Air-polishing or Conventional Treatment
Primary Purpose
Periodontitis, Adult Periodontitis
Status
Completed
Phase
Not Applicable
Locations
Study Type
Interventional
Intervention
Gracey curette.
Ultrasonic scaler.
Erythritol air-polishing.
Sponsored by
About this trial
This is an interventional treatment trial for Periodontitis focused on measuring Furcation involvement, Periodontal maintenance
Eligibility Criteria
Inclusion Criteria:
- Received supportive periodontal therapy (SPT) every 3-6 months for 2-3 years following periodontal therapy.
- Having bilateral non-mobile, fully erupted mandibular first, second or third molars with degree II furcation defects.
- PD≥4 mm with bleeding or pus on probing. -
Exclusion Criteria:
- Mobile mandibular molars, molars with clinical or radiographic evidence of supra-/subgingival calculus or apical pathology.
- Use of systemic antibiotics within 6 months or SPT within 3 months of study.
- Any current medical condition affecting periodontal treatment or use of the abrasive air-polishing device.
Subjects with diabetes, cancer, HIV/aids, acute infections, disorders that may compromise wound healing, or pregnant women.
-
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm Type
Active Comparator
Experimental
Arm Label
Titanium curette and ultrasonic.
Erythritol air-polishing.
Arm Description
Debridement of mandibular furcations with conventional ultrasonic/curette (control).
Treatment of mandibular furcations with erythritol powder/air-polishing system (test)
Outcomes
Primary Outcome Measures
In 20 patients with grade II mandibular molar furcation defects, probing depth (PD) will be measured.
PD: The vertical distance from the gingival margin to the probable base of the pocket in mm.
In 20 patients with grade II mandibular molar furcation defects clinical attachment level (CAL) will be measured.
CAL: The vertical distance in mm from the cemento-enamel junction or the margin of a dental restoration to the probable base of the pocket.
Secondary Outcome Measures
Bleeding on probing (BoP).
At site level, BoP was recorded as present upon gentle probing to the base of the vertical furcation pocket.
Gingival crevicular fluid (GCF).
Twenty test and control sites were isolated with cottons rolls, cleaned for supragingival plaque, and air-dried. A perio paper strip was then placed 1-2 mm into the orifice of the site and left in place for 30 sec. The perio strip was inserted into the Periotron 8000® (Oraflow, Smithtown, NY, USA) calibrated to estimate the volume of GCF collected.
Visual analogue scale (VAS).
VAS scores were used to estimate patient discomfort experienced during test and control treatment by drawing a vertical line on a 100-millimeter standardized horizontal line (0="no pain" and 100="worst pain I can imagine").
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT04493398
Brief Title
Air-polishing or Conventional Treatment
Official Title
Erythritol Air-polishing Versus Curette/Ultrasonic Debridement of Mandibular Furcation Lesions in Supportive Periodontal Therapy A 12-Month Randomized Controlled Trial
Study Type
Interventional
2. Study Status
Record Verification Date
July 2020
Overall Recruitment Status
Completed
Study Start Date
June 1, 2015 (Actual)
Primary Completion Date
June 30, 2016 (Actual)
Study Completion Date
December 1, 2018 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
University of Bergen
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No
5. Study Description
Brief Summary
Background: To effectively disrupt microbial biofilm and remove dental calculus with minimal damage to the root surface and soft tissues with limited patient discomfort constitute a significant tenet of periodontal therapy. The aim of the present prospective 12-month study was to compare clinical and microbiological effects following an erythritol air-polishing vs. conventional mechanical debridement of furcation defects in a cohort of periodontal maintenance patients.
Methods: Twenty patients with grade II mandibular molar furcation defects volunteered to enroll in this study. In a split-mouth design, two furcation sites in each patient were randomly assigned to either receive subgingival debridement using erythritol air-polishing (test) or conventional ultrasonic/curette debridement (control) at baseline, and at 3, 6, 9 and 12 months. Probing depth, clinical attachment level and bleeding on probing were recorded at 3-month intervals. Subgingival microbiological samples obtained at baseline, 6 and 12 months were analyzed using checkerboard DNA-DNA hybridization. Discomfort from treatment was scored at 12 months using a visual analogue scale.
