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Study to Gather Information on Safety and Use of High Dose Aflibercept Injection Into the Eye in Patients With an Age Related Eye Disorder That Causes Blurred Vision or a Blind Spot Due to Abnormal Blood Vessels That Leak Fluid Into the Light Sensitive Lining Inside the Eye (PULSAR)

Primary Purpose

Neovascular Age-Related Macular Degeneration

Status
Active
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Aflibercept High Dose VEGF Trap-Eye (BAY86-5321)
Aflibercept VEGF Trap-Eye (Eylea, BAY86-5321)
Sponsored by
Bayer
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Neovascular Age-Related Macular Degeneration focused on measuring nAMD

Eligibility Criteria

50 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Active subfoveal CNV secondary to nAMD, including juxtafoveal lesions that affect the fovea as assessed in the study eye.
  • Total area of CNV (including both classic and occult components) must comprise greater than 50% of the total lesion area in the study eye.
  • BCVA ETDRS letter score of 78 to 24 (corresponding to a Snellen equivalent of approximately 20/32 to 20/320) in the study eye.
  • Decrease in BCVA determined to be primarily the result of nAMD in the study eye.
  • Presence of IRF and/or SRF affecting the central subfield of the study eye on OCT.
  • Contraceptive use by men or women should be consistent with local regulations regarding the methods of highly effective contraception for those participating in clinical studies.
  • Other protocol-specified inclusion criteria.

Exclusion Criteria:

  • Causes of CNV other than nAMD in the study eye.
  • Scar, fibrosis, or atrophy involving the central subfield in the study eye.
  • Presence of retinal pigment epithelial tears or rips involving the central subfield in the study eye.
  • Uncontrolled glaucoma (defined as IOP >25 mmHg despite treatment with anti-glaucoma medication) in the study eye.
  • History of idiopathic or autoimmune uveitis in the study eye.
  • Myopia of a spherical equivalent of at least 8 diopters in the study eye prior to any refractive or cataract surgery.
  • History or clinical evidence of diabetic retinopathy, diabetic macular edema, or any retinal vascular disease other than nAMD in either eye.
  • Evidence of extraocular or periocular infection or inflammation (including infectious blepharitis, keratitis, scleritis, or conjunctivitis) in either eye at the time of screening/randomization.
  • Uncontrolled blood pressure (defined as systolic >160 mmHg or diastolic >95 mmHg).
  • Any prior or concomitant ocular (in the study eye) or systemic treatment (with an investigational or approved, anti-VEGF or other agent) or surgery for nAMD, except dietary supplements or vitamins.
  • Other protocol-specified exclusion criteria

