Surfactant Administration by Insure or Thin Catheter (SAINT)
RDS of Prematurity, Surfactant Deficiency Syndrome Neonatal, Analgesia
About this trial
This is an interventional treatment trial for RDS of Prematurity focused on measuring LISA (Less invasive surfactant administration), INSURE, CPAP
Eligibility Criteria
Inclusion Criteria:
- Infants born before 32 completed weeks of gestation on CPAP, with clinical and radiological signs of RDS and need for surfactant treatment.
Exclusion Criteria:
- Infants requiring surfactant as part of delivery room resuscitation are not eligible.
Infants will be excluded from the final analysis if they have a congenital abnormality or condition that might have an adverse effect on breathing or ventilation, including: congenital diaphragmatic hernia; tracheo-oesophageal fistula or cyanotic heart disease.
Sites / Locations
- Karolinska University HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
INSURE
LISA
Surfactant administration by Intubation-surfactant-extubation to CPAP according to standard protocol including premedication with analgesia and sedation.
Surfactant administration by thin catheter during spontaneous breathing and continued CPAP according to set protocol including premedication with analgesia.