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PLATON - Platform for Analyzing Targetable Tumor Mutations (Pilot-study) (PLATON)

Primary Purpose

Hepatocellular Cancer, Cholangiocarcinoma, Gallbladder Cancer

Status

Recruiting

Phase

Not Applicable

Locations

Germany

Study Type

Interventional

Intervention

FoundationOne®CDx and FoundationOne®Liquid

About this trial

This is an interventional other trial for Hepatocellular Cancer focused on measuring Gastric cancer, Individualized cancer therapy, Targetable mutations, Foundation Medicine assays, Hepatocellular Cancer, Cholangiocarcinoma, Gallbladder Cancer, Pancreatic Cancer, Oesophageal Cancer, Stomach Cancer, Platform-Design, Biobanking

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

Histologically confirmed diagnosis of hepatocellular carcinoma or intra-/extrahepatic cholangiocarcinoma or gallbladder carcinoma or pancreatic ductal adenocarcinoma or esophagogastric adenocarcinoma in the advanced setting (adjuvant or neoadjuvant therapy is allowed if completed 6 months prior to enrolment) and no local curative therapy available
Standard first line therapy is planned, or patient is currently receiving first line therapy (started within the last 2 months before enrolment)
ECOG 0-2
Life expectancy ≥ 6 months

Exclusion Criteria:

Not able to understand all implications of study participation
No written informed consent
age < 18 years

Sites / Locations

KHNW FrankfurtRecruiting
Hannover Medical SchoolRecruiting
Friedrich-Ebert-Krankenhaus NeumünsterRecruiting
HELIOS Klinikum Bad SaarowRecruiting
Klinikum BayreuthRecruiting
Vivantes Klinikum SpandauRecruiting
Charité - Universitätsmedizin BerlinRecruiting
Evangelisches Waldkrankenhaus SpandauRecruiting
MVZ Oskar-Helene-Heim BerlinRecruiting
Augusta-Kranken-Anstalt BochumRecruiting
Bochum UniRecruiting
Klinikum ChemnitzRecruiting
Klinikum DarmstadtRecruiting
GEFOS - Gesellschaft für onkologische Studien DortmundRecruiting
Onkozentrum DresdenRecruiting
Klinikum Frankfurt HöchstRecruiting
Klinikum FuldaRecruiting
MVZ Onkologische Kooperation HarzRecruiting
Universitätsklinikum Halle (Saale)Recruiting
Hamburg Onkologisch-Hämatologische SchwerpunktpraxisRecruiting
Evangelisches Krankenhaus HammRecruiting
St. Anna Hospital HerneRecruiting
Ortenau Klinikum Lahr-EttenheimRecruiting
ÜBAG - MVZ Dr. Vehling-Kaiser GmbHRecruiting
Langen, Gemeinschaftspraxis für Hämatologie und OnkologieRecruiting
Studienzentrum UnterEmsRecruiting
Klinikum LippeRecruiting
Klinikum LudwigsburgRecruiting
Universitätsklinikum Giessen und Marburg GmbHRecruiting
Klinik München-BogenhausenRecruiting
Münster, Gemeinschaftspraxis für Hämatologie und OnkologieRecruiting
Niels-Stensen-Kliniken OsnabrückRecruiting
Medius Klinik Osterfildern-RuitRecruiting
Krankenhaus Barmherzige BrüderRecruiting
Klinikum Rheine, Mathias-Spital RheineRecruiting
RoMed Klinikum RosenheimRecruiting
Klinikum Südstadt RostockRecruiting
CaritasKlinikum SaarbrückenRecruiting
Onkologie BodenseeRecruiting
Helios Dr. Horst Schmidt Kliniken Wiesbaden GmbHRecruiting
Marien Hospital WittenRecruiting
Klinikum WolfsburgRecruiting
Onkologisches Zentrum Wolfsburg-Helmstedt MVZ GmbHRecruiting

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm 4

Arm 5

Arm Type

Other

Arm Label

Hepatocellular Cancer

Cholangiocarcinoma

Gallbladder Cancer

Pancreatic Cancer

Oesophageal Cancer + Stomach Cancer

Arm Description

molecular profiling - hepatocellular cancer (HCC)

molecular profiling - intra- and extrahepatic cholangiocellular carcinoma (CCA)

molecular profiling - gallbladder carcinoma (GBCA)

molecular profiling - pancreatic cancer (PanCa)

molecular profiling - esophagogastric cancer (EC/GC)

Outcomes

Primary Outcome Measures

Distribution of mutations in patients with HCC, intra- and extrahepatic CCA, GBCA, PDAC and gastric cancer

Relative frequency of targetable mutations (incl. TMB and MSI status) computed as the number of patients who harbors at least one mutation divided by the number of total patients in the pooled patient population.