Sites / Locations

  • Arizona Retina and Vitreous Consultants - Research
  • Retina Consultants of Orange County
  • University of California San Diego
  • Northern California Retina-Vitreous Associates
  • California Eye Specialists
  • Retina Consultants San Diego
  • Retina Consultants of Southern California
  • Kaiser Permanente Riverside Medical Center
  • Retina Consultants of Southern Colorado, PC
  • New England Retina Associates
  • Rand Eye Institute
  • Retina Group of Florida
  • Vitreo-Retinal Associates
  • Florida Retina Institute
  • Florida Eye Associates
  • Retina Macula Specialists of Miami
  • Florida Retina Institute
  • Retina Specialists
  • Retina Vitreous Associates of Florida - Saint Petersburg
  • Southern Vitreoretinal Associates
  • Retina Consultants of Hawaii
  • Retina Associates IL
  • University Retina and Macula Associates
  • Wolfe Eye Clinic, PC
  • Retina Care Center
  • Ophthalmic Consultants of Boston
  • Vitreo Retinal Surgery PA
  • Retina Consultants of Nevada
  • Retina Center of New Jersey
  • NJ Retina
  • Eye Associates of New Mexico
  • Long Island Vitreoretinal Consultants
  • Long Island Vitreoretinal Consultants
  • Ophthalmic Consultants of Long Island
  • Ophthalmic Consultants of the Capital Region
  • Wake Forest Baptist Health
  • Midwest Retina - Main Office
  • Retina Northwest, PC
  • Retina Consultants, LLC
  • Mid Atlantic Retina
  • Erie Retinal Surgery, Inc.
  • Eye Care Specialists
  • Charleston Neuroscience Center
  • Palmetto Retina Center, LLC
  • Black Hills Regional Eye Institute
  • Charles Retina Institute
  • Vanderbilt University Medical School
  • Austin Retina Associates
  • Texas Retina Associates
  • Medical Center Ophthalmology Associates
  • Retinal Consultants of Texas - San Antonio
  • Retina Consultants of Houston
  • Retina Consultants of Texas - The Woodlands
  • Fletcher Allen Health Care
  • Spokane Eye Clinical Research
  • West Virginia University
  • University of Wisconsin - Madison
  • Organizacion Medica de Investigacion (OMI)
  • OFTALMOS, Instituto Oftalmologico de Alta Complejidad
  • Eyeclinic Albury Wodonga
  • Sydney Retina Clinic
  • Westmead Hospital
  • Hobart Eye Surgeons
  • Marsden Eye Surgery Center
  • Klinikum Klagenfurt am Wörthersee
  • Kepler Universitätsklinikum Campus III
  • Konventhospital Barmherzige Brüder Linz
  • Medizinische Universität Graz
  • Hanusch-Krankenhaus Wien
  • SEHAT Pentagram
  • Spec. Hosp. for Active Treatment for Eye Diseases Zrenie
  • UMHAT Alexandrovska EAD
  • Multiprofile Hospital for Active Treatment Sveta Sofia
  • Specialized Hospital For Active Treatment of Eye Diseases Zora
  • Sveta Petka Eye Hospital
  • St.Joseph's Health Care-London
  • Toronto Retina Institute
  • Institut de l'Oeil des Laurentides
  • The Second Hospital of Anhui medical university
  • The 1st Affiliated Hospital Fujian Medical University
  • Guangzhou Aier Eye Hospital
  • Shijiazhuang General Hospital
  • Hebei Eye Hospital
  • Henan Provincial Ophthalmology Hospital (Henan Eye Institute
  • Tongji Hosp. of Tongji Med Coll, Huazhong Uni of Sci & Tech.
  • Union Hospt Tongji Medical Colleg. Huazhong univ. Scien&Tech
  • The First People's Hospital of Xuzhou
  • Jiangxi Provincial People's Hospital
  • The First Affiliated Hospital of NanChang University
  • Eye Center of the second Bethune Hospital, jinlin University
  • Tonghua Central Hospital
  • Shenyang He Eye Hospital
  • The People's Hospital of Ningxia Hui Autonomous Region
  • The First Affiliated Hospital of Xi'an Jiaotong University
  • Aier Eye Hospital (Chengdu)
  • The First Affiliated Hospital of Xinjiang Medical University
  • The 1st Affiliated Hospital of Zhejiang University
  • ZheJiang Provincial People's Hospital
  • The Affiliated Eye Hospital of Wenzhou Medical College
  • Beijing Tongren Hospital, Capital Medical University (East)
  • Beijing Aier Intech Eye Hospital Co. LTD - Ophthalmology
  • Peking University People's Hospital
  • Beijing Hospital
  • Chongqing Aier Ophthalmology Hospital
  • Shanghai Tongji Hospital of Tongji University
  • Shanghai General Hospital
  • Tianjin Medical University General Hospital
  • Tianjin Medical University Eye Hospital
  • TianJin eye hospital
  • Fakultni Nemocnice Hradec Kralove
  • Fakultni nemocnice Ostrava
  • Fakultni nemocnice Plzen - Lochotin
  • Charles University in Prague
  • Fakultni nemocnice Kralovske Vinohrady
  • Lexum a.s., Evropska ocni klinika
  • AXON Clinical s.r.o.
  • East Tallinn Central Hospital
  • Tartu University Hospital
  • Centre d'Ophtalmologie - Paradis-Monticelli
  • Hôpital Lariboisière - Paris
  • Centre ophtalmologique Saint-Exupéry
  • LTD "Clinic LJ"
  • JSC "Evex Hospitals'
  • LTD "Innova"
  • LTD "Chichua Medical Center MZERA"
  • Budapest Retina Associates
  • Szent-Gyorgyi Albert Orvostudomanyi Egyetem
  • Rambam Health Corporation
  • Lady Davis Carmel Medical Center
  • Hadassah Hebrew University Hospital Ein Kerem
  • Meir Medical Center
  • Chaim Sheba Medical Center
  • Kaplan Medical Center
  • Assuta Medical Centers - HaShalom
  • Fondazione PTV Policlinico Tor Vergata
  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS
  • IRCCS Fondazione G.B. Bietti Studio e Ricerca in Otalmologia
  • Ospedale San Raffaele s.r.l.
  • ASST Fatebenefratelli Sacco
  • A.O.U. di Cagliari
  • A.O. di Perugia
  • Daiyukai Daiichi Hospital
  • Aichi Medical University Hospital
  • Nagoya University Hospital
  • Nagoya City University Hospital
  • Kokura Memorial Hospital
  • Kurume University Hospital
  • Southern Tohoku Eye Clinic
  • Gunma University Hospital
  • Sapporo City General Hospital
  • KKR Sapporo Medical Center
  • Hyogo Prefectural Amagasaki General Medical Center
  • Kobe University Hospital
  • Kozawa Eye Hospital and Diabetes Center
  • Kanazawa Medical University Hospital
  • Kanazawa University Hospital
  • Kagawa University Hospital
  • Medical corporation Eiwakai Dannoue Ophthalmology clinic
  • St. Marianna University Hospital
  • Otakeganka Tsukimino Clinic
  • Mie University Hospital
  • Shinshu University Hospital
  • Nara Medical University Hospital
  • Oita University Hospital
  • Kurashiki Medical Center
  • University of the Ryukyus Hospital
  • Kansai Medical University Hospital
  • Kansai Medical University Medical Center
  • Kindai University Hospital
  • The University of Tokyo Hospital
  • St.Luke's International Hospital
  • Nishikasai Inouye Eye Hospital
  • Tokyo Medical University Hachioji Medical Center
  • Tokiwadai Muranaka Eye Clinic
  • National Hospital Organization Tokyo Medical Center
  • Keio University Hospital
  • Tokyo Women's Medical University Hospital
  • Yamaguchi University Hospital
  • University of Yamanashi Hospital
  • Akita University Hospital
  • Hayashi Eye Hospital
  • Fukushima Medical University Hospital
  • Hiroshima University Hospital
  • University of Miyazaki Hospital
  • Japanese Red Cross Nagasaki Genbaku Hospital
  • Okayama University Hospital
  • Japanese Red Cross Saitama Hospital
  • Tokushima University Hospital
  • Japanese Red Cross Wakayama Medical center
  • Yamagata University Hospital
  • Seoul National University Bundang Hospital
  • Pusan National University Hospital
  • Inje University Haeundae Paik Hospital
  • Seoul National University Hospital
  • Asan Medical Center
  • Samsung Medical Center
  • Retina Center Nune Eye Hospital
  • Department of Ophthalmology
  • Riga East Clinical University Hospital "Gailezers"
  • Latvian American Eye Center
  • Hospital of LT University of Health Sciences Kaunas Clinics
  • PI Klaipedos University Hospital
  • Vilnius University Hospital Santaros Klinikos
  • ALM Oftalmolaser - Oftalmologia Medica e Cirurgica
  • AIBILI
  • Espaco Medico de Coimbra
  • Centro Hospitalar Universitario do Porto
  • Centro Hospitalar Vila Nova de Gaia/Espinho | Unit 1 - Clinical Research Office
  • Scientific Research Institution of Ophthalmic Diseases
  • FBSI IRTC Eye Microsurgery n.a. acad. S.N. Fyodorov
  • Clinical Center of Serbia
  • Clinical hospital center Zvezdara
  • Klinicki centar Vojvodine
  • National University Hospital
  • Singapore National Eye Centre
  • Fakultna nemocnica Nitra
  • Nemocnica s Poliklinikou Trebisov, Svet zdravia a.s.
  • Fakultna nemocnica Trencin
  • Fakultna nemocnica s poliklinikou Zilina
  • Instituto Oftalmológico Francisco Gomez Ulla
  • Hospital Clínic i Provincial de Barcelona
  • Hospital de la Santa Creu i Sant Pau | Gynecology Department
  • Hospital Reina Sofía
  • Hospital General Universitario de Valencia
  • Hospital Universitari i Politècnic La Fe
  • Hospital Miguel Servet
  • RétinElysée
  • Berner Augenklinik am Lindenhofspital
  • Stadtspital Triemli
  • Shin Kong Wu Ho-Su Memorial Hospital
  • Taipei Veterans General Hospital
  • Chang Gung Memorial Hospital at Linkou
  • Private enterprise private production company " Acinus"
  • Centralna Polyclinica MVS Ukraiiny
  • Poltava Regional Clinical Hospital n.a. M.V. Skliphosovskyi

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Active Comparator

Experimental

Experimental

Arm Label

Aflibercept 2q8

Aflibercept HDq12

Aflibercept HDq16

Arm Description

In the double-masked study part (Years 1 and 2), Aflibercept 2 mg administered every 8 weeks after a loading phase. (Active Comparator) In Year 3, high dose aflibercept administered according to individual patient response. (Experimental)

Aflibercept high dose (HD) administered every 12 weeks after an initiation phase. Treatment intervals adjusted according to individual patient response.

Aflibercept high dose administered every 16 weeks after an initiation phase. Treatment intervals adjusted according to individual patient response.

Outcomes

Primary Outcome Measures

Change From Baseline in BCVA Measured by the ETDRS Letter Score at Week 48
Visual function of the study eye was assessed at a distance of 4 meters using the Early Treatment Diabetic Retinopathy Study (ETDRS) Best Corrected Visual Acuity (BCVA) letter score. BCVA scale range is 0 (worst) to 100 (best).

