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COVID-19 Vaccine Messaging, Part 1

Primary Purpose

Vaccination, COVID-19

Status
Completed
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
Control message
Baseline message
Personal freedom message
Economic freedom message
Self-interest message
Community interest message
Economic benefit message
Guilt message
Embarrassment message
Anger message
Trust in science message
Not bravery message
Sponsored by
Yale University
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional other trial for Vaccination focused on measuring messaging

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

  • At least 18 years of age
  • US resident

Exclusion Criteria:

  • Younger than 18 years of age
  • Non-US resident
  • Do not consent

Sites / Locations

  • Yale University

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm 4

Arm 5

Arm 6

Arm 7

Arm 8

Arm 9

Arm 10

Arm 11

Arm 12

Arm Type

Sham Comparator

Active Comparator

Experimental

Experimental

Experimental

Experimental

Experimental

Experimental

Experimental

Experimental

Experimental

Experimental

Arm Label

Control

Baseline message

Personal freedom

Economic freedom

Social benefit, self-interest

Social benefit, community interest

Economic benefit

Social pressure- guilt

Social pressure- embarrassment

Social pressure- anger

Trust in science

Not bravery arm

Arm Description

Control message about birdfeeding

These participants will be assigned a message about the benefits of vaccination. All other treatment arms include this baseline language.

Experimental message arm.

Experimental message arm.

Experimental message arm.

Experimental message arm.

Experimental message arm.

Experimental message arm.

Experimental message arm.

Experimental message arm.

Experimental message arm.

Experimental message arm.

Outcomes

Primary Outcome Measures

Intention to get COVID-19 vaccine
This is a self reported measure, immediately after the intervention message, of the likelihood of getting a COVID-19 vaccination within 3 months and then 6 months of it becoming available. During analysis, responses among those assigned to different intervention messages will be compared to those in the control group.

Secondary Outcome Measures

Vaccine confidence scale
This is a validated scale. This scale will be used to assess the impact of the messages on vaccine confidence. (Outcome assessed only for the half of the sample that answers these items post-treatment)
Persuade others item
This is a measure of a willingness to persuade others to take the COVID-19 vaccine.
Fear of those who have not been vaccinated
This is a measure of a comfort with an unvaccinated individual visiting an elderly friend after a vaccine becomes available
Social judgment of those who do not vaccinate
This is a scale composed of 4 items measuring the trustworthiness, selfishness, likeableness, and competence of those who choose not to get vaccinated after a vaccine becomes available

Full Information

First Posted
July 2, 2020
Last Updated
April 29, 2022
Sponsor
Yale University
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1. Study Identification

Unique Protocol Identification Number
NCT04460703
Brief Title
COVID-19 Vaccine Messaging, Part 1
Official Title
Persuasive Messages for COVID-19 Vaccine Uptake: a Randomized Controlled Trial, Part 1
Study Type
Interventional

2. Study Status

Record Verification Date
April 2022
Overall Recruitment Status
Completed
Study Start Date
July 3, 2020 (Actual)
Primary Completion Date
July 8, 2020 (Actual)
Study Completion Date
July 8, 2020 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Yale University

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
This study tests different messages about vaccinating against COVID-19 once the vaccine becomes available. Participants are randomized to 1 of 12 arms, with one control arm and one baseline arm. We will compare the reported willingness to get a COVID-19 vaccine at 3 and 6 months of it becoming available between the 10 intervention arms to the 2 control arms. Study participants are recruited online by Lucid, which matches census based sampling in online recruitment.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Vaccination, COVID-19
Keywords
messaging

