Resin Infiltration Treatment Versus a Combined Treatment With Microabrasion for the Management of MIH Affected Incisors
Primary Purpose
Molar Incisor Hypomineralization
Status
Unknown status
Phase
Not Applicable
Locations
Study Type
Interventional
Intervention
Resin infiltration and microabrasion for MIH-affected incisors
Resin infiltration for MIH-affected incisors
Sponsored by
About this trial
This is an interventional treatment trial for Molar Incisor Hypomineralization
Eligibility Criteria
Inclusion Criteria:
- Cooperative children aged between 7-16 years old
- Children with MIH having enamel opacity involving at least one permanent incisor
- MIH- affected incisors which did not receive any previous treatment
- 1/3 of the crown should be visible in the oral cavity
- Lesions size should be more than 1mm
- Healthy children
Exclusion Criteria:
- Children with systemic diseases, allergies or any dental or facial anomaly other than MIH
- Children aged < 7 or > 16 years old
- Uncooperative children
- MIH patients without the affection of the incisors or with compromised incisor esthetics due to tooth surface loss, traumatic dental injury or caries
- MIH incisors which already received any kind of treatment
- Lesions which are smaller than 1mm in size
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm Type
Active Comparator
Experimental
Arm Label
Resin infiltration group
Microabrasion + resin infiltration group
Arm Description
Enamel lesions for this group will be treated only by resin infiltration.
Enamel lesions for this group will be treated first by microabrasion followed by resin infiltration.
Outcomes
Primary Outcome Measures
Change in the aesthetics and amount of color masking of the lesion
Vita Easyshade Advance® spectrophotometer (Vita Zahnfabrik, Sackingen, Germany) will be used to evaluate the change in color of the teeth selected in the study before and after the treatment. L*, a*, and b* values will be recorded for each tooth based on the CIEL*a* b* color space. The value of color differences or color masking (∆E) will be clinically evaluated by the formula ∆E=[(∆L*)2+(∆a*)2+(∆b*). Color readings will be taken before, immediately after, 1, 3, 6, and 12 months after treatment.
Secondary Outcome Measures
Change in the patient's oral health related quality of life following the treatment: Child Perceptions Questionnaire CPQ 8-10/11-14
It includes evaluating the patient's Oral Health Related Quality of life (OHRQoL) before and after treatment which is measured as difference in the scores of the Child Perceptions Questionnaire CPQ 8-10/11-14 before and after treatment. There are 36 items included in the questionnaire covering four different domains: oral symptoms, function related limitations as well as emotional and social well-being. The participants should answer regarding the frequency of certain events in the last six months. There are 5 responses to choose from: 0 = Never, 1 = Once or twice, 2 = Sometimes, 3 = Often and 4 = Every day or almost every day. The total score should range from 0 to 144. Higher scores indicate low oral health related quality of life (OHRQoL).
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT04471571
Brief Title
Resin Infiltration Treatment Versus a Combined Treatment With Microabrasion for the Management of MIH Affected Incisors
Official Title
A Comparison of the Effectiveness of Resin Infiltration Treatment Versus a Combined Treatment of Microabrasion and Resin Infiltration for the Management of Affected Incisors in Molar Incisor Hypomineralization (MIH) Cases
Study Type
Interventional
2. Study Status
Record Verification Date
July 2020
Overall Recruitment Status
Unknown status
Study Start Date
January 2021 (Anticipated)
Primary Completion Date
January 2022 (Anticipated)
Study Completion Date
June 2022 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Cairo University
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
5. Study Description
Brief Summary
The prevalence of molar incisor hypomineralization is relatively high. It has been reported that MIH-affected children experience a wide range of negative impacts because of having visible enamel opacities on their incisors whether these teeth show post eruptive breakdown or not. The management of MIH is challenging with a broad spectrum of treatment modalities being available. However, there are no clear guidelines available to aid in clinical decision making. Possible treatment options for anterior teeth with MIH include: Microabrasion, resin infiltration, tooth bleaching, etch-bleach and seal technique and composite restorations or veneers. It is believed that these methods could be used alone or in a combination of methods to achieve better aesthetic results.
For MIH affected-incisors microabrasion and resin infiltration are acceptable treatment options which could be used alone or in a combination. Accordingly, the aim of this study is to compare the clinical outcomes of using resin infiltration either alone or combined with microabrasion for the management of MIH affected incisors.
Detailed Description
The study will be conducted on a dental unit in postgraduate clinic of Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Cairo University, Egypt.The primary hypothesis of this study is that a resin infiltration and microabrasion combined treatment will result in better clinical outcomes than using resin infiltration alone. All treatment procedures will be carried out by the principal investigator.
36 patients will be included in the study. The teeth will be randomized into two groups according to the intervention. The study involves two types of interventions:
Group 1 (resin infiltration):
The treatment will follow the manufacturer's instructions (Icon, DMG, Hamburg, Germany). The procedure involves the application of Icon-Etch, Icon-Dry as well as Icon-Infiltrant. Followed by removal of excess and then polishing of the treated surfaces.
Group 2 (Micro-abrasion followed by resin infiltration):
The Micro-abrasion agent (Opalustre, Ultradent, South Jordan, UT, USA) will be applied to the tooth for 60 seconds using a standard rubber cup attached to a low speed hand piece followed by rinsing the tooth surface with water for 20 seconds. This procedure will be repeated up to 5 times.