Secondary Outcome Measures

Change From Baseline in BCVA Measured by the ETDRS Letter Score at Week 60
Percentage of Participants With no Intraretinal Fluid (IRF) and no Subretinal Fluid (SRF) in Central Subfield at Week 16
Percentage of Participants Gaining at Least 15 Letters in BCVA From Baseline at Week 48
Percentage of Participants Achieving an ETDRS Letter Score of at Least 69 (Approximate 20/40 Snellen Equivalent) at Week 48
Change in Choroidal Neovascularization (CNV) Size From Baseline to Week 48
Change in Total Lesion Area From Baseline to Week 48
Percentage of Participants With no Intraretinal Fluid (IRF) and no Subretinal Fluid (SRF) in the Center Subfield at Week 48
Change From Baseline in Central Subfield Retinal Thickness (CST) at Week 48
Change From Baseline in National Eye Institute Visual Functioning Questionnaire-25 (NEI-VFQ-25) Total Score at Week 48
NEI VFQ-25 was a 25-item questionnaire that gave a score on a scale from 0 (worst) to 100 (best = no vision problems)
Number of Participants With Treatment-emergent Adverse Events (TEAEs) and Serious AEs (SAEs)
Systemic Exposure to Aflibercept as Assessed by Plasma Concentrations of Free, Adjusted Bound and Total Aflibercept From Baseline Through Week 48
Assessment of Immunogenicity to Aflibercept by Measuring the Incidence of Treatment-emergent Anti-drug Antibodies (ADA) Response Through End of Masked Study

Full Information

First Posted
June 8, 2020
Last Updated
October 12, 2023
Sponsor
Bayer
Collaborators
Regeneron Pharmaceuticals
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1. Study Identification

Unique Protocol Identification Number
NCT04423718
Brief Title
Study to Gather Information on Safety and Use of High Dose Aflibercept Injection Into the Eye in Patients With an Age Related Eye Disorder That Causes Blurred Vision or a Blind Spot Due to Abnormal Blood Vessels That Leak Fluid Into the Light Sensitive Lining Inside the Eye
Acronym
PULSAR
Official Title
Randomized, Double-Masked, Active-Controlled, Phase 3 Study of the Efficacy and Safety of High Dose Aflibercept in Patients With Neovascular Age-Related Macular Degeneration
Study Type
Interventional

2. Study Status

Record Verification Date
October 2023
Overall Recruitment Status
Active, not recruiting
Study Start Date
August 11, 2020 (Actual)
Primary Completion Date
July 18, 2022 (Actual)
Study Completion Date
August 12, 2024 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Bayer
Collaborators
Regeneron Pharmaceuticals

4. Oversight

Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Product Manufactured in and Exported from the U.S.
Yes
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
In this study researchers want to learn more about changes in visual acuity (clarity of vision) with a high dose treatment with Aflibercept (Eylea) in patients suffering from neovascular age-related macular degeneration (nAMD). Neovascular AMD is an eye disease that causes blurred vision or a blind spot due to abnormal blood vessels that leak fluid or blood into the light sensitive lining inside the eye (retina). The fluid buildup causes the central part of the retina (macula) responsible for sharp, straight-ahead vision to swell and thicken (edema), which distorts vision.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Neovascular Age-Related Macular Degeneration
Keywords
nAMD

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Masking Description
Up to Week 108: Participant and Investigator masked. Week 108 to Week 156: Participant and Investigator unmasked to treatment intervals.
Allocation
Randomized
Enrollment
1011 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Aflibercept 2q8
Arm Type
Active Comparator
Arm Description
In the double-masked study part (Years 1 and 2), Aflibercept 2 mg administered every 8 weeks after a loading phase. (Active Comparator) In Year 3, high dose aflibercept administered according to individual patient response. (Experimental)
Arm Title
Aflibercept HDq12
Arm Type
Experimental
Arm Description
Aflibercept high dose (HD) administered every 12 weeks after an initiation phase. Treatment intervals adjusted according to individual patient response.
Arm Title
Aflibercept HDq16
Arm Type
Experimental
Arm Description
Aflibercept high dose administered every 16 weeks after an initiation phase. Treatment intervals adjusted according to individual patient response.
Intervention Type
Drug
Intervention Name(s)
Aflibercept High Dose VEGF Trap-Eye (BAY86-5321)
Intervention Description
Solution in Vial, intravitreal (IVT) injection
Intervention Type
Drug
Intervention Name(s)
Aflibercept VEGF Trap-Eye (Eylea, BAY86-5321)
Intervention Description
Solution in Vial, 2 mg, intravitreal (IVT) injection
Primary Outcome Measure Information:
Title
Change From Baseline in BCVA Measured by the ETDRS Letter Score at Week 48
Description
Visual function of the study eye was assessed at a distance of 4 meters using the Early Treatment Diabetic Retinopathy Study (ETDRS) Best Corrected Visual Acuity (BCVA) letter score. BCVA scale range is 0 (worst) to 100 (best).
Time Frame
At baseline and Week 48
Secondary Outcome Measure Information:
Title
Change From Baseline in BCVA Measured by the ETDRS Letter Score at Week 60
Time Frame
At baseline and Week 60
Title
Percentage of Participants With no Intraretinal Fluid (IRF) and no Subretinal Fluid (SRF) in Central Subfield at Week 16
Time Frame
At Week 16
Title
Percentage of Participants Gaining at Least 15 Letters in BCVA From Baseline at Week 48
Time Frame
At baseline and Week 48
Title
Percentage of Participants Achieving an ETDRS Letter Score of at Least 69 (Approximate 20/40 Snellen Equivalent) at Week 48
Time Frame
At Week 48
Title
Change in Choroidal Neovascularization (CNV) Size From Baseline to Week 48
Time Frame
At baseline and Week 48
Title
Change in Total Lesion Area From Baseline to Week 48
Time Frame
At baseline and Week 48
Title
Percentage of Participants With no Intraretinal Fluid (IRF) and no Subretinal Fluid (SRF) in the Center Subfield at Week 48
Time Frame
At Week 48
Title
Change From Baseline in Central Subfield Retinal Thickness (CST) at Week 48
Time Frame
At baseline and Week 48
Title
Change From Baseline in National Eye Institute Visual Functioning Questionnaire-25 (NEI-VFQ-25) Total Score at Week 48
Description
NEI VFQ-25 was a 25-item questionnaire that gave a score on a scale from 0 (worst) to 100 (best = no vision problems)
Time Frame
At baseline and Week 48
Title
Number of Participants With Treatment-emergent Adverse Events (TEAEs) and Serious AEs (SAEs)
Time Frame
Up to 156 weeks
Title
Systemic Exposure to Aflibercept as Assessed by Plasma Concentrations of Free, Adjusted Bound and Total Aflibercept From Baseline Through Week 48
Time Frame
Up to Week 48
Title
Assessment of Immunogenicity to Aflibercept by Measuring the Incidence of Treatment-emergent Anti-drug Antibodies (ADA) Response Through End of Masked Study
Time Frame
Up to week 96

