Oscillatory Acoustic-electric Stimulation in Patients With Disorders of Consciousness
Consciousness Disorder
About this trial
This is an interventional treatment trial for Consciousness Disorder focused on measuring disorders of consciousness, electric stimulation
Eligibility Criteria
Inclusion Criteria:
- Clinical diagnosis of disorders of consciousness based on CRS-R
- Time post-injury ranging from one to twelve months
- No history of acquired brain injury or psychiatric or neurological diseases
Exclusion Criteria:
- Not medically stable
- Any contraindication to electric stimulation
- Hearing impairment before brain injury
Sites / Locations
- First Affiliated Hospital,Zhejiang University
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Sham Comparator
Gamma modulation effect
Beta modulation effect
Sham modulation group
40Hz current is applied by a battery-driven current stimulator(NeuroConn, Germany). Two pairs of electrodes are attached to the middle and lower part of the face to stimulate the maxillary nerve (V2) and the mandibular nerve (V3), respectively. 40Hz acoustic stimuli and 40Hz electric stimuli are synchronously applied for 40min/day, for a total of 5 days.
28Hz current is applied by a battery-driven current stimulator. Two pairs of electrodes are attached to the middle and lower part of the face to stimulate the maxillary nerve (V2) and the mandibular nerve (V3). 28Hz acoustic stimuli and 28Hz electric stimuli are synchronously applied for 40min/day, for a total of 5 days.
Sham stimulation was identical to the 40Hz stimulation, except that the acoustic and electric stimulation were ramped down after 0.5 min to remain turned off for the remaining 39.5 min. Sham stimuli are applied for 40min/day, for a total of 5 days.