Resin infiltration will then be carried out as discussed before.
Vita Easyshade Advance® spectrophotometer (Vita Zahnfabrik, Sackingen, Germany) will be used to evaluate the masking color of the teeth selected in the study.
Measurements will be taken before, immediately after, 1 month, 3 months, 6 months and 12 months after treatment.
A standardized Photograph will be taken at 5 different times (before treatment, immediately afterwards, one month, 6 months and 12 months after treatment with the exact same camera and conditions. The images collected will be analyzed and evaluated by 2 different dentists.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Molar Incisor Hypomineralization
7. Study Design
Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Model Description
two-arm parallel group randomized controlled trial
Masking
ParticipantCare ProviderOutcomes Assessor
Masking Description
Selection bias: will be overcome by randomization and allocation concealment. Performance bias: will be overcome by standardized method of application by single operator.
Detection bias: will be overcome by blinding of the outcome assessor. Reporting bias: All the outcomes will be reported and published.
Allocation
Randomized
Enrollment
30 (Anticipated)
8. Arms, Groups, and Interventions
Arm Title
Resin infiltration group
Arm Type
Active Comparator
Arm Description
Enamel lesions for this group will be treated only by resin infiltration.
Arm Title
Microabrasion + resin infiltration group
Arm Type
Experimental
Arm Description
Enamel lesions for this group will be treated first by microabrasion followed by resin infiltration.
Intervention Type
Other
Intervention Name(s)
Resin infiltration and microabrasion for MIH-affected incisors
Intervention Description
MIH-affected incisors will be treated with microabrasion followed by resin infiltration as a combined treatment
Intervention Type
Other
Intervention Name(s)
Resin infiltration for MIH-affected incisors
Intervention Description
MIH-affected incisors will be treated with resin infiltration alone
Primary Outcome Measure Information:
Title
Change in the aesthetics and amount of color masking of the lesion
Description
Vita Easyshade Advance® spectrophotometer (Vita Zahnfabrik, Sackingen, Germany) will be used to evaluate the change in color of the teeth selected in the study before and after the treatment. L*, a*, and b* values will be recorded for each tooth based on the CIEL*a* b* color space. The value of color differences or color masking (∆E) will be clinically evaluated by the formula ∆E=[(∆L*)2+(∆a*)2+(∆b*). Color readings will be taken before, immediately after, 1, 3, 6, and 12 months after treatment.
Time Frame
12 months
Secondary Outcome Measure Information:
Title
Change in the patient's oral health related quality of life following the treatment: Child Perceptions Questionnaire CPQ 8-10/11-14
Description
It includes evaluating the patient's Oral Health Related Quality of life (OHRQoL) before and after treatment which is measured as difference in the scores of the Child Perceptions Questionnaire CPQ 8-10/11-14 before and after treatment. There are 36 items included in the questionnaire covering four different domains: oral symptoms, function related limitations as well as emotional and social well-being. The participants should answer regarding the frequency of certain events in the last six months. There are 5 responses to choose from: 0 = Never, 1 = Once or twice, 2 = Sometimes, 3 = Often and 4 = Every day or almost every day. The total score should range from 0 to 144. Higher scores indicate low oral health related quality of life (OHRQoL).
Time Frame
12 months
10. Eligibility
Sex
All
Minimum Age & Unit of Time
7 Years
Maximum Age & Unit of Time
16 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
Cooperative children aged between 7-16 years old
Children with MIH having enamel opacity involving at least one permanent incisor
MIH- affected incisors which did not receive any previous treatment
1/3 of the crown should be visible in the oral cavity
Lesions size should be more than 1mm
Healthy children
Exclusion Criteria:
Children with systemic diseases, allergies or any dental or facial anomaly other than MIH
Children aged < 7 or > 16 years old
Uncooperative children
MIH patients without the affection of the incisors or with compromised incisor esthetics due to tooth surface loss, traumatic dental injury or caries
MIH incisors which already received any kind of treatment
Lesions which are smaller than 1mm in size
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Shehab El-Din
Phone
201066695543
Email
dinanasrshehab@hotmail.com
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Shehab El-Din
Organizational Affiliation
Cairo University
Official's Role
Principal Investigator
12. IPD Sharing Statement
Plan to Share IPD
No
Citations:
PubMed Identifier
30287963
Citation
Almuallem Z, Busuttil-Naudi A. Molar incisor hypomineralisation (MIH) - an overview. Br Dent J. 2018 Oct 5. doi: 10.1038/sj.bdj.2018.814. Online ahead of print.
Results Reference
background
PubMed Identifier
30388743
Citation
Hasmun N, Lawson J, Vettore MV, Elcock C, Zaitoun H, Rodd H. Change in Oral Health-Related Quality of Life Following Minimally Invasive Aesthetic Treatment for Children with Molar Incisor Hypomineralisation: A Prospective Study. Dent J (Basel). 2018 Nov 1;6(4):61. doi: 10.3390/dj6040061.
Results Reference
background
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Resin Infiltration Treatment Versus a Combined Treatment With Microabrasion for the Management of MIH Affected Incisors
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