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Comparison of Vortioxetine and Desvenlafaxine in Adult Patients Suffering From Depression (VIVRE)

Primary Purpose

Major Depressive Disorder

Status
Completed
Phase
Phase 4
Locations
International
Study Type
Interventional
Intervention
Vortioxetine
Desvenlafaxine
Sponsored by
H. Lundbeck A/S
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Major Depressive Disorder

Eligibility Criteria

18 Years - 65 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • The patient has a primary diagnosis of single or recurrent MDD, diagnosed according to DSM-5®. The current MDE must be confirmed using the Mini International Neuropsychiatric Interview (MINI).
  • The patient has a MADRS total score ≥24 at screening and baseline.
  • The patient has had the current MDE for ≥3 months and < 12 months.
  • The patient has been treated with an SSRI as monotherapy (citalopram, escitalopram, paroxetine, sertraline) for at least 6 weeks at licensed dose for the current MDE with a partial response and is a candidate for a switch in the investigator's opinion.
  • The patient wants to switch antidepressant treatment.

Exclusion Criteria:

  • The patient has any other disorder for which the treatment takes priority over treatment of MDD or is likely to interfere with study treatment or impair treatment compliance.

Other in- and exclusion criteria may apply

Sites / Locations

  • Clinica Privada Banfield
  • Cenydet-Centro Neurobiologico Y De Estres Traumatico-Biopsychomedical Research Group Srl
  • Fundacion para el Estudio y Tratamiento de las enfermedades mentales FETEM
  • INAPsi (Instituto Nacional de Psicopatologia)
  • Clinica Privada De Salud Mental Santa Teresa De Avila
  • Instituto De Neurociencias San Agustin SA
  • Sanatorio Prof. Leon S. Morra S.A.
  • CIAP (Centro de Investigacion y Asistencia en Psiquiatria)
  • CINME (Centro de Investigaciones Metabolicas de Buenos Aires)
  • CEN (Centro Especializado Neurociencias)
  • Instituto Modelo de Neurologia Fundacion Lennox
  • Instituto Medico DAMIC - Fundacion Rusculleda
  • Centro De Asistencia E Investigacion En Neurociencias CENAIN
  • Resolution Psicopharmacology Research Institute
  • Algemeen Ziekenhuis St. Lucas-St. Jozef
  • SINAPS - University Antwerpe- Psychiatrisch Ziekenhuis Duffel
  • Cliniques De Mont-Godinne
  • MHAT Dr. Hristo Stambolski
  • UMHAT Sv. Ivan Rilski EAD
  • Center For Mental Health-Rousse
  • MC Complete Medical Solutions
  • Centre for Mental Health- Sofia
  • Diagnostic Consultative Center Mladost-M Varna OOD
  • Clintrial s.r.o.
  • Dr.Jan Holan MD, Office of
  • Meditrine s.r.o. - Psychiatricka Ambulance, Lecebne Centrum
  • Clinline services s.r.o.
  • Neuropsychiatrie HK, s.r.o.
  • National Institute of Mental Health
  • Psychiatricka Ambulance
  • A-Shine s.r.o.
  • Institut neuropsychiatricke pece
  • Marienthali Kliinik
  • Psihiatrijas Centrs
  • Riga Centre Of Psychiatry And Addiction Disorders
  • Sigulda Hospital Outpatient Clinic
  • CRI Centro Regiomontano de Investigacion SC
  • Medical Care and Research S.A. de C.V.
  • Health Pharma Professional Research S.A. de C.V.
  • Region Specialized Psychiatric Hospital No.2
  • Leningrad Regional Psychoneurological Dispensary
  • Arkhangelsk Regional Clinical Mental Hospital
  • GUZ Engels Psychiatric Hospital
  • Moscow Scientific Research Institute of Psychiatry
  • Clinic named after professor Yu. N. Kasatkin FGBOU DPO RMANPO Minzdrava Rossii
  • Nizhny Novgorod Region State Institution Of Healthcare Clinical Psychiatric Hospital 1 Of Nizhny ...
  • Rostov State Medical University of the Minzdravsotsrazvitiya of Russia
  • LLC Medical Center Nova Vita
  • Hospital OrKli , LLC
  • LLC Astarta
  • Saratov State Medical University
  • State Budgetery Educational Institution Of Higher Professional Education Smolensk State Medical U...
  • St. Nicolas State Psychiatric Hospital
  • Yaroslavl Regional Clinical Psychiatry Hospital
  • Psychiatricka ambulancia, MENTUM, s.r.o.
  • Epamed, S.R.O
  • Psycholine S.R.O.
  • Crystal Comfort, s.r.o.
  • BONA MEDIC s.r.o.
  • Psychiatricka Ambulancia
  • Centro De Salud Mental La Corredoria
  • Hospital Universitario Fundacion Alcorcon
  • Hospital De La Santa Creu I Sant Pau
  • Hospital Psiquiatric de Palma de Mallorca
  • Smaert & Psykiatricentrum Malmoe
  • Affecta Psyikiatri AB
  • ProbarE i Lund
  • ONE LIFETIME Lakarmottagning
  • ProbarE
  • Communal Non-commercial Enterprise Cherkasy regional psychiatric hospital of Cherkasy regional co...
  • Communal Non-Commercial Enterprise of Kharkiv Regional Council Regional clinical psychiatric hosp...
  • Municipal Non-profit Enterprise Odesa Regional Psychiatric Hospital No.2 of Odesa Regional Council
  • CI of KRC Regional psychiatric and narcological medical association
  • Ivano-Frankivsk Oblast neuropsychiatric hospital No. 3
  • Academy of Medical Sciences of Ukraine - Institute of Neurology, Psychiatry and Narcology
  • SI INPN Namsu
  • Lviv Regional State Clinical Psychiatric Hospital, Lviv Danylo Galytsky National Medical University
  • Odessa Regional Medical Centre of Mental Health
  • Ukrainian Medical Stomatological Academy, Chair Of Psychiatry, Narcology And Medical Psychology B...
  • Vinnitsa National Medical University