10. Eligibility

Sex
All
Minimum Age & Unit of Time
50 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Active subfoveal CNV secondary to nAMD, including juxtafoveal lesions that affect the fovea as assessed in the study eye. Total area of CNV (including both classic and occult components) must comprise greater than 50% of the total lesion area in the study eye. BCVA ETDRS letter score of 78 to 24 (corresponding to a Snellen equivalent of approximately 20/32 to 20/320) in the study eye. Decrease in BCVA determined to be primarily the result of nAMD in the study eye. Presence of IRF and/or SRF affecting the central subfield of the study eye on OCT. Contraceptive use by men or women should be consistent with local regulations regarding the methods of highly effective contraception for those participating in clinical studies. Other protocol-specified inclusion criteria. Additional inclusion criteria for Year 3: At least one BCVA value and one central subfield retinal thickness (CST) value from measurements at one of the following visits: Visit 24 (Week 84), Visit 25 (Week 88) or Visit 26 (Week 92). Participant is enrolled at a site that participates in the extension period. Exclusion Criteria: Causes of CNV other than nAMD in the study eye. Scar, fibrosis, or atrophy involving the central subfield in the study eye. Presence of retinal pigment epithelial tears or rips involving the central subfield in the study eye. Uncontrolled glaucoma (defined as IOP >25 mmHg despite treatment with anti-glaucoma medication) in the study eye. History of idiopathic or autoimmune uveitis in the study eye. Myopia of a spherical equivalent of at least 8 diopters in the study eye prior to any refractive or cataract surgery. History or clinical evidence of diabetic retinopathy, diabetic macular edema, or any retinal vascular disease other than nAMD in either eye. Evidence of extraocular or periocular infection or inflammation (including infectious blepharitis, keratitis, scleritis, or conjunctivitis) in either eye at the time of screening/randomization. Uncontrolled blood pressure (defined as systolic >160 mmHg or diastolic >95 mmHg). Any prior or concomitant ocular (in the study eye) or systemic treatment (with an investigational or approved, anti-VEGF or other agent) or surgery for nAMD, except dietary supplements or vitamins. Other protocol-specified exclusion criteria
Facility Information:
Facility Name
Arizona Retina and Vitreous Consultants - Research
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85021
Country
United States
Facility Name
Retina Consultants of Orange County
City
Fullerton
State/Province
California
ZIP/Postal Code
92835
Country
United States
Facility Name
University of California San Diego
City
La Jolla
State/Province
California
ZIP/Postal Code
92093-0698
Country
United States
Facility Name
Northern California Retina-Vitreous Associates
City
Mountain View
State/Province
California
ZIP/Postal Code
94040
Country
United States
Facility Name
California Eye Specialists
City
Pasadena
State/Province
California
ZIP/Postal Code
91107
Country
United States
Facility Name
Retina Consultants San Diego
City
Poway
State/Province
California
ZIP/Postal Code
92064-2526
Country
United States
Facility Name
Retina Consultants of Southern California
City
Redlands
State/Province
California
ZIP/Postal Code
92374
Country
United States
Facility Name
Kaiser Permanente Riverside Medical Center
City
Riverside
State/Province
California
ZIP/Postal Code
92505
Country
United States
Facility Name
Retina Consultants of Southern Colorado, PC
City
Colorado Springs
State/Province
Colorado
ZIP/Postal Code
80909
Country
United States
Facility Name
New England Retina Associates
City
New London
State/Province
Connecticut
ZIP/Postal Code
06320
Country
United States
Facility Name
Rand Eye Institute
City
Deerfield Beach
State/Province
Florida
ZIP/Postal Code
33064
Country
United States
Facility Name
Retina Group of Florida
City
Fort Lauderdale
State/Province
Florida
ZIP/Postal Code
33308
Country
United States
Facility Name
Vitreo-Retinal Associates
City
Gainesville
State/Province
Florida
ZIP/Postal Code
32607
Country
United States
Facility Name
Florida Retina Institute
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32204
Country
United States
Facility Name
Florida Eye Associates
City
Melbourne
State/Province
Florida
ZIP/Postal Code
32901
Country
United States
Facility Name
Retina Macula Specialists of Miami
City
Miami
State/Province
Florida
ZIP/Postal Code
33126
Country
United States
Facility Name
Florida Retina Institute
City
Orlando
State/Province
Florida
ZIP/Postal Code
32806
Country
United States
Facility Name
Retina Specialists
City
Pensacola
State/Province
Florida
ZIP/Postal Code
32503
Country
United States
Facility Name
Retina Vitreous Associates of Florida - Saint Petersburg
City
Saint Petersburg
State/Province
Florida
ZIP/Postal Code
33711-1141
Country
United States
Facility Name
Southern Vitreoretinal Associates
City
Tallahassee
State/Province
Florida
ZIP/Postal Code
32308
Country
United States
Facility Name
Retina Consultants of Hawaii
City
'Aiea
State/Province
Hawaii
ZIP/Postal Code
96701
Country
United States
Facility Name
Retina Associates IL
City
Elmhurst
State/Province
Illinois
ZIP/Postal Code
60126
Country
United States
Facility Name
University Retina and Macula Associates
City
Oak Forest
State/Province
Illinois
ZIP/Postal Code
60452
Country
United States
Facility Name
Wolfe Eye Clinic, PC
City
West Des Moines
State/Province
Iowa
ZIP/Postal Code
50266
Country
United States
Facility Name
Retina Care Center
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21209
Country
United States
Facility Name
Ophthalmic Consultants of Boston
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02114
Country
United States
Facility Name
Vitreo Retinal Surgery PA
City
Edina
State/Province
Minnesota
ZIP/Postal Code
55435
Country
United States
Facility Name
Retina Consultants of Nevada
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89144
Country
United States
Facility Name
Retina Center of New Jersey
City
Bloomfield
State/Province
New Jersey
ZIP/Postal Code
07003
Country
United States
Facility Name
NJ Retina
City
Edison
State/Province
New Jersey
ZIP/Postal Code
08820
Country
United States
Facility Name
Eye Associates of New Mexico
City
Albuquerque
State/Province
New Mexico
ZIP/Postal Code
87109-5853
Country
United States
Facility Name
Long Island Vitreoretinal Consultants
City
Great Neck
State/Province
New York
ZIP/Postal Code
11021
Country
United States
Facility Name
Long Island Vitreoretinal Consultants
City
Hauppauge
State/Province
New York
ZIP/Postal Code
11788
Country
United States
Facility Name
Ophthalmic Consultants of Long Island
City
Lynbrook
State/Province
New York
ZIP/Postal Code
11563
Country
United States
Facility Name
Ophthalmic Consultants of the Capital Region
City
Troy
State/Province
New York
ZIP/Postal Code
12180
Country
United States
Facility Name
Wake Forest Baptist Health
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27157-1082
Country
United States
Facility Name
Midwest Retina - Main Office
City
Dublin
State/Province
Ohio
ZIP/Postal Code
43016
Country
United States
Facility Name
Retina Northwest, PC
City
Portland
State/Province
Oregon
ZIP/Postal Code
97210
Country
United States
Facility Name
Retina Consultants, LLC
City
Salem
State/Province
Oregon
ZIP/Postal Code
97302-2152