Detailed Description
INTRODUCTION.Traditionally, periodontal debridement is accomplished using curettes, sonic or ultrasonic scalers, all presenting comparable outcomes.1,2 However, periodic root instrumentation may lead to dental hard tissue3-6 and soft tissue damage,7 and sensitivity due to exposure of dentinal tubules.8-10 Air-polishing using low abrasive glycine or trehalose powder has been shown to reach similar clinical outcomes as hand and ultrasonic instrumentation, but with less hard tissue loss.11-16 Moreover, air-polishing provides superior outcomes relative to patient comfort and time efficiency.7,11,12,14 Recently, a low abrasive erythritol powder with comparable physical properties to glycine air-polishing powder was introduced for subgingival air-polishing.17 Erythritol, a non-toxic, chemically neutral and completely water-soluble polyol is widely used in food industry as an artificial sweetener. Two studies comparing conventional mechanical debridement with erythritol air-polishing, reported similar results in supportive periodontal therapy (SPT) relative to clinical and microbiological outcomes.18,19 Such observations are also reflected in a systematic review concluding that air-polishing systems as a monotherapy are comparable to conventional therapy in patients undergoing SPT in single- and multi-rooted teeth without furcations.20 Moreover, inhibitory effects on pathogenic bacteria including Porphyromonas gingivalis have also been observed.21 To the investigator's knowledge, no prospective studies investigating the efficacy of a low abrasive erythritol air-polishing system in molar furcation defects during SPT have been reported. The objective of this 12-month prospective study was to compare clinical and microbiological effects following an erythritol air-polishing system vs. conventional mechanical debridement of furcation defects in a cohort of periodontal maintenance patients.
METHOD AND MATERIALS. The study protocol and informed consent following the Helsinki Declaration of 1975 (version 2008) was approved by the Medical Research Ethics Committee (2016/793), University of Bergen, Norway. Participating subjects read and signed the informed consent prior to enrolling in the study.
Prestudy calibration and training. Two operators performed the clinical aspects of this study. Author TS, masked to treatment assignments, performed all clinical recordings and sampling, author IU performed all treatments.
Sample size. The sample size estimation was based on change in PD. A difference of 0.5 mm was considered clinically relevant.22 Standard deviation of the difference between repeated PD measurements from the intra-calibration exercise was 0.5 mm. A power analysis based on 20 subjects and with the level of significance (α) set to 0.05, resulted in 98.9% power to detect a true difference of 0.5 mm.
Treatments. Following baseline examination, mandibular jaw quadrants were randomized (coin toss) to either receive debridement using the erythritol powder/air-polishing system (test) or conventional ultrasonic/curette instrumentation (control) using a split-mouth study design. Sequence of treatments was randomized in a similar fashion. Treatments were delivered at baseline, and repeated at 3, 6, 9 and 12 months. Test sites thus received root debridement using the low abrasive erythritol powder (Air-flow powder plus®, EMS, Nyon, Switzerland ) applied through a Perio-Flow hand piece connected to an airflow unit (Air-Flow Master®, EMS, Nyon, Switzerland). The hand piece was fitted with a nozzle for subgingival delivery directing the power/air jet perpendicular to the root surface at the water exit at the tip of the nozzle. The nozzle was inserted to the apical aspect of furcation sites with PD≥ 4 mm using striking movements over the furcation area for 5 sec.12 Sites adjoining the test site with PD≥ 4 mm were similarly treated.
Control sites were debrided using an ultrasonic scaler (Piezon Master 400 Perio Slim Tip®; Electro Medical System, Nyon, Switzerland) with power set at 75% and water as coolant, and root planed with sharp curettes (Gracey SAS, Hu-Friedy, Chicago, IL, USA).
Patients were returned to their regular SPT upon completion of study. Gingival crevicular fluid assessments. Gingival crevicular fluid (GCF) was recorded at baseline, and at 6 and 12 months. Briefly, furcation sites were isolated with cottons rolls, cleaned for supragingival plaque, and air-dried. A perio paper strip was then placed 1-2 mm into the orifice of the site and left in place for 30 sec. Next, the perio strip was inserted into the Periotron 8000® (Oraflow, Smithtown, NY, USA) calibrated to estimate the volume of GCF collected.