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

Vortioxetine

Desvenlafaxine

Arm Description

8 weeks treatment

8 weeks treatment

Outcomes

Primary Outcome Measures

Change in Montgomery and Åsberg Depression Rating Scale (MADRS) total score
The Montgomery and Åsberg Depression Rating Scale (MADRS) is a 10-item rating scale designed to assess the severity of the symptoms in depressive illness and to be sensitive to treatment effects. Symptoms are rated on a 7-point scale from 0 (no symptom) to 6 (severe symptom). The total score of the 10 items ranges from 0 to 60, with higher values indicating worse outcome.

Secondary Outcome Measures

Remission (defined as a MADRS total score =<10)
The Montgomery and Åsberg Depression Rating Scale (MADRS) is a 10-item rating scale designed to assess the severity of the symptoms in depressive illness and to be sensitive to treatment effects. Symptoms are rated on a 7-point scale from 0 (no symptom) to 6 (severe symptom). The total score of the 10 items ranges from 0 to 60, with higher values indicating worse outcome.
Response (defined as a => 50% decrease from baseline in MADRS total score)
The Montgomery and Åsberg Depression Rating Scale (MADRS) is a 10-item rating scale designed to assess the severity of the symptoms in depressive illness and to be sensitive to treatment effects. Symptoms are rated on a 7-point scale from 0 (no symptom) to 6 (severe symptom). The total score of the 10 items ranges from 0 to 60, with higher values indicating worse outcome.
Change in MADRS anhedonia factor score
(based on items 1(apparent sadness),2 (reported sadness),6 (concentration difficulties),7 (lassitude),8 (inability to feel))
Change in Digital Symbol Substitution Test (DSST) total score
DSST assesses psychomotor speed of performance requiring visual perception, spatial decision-making, and motor skills. It consists of 133 digits and requires the patient to substitute each digit with a simple symbol in a 90-s period. Each correct symbol is counted, and the total score ranges from 0 (< normal functioning) to 133 (> normal functioning).
The proportion number of Hard Choice/number of High Reward trials and number of Low choice/number of Low Reward trials when performing the Effort- Expenditure for Rewards Task (EEfRT)
The EEfRT is a computerized task which measures reward motivation in which participants are presented with a series of repeated trials during which they choose between performing a ''hard-task'' or an ''easy-task'' in order to earn varying amounts of monetary rewards.
Change in Clinical Global Impression - Severity of Illness (CGI-S) score
The CGI-S scale measures the severity of psychiatric symptoms on a 7-point scale from 1-7. The scores indicated the following: 1 = normal, not at all ill; 2 = borderline mentally ill; 3 = mildly ill; 4 = moderately ill; 5 = markedly ill; 6 = severely ill; 7 = among the most extremely ill participants. The score ranged from 1-7, where 1 indicated absence of symptoms and higher score indicated greater severity of symptoms.
Clinical Global Impression Scale- Global Improvement (CGI-I) score
The Clinical Global Impression - global improvement CGI-I provides the clinician's impression of the patient's improvement (or worsening). The clinician assesses the patient's condition relative to a baseline on a 7-point scale ranging from 1 (very much improved) to 7 (very much worse)
Change in Functioning Assessment Short Test (FAST) total score
The FAST is a valid and reliable instrument, easy to apply which requires a short period of time to administer. Evaluates functioning taking into account the last 15 days. It was developed for the clinical evaluation of the main difficulties presented by psychiatric patients, and has been validated in several languages for patients with bipolar disorder. The FAST scale consists of 24 items which allow the assessment of six specific areas of functioning: autonomy, occupational functioning, cognitive functioning, financial issues, interpersonal relationships and leisure time
Change in FAST sub-domain scores
