
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jerome Paillassa, MD
Facility Name
Centre de Lutte Contre le Cancer (CLCC) - Institut Bergonie
City
Bordeaux
State/Province
Other
ZIP/Postal Code
33000
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fontanet Bijou
Facility Name
Centre Hospitalier Regional Universitaire (CHRU) Brest - Hopital Morvan
City
Brest Cedex
State/Province
Other
ZIP/Postal Code
29609
Country
France
Individual Site Status
Completed
Facility Name
CHD Vendee, Site de La Roche-sur-Yon, Les Oudairies
City
Cedex 9
State/Province
Other
ZIP/Postal Code
85925
Country
France
Individual Site Status
Completed
Facility Name
Centre Hospitalier Metropole Savoie - Chambery
City
Chambery
State/Province
Other
ZIP/Postal Code
73000
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gian Pica
Facility Name
Centre Hospitalier Sud Francilien
City
Corbeil-Essonnes
State/Province
Other
ZIP/Postal Code
91100
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bertrand Joly
Facility Name
Centre Hospitalier Universitaire (CHU) Dijon Bourgogne
City
Dijon
State/Province
Other
ZIP/Postal Code
21000
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Olivier Casasnovas, MD
Facility Name
Centre Hospitalier Universitaire de Grenoble
City
Grenoble
State/Province
Other
ZIP/Postal Code
38043 CEDEX 9
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lysiane Molina
Facility Name
Centre Hospitalier Le Mans
City
Le Mans
State/Province
Other
ZIP/Postal Code
72000
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kamel Laribi
Facility Name
Centre Hospitalier Universitaire (CHU) De Limoges - Hopital Dupuytren
City
Limoges Cedex
State/Province
Other
ZIP/Postal Code
87042
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Julie Abraham
Facility Name
Centre Leon Berard - Centre regional de lutte contre le cancer Rhone-Alpes
City
Lyon
State/Province
Other
ZIP/Postal Code
69373
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Laure Lebras, DM
Facility Name
Centre Hospitalier Regional Metz-Thionville, Hopital Mercy
City
Metz
State/Province
Other
ZIP/Postal Code
57085
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Philippe Carassou
Facility Name
Hopital Emile Muller
City
Mulhouse
State/Province
Other
ZIP/Postal Code
68100
Country
France
Individual Site Status
Completed
Facility Name
Centre Hospitalier Universitaire Nantes-Hotel Dieu
City
Nantes cedex 1
State/Province
Other
ZIP/Postal Code
44093
Country
France
Individual Site Status
Completed
Facility Name
Centre de Lutte contre le Cancer (CLCC) - Centre Antoine Lacassagne
City
Nice Cedex 2
State/Province
Other
ZIP/Postal Code
06189
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Frederic Peyrade, MD
Facility Name
Centre Hospitalier de Perpignan
City
Perpignan CEDEX
State/Province
Other
ZIP/Postal Code
66000
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Caroline Serrier, MD
Facility Name
CHU Bordeaux Hopital Haut-Leveque
City
Pessac Cedex
State/Province
Other
ZIP/Postal Code
33600
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kamal Krimo Bouabdallah
Facility Name
Centre Hospitalier Lyon Sud
City
Pierre-Benite Cedex
State/Province
Other
ZIP/Postal Code
69495
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Herve Ghesquieres, MD
Facility Name
Centre Henri Becquerel / Centre Regional de Lutte Contre le Cancer
City
Rouen
State/Province
Other
ZIP/Postal Code
76038
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Vincent Camus
Facility Name
Institut de Cancerologie Hematologie Universitaire de Saint Etienne (I.CHU.SE)
City
Saint Etienne Cedex 2
State/Province
Other
ZIP/Postal Code
42055
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ludovic Fouillet, MD
Facility Name
Centre Hospitalier Universitaire de Nancy - Hopital de Brabois
City
Vandoeuvre-Les-Nancy Cedex 9
State/Province
Other
ZIP/Postal Code
54511
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pierre Feugier