Secondary Outcome Measures

Heterogeneity of targetable alterations in paraffin embedded specimen vs. cfDNA

Number of differences (heterogeneity) in targetable alterations in paraffin specimen vs. cfDNA

Relative frequency of targetable mutations (incl. TMB and MSI status) per disease group

Number of patients receiving therapies in accordance to their genomic profiles

Full Information

NCT ID

NCT04484636

First Posted

July 10, 2020

Last Updated

July 17, 2023

Sponsor

Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest

Collaborators

Roche Pharma AG

1. Study Identification

Unique Protocol Identification Number

NCT04484636

Brief Title

PLATON - Platform for Analyzing Targetable Tumor Mutations (Pilot-study)

Acronym

PLATON

Official Title

PLATON - Platform for Analyzing Targetable Tumor Mutations (Pilot-study) A Multicenter, Prospective, Cohort Study To Assess The Genomic Profiles And Associated Therapy Decision In Gastrointestinal Cancer

Study Type

Interventional

2. Study Status

Record Verification Date

July 2023

Overall Recruitment Status

Recruiting

Study Start Date

October 28, 2020 (Actual)

Primary Completion Date

December 31, 2023 (Anticipated)

Study Completion Date

June 30, 2024 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest

Collaborators

Roche Pharma AG

4. Oversight

Studies a U.S. FDA-regulated Drug Product

Studies a U.S. FDA-regulated Device Product

Data Monitoring Committee

5. Study Description

Brief Summary

PLATON (Platform for Analyzing Targetable Mutations) is a prospective, multicentre, observational cohort study with biobanking. In a first approach PLATON's pilot-study assesses genomic profiling in gastrointestinal cancer therapy and the frequencies of targetable mutations including Tumor Mutational Burden (TMB) and Microsatellite Instability Status (MSI), performing Next-generation deep sequencing (NGS) using the Foundation Medicine assays on tumor specimen and EDTA-whole blood samples. The Study Protocol does not define any further medical intervention or evaluate the efficacy or safety of the treatment decision made by the investigator. Another important objective of PLATON's pilot project is to evaluate whether and how many patients are treated based on their genomic profiles.

Detailed Description

PLATON (Platform for Analyzing Targetable Mutations) is designed to improve personalized therapy for patients in different cancer entities, such as in hepatocellular cancer (HCC), intra- and extrahepatic cholangiocellular carcinoma (CCA), gallbladder carcinoma (GBCA), pancreatic cancer (PanCa) and esophagogastric cancer (EC/GC), and elevate the treatment guidance within its framework. The key to understand the mechanisms in initiation, progression and response to treatment of cancer is the data integration of genetic mutational signatures with medical and physiological data of diseased cohorts. PLATON is a prospective, multicentre, observational cohort study with biobanking and does not define any medical intervention or evaluate the efficacy or safety of the treatment decision made by the investigator.In a first approach PLATON's pilot-study assess genomic profiling in gastrointestinal cancer therapy and the frequencies of targetable mutations including Tumor Mutational Burden (TMB) and Microsatellite Instability Status (MSI), performing Next-generation deep sequencing (NGS) using the Foundation Medicine assays on tumor specimen and EDTA-whole blood samples. Another important objective of PLATON's pilot project is to evaluate whether and how many patients are treated based on their genomic profiles. The pilot-study starts with the national-wide enrolment of 200 participants of both sexes and ages over 18 at 40 german study sites. The long-term vision is to enable cancer patients to receive the best available, scientifically founded, biomarker-based care, tailored to his or her individual needs

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Hepatocellular Cancer, Cholangiocarcinoma, Gallbladder Cancer, Pancreatic Cancer, Oesophageal Cancer, Stomach Cancer

Keywords

Gastric cancer, Individualized cancer therapy, Targetable mutations, Foundation Medicine assays, Hepatocellular Cancer, Cholangiocarcinoma, Gallbladder Cancer, Pancreatic Cancer, Oesophageal Cancer, Stomach Cancer, Platform-Design, Biobanking

7. Study Design

Primary Purpose

Other

Study Phase

Not Applicable

Interventional Study Model

Single Group Assignment

Model Description

Experimental Study

Masking

None (Open Label)

Allocation

Non-Randomized

Enrollment

400 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title

Hepatocellular Cancer

Arm Type

Other

Arm Description

molecular profiling - hepatocellular cancer (HCC)