The FAST is a clinician-rated scale designed to assess difficulty in functioning. The FAST consists of 24 items in 6 specific areas of functioning: autonomy, occupational functioning, cognitive functioning, financial issues, interpersonal relationships, leisure time. Each item is rated on a 4-point scale from 0 (no difficulty) to 3 (severe difficulty). The items are summed to yield a total score ranging from 0 to 72 with higher scores reflecting more serious difficulties.
Change in Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q) total score
The original Q-LES-Q is a patient self-rated scale designed to measure the degree of enjoyment and satisfaction experienced by patients in various areas of daily life. It consists of 93 items to measure: physical health, feelings, work, household duties, school, leisure time activities, social relations, and general activities. Each item is rated on a 5-point scale ranging from 1 (very poor) to 5 (very good)
Change in Q-LES-Q work subscale
The original Q-LES-Q is a patient self-rated scale designed to measure the degree of enjoyment and satisfaction experienced by patients in various areas of daily life. It consists of 93 items to measure: physical health, feelings, work, household duties, school, leisure time activities, social relations, and general activities. Each item is rated on a 5-point scale ranging from 1 (very poor) to 5 (very good)
Change in Q-LES-Q household duties subscale
The original Q-LES-Q is a patient self-rated scale designed to measure the degree of enjoyment and satisfaction experienced by patients in various areas of daily life. It consists of 93 items to measure: physical health, feelings, work, household duties, school, leisure time activities, social relations, and general activities. Each item is rated on a 5-point scale ranging from 1 (very poor) to 5 (very good)
Change in Q-LES-Q school/course subscale
The original Q-LES-Q is a patient self-rated scale designed to measure the degree of enjoyment and satisfaction experienced by patients in various areas of daily life. It consists of 93 items to measure: physical health, feelings, work, household duties, school, leisure time activities, social relations, and general activities. Each item is rated on a 5-point scale ranging from 1 (very poor) to 5 (very good)
Change in Q-LES-Q leisure time activities subscale
The original Q-LES-Q is a patient self-rated scale designed to measure the degree of enjoyment and satisfaction experienced by patients in various areas of daily life. It consists of 93 items to measure: physical health, feelings, work, household duties, school, leisure time activities, social relations, and general activities. Each item is rated on a 5-point scale ranging from 1 (very poor) to 5 (very good)
Change in Q-LES-Q social relations subscale
The original Q-LES-Q is a patient self-rated scale designed to measure the degree of enjoyment and satisfaction experienced by patients in various areas of daily life. It consists of 93 items to measure: physical health, feelings, work, household duties, school, leisure time activities, social relations, and general activities. Each item is rated on a 5-point scale ranging from 1 (very poor) to 5 (very good)

Full Information

First Posted
June 23, 2020
Last Updated
February 11, 2022
Sponsor
H. Lundbeck A/S
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1. Study Identification

Unique Protocol Identification Number
NCT04448431
Brief Title
Comparison of Vortioxetine and Desvenlafaxine in Adult Patients Suffering From Depression
Acronym
VIVRE
Official Title
A Randomised, Double-blind, Parallel-group, Active Controlled Study Evaluating the Efficacy of Vortioxetine Versus Desvenlafaxine in Adult Patients Suffering From Major Depressive Disorder With Partial Response to SSRI Treatment
Study Type
Interventional

2. Study Status

Record Verification Date
February 2022
Overall Recruitment Status
Completed
Study Start Date
June 18, 2020 (Actual)
Primary Completion Date
January 6, 2022 (Actual)
Study Completion Date
February 4, 2022 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
H. Lundbeck A/S

