eIMPACT-DM Pilot Trial: Depression Treatment to Reduce Diabetes Risk
Depression, Major Depressive Disorder, Dysthymic Disorder
About this trial
This is an interventional treatment trial for Depression focused on measuring Primary Care, Cognitive-Behavioral Therapy, Computer-Based Psychotherapy, Antidepressant Medications
Eligibility Criteria
Inclusion Criteria:
- Current primary care patient in Eskenazi Health
- Age ≥18 years
- Depressive disorder at screening
- Prediabetes at screening
Exclusion Criteria:
- History of type 1 or type 2 diabetes
- Major inflammatory conditions: HIV/AIDS, chronic kidney disease, systemic inflammatory disease (e.g., rheumatoid arthritis, lupus, Crohn's disease, and ulcerative colitis), or active cancer/current cancer treatment
- Current pregnancy
- Severe cognitive impairment
- Acute risk of suicide
- History of bipolar disorder or psychosis or current use of an atypical antipsychotic medication:
- Participation in our prior eIMPACT Trial
Sites / Locations
- IUPUI Department of Psychology
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
eIMPACT-DM intervention
Active Control
eIMPACT-DM is a 6-month, modernized, collaborative, stepped care intervention consisting of (1) computerized and telephonic cognitive-behavioral therapy for depression and (2) select antidepressant medications included in an algorithm optimized for diabetes risk reduction. It is a collaborative care intervention in which a multidisciplinary team delivers established depression treatments consistent with patient preference. It uses a stepped, flexible, treat-to-target approach that modernizes the IMPACT intervention by harnessing technology to minimize staff and space requirements. Interventions are Good Days Ahead, Problem Solving Treatment in Primary Care, and select FDA-approved antidepressants. The treatment team consists of a depression clinical specialist, a supervising MD with expertise in primary care and IMPACT, and the patients' primary care providers (PCPs).
Active Control (AC) consists of depression education (study staff), symptom monitoring (study staff), and primary care for depression (clinical staff).