Arm Title

Cholangiocarcinoma

Arm Type

Other

Arm Description

molecular profiling - intra- and extrahepatic cholangiocellular carcinoma (CCA)

Arm Title

Gallbladder Cancer

Arm Type

Other

Arm Description

molecular profiling - gallbladder carcinoma (GBCA)

Arm Title

Pancreatic Cancer

Arm Type

Other

Arm Description

molecular profiling - pancreatic cancer (PanCa)

Arm Title

Oesophageal Cancer + Stomach Cancer

Arm Type

Other

Arm Description

molecular profiling - esophagogastric cancer (EC/GC)

Intervention Type

Diagnostic Test

Intervention Name(s)

FoundationOne®CDx and FoundationOne®Liquid

Intervention Description

FoundationOne CDx is a FDA-approved broad companion diagnostic (CDx) that is clinically and analytically validated for solid tumors. The test is designed to provide physicians with clinically actionable information - both to consider appropriate therapies for patients and understand results with evidence of resistance - based on the individual genomic profile of each patient's cancer. Every test result includes microsatellite instability (MSI) and tumor mutational burden (TMB) to help inform immunotherapy decisions. FoundationOne®Liquid is a liquid biopsy test for solid tumors that analyzes circulating tumor DNA (ctDNA) in blood.

Primary Outcome Measure Information:

Title

Distribution of mutations in patients with HCC, intra- and extrahepatic CCA, GBCA, PDAC and gastric cancer

Description

Time Frame

up to 4 weeks after biospecimen provision

Secondary Outcome Measure Information:

Title

Heterogeneity of targetable alterations in paraffin embedded specimen vs. cfDNA

Description

Number of differences (heterogeneity) in targetable alterations in paraffin specimen vs. cfDNA

Time Frame

up to 4 weeks after biospecimen provision

Title

Relative frequency of targetable mutations (incl. TMB and MSI status) per disease group

Description

Relative frequency of targetable mutations (incl. TMB and MSI status) per disease group

Time Frame

up to 4 weeks after biospecimen provision

Title

Number of patients receiving therapies in accordance to their genomic profiles

Description

Number of patients receiving therapies in accordance to their genomic profiles

Time Frame

up to 4 weeks after biospecimen provision

10. Eligibility

Sex

All

Minimum Age & Unit of Time

18 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: Histologically confirmed diagnosis of hepatocellular carcinoma or intra-/extrahepatic cholangiocarcinoma or gallbladder carcinoma or pancreatic ductal adenocarcinoma or esophagogastric adenocarcinoma in the advanced setting and no local curative therapy available. Standard first line therapy is planned, or patient is currently receiving first line therapy (started within the last 2 months before enrolment) ECOG 0-2 Life expectancy ≥ 6 months Exclusion Criteria: Not able to understand all implications of study participation No written informed consent age < 18 years

Central Contact Person:

First Name & Middle Initial & Last Name or Official Title & Degree

Arndt Vogel, Prof. Dr.

Phone

+4969-7601-4420

vogela@me.com

First Name & Middle Initial & Last Name or Official Title & Degree

Bianca Zäpf

Phone

+4969-7601-4636

zaepf.bianca@ikf-khnw.de

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Salah-Eddin Al-Batran, Prof.

Organizational Affiliation

Institut für Klinische Krebsforschung IKF GmbH

Official's Role

Study Director

First Name & Middle Initial & Last Name & Degree

Arndt Vogel, Prof.

Organizational Affiliation

Hannover Medical School

Official's Role

Principal Investigator

Facility Information:

Facility Name

KHNW Frankfurt

City

Frankfurt

State/Province

Hessen

ZIP/Postal Code

60488

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Thorsten Götze, Prof.

First Name & Middle Initial & Last Name & Degree

Ulli Bankstahl

First Name & Middle Initial & Last Name & Degree

Thorsten Götze, Prof.

First Name & Middle Initial & Last Name & Degree

Timursah Habibzade, Dr.

Facility Name

Hannover Medical School

City

Hannover

State/Province

Niedersachsen

ZIP/Postal Code

30625

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Arndt Vogel, Prof. Dr.

First Name & Middle Initial & Last Name & Degree

Bianca Lavae-Mokhtari

First Name & Middle Initial & Last Name & Degree

Arndt Vogel, Prof. Dr.

First Name & Middle Initial & Last Name & Degree

Anna Saborowski, Dr.

Facility Name

Friedrich-Ebert-Krankenhaus Neumünster

City

Neumünster

State/Province

Schleswig-Holstein

ZIP/Postal Code

24534

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Siegfried Haas, Dr.