Country
United States
Facility Name
Mid Atlantic Retina
City
Bethlehem
State/Province
Pennsylvania
ZIP/Postal Code
18017
Country
United States
Facility Name
Erie Retinal Surgery, Inc.
City
Erie
State/Province
Pennsylvania
ZIP/Postal Code
16507
Country
United States
Facility Name
Eye Care Specialists
City
Kingston
State/Province
Pennsylvania
ZIP/Postal Code
18704
Country
United States
Facility Name
Charleston Neuroscience Center
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29414
Country
United States
Facility Name
Palmetto Retina Center, LLC
City
West Columbia
State/Province
South Carolina
ZIP/Postal Code
29169
Country
United States
Facility Name
Black Hills Regional Eye Institute
City
Rapid City
State/Province
South Dakota
ZIP/Postal Code
57701-7374
Country
United States
Facility Name
Charles Retina Institute
City
Memphis
State/Province
Tennessee
ZIP/Postal Code
38119
Country
United States
Facility Name
Vanderbilt University Medical School
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37232
Country
United States
Facility Name
Austin Retina Associates
City
Austin
State/Province
Texas
ZIP/Postal Code
78705
Country
United States
Facility Name
Texas Retina Associates
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76104
Country
United States
Facility Name
Medical Center Ophthalmology Associates
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78240
Country
United States
Facility Name
Retinal Consultants of Texas - San Antonio
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78240
Country
United States
Facility Name
Retina Consultants of Houston
City
The Woodlands
State/Province
Texas
ZIP/Postal Code
77384
Country
United States
Facility Name
Retina Consultants of Texas - The Woodlands
City
The Woodlands
State/Province
Texas
ZIP/Postal Code
77384
Country
United States
Facility Name
Fletcher Allen Health Care
City
Burlington
State/Province
Vermont
ZIP/Postal Code
05401-1420
Country
United States
Facility Name
Spokane Eye Clinical Research
City
Spokane
State/Province
Washington
ZIP/Postal Code
99204
Country
United States
Facility Name
West Virginia University
City
Morgantown
State/Province
West Virginia
ZIP/Postal Code
26506
Country
United States
Facility Name
University of Wisconsin - Madison
City
Madison
State/Province
Wisconsin
ZIP/Postal Code
53792
Country
United States
Facility Name
Organizacion Medica de Investigacion (OMI)
City
Buenos Aires
State/Province
Ciudad Auton. De Buenos Aires
ZIP/Postal Code
C1015ABO
Country
Argentina
Facility Name
OFTALMOS, Instituto Oftalmologico de Alta Complejidad
City
Buenos Aires
State/Province
Ciudad Auton. De Buenos Aires
ZIP/Postal Code
C1120AAN
Country
Argentina
Facility Name
Eyeclinic Albury Wodonga
City
Albury
State/Province
New South Wales
ZIP/Postal Code
2640
Country
Australia
Facility Name
Sydney Retina Clinic
City
Sydney
State/Province
New South Wales
ZIP/Postal Code
2000
Country
Australia
Facility Name
Westmead Hospital
City
Westmead
State/Province
New South Wales
ZIP/Postal Code
2145
Country
Australia
Facility Name
Hobart Eye Surgeons
City
Hobart
State/Province
Tasmania
ZIP/Postal Code
7000
Country
Australia
Facility Name
Marsden Eye Surgery Center
City
Parramatta
ZIP/Postal Code
2150
Country
Australia
Facility Name
Klinikum Klagenfurt am Wörthersee
City
Klagenfurt
State/Province
Kärnten
ZIP/Postal Code
9020
Country
Austria
Facility Name
Kepler Universitätsklinikum Campus III
City
Linz
State/Province
Oberösterreich
ZIP/Postal Code
4020
Country
Austria
Facility Name
Konventhospital Barmherzige Brüder Linz
City
Linz
State/Province
Oberösterreich
ZIP/Postal Code
4021
Country
Austria
Facility Name
Medizinische Universität Graz
City
Graz
State/Province
Steiermark
ZIP/Postal Code
8036
Country
Austria
Facility Name
Hanusch-Krankenhaus Wien
City
Wien
ZIP/Postal Code
1140
Country
Austria
Facility Name
SEHAT Pentagram
City
Sofia
ZIP/Postal Code
1309
Country
Bulgaria
Facility Name
Spec. Hosp. for Active Treatment for Eye Diseases Zrenie
City
Sofia
ZIP/Postal Code
1408
Country
Bulgaria
Facility Name
UMHAT Alexandrovska EAD
City
Sofia
ZIP/Postal Code
1431
Country
Bulgaria
Facility Name
Multiprofile Hospital for Active Treatment Sveta Sofia
City
Sofia
ZIP/Postal Code
1618
Country
Bulgaria
Facility Name
Specialized Hospital For Active Treatment of Eye Diseases Zora
City
Sofia
ZIP/Postal Code
1784
Country
Bulgaria
Facility Name
Sveta Petka Eye Hospital
City
Varna
ZIP/Postal Code
9002
Country
Bulgaria
Facility Name
St.Joseph's Health Care-London
City
London
State/Province
Ontario
ZIP/Postal Code
N6A 4V2
Country
Canada
Facility Name
Toronto Retina Institute
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M3C 0G9
Country
Canada
Facility Name
Institut de l'Oeil des Laurentides
City
Boisbriand
State/Province
Quebec
ZIP/Postal Code
J7H1S6
Country
Canada
Facility Name
The Second Hospital of Anhui medical university
City
Hefei
State/Province
Anhui
ZIP/Postal Code
230601
Country
China
Facility Name
The 1st Affiliated Hospital Fujian Medical University
City
Fuzhou
State/Province
Fujian
Country
China
Facility Name
Guangzhou Aier Eye Hospital
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
634050
Country
China
Facility Name
Shijiazhuang General Hospital
City
Shijiazhuang
State/Province
Hebei
ZIP/Postal Code
050000
Country
China
Facility Name
Hebei Eye Hospital
City
Xingtai
State/Province
Hebei
Country
China
Facility Name
Henan Provincial Ophthalmology Hospital (Henan Eye Institute
City
Zhengzhou
State/Province
Henan
ZIP/Postal Code
450003
Country
China
Facility Name
Tongji Hosp. of Tongji Med Coll, Huazhong Uni of Sci & Tech.
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
430030
Country
China
Facility Name
Union Hospt Tongji Medical Colleg. Huazhong univ. Scien&Tech
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
430030
Country
China
Facility Name
The First People's Hospital of Xuzhou
City
Xuzhou
State/Province
Jiangsu
ZIP/Postal Code
221002
Country
China
Facility Name
Jiangxi Provincial People's Hospital
City
Nanchang
State/Province
Jiangxi
ZIP/Postal Code
330006
Country
China
Facility Name
The First Affiliated Hospital of NanChang University
City
Nanchang
State/Province
Jiangxi
ZIP/Postal Code
330006
Country
China
Facility Name
Eye Center of the second Bethune Hospital, jinlin University
City
Changchun
State/Province
Jilin
ZIP/Postal Code
130022
Country
China
Facility Name
Tonghua Central Hospital
City
Tonghua
State/Province
Jilin
ZIP/Postal Code
134001
Country
China
Facility Name
Shenyang He Eye Hospital
City
Shenyang
State/Province
Liaoning
ZIP/Postal Code
110034
Country
China
Facility Name
The People's Hospital of Ningxia Hui Autonomous Region
City
Yinchuan
State/Province
Ningxia
ZIP/Postal Code
750000
Country
China
Facility Name
The First Affiliated Hospital of Xi'an Jiaotong University
City
Xi'an
State/Province
Shanxi
ZIP/Postal Code
710061
Country
China
Facility Name
Aier Eye Hospital (Chengdu)
City
Chengdu
State/Province
Sichuan
Country
China
Facility Name
The First Affiliated Hospital of Xinjiang Medical University
City
Urumqi
State/Province
Xinjiang
ZIP/Postal Code
830054
Country
China
Facility Name
The 1st Affiliated Hospital of Zhejiang University
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310000
Country
China
Facility Name
ZheJiang Provincial People's Hospital
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310014
Country
China
Facility Name
The Affiliated Eye Hospital of Wenzhou Medical College
