Social Cognition in Patients With Amyotrophic Lateral Sclerosis (COSISLA)

Amyotrophic Lateral Sclerosis, also known as Charcot disease, is a neurodegenerative disease evidenced by gradual paralysis of the muscles involved in voluntary motor function. The clinical hallmark of Amyotrophic Lateral Sclerosis is the combination of upper and lower motor neuron signs and symptoms. The most recent studies suggest that up to 50% of Amyotrophic Lateral Sclerosis patients demonstrate mild to moderate cognitive disturbance. Impaired social cognition, including a deficit in the recognition of facial emotions and the identification of vocal prosody, is recognized as a part of the cognitive phenotype of Amyotrophic Lateral Sclerosis, with crucial implications for patients' and caregivers' training. However, studies remain scarce and the data acquired must be supported. The evolution of these manifestations during the disease is still poorly understood. In this study the investigators aim to assess the social cognition capacities of patients with Amyotrophic Lateral Sclerosis compared to healthy matched control subjects.

Evaluate the social cognition capacities of patients with Amyotrophic Lateral Sclerosis compared to control subjects using dynamic social cognition tests : Movie for the Assessment of Social Cognition. The maximum score is 48 points. The higher the score for correct answers, the better the performance.

Inclusion Criteria: Patient Amyotrophic Lateral Sclerosis : Education of at least 7 years Native language: French Patients Amyotrophic Lateral Sclerosis Signature of informed consent to participate in the study Accompanied patient Control subject : People without any pathology Education of at least 7 years Native language: French Signature of informed consent to participate in the study Exclusion Criteria: Patient Amyotrophic Lateral Sclerosis and control subject : Simultaneous participation in another interventional protocol with experimental treatment Inability to perform cognitive study tests Pregnant, lactating or parturient women Persons deprived of their liberty by administrative or judicial decision Persons under psychiatric care under duress Persons subject to legal protection measures Persons out of state to express their consent People not affiliated or not beneficiaries of a social security scheme History likely to disturb cognition