First Name & Middle Initial & Last Name & Degree

Stefan Mahlmann, Dr.

First Name & Middle Initial & Last Name & Degree

Kristin Bajorat

First Name & Middle Initial & Last Name & Degree

Paul Zimmermann, Dr.

First Name & Middle Initial & Last Name & Degree

Karsten Hamann, Dr.

Facility Name

HELIOS Klinikum Bad Saarow

City

Bad Saarow

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Daniel Pink, Dr.

First Name & Middle Initial & Last Name & Degree

Simone Micheel

First Name & Middle Initial & Last Name & Degree

Daniel Pink, Dr.

First Name & Middle Initial & Last Name & Degree

Janina Bertz-Lepel, Dr.

First Name & Middle Initial & Last Name & Degree

Antje West, Dr.

Facility Name

Klinikum Bayreuth

City

Bayreuth

ZIP/Postal Code

95445

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Alexander Kiani, Prof. Dr.

First Name & Middle Initial & Last Name & Degree

Nadine Zeitler

First Name & Middle Initial & Last Name & Degree

Alexander Kiani, Prof. Dr.

First Name & Middle Initial & Last Name & Degree

Carla Dorn

First Name & Middle Initial & Last Name & Degree

Martina Katzenberger

First Name & Middle Initial & Last Name & Degree

Werner Kippes

First Name & Middle Initial & Last Name & Degree

Viktor Martens

First Name & Middle Initial & Last Name & Degree

Melanie Wiederseiner

First Name & Middle Initial & Last Name & Degree

Urlah Mbour

Facility Name

Vivantes Klinikum Spandau

City

Berlin

ZIP/Postal Code

13585

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Jan Eucker, Dr.

First Name & Middle Initial & Last Name & Degree

Juliane Skerra

First Name & Middle Initial & Last Name & Degree

Jan Eucker, Dr.

First Name & Middle Initial & Last Name & Degree

Jörg-Christian Rath, Dr.

First Name & Middle Initial & Last Name & Degree

Annegret Kunitz, Dr.

First Name & Middle Initial & Last Name & Degree

Anna Kohlhaas, Dr.

Facility Name

Charité - Universitätsmedizin Berlin

City

Berlin

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Dominik Modest, Prof. Dr.

First Name & Middle Initial & Last Name & Degree

Susanne Grüneberg

First Name & Middle Initial & Last Name & Degree

Dominik Modest, Prof. Dr.

First Name & Middle Initial & Last Name & Degree

Sebastian Stintzing, Prof. Dr.

First Name & Middle Initial & Last Name & Degree

Annika Kurreck, Dr.

Facility Name

Evangelisches Waldkrankenhaus Spandau

City

Berlin

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Silke Polata, Dr

First Name & Middle Initial & Last Name & Degree

Ute Moritz

First Name & Middle Initial & Last Name & Degree

Silke Polata, Dr.

First Name & Middle Initial & Last Name & Degree

Kristin Lindemann, Dr.

Facility Name

MVZ Oskar-Helene-Heim Berlin

City

Berlin

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Markus Schuler, Dr. med.

First Name & Middle Initial & Last Name & Degree

Leffers Elvira

First Name & Middle Initial & Last Name & Degree

Markus Schuler, Dr. med.

First Name & Middle Initial & Last Name & Degree

Philipp Kiewe, Dr. med.

Facility Name

Augusta-Kranken-Anstalt Bochum

City

Bochum

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Dirk Behringer, Prof. Dr.

First Name & Middle Initial & Last Name & Degree

Dorothee Henzler

First Name & Middle Initial & Last Name & Degree

Dirk Behringer, Prof. Dr.

First Name & Middle Initial & Last Name & Degree

Annette Nolte, Dr.

First Name & Middle Initial & Last Name & Degree

Iris Dieck-Stiller

First Name & Middle Initial & Last Name & Degree

Anna E Zdebik

First Name & Middle Initial & Last Name & Degree

Tanja Woiwod

First Name & Middle Initial & Last Name & Degree

Stefan Lukic

Facility Name

Bochum Uni

City

Bochum

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Michael Pohl, Dr.

First Name & Middle Initial & Last Name & Degree

Julia Buß

First Name & Middle Initial & Last Name & Degree

Michael Pohl, Dr.

First Name & Middle Initial & Last Name & Degree

Deepak Vangala, Dr.

Facility Name

Klinikum Chemnitz

City

Chemnitz

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Jack Chater, Dr.