City
Wenzhou
State/Province
Zhejiang
Country
China
Facility Name
Beijing Tongren Hospital, Capital Medical University (East)
City
Beijing
ZIP/Postal Code
100005
Country
China
Facility Name
Beijing Aier Intech Eye Hospital Co. LTD - Ophthalmology
City
Beijing
ZIP/Postal Code
100021
Country
China
Facility Name
Peking University People's Hospital
City
Beijing
ZIP/Postal Code
100044
Country
China
Facility Name
Beijing Hospital
City
Beijing
ZIP/Postal Code
100730
Country
China
Facility Name
Chongqing Aier Ophthalmology Hospital
City
Chongqing
ZIP/Postal Code
400020
Country
China
Facility Name
Shanghai Tongji Hospital of Tongji University
City
Shanghai
ZIP/Postal Code
200065
Country
China
Facility Name
Shanghai General Hospital
City
Shanghai
ZIP/Postal Code
200080
Country
China
Facility Name
Tianjin Medical University General Hospital
City
Tianjin
ZIP/Postal Code
300052
Country
China
Facility Name
Tianjin Medical University Eye Hospital
City
Tianjin
ZIP/Postal Code
300384
Country
China
Facility Name
TianJin eye hospital
City
Tianjin
Country
China
Facility Name
Fakultni Nemocnice Hradec Kralove
City
Hradec Kralove
ZIP/Postal Code
500 05
Country
Czechia
Facility Name
Fakultni nemocnice Ostrava
City
Ostrava
ZIP/Postal Code
708 52
Country
Czechia
Facility Name
Fakultni nemocnice Plzen - Lochotin
City
Plzen-Lochotin
ZIP/Postal Code
323 00
Country
Czechia
Facility Name
Charles University in Prague
City
Prague
ZIP/Postal Code
110 00
Country
Czechia
Facility Name
Fakultni nemocnice Kralovske Vinohrady
City
Praha 10
ZIP/Postal Code
10034
Country
Czechia
Facility Name
Lexum a.s., Evropska ocni klinika
City
Praha 4
ZIP/Postal Code
140 00
Country
Czechia
Facility Name
AXON Clinical s.r.o.
City
Praha 5
ZIP/Postal Code
150 00
Country
Czechia
Facility Name
East Tallinn Central Hospital
City
Tallinn
ZIP/Postal Code
10138
Country
Estonia
Facility Name
Tartu University Hospital
City
Tartu
Country
Estonia
Facility Name
Centre d'Ophtalmologie - Paradis-Monticelli
City
Marseille
ZIP/Postal Code
13008
Country
France
Facility Name
Hôpital Lariboisière - Paris
City
Paris
ZIP/Postal Code
75475
Country
France
Facility Name
Centre ophtalmologique Saint-Exupéry
City
Saint-Cyr-Sur-Loire
ZIP/Postal Code
37540
Country
France
Facility Name
LTD "Clinic LJ"
City
Kutaisi
ZIP/Postal Code
4600
Country
Georgia
Facility Name
JSC "Evex Hospitals'
City
Tbilisi
ZIP/Postal Code
0186
Country
Georgia
Facility Name
LTD "Innova"
City
Tbilisi
ZIP/Postal Code
105
Country
Georgia
Facility Name
LTD "Chichua Medical Center MZERA"
City
Tbilisi
ZIP/Postal Code
114
Country
Georgia
Facility Name
Budapest Retina Associates
City
Budapest
ZIP/Postal Code
1133
Country
Hungary
Facility Name
Szent-Gyorgyi Albert Orvostudomanyi Egyetem
City
Szeged
ZIP/Postal Code
6720
Country
Hungary
Facility Name
Rambam Health Corporation
City
Haifa
ZIP/Postal Code
3109601
Country
Israel
Facility Name
Lady Davis Carmel Medical Center
City
Haifa
ZIP/Postal Code
3436212
Country
Israel
Facility Name
Hadassah Hebrew University Hospital Ein Kerem
City
Jerusalem
ZIP/Postal Code
9112001
Country
Israel
Facility Name
Meir Medical Center
City
Kfar Saba
ZIP/Postal Code
4428164
Country
Israel
Facility Name
Chaim Sheba Medical Center
City
Ramat Gan
ZIP/Postal Code
5262000
Country
Israel
Facility Name
Kaplan Medical Center
City
Rehovot
ZIP/Postal Code
7610001
Country
Israel
Facility Name
Assuta Medical Centers - HaShalom
City
Tel Aviv
ZIP/Postal Code
6789140
Country
Israel
Facility Name
Fondazione PTV Policlinico Tor Vergata
City
Roma
State/Province
Lazio
ZIP/Postal Code
00133
Country
Italy
Facility Name
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
City
Roma
State/Province
Lazio
ZIP/Postal Code
00168
Country
Italy
Facility Name
IRCCS Fondazione G.B. Bietti Studio e Ricerca in Otalmologia
City
Roma
State/Province
Lazio
ZIP/Postal Code
00198
Country
Italy
Facility Name
Ospedale San Raffaele s.r.l.
City
Milano
State/Province
Lombardia
ZIP/Postal Code
20132
Country
Italy
Facility Name
ASST Fatebenefratelli Sacco
City
Milano
State/Province
Lombardia
ZIP/Postal Code
20157
Country
Italy
Facility Name
A.O.U. di Cagliari
City
Cagliari
State/Province
Sardegna
ZIP/Postal Code
09124
Country
Italy
Facility Name
A.O. di Perugia
City
Perugia
State/Province
Umbria
ZIP/Postal Code
06129
Country
Italy
Facility Name
Daiyukai Daiichi Hospital
City
Ichinomiya
State/Province
Aichi
ZIP/Postal Code
491-8551
Country
Japan
Facility Name
Aichi Medical University Hospital
City
Nagakute
State/Province
Aichi
ZIP/Postal Code
480-1195
Country
Japan
Facility Name
Nagoya University Hospital
City
Nagoya
State/Province
Aichi
ZIP/Postal Code
466-8560
Country
Japan
Facility Name
Nagoya City University Hospital
City
Nagoya
State/Province
Aichi
ZIP/Postal Code
467-8602
Country
Japan
Facility Name
Kokura Memorial Hospital
City
Kitakyushu
State/Province
Fukuoka
ZIP/Postal Code
802-8555
Country
Japan
Facility Name
Kurume University Hospital
City
Kurume
State/Province
Fukuoka
ZIP/Postal Code
830-0011
Country
Japan
Facility Name
Southern Tohoku Eye Clinic
City
Koriyama
State/Province
Fukushima
ZIP/Postal Code
963-8052
Country
Japan
Facility Name
Gunma University Hospital
City
Maebashi
State/Province
Gunma
ZIP/Postal Code
371-8511
Country
Japan
Facility Name
Sapporo City General Hospital
City
Sapporo
State/Province
Hokkaido
ZIP/Postal Code
060-8604
Country
Japan
Facility Name
KKR Sapporo Medical Center
City
Sapporo
State/Province
Hokkaido
ZIP/Postal Code
062-0931
Country
Japan
Facility Name
Hyogo Prefectural Amagasaki General Medical Center
City
Amagasaki
State/Province
Hyogo
ZIP/Postal Code
660-8550
Country
Japan
Facility Name
Kobe University Hospital
City
Kobe
State/Province
Hyogo
ZIP/Postal Code
650-0017
Country
Japan
Facility Name
Kozawa Eye Hospital and Diabetes Center
City
Mito
State/Province
Ibaraki
ZIP/Postal Code
310-0845
Country
Japan
Facility Name
Kanazawa Medical University Hospital
City
Kahoku-gun
State/Province
Ishikawa
ZIP/Postal Code
920-0293
Country
Japan
Facility Name
Kanazawa University Hospital
City
Kanazawa
State/Province
Ishikawa
ZIP/Postal Code
920-8641
Country
Japan
Facility Name
Kagawa University Hospital
City
Kita-gun
State/Province
Kagawa
ZIP/Postal Code
761-0793
Country
Japan
Facility Name
Medical corporation Eiwakai Dannoue Ophthalmology clinic
City
Kawasaki
State/Province
Kanagawa
ZIP/Postal Code
211-0053
Country
Japan
Facility Name
St. Marianna University Hospital
City
Kawasaki
State/Province
Kanagawa
ZIP/Postal Code
216-8511
Country
Japan
Facility Name
Otakeganka Tsukimino Clinic
City
Yamato
State/Province
Kanagawa
ZIP/Postal Code
242-0001
Country
Japan
Facility Name
Mie University Hospital
City
Tsu
State/Province
Mie
ZIP/Postal Code
514-8507
Country
Japan
Facility Name
Shinshu University Hospital
City
Matsumoto
State/Province
Nagano
ZIP/Postal Code
390-8621
Country
Japan
Facility Name
Nara Medical University Hospital
City
Kashihara
State/Province
Nara
ZIP/Postal Code
634-8522
Country
Japan
Facility Name
Oita University Hospital
City
Yufu
State/Province
Oita
ZIP/Postal Code
879-5593
Country
Japan
Facility Name
Kurashiki Medical Center
City
Kurashiki
State/Province
Okayama
ZIP/Postal Code
710-8522
Country
Japan
Facility Name
University of the Ryukyus Hospital
City
Nakagami
State/Province
Okinawa
ZIP/Postal Code
903-0215
Country
Japan
Facility Name
Kansai Medical University Hospital
City
Hirakata
State/Province
Osaka
ZIP/Postal Code
573-1191
Country
Japan
Facility Name