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No

5. Study Description

Brief Summary
The purpose of this study is to compare the efficacy of vortioxetine versus desvenlafaxine after 8 weeks of treatment in patients that have tried one available treatment without getting the full benefit
Detailed Description
The study will consist of a screening period of up to 14 days before the Baseline Visit, followed by an 8-week Treatment Period with vortioxetine or desvenlafaxine. A Safety Follow-up Visit will be performed approximately 4 weeks after the Primary Outcome/Withdrawal Visit. At Baseline, patients will be equally randomised (1:1) to 1 of the 2 treatment groups for an 8-week, double-blind Treatment Period.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Major Depressive Disorder

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 4
Interventional Study Model
Parallel Assignment
Masking
ParticipantInvestigator
Allocation
Randomized
Enrollment
605 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Vortioxetine
Arm Type
Experimental
Arm Description
8 weeks treatment
Arm Title
Desvenlafaxine
Arm Type
Active Comparator
Arm Description
8 weeks treatment
Intervention Type
Drug
Intervention Name(s)
Vortioxetine
Intervention Description
10 or 20 mg/day, capsules, orally
Intervention Type
Drug
Intervention Name(s)
Desvenlafaxine
Intervention Description
50 mg/day capsules, orally
Primary Outcome Measure Information:
Title
Change in Montgomery and Åsberg Depression Rating Scale (MADRS) total score
Description
The Montgomery and Åsberg Depression Rating Scale (MADRS) is a 10-item rating scale designed to assess the severity of the symptoms in depressive illness and to be sensitive to treatment effects. Symptoms are rated on a 7-point scale from 0 (no symptom) to 6 (severe symptom). The total score of the 10 items ranges from 0 to 60, with higher values indicating worse outcome.
Time Frame
From baseline to Week 8
Secondary Outcome Measure Information:
Title
Remission (defined as a MADRS total score =<10)
Description
The Montgomery and Åsberg Depression Rating Scale (MADRS) is a 10-item rating scale designed to assess the severity of the symptoms in depressive illness and to be sensitive to treatment effects. Symptoms are rated on a 7-point scale from 0 (no symptom) to 6 (severe symptom). The total score of the 10 items ranges from 0 to 60, with higher values indicating worse outcome.
Time Frame
At Week 8
Title
Response (defined as a => 50% decrease from baseline in MADRS total score)
Description
The Montgomery and Åsberg Depression Rating Scale (MADRS) is a 10-item rating scale designed to assess the severity of the symptoms in depressive illness and to be sensitive to treatment effects. Symptoms are rated on a 7-point scale from 0 (no symptom) to 6 (severe symptom). The total score of the 10 items ranges from 0 to 60, with higher values indicating worse outcome.
Time Frame
At Week 8
Title
Change in MADRS anhedonia factor score
Description
(based on items 1(apparent sadness),2 (reported sadness),6 (concentration difficulties),7 (lassitude),8 (inability to feel))
Time Frame
From baseline to Week 8
Title
Change in Digital Symbol Substitution Test (DSST) total score
Description
DSST assesses psychomotor speed of performance requiring visual perception, spatial decision-making, and motor skills. It consists of 133 digits and requires the patient to substitute each digit with a simple symbol in a 90-s period. Each correct symbol is counted, and the total score ranges from 0 (< normal functioning) to 133 (> normal functioning).
Time Frame
From baseline to Week 8
Title
The proportion number of Hard Choice/number of High Reward trials and number of Low choice/number of Low Reward trials when performing the Effort- Expenditure for Rewards Task (EEfRT)
Description
The EEfRT is a computerized task which measures reward motivation in which participants are presented with a series of repeated trials during which they choose between performing a ''hard-task'' or an ''easy-task'' in order to earn varying amounts of monetary rewards.
Time Frame
From baseline to Week 8
Title
Change in Clinical Global Impression - Severity of Illness (CGI-S) score
Description
The CGI-S scale measures the severity of psychiatric symptoms on a 7-point scale from 1-7. The scores indicated the following: 1 = normal, not at all ill; 2 = borderline mentally ill; 3 = mildly ill; 4 = moderately ill; 5 = markedly ill; 6 = severely ill; 7 = among the most extremely ill participants. The score ranged from 1-7, where 1 indicated absence of symptoms and higher score indicated greater severity of symptoms.
Time Frame
from baseline to Week 8
Title