First Name & Middle Initial & Last Name & Degree

Katja Schaarschmidt

First Name & Middle Initial & Last Name & Degree

Jack Chater, Dr.

First Name & Middle Initial & Last Name & Degree

Hagen Rudolph, Dr.

First Name & Middle Initial & Last Name & Degree

Ilja Kubisch, Dr.

Facility Name

Klinikum Darmstadt

City

Darmstadt

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Helga Bernhard, Prof. Dr.

First Name & Middle Initial & Last Name & Degree

Cora Schwebel-Kottke

First Name & Middle Initial & Last Name & Degree

Helga Bernhard, Prof. Dr.

First Name & Middle Initial & Last Name & Degree

Rainer Schuker, Dr.

First Name & Middle Initial & Last Name & Degree

Stephan Schäfer, Dr.

First Name & Middle Initial & Last Name & Degree

Petra Dörner-Mann, Dr.

First Name & Middle Initial & Last Name & Degree

Thorsten Wenzel, Dr.

First Name & Middle Initial & Last Name & Degree

Corinna Gobst, Dr.

First Name & Middle Initial & Last Name & Degree

Tu-Anh Dang, Dr.

Facility Name

GEFOS - Gesellschaft für onkologische Studien Dortmund

City

Dortmund

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Clemens Schulte, Dr.

First Name & Middle Initial & Last Name & Degree

Monika Ludwig, Dr.

First Name & Middle Initial & Last Name & Degree

Clemens Schulte, Dr.

First Name & Middle Initial & Last Name & Degree

Jörg Lipke, Dr.

First Name & Middle Initial & Last Name & Degree

Christiane Dr. Christiane Bernhardt, Dr.

First Name & Middle Initial & Last Name & Degree

Daniela Collette

First Name & Middle Initial & Last Name & Degree

Sandra Ketzler-Henkel

Facility Name

Onkozentrum Dresden

City

Dresden

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Steffen Dörfel

First Name & Middle Initial & Last Name & Degree

Franziska Schwarzbach

First Name & Middle Initial & Last Name & Degree

Steffen Dörfel

First Name & Middle Initial & Last Name & Degree

Thomas Göhler, Dr.

First Name & Middle Initial & Last Name & Degree

Sebastian Thiele, Dr.

First Name & Middle Initial & Last Name & Degree

Susann Melzer, Dr.

First Name & Middle Initial & Last Name & Degree

Thomas Boldt

Facility Name

Klinikum Frankfurt Höchst

City

Frankfurt

ZIP/Postal Code

65929

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Hans-Günter Derigs, Prof. Dr.

First Name & Middle Initial & Last Name & Degree

Kim-Cybil Hermann

First Name & Middle Initial & Last Name & Degree

Hans-Günter Derigs, Prof. Dr.

First Name & Middle Initial & Last Name & Degree

Felicitas Scholten, Dr.

Facility Name

Klinikum Fulda

City

Fulda

ZIP/Postal Code

36043

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Andreas Dickhut, Dr.

First Name & Middle Initial & Last Name & Degree

Christine Lochner

First Name & Middle Initial & Last Name & Degree

Andreas Dickhut, Dr.

First Name & Middle Initial & Last Name & Degree

Philippe Kostrewa, Dr.

First Name & Middle Initial & Last Name & Degree

Heinz-Gert Höffkes, Prof. Dr.

First Name & Middle Initial & Last Name & Degree

Ulrich Bonse-Geuking, Dr.

Facility Name

MVZ Onkologische Kooperation Harz

City

Goslar

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Mark-Oliver Zahn, Dr.

First Name & Middle Initial & Last Name & Degree

Alexandra Hess

First Name & Middle Initial & Last Name & Degree

Mark-Oliver Zahn, Dr.

First Name & Middle Initial & Last Name & Degree

Timo Kambach, Dr.

First Name & Middle Initial & Last Name & Degree

Bijan Zomorodbakhsch, Dr.

First Name & Middle Initial & Last Name & Degree

Martin Stolze, Dr.

Facility Name

Universitätsklinikum Halle (Saale)

City

Halle

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Petra Büchner-Steudel, Dr.

First Name & Middle Initial & Last Name & Degree

Susanne Behl

First Name & Middle Initial & Last Name & Degree

Petra Büchner-Steudel, Dr.

First Name & Middle Initial & Last Name & Degree

Sebastian Krug

First Name & Middle Initial & Last Name & Degree

Nora Schweitzer

Facility Name

Hamburg Onkologisch-Hämatologische Schwerpunktpraxis

City

Hamburg

ZIP/Postal Code

22457

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Tobias Graefe

First Name & Middle Initial & Last Name & Degree

Mona Porep

First Name & Middle Initial & Last Name & Degree

Tobias Graefe

First Name & Middle Initial & Last Name & Degree

Stefan Bonmann, Dr.