Facility Name
Institut Gustave Roussy
City
Villejuif Cedex
State/Province
Other
ZIP/Postal Code
94805
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Vincent Ribrag
Facility Name
CHU Tours - Hopital Bretonneau
City
Paris
ZIP/Postal Code
75012
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Laurianne Drieu La Rochelle
Facility Name
Hopital Saint-Antoine
City
Paris
ZIP/Postal Code
75012
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Remy Dulery, MD
Facility Name
Medizinische Klinik & Poliklinik III (Bonn)nUniversitätsklinikum Bonn
City
Bonn
State/Province
Other
ZIP/Postal Code
53127
Country
Germany
Individual Site Status
Completed
Facility Name
Stadtisches Klinikum Brandenburg GmbH
City
Brandenburg
State/Province
Other
ZIP/Postal Code
14770
Country
Germany
Individual Site Status
Completed
Facility Name
Universitaetsklinikum Dusseldorf
City
Duesseldorf
State/Province
Other
ZIP/Postal Code
40225
Country
Germany
Individual Site Status
Completed
Facility Name
Universitaetsklinikum Halle (Saale)
City
Halle (S.)
State/Province
Other
ZIP/Postal Code
06120
Country
Germany
Individual Site Status
Completed
Facility Name
Centro di Riferimento Oncologico di Aviano
City
Aviano (Pordenone)
State/Province
Other
ZIP/Postal Code
33081
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Michele Spina
Facility Name
IRCCS Istituto Tumori Giovanni Paolo II
City
Bari
State/Province
Other
ZIP/Postal Code
70124
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Attilio Guarini, MD
Facility Name
Azienda Ospedaliero-Universitaria di Bologna Policlinico S. Orsola-Malpighi
City
Bologna
State/Province
Other
ZIP/Postal Code
40138
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pier Luigi Zinzani
Facility Name
Azienda Ospedaliero Universitaria Careggi
City
Firenze
State/Province
Other
ZIP/Postal Code
50134
Country
Italy
Individual Site Status
Completed
Facility Name
Azienda Ospedaliera Universitaria San Martino
City
Genova
State/Province
Other
ZIP/Postal Code
16132
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Emanuele Angelucci
Facility Name
Azienda Ospedaliera Cardinale Giovanni Panico
City
Lecce
State/Province
Other
ZIP/Postal Code
73039
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Vincenzo Pavone
Facility Name
IRCCS Ospedale San Raffaele
City
Milano
State/Province
Other
ZIP/Postal Code
20132
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Andres Jose Maria Ferreri
Facility Name
Istituto Europeo di Oncologia
City
Milano
State/Province
Other
ZIP/Postal Code
20132
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Enrico Derenzini, MD
Facility Name
Azienda Ospedaliera Universitaria (AOU) Federico II
City
Napoli
State/Province
Other
ZIP/Postal Code
80131
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fabrizio Pane
Facility Name
AOOR Villa Sofia Cervello - Presidio V. Cervello
City
Palermo
State/Province
Other
ZIP/Postal Code
90146
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Caterina Patti
Facility Name
Azienda Ospedaliero Universitaria di Parma
City
Parma
State/Province
Other
ZIP/Postal Code
43126
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Caterina Plenteda, MD
Facility Name
IRCSS Policlinico San Matteo
City
Pavia
State/Province
Other
ZIP/Postal Code
27100
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Luca Arcaini
Facility Name
Universita degli Studi di Perugia Azienda Ospedaliera di Perugia (Ospedale Santa Maria della Misericordia)
City
Perugia
State/Province
Other
ZIP/Postal Code
06100
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Leonardo Flenghi
Facility Name
UO Ematologia Ravenna
City
Ravenna
State/Province
Other
ZIP/Postal Code
48121
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Monica Tani
Facility Name
AUSL della Romagna Ospedale Infermi
City
Rimini
State/Province
Other
ZIP/Postal Code
47923
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Anna Merli, MD
Facility Name