Clinical Global Impression Scale- Global Improvement (CGI-I) score
Description
The Clinical Global Impression - global improvement CGI-I provides the clinician's impression of the patient's improvement (or worsening). The clinician assesses the patient's condition relative to a baseline on a 7-point scale ranging from 1 (very much improved) to 7 (very much worse)
Time Frame
at Day 7,28,56
Title
Change in Functioning Assessment Short Test (FAST) total score
Description
The FAST is a valid and reliable instrument, easy to apply which requires a short period of time to administer. Evaluates functioning taking into account the last 15 days. It was developed for the clinical evaluation of the main difficulties presented by psychiatric patients, and has been validated in several languages for patients with bipolar disorder. The FAST scale consists of 24 items which allow the assessment of six specific areas of functioning: autonomy, occupational functioning, cognitive functioning, financial issues, interpersonal relationships and leisure time
Time Frame
From baseline to Week 8
Title
Change in FAST sub-domain scores
Description
The FAST is a clinician-rated scale designed to assess difficulty in functioning. The FAST consists of 24 items in 6 specific areas of functioning: autonomy, occupational functioning, cognitive functioning, financial issues, interpersonal relationships, leisure time. Each item is rated on a 4-point scale from 0 (no difficulty) to 3 (severe difficulty). The items are summed to yield a total score ranging from 0 to 72 with higher scores reflecting more serious difficulties.
Time Frame
From baseline to Week 8
Title
Change in Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q) total score
Description
The original Q-LES-Q is a patient self-rated scale designed to measure the degree of enjoyment and satisfaction experienced by patients in various areas of daily life. It consists of 93 items to measure: physical health, feelings, work, household duties, school, leisure time activities, social relations, and general activities. Each item is rated on a 5-point scale ranging from 1 (very poor) to 5 (very good)
Time Frame
From baseline to Week 8
Title
Change in Q-LES-Q work subscale
Description
The original Q-LES-Q is a patient self-rated scale designed to measure the degree of enjoyment and satisfaction experienced by patients in various areas of daily life. It consists of 93 items to measure: physical health, feelings, work, household duties, school, leisure time activities, social relations, and general activities. Each item is rated on a 5-point scale ranging from 1 (very poor) to 5 (very good)
Time Frame
From baseline to Week 8
Title
Change in Q-LES-Q household duties subscale
Description
The original Q-LES-Q is a patient self-rated scale designed to measure the degree of enjoyment and satisfaction experienced by patients in various areas of daily life. It consists of 93 items to measure: physical health, feelings, work, household duties, school, leisure time activities, social relations, and general activities. Each item is rated on a 5-point scale ranging from 1 (very poor) to 5 (very good)
Time Frame
From baseline to Week 8
Title
Change in Q-LES-Q school/course subscale
Description
The original Q-LES-Q is a patient self-rated scale designed to measure the degree of enjoyment and satisfaction experienced by patients in various areas of daily life. It consists of 93 items to measure: physical health, feelings, work, household duties, school, leisure time activities, social relations, and general activities. Each item is rated on a 5-point scale ranging from 1 (very poor) to 5 (very good)
Time Frame
From baseline to Week 8
Title
Change in Q-LES-Q leisure time activities subscale
Description
The original Q-LES-Q is a patient self-rated scale designed to measure the degree of enjoyment and satisfaction experienced by patients in various areas of daily life. It consists of 93 items to measure: physical health, feelings, work, household duties, school, leisure time activities, social relations, and general activities. Each item is rated on a 5-point scale ranging from 1 (very poor) to 5 (very good)
Time Frame
From baseline to Week 8
Title
Change in Q-LES-Q social relations subscale
Description
The original Q-LES-Q is a patient self-rated scale designed to measure the degree of enjoyment and satisfaction experienced by patients in various areas of daily life. It consists of 93 items to measure: physical health, feelings, work, household duties, school, leisure time activities, social relations, and general activities. Each item is rated on a 5-point scale ranging from 1 (very poor) to 5 (very good)
Time Frame
From baseline to Week 8