First Name & Middle Initial & Last Name & Degree

Kristine Hochgartz, Dr.

First Name & Middle Initial & Last Name & Degree

Christine Lange-Hüsken

First Name & Middle Initial & Last Name & Degree

Sigrun Müller-Hagen, Dr.

First Name & Middle Initial & Last Name & Degree

Torsten Winterberg, Dr.

Facility Name

Evangelisches Krankenhaus Hamm

City

Hamm

ZIP/Postal Code

59063

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Alexander Baraniskin, Prof. Dr.

First Name & Middle Initial & Last Name & Degree

Claudia Pospiech

First Name & Middle Initial & Last Name & Degree

Alexander Baraniskin, Prof. Dr.

First Name & Middle Initial & Last Name & Degree

Ruxandra Elena Parascan, Dr.

First Name & Middle Initial & Last Name & Degree

Marina Dreglea

First Name & Middle Initial & Last Name & Degree

Andrea Stoltefuß

Facility Name

St. Anna Hospital Herne

City

Herne

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Vera Heuer, Dr.

First Name & Middle Initial & Last Name & Degree

Monika Stache

First Name & Middle Initial & Last Name & Degree

Vera Heuer, Dr.

First Name & Middle Initial & Last Name & Degree

Christoph Dobrescu

First Name & Middle Initial & Last Name & Degree

Tjorven K Förster

First Name & Middle Initial & Last Name & Degree

Philipp J Haubold

First Name & Middle Initial & Last Name & Degree

Martin Jazra, Dr.

First Name & Middle Initial & Last Name & Degree

Viktor Rempel, Dr.

Facility Name

Ortenau Klinikum Lahr-Ettenheim

City

Lahr

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Jean-Charles Moulin, Dr.

First Name & Middle Initial & Last Name & Degree

Kerstin Riedel

First Name & Middle Initial & Last Name & Degree

Jean-Charles Moulin, Dr.

First Name & Middle Initial & Last Name & Degree

Oliver Delic, Dr.

First Name & Middle Initial & Last Name & Degree

Angela Nieder, Dr.

First Name & Middle Initial & Last Name & Degree

Oliver Schmah, Dr.

Facility Name

ÜBAG - MVZ Dr. Vehling-Kaiser GmbH

City

Landshut

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Michael Sohm, Dr.

First Name & Middle Initial & Last Name & Degree

Ana Hoffmann, Dr.

First Name & Middle Initial & Last Name & Degree

Michael Sohm, Dr.

First Name & Middle Initial & Last Name & Degree

Ursula Vehling-Kaiser, Dr.

First Name & Middle Initial & Last Name & Degree

Florian Kaiser, Dr.

First Name & Middle Initial & Last Name & Degree

Franziskus Finsterwalder, Dr.

First Name & Middle Initial & Last Name & Degree

Mike Haberkorn

First Name & Middle Initial & Last Name & Degree

Maximilian Müller, Dr.

Facility Name

Langen, Gemeinschaftspraxis für Hämatologie und Onkologie

City

Langen

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Andreas Köhler, Dr.

First Name & Middle Initial & Last Name & Degree

Beate Jung

First Name & Middle Initial & Last Name & Degree

Andreas Köhler, Dr.

First Name & Middle Initial & Last Name & Degree

Roswitha Fuchs, Dr.

First Name & Middle Initial & Last Name & Degree

Katharina Girod, Dr.

Facility Name

Studienzentrum UnterEms

City

Leer

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Lothar Müller, Dr.

First Name & Middle Initial & Last Name & Degree

Christine Strohschnieder

First Name & Middle Initial & Last Name & Degree

Lothar Müller, Dr.

Facility Name

Klinikum Lippe

City

Lemgo

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Frank Hartmann, Prof. Dr.

First Name & Middle Initial & Last Name & Degree

Melanie Kriete

First Name & Middle Initial & Last Name & Degree

Frank Hartmann, Prof. Dr.

First Name & Middle Initial & Last Name & Degree

Christian Constantin, Dr.

First Name & Middle Initial & Last Name & Degree

Sarunas Bagdonas, Dr.

Facility Name

Klinikum Ludwigsburg

City

Ludwigsburg

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Stefan Angermeier, Dr.