Policlinico Universitario Agostino Gemelli
City
Roma
State/Province
Other
ZIP/Postal Code
00168
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Stefan Hohaus, MD
Facility Name
IRCCS Ospedale Casa Sollievo della Sofferenza
City
San Giovanni Rotondo (Foggia)
State/Province
Other
ZIP/Postal Code
71013
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Potito Rosario Scalzulli
Facility Name
Azienda Sanitaria Universitaria Giuliano Isontina
City
Trieste
State/Province
Other
ZIP/Postal Code
34125
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Francesco Zaja, MD
Facility Name
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
City
Milano
ZIP/Postal Code
20122
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Francesca Gaia Rossi
Facility Name
Dong-A University Hospital
City
Busan
State/Province
Other
ZIP/Postal Code
49201
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sung Yong Oh
Facility Name
Pusan National University Hospital
City
Busan
State/Province
Other
ZIP/Postal Code
49241
Country
Korea, Republic of
Individual Site Status
Completed
Facility Name
Kosin University Gospel Hospital
City
Busan
State/Province
Other
ZIP/Postal Code
49267
Country
Korea, Republic of
Individual Site Status
Completed
Facility Name
Inje University Busan-Paik Hospital
City
Busan
State/Province
Other
ZIP/Postal Code
614-735
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Won Sik Lee, MD
Facility Name
Keimyung University Dongsan Medical Center
City
Daegu
State/Province
Other
ZIP/Postal Code
42601
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Young Rok Do
Facility Name
National Cancer Center
City
Goyang-si
State/Province
Other
ZIP/Postal Code
410-769
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
HyeonSeok Eom, MD
Facility Name
Gachon University Gil Medical Center
City
Incheon
State/Province
Other
ZIP/Postal Code
21565
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jin-Hee Jinny Park
Facility Name
Jeonbuk National University Hospital
City
Jeonju-Si
State/Province
Other
ZIP/Postal Code
561-712
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jae-Yong Kwak
Facility Name
Severance Hospital, Yonsei University Health System
City
Seoul
State/Province
Other
ZIP/Postal Code
03722
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jin Seok Kim, MD
Facility Name
Soon Chun Hyang University Hospital Seoul
City
Seoul
State/Province
Other
ZIP/Postal Code
04401
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jong-Ho Won, MD
Facility Name
Asan Medical Center - Oncology
City
Seoul
State/Province
Other
ZIP/Postal Code
05505
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hyungwoo Cho
Facility Name
Samsung Medical Center
City
Seoul
State/Province
Other
ZIP/Postal Code
06351
Country
Korea, Republic of
Individual Site Status
Completed
Facility Name
Seoul Saint Mary's Hospital
City
Seoul
State/Province
Other
ZIP/Postal Code
137-040
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Seok-Goo Cho
Facility Name
St. Vincent's Hospital, The Catholic University of Korea
City
Suwon-si
State/Province
Other
ZIP/Postal Code
16247
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jeong A Kim, MD
Facility Name
Slingeland ziekenhuis
City
Doetinchem
State/Province
Other
ZIP/Postal Code
7009 BL
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nail Aboosy
Facility Name
Pratia Onkologia Katowice
City
Katowice
State/Province
Other
ZIP/Postal Code
40-519
Country
Poland
Individual Site Status
Completed
Facility Name
Pratia MCM Krakow
City
Krakow
State/Province
Other
ZIP/Postal Code
30-727
Country
Poland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Wojciech Jurczak
Facility Name
Warmian-Masurian Cancer Center of The Ministry of The Interior and Administraton's Hospital
City
Olsztyn
State/Province
Other
ZIP/Postal Code
10-228
Country
Poland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Janusz Halka
Facility Name
Pratia Poznan
City
Skorzewo