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
65 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: The patient has a primary diagnosis of single or recurrent MDD, diagnosed according to DSM-5®. The current MDE must be confirmed using the Mini International Neuropsychiatric Interview (MINI). The patient has a MADRS total score ≥24 at screening and baseline. The patient has had the current MDE for ≥3 months and < 12 months. The patient has been treated with an SSRI as monotherapy (citalopram, escitalopram, paroxetine, sertraline) for at least 6 weeks at licensed dose for the current MDE with a partial response and is a candidate for a switch in the investigator's opinion. The patient wants to switch antidepressant treatment. Exclusion Criteria: The patient has any other disorder for which the treatment takes priority over treatment of MDD or is likely to interfere with study treatment or impair treatment compliance. Other in- and exclusion criteria may apply
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Email contact via H. Lundbeck A/S
Organizational Affiliation
LundbeckClinicalTrials@Lundbeck.com
Official's Role
Study Director
Facility Information:
Facility Name
Clinica Privada Banfield
City
Banfield
State/Province
Buenos Aires
ZIP/Postal Code
B1828CKR
Country
Argentina
Facility Name
Cenydet-Centro Neurobiologico Y De Estres Traumatico-Biopsychomedical Research Group Srl
City
Ciudad Autonoma De Buenos Aires
State/Province
Buenos Aires
ZIP/Postal Code
C1058AAJ
Country
Argentina
Facility Name
Fundacion para el Estudio y Tratamiento de las enfermedades mentales FETEM
City
Ciudad Autonoma De Buenos Aires
State/Province
Buenos Aires
ZIP/Postal Code
C1133AAH
Country
Argentina
Facility Name
INAPsi (Instituto Nacional de Psicopatologia)
City
Ciudad Autonoma de Buenos Aires
State/Province
Buenos Aires
ZIP/Postal Code
C1405BOA
Country
Argentina
Facility Name
Clinica Privada De Salud Mental Santa Teresa De Avila
City
La Plata
State/Province
Buenos Aires
ZIP/Postal Code
1900
Country
Argentina
Facility Name
Instituto De Neurociencias San Agustin SA
City
La Plata
State/Province
Buenos Aires
ZIP/Postal Code
B1900BHE
Country
Argentina
Facility Name
Sanatorio Prof. Leon S. Morra S.A.
City
Cordoba
State/Province
Providencia De Cordo
ZIP/Postal Code
X5009BIN
Country
Argentina
Facility Name
CIAP (Centro de Investigacion y Asistencia en Psiquiatria)
City
Rosario
State/Province
Santa Fe
ZIP/Postal Code
2000
Country
Argentina
Facility Name
CINME (Centro de Investigaciones Metabolicas de Buenos Aires)
City
Ciudad Autonoma De Buenos Aires
ZIP/Postal Code
C1056ABJ
Country
Argentina
Facility Name
CEN (Centro Especializado Neurociencias)
City
Cordoba
ZIP/Postal Code
5000
Country
Argentina
Facility Name
Instituto Modelo de Neurologia Fundacion Lennox
City
Cordoba
ZIP/Postal Code
X5000FAL
Country
Argentina
Facility Name
Instituto Medico DAMIC - Fundacion Rusculleda
City
Cordoba
ZIP/Postal Code
X5003DCE
Country
Argentina
Facility Name
Centro De Asistencia E Investigacion En Neurociencias CENAIN
City
Mendoza
ZIP/Postal Code
5500
Country
Argentina
Facility Name
Resolution Psicopharmacology Research Institute
City
Mendoza
ZIP/Postal Code
M5500BCR
Country
Argentina
Facility Name
Algemeen Ziekenhuis St. Lucas-St. Jozef
City
Brugge
ZIP/Postal Code
8310
Country
Belgium
Facility Name
SINAPS - University Antwerpe- Psychiatrisch Ziekenhuis Duffel
City
Duffel
ZIP/Postal Code
2570
Country
Belgium
Facility Name
Cliniques De Mont-Godinne
City
Yvoir
ZIP/Postal Code
5530
Country
Belgium
Facility Name
MHAT Dr. Hristo Stambolski
City
Kazanlak
ZIP/Postal Code
6100
Country
Bulgaria
Facility Name
UMHAT Sv. Ivan Rilski EAD
City
Plovdiv
ZIP/Postal Code
4002
Country
Bulgaria