7. Study Design

Primary Purpose
Other
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Model Description
In this study, 2/15 of participants will be assigned to a control message (bird feeding passage), 3/15 of sample to a baseline vaccine message, and 1/15 to each of the 10 other treatment arms.
Masking
None (Open Label)
Allocation
Randomized
Enrollment
4000 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Control
Arm Type
Sham Comparator
Arm Description
Control message about birdfeeding
Arm Title
Baseline message
Arm Type
Active Comparator
Arm Description
These participants will be assigned a message about the benefits of vaccination. All other treatment arms include this baseline language.
Arm Title
Personal freedom
Arm Type
Experimental
Arm Description
Experimental message arm.
Arm Title
Economic freedom
Arm Type
Experimental
Arm Description
Experimental message arm.
Arm Title
Social benefit, self-interest
Arm Type
Experimental
Arm Description
Experimental message arm.
Arm Title
Social benefit, community interest
Arm Type
Experimental
Arm Description
Experimental message arm.
Arm Title
Economic benefit
Arm Type
Experimental
Arm Description
Experimental message arm.
Arm Title
Social pressure- guilt
Arm Type
Experimental
Arm Description
Experimental message arm.
Arm Title
Social pressure- embarrassment
Arm Type
Experimental
Arm Description
Experimental message arm.
Arm Title
Social pressure- anger
Arm Type
Experimental
Arm Description
Experimental message arm.
Arm Title
Trust in science
Arm Type
Experimental
Arm Description
Experimental message arm.
Arm Title
Not bravery arm
Arm Type
Experimental
Arm Description
Experimental message arm.
Intervention Type
Other
Intervention Name(s)
Control message
Intervention Description
2/15 of the sample will be assigned to the pure control group, which is a passage on the costs and benefits of bird feeding.
Intervention Type
Other
Intervention Name(s)
Baseline message
Intervention Description
3/15 of the sample will be assigned to a control group with a message about the effectiveness and safety of vaccines.
Intervention Type
Other
Intervention Name(s)
Personal freedom message
Intervention Description
1/15 of the sample will be assigned to this intervention, which is a message about how COVID-19 is limiting people's personal freedom and by working together to get enough people vaccinated society can preserve its personal freedom.
Intervention Type
Other
Intervention Name(s)
Economic freedom message
Intervention Description
1/15 of the sample will be assigned to this intervention, which is a message about how COVID-19 is limiting peoples's economic freedom and by working together to get enough people vaccinated society can preserve its economic freedom.
Intervention Type
Other
Intervention Name(s)
Self-interest message
Intervention Description
1/15 of the sample will be assigned to this intervention, which is a message that COVID-19 presents a real danger to one's health, even if one is young and healthy. Getting vaccinated against COVID-19 is the best way to prevent oneself from getting sick.
Intervention Type
Other
Intervention Name(s)
Community interest message
Intervention Description
1/15 of the sample will be assigned to this intervention, which is a message about the dangers of COVID-19 to the health of loved ones. The more people who get vaccinated against COVID-19, the lower the risk that one's loved ones will get sick. Society must work together and all get vaccinated.
Intervention Type
Other
Intervention Name(s)
Economic benefit message
Intervention Description
1/15 of the sample will be assigned to this group, which is a message about how COVID-19 is wreaking havoc on the economy and the only way to strengthen the economy is to work together to get enough people vaccinated.
Intervention Type
Other
Intervention Name(s)
Guilt message
Intervention Description
1/15 of the sample will be assigned to this message. The message is about the danger that COVID-19 presents to the health of one's family and community. The best way to protect them is by getting vaccinated and society must work together to get enough people vaccinated. Then it asks the participant to imagine the guilt they will feel if they don't get vaccinated and spread the disease.
Intervention Type
Other
Intervention Name(s)
Embarrassment message
Intervention Description
1/15 of the sample will be assigned to this message. The message is about the danger that COVID-19 presents to the health of one's family and community. The best way to protect them is by getting vaccinated and by working together to make sure that enough people get vaccinated. Then it asks the participant to imagine the embarrassment they will feel if they don't get vaccinated and spread the disease.
Intervention Type
Other
Intervention Name(s)
Anger message
Intervention Description
1/15 of the sample will be assigned to this message. The message is about the danger that COVID-19 presents to the health of one's family and community. The best way to protect them is by getting vaccinated and by working together to make sure that enough people get vaccinated. Then it asks the participant to imagine the anger they will feel if they don't get vaccinated and spread the disease.
Intervention Type
Other
Intervention Name(s)
Trust in science message
Intervention Description
1/15 of the sample will be assigned to this message about how getting vaccinated against COVID-19 is the most effective way of protecting one's community. Vaccination is backed by science. If one doesn't get vaccinated that means that one doesn't understand how infections are spread or who ignores science.
Intervention Type
Other
Intervention Name(s)
Not bravery message
Intervention Description
1/15 of the sample will be assigned to this message which describes how firefighters, doctors, and front line medical workers are brave. Those who choose not to get vaccinated against COVID-19 are not brave.
Primary Outcome Measure Information:
Title
Intention to get COVID-19 vaccine
Description
This is a self reported measure, immediately after the intervention message, of the likelihood of getting a COVID-19 vaccination within 3 months and then 6 months of it becoming available. During analysis, responses among those assigned to different intervention messages will be compared to those in the control group.
Time Frame
Immediately after intervention, in the same survey in which the intervention message is provided
Secondary Outcome Measure Information:
Title
Vaccine confidence scale
Description
This is a validated scale. This scale will be used to assess the impact of the messages on vaccine confidence. (Outcome assessed only for the half of the sample that answers these items post-treatment)
Time Frame
Immediately after intervention, in the same survey in which the intervention message is provided
Title
Persuade others item
Description
This is a measure of a willingness to persuade others to take the COVID-19 vaccine.
Time Frame
Immediately after intervention, in the same survey in which the intervention message is provided
Title
Fear of those who have not been vaccinated
Description
This is a measure of a comfort with an unvaccinated individual visiting an elderly friend after a vaccine becomes available
Time Frame
Immediately after intervention, in the same survey in which the intervention message is provided
Title
Social judgment of those who do not vaccinate
Description
This is a scale composed of 4 items measuring the trustworthiness, selfishness, likeableness, and competence of those who choose not to get vaccinated after a vaccine becomes available
Time Frame
Immediately after intervention, in the same survey in which the intervention message is provided

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: At least 18 years of age US resident Exclusion Criteria: Younger than 18 years of age Non-US resident Do not consent
Facility Information:
Facility Name
Yale University
City
New Haven
State/Province
Connecticut
ZIP/Postal Code
06510
Country
United States

12. IPD Sharing Statement

Plan to Share IPD
Yes
IPD Sharing Plan Description
Anonymized data and analysis code will be posted in a public replication archive after publication.
IPD Sharing Time Frame
After publication
IPD Sharing Access Criteria
Anonymized data and analysis code will be posted in a public replication archive
Citations:
PubMed Identifier
34774363
Citation
James EK, Bokemper SE, Gerber AS, Omer SB, Huber GA. Persuasive messaging to increase COVID-19 vaccine uptake intentions. Vaccine. 2021 Dec 3;39(49):7158-7165. doi: 10.1016/j.vaccine.2021.10.039. Epub 2021 Oct 22.
Results Reference
result

Learn more about this trial

COVID-19 Vaccine Messaging, Part 1

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