First Name & Middle Initial & Last Name & Degree

Juliane Behn

First Name & Middle Initial & Last Name & Degree

Stefan Angermeier, Dr.

First Name & Middle Initial & Last Name & Degree

Matthias Ulmer, Dr.

Facility Name

Universitätsklinikum Giessen und Marburg GmbH

City

Marburg

ZIP/Postal Code

35043

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Anja Rinke, Dr.

First Name & Middle Initial & Last Name & Degree

Erich Kort

First Name & Middle Initial & Last Name & Degree

Anja Rinke, Dr.

First Name & Middle Initial & Last Name & Degree

Malte Zumblick, Dr.

First Name & Middle Initial & Last Name & Degree

Sonja Gehring, Dr.

Facility Name

Klinik München-Bogenhausen

City

München

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Martin Fuchs, Dr.

First Name & Middle Initial & Last Name & Degree

Bettina Huß

First Name & Middle Initial & Last Name & Degree

Martin Fuchs, Dr.

First Name & Middle Initial & Last Name & Degree

Irene Klingenberg, Dr.

First Name & Middle Initial & Last Name & Degree

Jael Nisenbaum, Dr.

First Name & Middle Initial & Last Name & Degree

Fabian Hartmann, Dr.

Facility Name

Münster, Gemeinschaftspraxis für Hämatologie und Onkologie

City

Münster

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Rüdiger Liersch, Dr.

First Name & Middle Initial & Last Name & Degree

Martina Ester

First Name & Middle Initial & Last Name & Degree

Rüdiger Liersch, Dr.

First Name & Middle Initial & Last Name & Degree

Christian Lerchenüller, Dr.

First Name & Middle Initial & Last Name & Degree

Ralf Bieker, Dr.

First Name & Middle Initial & Last Name & Degree

Karsten Kratz-Albers, Dr.

First Name & Middle Initial & Last Name & Degree

Holger Timmer, Dr.

First Name & Middle Initial & Last Name & Degree

Daniela Schüler, Dr.

Facility Name

Niels-Stensen-Kliniken Osnabrück

City

Osnabrück

ZIP/Postal Code

49074

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Kerstin Schütte, Dr.

First Name & Middle Initial & Last Name & Degree

Birgit Unterberg

First Name & Middle Initial & Last Name & Degree

Kerstin Schütte, Dr.

First Name & Middle Initial & Last Name & Degree

Kristina Middelberg-Bisping, Dr.

Facility Name

Medius Klinik Osterfildern-Ruit

City

Ostfildern

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Bodo Klump, Prof. Dr.

First Name & Middle Initial & Last Name & Degree

Chistine Neumann

First Name & Middle Initial & Last Name & Degree

Bodo Klump, Prof. Dr.

First Name & Middle Initial & Last Name & Degree

Alberta-May Daraban-Brixner, Dr.

First Name & Middle Initial & Last Name & Degree

Nikolai Schuelper, Dr.

First Name & Middle Initial & Last Name & Degree

Karin Waibel, Dr.

Facility Name

Krankenhaus Barmherzige Brüder

City

Regensburg

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Nicolas Moosmann, Dr.

First Name & Middle Initial & Last Name & Degree

Christiane Reinert

First Name & Middle Initial & Last Name & Degree

Nicolas Moosmann, Dr.

First Name & Middle Initial & Last Name & Degree

Anke Schlenska-Lange, Dr.

First Name & Middle Initial & Last Name & Degree

Nadia Maguire, Dr.

First Name & Middle Initial & Last Name & Degree

V. Berberich, Dr.

First Name & Middle Initial & Last Name & Degree

Jan Braess, Prof. Dr.

First Name & Middle Initial & Last Name & Degree

Susanne Thalmeier, Dr.

First Name & Middle Initial & Last Name & Degree

Heribert Stauder, Dr.

First Name & Middle Initial & Last Name & Degree

Michael Schenk, Dr.

First Name & Middle Initial & Last Name & Degree

Bernhard Heilmeier, Dr.

First Name & Middle Initial & Last Name & Degree

Bernard Braun, Dr.

Facility Name

Klinikum Rheine, Mathias-Spital Rheine

City

Rheine

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Sebastian Broeckling, Dr.

First Name & Middle Initial & Last Name & Degree

Kerstin Vehring

First Name & Middle Initial & Last Name & Degree

Sebastian Broeckling, Dr.

First Name & Middle Initial & Last Name & Degree

Stefan Zicholl, Dr.

First Name & Middle Initial & Last Name & Degree

Antonia Hansmeier, Dr.

First Name & Middle Initial & Last Name & Degree

Guido Bisping, Dr.