Facility Name
Center For Mental Health-Rousse
City
Rousse
ZIP/Postal Code
7003
Country
Bulgaria
Facility Name
MC Complete Medical Solutions
City
Samokov
ZIP/Postal Code
2000
Country
Bulgaria
Facility Name
Centre for Mental Health- Sofia
City
Sofia
ZIP/Postal Code
1202
Country
Bulgaria
Facility Name
Diagnostic Consultative Center Mladost-M Varna OOD
City
Varna
ZIP/Postal Code
9020
Country
Bulgaria
Facility Name
Clintrial s.r.o.
City
Prague
State/Province
Prague 10
ZIP/Postal Code
100 00
Country
Czechia
Facility Name
Dr.Jan Holan MD, Office of
City
Brno
ZIP/Postal Code
61500
Country
Czechia
Facility Name
Meditrine s.r.o. - Psychiatricka Ambulance, Lecebne Centrum
City
Havirov
ZIP/Postal Code
73601
Country
Czechia
Facility Name
Clinline services s.r.o.
City
Hostivice
ZIP/Postal Code
25301
Country
Czechia
Facility Name
Neuropsychiatrie HK, s.r.o.
City
Hradec Kralove
ZIP/Postal Code
50009
Country
Czechia
Facility Name
National Institute of Mental Health
City
Klecany
ZIP/Postal Code
25067
Country
Czechia
Facility Name
Psychiatricka Ambulance
City
Kutna Hora
ZIP/Postal Code
28401
Country
Czechia
Facility Name
A-Shine s.r.o.
City
Plzen
ZIP/Postal Code
31200
Country
Czechia
Facility Name
Institut neuropsychiatricke pece
City
Praha 8
ZIP/Postal Code
18600
Country
Czechia
Facility Name
Marienthali Kliinik
City
Tallinn
ZIP/Postal Code
11315
Country
Estonia
Facility Name
Psihiatrijas Centrs
City
Liepaja
State/Province
Liepajas Rajons
ZIP/Postal Code
3401
Country
Latvia
Facility Name
Riga Centre Of Psychiatry And Addiction Disorders
City
Riga
ZIP/Postal Code
1005
Country
Latvia
Facility Name
Sigulda Hospital Outpatient Clinic
City
Sigulda
ZIP/Postal Code
LV-2150
Country
Latvia
Facility Name
CRI Centro Regiomontano de Investigacion SC
City
Monterrey
State/Province
Nuevo Leon
ZIP/Postal Code
64060
Country
Mexico
Facility Name
Medical Care and Research S.A. de C.V.
City
Merida
State/Province
Yucatan
ZIP/Postal Code
97070
Country
Mexico
Facility Name
Health Pharma Professional Research S.A. de C.V.
City
Ciudad de Mexico
ZIP/Postal Code
03100
Country
Mexico
Facility Name
Region Specialized Psychiatric Hospital No.2
City
Stavropol Region
State/Province
Kochubeev District
ZIP/Postal Code
357034
Country
Russian Federation
Facility Name
Leningrad Regional Psychoneurological Dispensary
City
Roshchino
State/Province
Leningrad Region
ZIP/Postal Code
188820
Country
Russian Federation
Facility Name
Arkhangelsk Regional Clinical Mental Hospital
City
Arkhangelsk
ZIP/Postal Code
163530
Country
Russian Federation
Facility Name
GUZ Engels Psychiatric Hospital
City
Engels
ZIP/Postal Code
413124
Country
Russian Federation
Facility Name
Moscow Scientific Research Institute of Psychiatry
City
Moscow
ZIP/Postal Code
107076
Country
Russian Federation
Facility Name
Clinic named after professor Yu. N. Kasatkin FGBOU DPO RMANPO Minzdrava Rossii
City
Moscow
ZIP/Postal Code
125284
Country
Russian Federation
Facility Name
Nizhny Novgorod Region State Institution Of Healthcare Clinical Psychiatric Hospital 1 Of Nizhny ...
City
Nizhny Novgorod
ZIP/Postal Code
603155
Country
Russian Federation
Facility Name
Rostov State Medical University of the Minzdravsotsrazvitiya of Russia
City
Rostov-on-Don
ZIP/Postal Code
344022
Country
Russian Federation
Facility Name
LLC Medical Center Nova Vita
City
Rostov-on-Don
ZIP/Postal Code
344082
Country
Russian Federation
Facility Name
Hospital OrKli , LLC
City
Saint-Petersburg
ZIP/Postal Code
199178
Country
Russian Federation
Facility Name
LLC Astarta
City
Saint-Petersburg
ZIP/Postal Code
199226
Country
Russian Federation
Facility Name
Saratov State Medical University
City
Saratov
ZIP/Postal Code
410028
Country
Russian Federation
Facility Name