Kansai Medical University Medical Center
City
Moriguchi
State/Province
Osaka
ZIP/Postal Code
570-8507
Country
Japan
Facility Name
Kindai University Hospital
City
Osakasayama
State/Province
Osaka
ZIP/Postal Code
589-8511
Country
Japan
Facility Name
The University of Tokyo Hospital
City
Bunkyo-ku
State/Province
Tokyo
ZIP/Postal Code
113-8655
Country
Japan
Facility Name
St.Luke's International Hospital
City
Chuoku
State/Province
Tokyo
ZIP/Postal Code
104-8560
Country
Japan
Facility Name
Nishikasai Inouye Eye Hospital
City
Edogawa-ku
State/Province
Tokyo
ZIP/Postal Code
134-0088
Country
Japan
Facility Name
Tokyo Medical University Hachioji Medical Center
City
Hachioji
State/Province
Tokyo
ZIP/Postal Code
193-0998
Country
Japan
Facility Name
Tokiwadai Muranaka Eye Clinic
City
Itabashi-ku
State/Province
Tokyo
ZIP/Postal Code
174-0071
Country
Japan
Facility Name
National Hospital Organization Tokyo Medical Center
City
Meguro-ku
State/Province
Tokyo
ZIP/Postal Code
152-8902
Country
Japan
Facility Name
Keio University Hospital
City
Shinjuku-ku
State/Province
Tokyo
ZIP/Postal Code
160-8582
Country
Japan
Facility Name
Tokyo Women's Medical University Hospital
City
Shinjuku-ku
State/Province
Tokyo
ZIP/Postal Code
162-8666
Country
Japan
Facility Name
Yamaguchi University Hospital
City
Ube
State/Province
Yamaguchi
ZIP/Postal Code
755-8505
Country
Japan
Facility Name
University of Yamanashi Hospital
City
Chuo
State/Province
Yamanashi
ZIP/Postal Code
409-3898
Country
Japan
Facility Name
Akita University Hospital
City
Akita
ZIP/Postal Code
010-8543
Country
Japan
Facility Name
Hayashi Eye Hospital
City
Fukuoka
ZIP/Postal Code
812-0011
Country
Japan
Facility Name
Fukushima Medical University Hospital
City
Fukushima
ZIP/Postal Code
960-1295
Country
Japan
Facility Name
Hiroshima University Hospital
City
Hiroshima
ZIP/Postal Code
734-8551
Country
Japan
Facility Name
University of Miyazaki Hospital
City
Miyazaki
ZIP/Postal Code
889-1692
Country
Japan
Facility Name
Japanese Red Cross Nagasaki Genbaku Hospital
City
Nagasaki
ZIP/Postal Code
852-8511
Country
Japan
Facility Name
Okayama University Hospital
City
Okayama
ZIP/Postal Code
700-8558
Country
Japan
Facility Name
Japanese Red Cross Saitama Hospital
City
Saitama
ZIP/Postal Code
330-8553
Country
Japan
Facility Name
Tokushima University Hospital
City
Tokushima
ZIP/Postal Code
770-8503
Country
Japan
Facility Name
Japanese Red Cross Wakayama Medical center
City
Wakayama
ZIP/Postal Code
640-8558
Country
Japan
Facility Name
Yamagata University Hospital
City
Yamagata
ZIP/Postal Code
990-9585
Country
Japan
Facility Name
Seoul National University Bundang Hospital
City
Seongnam-si
State/Province
Gyeonggido
ZIP/Postal Code
13620
Country
Korea, Republic of
Facility Name
Pusan National University Hospital
City
Busan
ZIP/Postal Code
49241
Country
Korea, Republic of
Facility Name
Inje University Haeundae Paik Hospital
City
Busan
ZIP/Postal Code
612-862
Country
Korea, Republic of
Facility Name
Seoul National University Hospital
City
Seoul
ZIP/Postal Code
03080
Country
Korea, Republic of
Facility Name
Asan Medical Center
City
Seoul
ZIP/Postal Code
05505
Country
Korea, Republic of
Facility Name
Samsung Medical Center
City
Seoul
ZIP/Postal Code
06351
Country
Korea, Republic of
Facility Name
Retina Center Nune Eye Hospital
City
Seoul
ZIP/Postal Code
135-280
Country
Korea, Republic of
Facility Name
Department of Ophthalmology
City
Riga
ZIP/Postal Code
1002
Country
Latvia
Facility Name
Riga East Clinical University Hospital "Gailezers"
City
Riga
ZIP/Postal Code
LV-1006
Country
Latvia
Facility Name
Latvian American Eye Center
City
Riga
ZIP/Postal Code
LV-1009
Country
Latvia
Facility Name
Hospital of LT University of Health Sciences Kaunas Clinics
City
Kaunas
ZIP/Postal Code
LT-50161
Country
Lithuania
Facility Name
PI Klaipedos University Hospital
City
Klaipeda
ZIP/Postal Code
LT-92288
Country
Lithuania
Facility Name
Vilnius University Hospital Santaros Klinikos
City
Vilnius
ZIP/Postal Code
LT-08661
Country
Lithuania
Facility Name
ALM Oftalmolaser - Oftalmologia Medica e Cirurgica
City
Lisbon
State/Province
Lisboa
ZIP/Postal Code
1050-078
Country
Portugal
Facility Name
AIBILI
City
Coimbra
ZIP/Postal Code
3000-548
Country
Portugal
Facility Name
Espaco Medico de Coimbra
City
Coimbra
ZIP/Postal Code
3000-548
Country
Portugal
Facility Name
Centro Hospitalar Universitario do Porto
City
Porto
ZIP/Postal Code
4099-001
Country
Portugal
Facility Name
Centro Hospitalar Vila Nova de Gaia/Espinho | Unit 1 - Clinical Research Office
City
Porto
ZIP/Postal Code
4434-502
Country
Portugal
Facility Name
Scientific Research Institution of Ophthalmic Diseases
City
Moscow
ZIP/Postal Code
119021
Country
Russian Federation
Facility Name
FBSI IRTC Eye Microsurgery n.a. acad. S.N. Fyodorov
City
Moscow
ZIP/Postal Code
127486
Country
Russian Federation
Facility Name
Clinical Center of Serbia
City
Belgrade
ZIP/Postal Code
11000
Country
Serbia
Facility Name
Clinical hospital center Zvezdara
City
Belgrade
ZIP/Postal Code
11000
Country
Serbia
Facility Name
Klinicki centar Vojvodine
City
Novi Sad
ZIP/Postal Code
21000
Country
Serbia
Facility Name
National University Hospital
City
Singapore
ZIP/Postal Code
119074
Country
Singapore
Facility Name
Singapore National Eye Centre
City
Singapore
ZIP/Postal Code
168751
Country
Singapore
Facility Name
Fakultna nemocnica Nitra
City
Nitra
ZIP/Postal Code
950 01
Country
Slovakia
Facility Name
Nemocnica s Poliklinikou Trebisov, Svet zdravia a.s.
City
Trebisov
ZIP/Postal Code
075 01
Country
Slovakia
Facility Name
Fakultna nemocnica Trencin
City
Trencin
ZIP/Postal Code
911 71
Country
Slovakia
Facility Name
Fakultna nemocnica s poliklinikou Zilina
City
Zilina
ZIP/Postal Code
012 07
Country
Slovakia
Facility Name
Instituto Oftalmológico Francisco Gomez Ulla
City
Santiago de Compostela
State/Province
A Coruña
ZIP/Postal Code
15706
Country
Spain
Facility Name
Hospital Clínic i Provincial de Barcelona
City
Barcelona
ZIP/Postal Code
8036
Country
Spain
Facility Name
Hospital de la Santa Creu i Sant Pau | Gynecology Department
City
Barcelona
ZIP/Postal Code
8041
Country
Spain
Facility Name
Hospital Reina Sofía
City
Córdoba
ZIP/Postal Code
14004
Country
Spain
Facility Name
Hospital General Universitario de Valencia
City
Valencia
ZIP/Postal Code
46014
Country
Spain
Facility Name
Hospital Universitari i Politècnic La Fe
City
Valencia
ZIP/Postal Code
46026
Country
Spain
Facility Name
Hospital Miguel Servet
City
Zaragoza
ZIP/Postal Code
50009
Country
Spain
Facility Name
RétinElysée
City
Lausanne
State/Province
Vaud
ZIP/Postal Code
1006
Country
Switzerland
Facility Name
Berner Augenklinik am Lindenhofspital
City
Bern
Country
Switzerland
Facility Name
Stadtspital Triemli
City
Zürich
ZIP/Postal Code
8063
Country
Switzerland
Facility Name
Shin Kong Wu Ho-Su Memorial Hospital
City
Taipei City
State/Province
Taipei
ZIP/Postal Code
111
Country
Taiwan
Facility Name
Taipei Veterans General Hospital
City
Taipei
ZIP/Postal Code
11217
Country
Taiwan
Facility Name
Chang Gung Memorial Hospital at Linkou
City
Taoyuan
ZIP/Postal Code
33305
Country
Taiwan
Facility Name
Private enterprise private production company " Acinus"
City
Kropyvnytskyi
ZIP/Postal Code
25006
Country
Ukraine
Facility Name
Centralna Polyclinica MVS Ukraiiny
City
Kyiv
ZIP/Postal Code
01024
Country
Ukraine
Facility Name
Poltava Regional Clinical Hospital n.a. M.V. Skliphosovskyi
City
Poltava
ZIP/Postal Code
36011
Country
Ukraine