State/Province
Other
ZIP/Postal Code
60185
Country
Poland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Michal Kwiatek
Facility Name
Nasz Lekarz Osrodek Badan Klinicznych
City
Torun
State/Province
Other
ZIP/Postal Code
87-100
Country
Poland
Individual Site Status
Completed
Facility Name
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy
City
Warsaw
State/Province
Other
ZIP/Postal Code
02-781
Country
Poland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jan Walewski
Facility Name
Hospital Universitari Germans Trias i Pujol
City
Badalona
State/Province
Other
ZIP/Postal Code
08916
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Juan Manuel Sancho
Facility Name
Hospital del Mar
City
Barcelona
State/Province
Other
ZIP/Postal Code
08003
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Blanca Sanchez Gonzalez, MD
Facility Name
Hospital Universitari Vall d'Hebron
City
Barcelona
State/Province
Other
ZIP/Postal Code
08035
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pablo Abrisqueta Costa
Facility Name
Hospital de la Santa Creu i Sant Pau
City
Barcelona
State/Province
Other
ZIP/Postal Code
08041
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Javier Briones
Facility Name
Hospital San Pedro de Alcantara
City
Caceres
State/Province
Other
ZIP/Postal Code
10005
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Juan Miguel Bergua
Facility Name
Institut Catala d'Oncologia - Hospital Duran i Reynals (ICO L'Hospitalet)
City
L'Hospitalet de Llobregat
State/Province
Other
ZIP/Postal Code
08908
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Eva Gonzalez Barca
Facility Name
Clinica Universidad de Navarra
City
Madrid
State/Province
Other
ZIP/Postal Code
28027
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Miguel Angel Canales
Facility Name
Hospital Universitario Infanta Leonor
City
Madrid
State/Province
Other
ZIP/Postal Code
28031
Country
Spain
Individual Site Status
Completed
Facility Name
Hospital Puerta de Hierro Majadahonda
City
Madrid
State/Province
Other
ZIP/Postal Code
28036
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mariano Provencio Pulla
Facility Name
Hospital Universitario Fundacion Jimenez Diaz
City
Madrid
State/Province
Other
ZIP/Postal Code
28040
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Raul Cordoba Mascunano, MD
Facility Name
Hospital Universitario 12 de Octubre
City
Madrid
State/Province
Other
ZIP/Postal Code
28041
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tycho Stephan Baumann, MD
Facility Name
Hospital Universitario La Paz
City
Madrid
State/Province
Other
ZIP/Postal Code
28046
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Victor Jimenez Yuste
Facility Name
Hospital Regional Universitario de Malaga - Hospital General
City
Malaga
State/Province
Other
ZIP/Postal Code
29010
Country
Spain
Individual Site Status
Completed
Facility Name
Hospital Costa del Sol
City
Marbella
State/Province
Other
ZIP/Postal Code
29603
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Maria Casanova
Facility Name
Hospital Universitario Central de Asturias
City
Oviedo
State/Province
Other
ZIP/Postal Code
33011
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Angel Ramirez Payer
Facility Name
Clinica Universidad de Navarra
City
Pamplona
State/Province
Other
ZIP/Postal Code
31008
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Miguel Angel Canales
Facility Name
Complejo Hospitalario de Navarra
City
Pamplona
State/Province
Other
ZIP/Postal Code
31008
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jose Maria Arguinano
Facility Name
Hospital Universitario Quironsalud Madrid
City
Pozuelo de Alarcon
State/Province
Other
ZIP/Postal Code
28223
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Carmen Martinez Chamorro, MD
Facility Name
Hospital Clínico Universitario de Salamanca
City
Salamanca
State/Province
Other
ZIP/Postal Code
37007
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alejandro Martin Garcia Sancho
