Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit (BCI-FIT)
Amyotrophic Lateral Sclerosis, Brainstem Stroke, Muscular Dystrophies
About this trial
This is an interventional basic science trial for Amyotrophic Lateral Sclerosis focused on measuring brain-computer interface
Eligibility Criteria
Inclusion Criteria:
Controls
- Able to read and communicate in English
- Capable of participating in study visits lasting 1-3 hours
- Adequate visuospatial skills to select letters, words, or icons to copy or generate messages
- Live within a 2-hour drive of OHSU or is willing to travel to OHSU
Participants with severe speech and physical impairment:
- Adults between 18-89 years of age
SSPI that may result from a variety of degenerative or neurodevelopmental conditions, including but not limited to: Duchenne muscular dystrophy, Rett Syndrome, ALS, brainstem CVA, SCI, and Parkinson-plus disorders (MSA, PSP)
- Able to read and communicate in English with speech or AAC device
- Capable of participating in study visits lasting 1-3 hours
- Adequate visuospatial skills to select letters, words or icons to copy or generate basic messages
- Life expectancy greater than 6 months
- Able to give informed consent or assent according to IRB approved policy
Exclusion Criteria:
Participants with severe speech and physical impairment:
Unstable medical conditions (fluctuating health status resulting in multiple hospitalizations within a 6 week interval)
- Unable to tolerate weekly data collection visits
- Photosensitive seizure disorder
- Presence of implanted hydrocephalus shunt, cochlear implant or deep brain stimulator
- High risk of skin breakdown from contact with data acquisition hardware.
Sites / Locations
- Oregon Health & Science UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Experimental
BCI-FIT multi-modal configuration
Adaptive signal modeling
Active querying techniques
Language modeling
For this single case research design with alternating treatments without baseline, 5 participants with severe speech and physical impairment will complete copy spelling tasks with a standard P300 matrix speller layout and with the multi-modal configurations optimized from the BCI-FIT algorithms. Outcome measures are typing accuracy, typing speed and user experience.
For this single case research design with alternating treatments without baseline, 5 participants with severe speech and physical impairment will complete copy spelling tasks with 3 signal adaptive modeling configurations. Outcome measures are typing accuracy, typing speed and user experience.
For this single case research design with alternating treatments without baseline, 5 control volunteers and 5 participants with severe speech and physical impairment who have AUC scores between 70-80% will complete copy spelling tasks with BCI-FIT active querying technique on and with BCI-FIT active querying technique off. Outcome measures are typing accuracy, typing speed and user experience.
For this single case research design with alternating treatments, 5 control volunteers and 5 participants with severe speech and physical impairment, each with a control partner for partner input will complete a story retell task with BCI-FIT language modeling features on and with BCI-FIT language modeling features off. Outcome measures are information transfer rate and user experience.