12. IPD Sharing Statement

Plan to Share IPD
No
IPD Sharing Plan Description
Availability of this study's data will later be determined according to Bayer's commitment to the EFPIA/PhRMA "Principles for responsible clinical trial data sharing". This pertains to scope, timepoint and process of data access. As such, Bayer commits to sharing upon request from qualified researchers patient-level clinical trial data, study-level clinical trial data, and protocols from clinical trials in patients for medicines and indications approved in the US and EU as necessary for conducting legitimate research. This applies to data on new medicines and indications that have been approved by the EU and US regulatory agencies on or after January 01, 2014. Interested researchers can use www.vivli.org to request access to anonymized patient-level data and supporting documents from clinical studies to conduct research. Information on the Bayer criteria for listing studies and other relevant information is provided in the member section of the portal.
Links:
URL
https://clinicaltrials.bayer.com/
Description
Click here to find information for studies related to Bayer products. To find this study enter the ClinicalTrials.gov identifier (NCT) number or Bayer Study Identifier (ID) in the search field.

Learn more about this trial

Study to Gather Information on Safety and Use of High Dose Aflibercept Injection Into the Eye in Patients With an Age Related Eye Disorder That Causes Blurred Vision or a Blind Spot Due to Abnormal Blood Vessels That Leak Fluid Into the Light Sensitive Lining Inside the Eye

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