Facility Name
Universitatsspital Basel
City
Basel
State/Province
Other
ZIP/Postal Code
4031
Country
Switzerland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Frank Stenner
Facility Name
Kantonsspital Winterthur (KSW)
City
Winterthur
State/Province
Other
ZIP/Postal Code
8401
Country
Switzerland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Natalie Fischer
Facility Name
Universitatsspital Zurich
City
Zurich
State/Province
Other
ZIP/Postal Code
8091
Country
Switzerland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Thorsten Zenz
Facility Name
Chang Gung Memorial Hospital - Kaohsiung
City
Kaohsiung
State/Province
Other
ZIP/Postal Code
83301
Country
Taiwan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ming Chung Wang
Facility Name
China Medical University Hospital
City
Taichung
State/Province
Other
ZIP/Postal Code
404
Country
Taiwan
Individual Site Status
Completed
Facility Name
Chang Gung Memorial Hospital - Taoyuan
City
Tainan
State/Province
Other
ZIP/Postal Code
704
Country
Taiwan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hung Chang
Facility Name
National Cheng-Kung University Hospital
City
Tainan
State/Province
Other
ZIP/Postal Code
704
Country
Taiwan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tsai-Yun Chen
Facility Name
Chi Mei Hospital Liouying
City
Tainan
State/Province
Other
ZIP/Postal Code
73657
Country
Taiwan
Individual Site Status
Completed
Facility Name
National Taiwan University Hospital
City
Taipei
State/Province
Other
ZIP/Postal Code
10002
Country
Taiwan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tai-Chung Huang, MD
Facility Name
Taipei Veterans General Hospital
City
Taipei
State/Province
Other
ZIP/Postal Code
11217
Country
Taiwan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hao-Yuan Wang, MD
Facility Name
East Sussex Healthcare NHS Trust
City
Eastbourne
State/Province
Other
ZIP/Postal Code
BN21 2UD
Country
United Kingdom
Individual Site Status
Completed
Facility Name
University Hospitals Birmingham NHS Foundation Trust
City
Edgbaston, Birmingham
State/Province
Other
ZIP/Postal Code
B15 2TH
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Burns
Facility Name
St Bartholomew's Hospital
City
London
State/Province
Other
ZIP/Postal Code
EC1A 7BE
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
John Gribben
Facility Name
Guy's and St Thomas' NHS Foundation
City
London
State/Province
Other
ZIP/Postal Code
SE1 9RT
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mary Gleeson
Facility Name
The Royal Marsden Hospital
City
London
State/Province
Other
ZIP/Postal Code
SW3 6JJ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Cunningham
Facility Name
Maidstone and Tunbridge Wells NHS Trust
City
Maidstone
State/Province
Other
ZIP/Postal Code
ME16 9QQ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lalita Banerjee
Facility Name
The Royal Marsden Hospital (Surrey)
City
Sutton
State/Province
Other
ZIP/Postal Code
SM2 5PT
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Cunningham
Facility Name
Singleton Hospital
City
Swansea
State/Province
Other
ZIP/Postal Code
SA2 8QA
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Unmesh Mohite

12. IPD Sharing Statement

Citations:
PubMed Identifier
34780623
Citation
Ward JP, Berrien-Elliott MM, Gomez F, Luo J, Becker-Hapak M, Cashen AF, Wagner-Johnston ND, Maddocks K, Mosior M, Foster M, Krysiak K, Schmidt A, Skidmore ZL, Desai S, Watkins MP, Fischer A, Griffith M, Griffith OL, Fehniger TA, Bartlett NL. Phase 1/dose expansion trial of brentuximab vedotin and lenalidomide in relapsed or refractory diffuse large B-cell lymphoma. Blood. 2022 Mar 31;139(13):1999-2010. doi: 10.1182/blood.2021011894.
Results Reference
derived

Learn more about this trial

Brentuximab Vedotin Plus Lenalidomide and Rituximab for the Treatment of Relapsed/Refractory DLBCL

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