Facility Name

RoMed Klinikum Rosenheim

City

Rosenheim

ZIP/Postal Code

83022

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Gerhard Puchtler, Dr.

First Name & Middle Initial & Last Name & Degree

Senada Herrmann

First Name & Middle Initial & Last Name & Degree

Gerhard Puchtler, Dr.

First Name & Middle Initial & Last Name & Degree

Ulrike Kolar-Michaelis, Dr.

Facility Name

Klinikum Südstadt Rostock

City

Rostock

ZIP/Postal Code

18059

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Beate Krammer-Steiner, Dr.

First Name & Middle Initial & Last Name & Degree

Dèsirèe Pürschel

First Name & Middle Initial & Last Name & Degree

Beate Krammer-Steiner, Dr.

First Name & Middle Initial & Last Name & Degree

Kerstin Peters, Dr.

First Name & Middle Initial & Last Name & Degree

Sora Schipper, Dr.

First Name & Middle Initial & Last Name & Degree

Henrike Broer

Facility Name

CaritasKlinikum Saarbrücken

City

Saarbrücken

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Manfred Lutz, Prof. Dr.

First Name & Middle Initial & Last Name & Degree

Ulrike Schilling

First Name & Middle Initial & Last Name & Degree

Manfred Lutz, Prof. Dr.

First Name & Middle Initial & Last Name & Degree

Michael Clemens, Prof. Dr.

First Name & Middle Initial & Last Name & Degree

Anca A Cura, Dr.

First Name & Middle Initial & Last Name & Degree

Jérôme Schwingel

Facility Name

Onkologie Bodensee

City

Singen

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Thomas Fietz, Dr.

First Name & Middle Initial & Last Name & Degree

Karin Kingerter

First Name & Middle Initial & Last Name & Degree

Thomas Fietz, Dr.

First Name & Middle Initial & Last Name & Degree

Christian Hertkorn, Dr.

First Name & Middle Initial & Last Name & Degree

Niels Steinebrunner, Dr.

Facility Name

Helios Dr. Horst Schmidt Kliniken Wiesbaden GmbH

City

Wiesbaden

ZIP/Postal Code

65199

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Wolfgang Blau, Dr.

First Name & Middle Initial & Last Name & Degree

Sibylle Kerth-Krick

First Name & Middle Initial & Last Name & Degree

Wolfgang Blau, Dr.

First Name & Middle Initial & Last Name & Degree

Natalia Heinz, Dr.

First Name & Middle Initial & Last Name & Degree

Moritz Lesse, Dr.

Facility Name

Marien Hospital Witten

City

Witten

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Matthias Zeth, Dr.

First Name & Middle Initial & Last Name & Degree

Katja Fritz

First Name & Middle Initial & Last Name & Degree

Matthias Zeth, Dr.

First Name & Middle Initial & Last Name & Degree

Metin Senkal, Prof. Dr.

Facility Name

Klinikum Wolfsburg

City

Wolfsburg

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Nils Homann, Prof. Dr.

First Name & Middle Initial & Last Name & Degree

Jeannette Wertmann

First Name & Middle Initial & Last Name & Degree

Nils Homann, Prof. Dr.

First Name & Middle Initial & Last Name & Degree

Steffen Neumann, Dr.

First Name & Middle Initial & Last Name & Degree

Janine Markgraf

First Name & Middle Initial & Last Name & Degree

Alexander Behrens, Dr.

First Name & Middle Initial & Last Name & Degree

Ulrike Weber

Facility Name

Onkologisches Zentrum Wolfsburg-Helmstedt MVZ GmbH

City

Wolfsburg

Country

Germany

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Thomas Gabrysiak, Dr.

First Name & Middle Initial & Last Name & Degree

Carina Kupke

First Name & Middle Initial & Last Name & Degree

Thomas Gabrysiak, Dr.

First Name & Middle Initial & Last Name & Degree

Joachim Haessner, Dr.

First Name & Middle Initial & Last Name & Degree

Katrin Heine, Dr.

First Name & Middle Initial & Last Name & Degree

Jens Kersten

12. IPD Sharing Statement

Plan to Share IPD

IPD Sharing Plan Description

Depending on particpant informed concent individual-participant data (IPD) will only be shared in research-cooperations according the terms of PLATON's Use and Access Regulation. Scientific projects have to be approved by PLATON'S Scientific Steering Committee.

Links:

URL

https://platon-network.de/

Description

The PLATON Network

Learn more about this trial

PLATON - Platform for Analyzing Targetable Tumor Mutations (Pilot-study)

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