State Budgetery Educational Institution Of Higher Professional Education Smolensk State Medical U...
City
Smolensk
ZIP/Postal Code
214019
Country
Russian Federation
Facility Name
St. Nicolas State Psychiatric Hospital
City
St. Petersburg
ZIP/Postal Code
190121
Country
Russian Federation
Facility Name
Yaroslavl Regional Clinical Psychiatry Hospital
City
Yaroslavl
ZIP/Postal Code
150003
Country
Russian Federation
Facility Name
Psychiatricka ambulancia, MENTUM, s.r.o.
City
Bratislava
ZIP/Postal Code
82007
Country
Slovakia
Facility Name
Epamed, S.R.O
City
Kosice
ZIP/Postal Code
040 01
Country
Slovakia
Facility Name
Psycholine S.R.O.
City
Rimavska Sobota
ZIP/Postal Code
97901
Country
Slovakia
Facility Name
Crystal Comfort, s.r.o.
City
Vranov Nad Topou
ZIP/Postal Code
09301
Country
Slovakia
Facility Name
BONA MEDIC s.r.o.
City
Zlate Moravce
ZIP/Postal Code
95301
Country
Slovakia
Facility Name
Psychiatricka Ambulancia
City
Zlate Moravce
ZIP/Postal Code
95301
Country
Slovakia
Facility Name
Centro De Salud Mental La Corredoria
City
Oviedo
State/Province
Asturias
ZIP/Postal Code
33011
Country
Spain
Facility Name
Hospital Universitario Fundacion Alcorcon
City
Alcorcon
State/Province
Madrid
ZIP/Postal Code
28922
Country
Spain
Facility Name
Hospital De La Santa Creu I Sant Pau
City
Barcelona
ZIP/Postal Code
08041
Country
Spain
Facility Name
Hospital Psiquiatric de Palma de Mallorca
City
Palma de Mallorca
ZIP/Postal Code
07011
Country
Spain
Facility Name
Smaert & Psykiatricentrum Malmoe
City
Malmo
State/Province
Skane
ZIP/Postal Code
21137
Country
Sweden
Facility Name
Affecta Psyikiatri AB
City
Halmstad
ZIP/Postal Code
302 48
Country
Sweden
Facility Name
ProbarE i Lund
City
Lund
ZIP/Postal Code
22222
Country
Sweden
Facility Name
ONE LIFETIME Lakarmottagning
City
Skövde
ZIP/Postal Code
541 50
Country
Sweden
Facility Name
ProbarE
City
Stockholm
ZIP/Postal Code
11329
Country
Sweden
Facility Name
Communal Non-commercial Enterprise Cherkasy regional psychiatric hospital of Cherkasy regional co...
City
Smila
State/Province
Cherkasy
ZIP/Postal Code
20708
Country
Ukraine
Facility Name
Communal Non-Commercial Enterprise of Kharkiv Regional Council Regional clinical psychiatric hosp...
City
Kharkiv
State/Province
Kharkivska
ZIP/Postal Code
61068
Country
Ukraine
Facility Name
Municipal Non-profit Enterprise Odesa Regional Psychiatric Hospital No.2 of Odesa Regional Council
City
Kominternivskyy
State/Province
Odesa
ZIP/Postal Code
67513
Country
Ukraine
Facility Name
CI of KRC Regional psychiatric and narcological medical association
City
Glevakha
ZIP/Postal Code
8631
Country
Ukraine
Facility Name
Ivano-Frankivsk Oblast neuropsychiatric hospital No. 3
City
Ivano-Frankivsk
ZIP/Postal Code
76014
Country
Ukraine
Facility Name
Academy of Medical Sciences of Ukraine - Institute of Neurology, Psychiatry and Narcology
City
Kharkiv
ZIP/Postal Code
61068
Country
Ukraine
Facility Name
SI INPN Namsu
City
Kharkiv
ZIP/Postal Code
61068
Country
Ukraine
Facility Name
Lviv Regional State Clinical Psychiatric Hospital, Lviv Danylo Galytsky National Medical University
City
Lviv
ZIP/Postal Code
79021
Country
Ukraine
Facility Name
Odessa Regional Medical Centre of Mental Health
City
Odessa
ZIP/Postal Code
65006
Country
Ukraine
Facility Name
Ukrainian Medical Stomatological Academy, Chair Of Psychiatry, Narcology And Medical Psychology B...
City
Poltava
ZIP/Postal Code
36006
Country
Ukraine
Facility Name
Vinnitsa National Medical University
City
Vinnitsa
ZIP/Postal Code
21005
Country
Ukraine

12. IPD Sharing Statement

Plan to Share IPD
Yes

Learn more about this trial

Comparison of Vortioxetine and Desvenlafaxine in Adult Patients Suffering From Depression

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