Microbiological assessments. At baseline, and at 6 and 12 months the supragingival area above the furcation site was wiped clean using sterile cotton pellets. Three sterile paper points were then inserted into the pocket of the furcation site. The paper points were kept in place 20 sec27 removed and immersed into pre-reduced, anaerobic transport medium (PRAS; Dental Transport Medium, Morgan Hill, CA, USA).
Pain experience assessments. Visual analogue scale (VAS) scores were used to estimate patient discomfort experienced during test and control treatment.31 Scoring was performed at 12 months following completion of the debridement with 0="no pain" and 100="worst pain I can imagine".
Statistical analysis Data were entered into MS-Excel (Microsoft, Redmond, WA, USA ) proofed for errors and then imported into Stata, version 15 (StataCorp, College Station, TX, USA).
Summary statistics (means ± SEM) for the clinical variables were calculated for the test and control at baseline, and at 6 and 12 months. Due to the repeated nature of data, a mixed effect model taking into consideration incomplete data at 12 months was applied to analyze the data at patient and tooth level. Time and treatment were considered fixed factors. Mixed models were applied for both primary and secondary outcome variables.
For testing differences in microbial composition at test and control sites harboring different proportions of bacteria >105 at baseline, and at 6 and 12 months, logistic regression models with robust standard error were applied. VAS scores were analyzed using ordinary linear regression models with robust standard error. The level of significance was set at 0.05.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Periodontitis, Adult Periodontitis
Keywords
Furcation involvement, Periodontal maintenance
7. Study Design
Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Crossover Assignment
Model Description
Randomized, single-masked controlled trial (RCT). A split-mouth study design where each of the furcation in the lower jaw molars was randomized to the two specific treatments. Hence, each patient received both interventions randomly allocated to each side of the lower jaw.
Masking
InvestigatorOutcomes Assessor
Masking Description
Two operators performed the clinical aspects of this study. Author TS, masked to treatment assignments, performed all clinical recordings and sampling, author IU performed all treatments. All analyses were performed by a statistician (SAL) who had not taken part in data collection or treatments.
Allocation
Randomized
Enrollment
20 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Titanium curette and ultrasonic.
Arm Type
Active Comparator
Arm Description
Debridement of mandibular furcations with conventional ultrasonic/curette (control).
Arm Title
Erythritol air-polishing.
Arm Type
Experimental
Arm Description
Treatment of mandibular furcations with erythritol powder/air-polishing system (test)
Intervention Type
Procedure
Intervention Name(s)
Gracey curette.
Intervention Description
Root planed was performed with curettes (Gracey SAS, Hu-Friedy, Chicago, IL, USA).
Intervention Type
Procedure
Intervention Name(s)
Ultrasonic scaler.
Intervention Description
Debridement was performed with an ultrasonic scaler (Piezon Master 400 Perio Slim Tip®; Electro Medical System, Nyon, Switzerland).
Intervention Type
Procedure
Intervention Name(s)
Erythritol air-polishing.
Intervention Description
Treatment was performed with a low abrasive erythritol powder (Air-flow powder plus®, EMS, Nyon, Switzerland ) applied through a Perio-Flow hand piece connected to an airflow unit (Air-Flow Master®, EMS, Nyon, Switzerland).
Primary Outcome Measure Information:
Title
In 20 patients with grade II mandibular molar furcation defects, probing depth (PD) will be measured.
Description
PD: The vertical distance from the gingival margin to the probable base of the pocket in mm.
Time Frame
12 months.
Title
In 20 patients with grade II mandibular molar furcation defects clinical attachment level (CAL) will be measured.
Description
CAL: The vertical distance in mm from the cemento-enamel junction or the margin of a dental restoration to the probable base of the pocket.
Time Frame
12 months.
Secondary Outcome Measure Information:
Title
Bleeding on probing (BoP).
Description
At site level, BoP was recorded as present upon gentle probing to the base of the vertical furcation pocket.
Time Frame
12 months.
Title
Gingival crevicular fluid (GCF).
Description
Twenty test and control sites were isolated with cottons rolls, cleaned for supragingival plaque, and air-dried. A perio paper strip was then placed 1-2 mm into the orifice of the site and left in place for 30 sec. The perio strip was inserted into the Periotron 8000® (Oraflow, Smithtown, NY, USA) calibrated to estimate the volume of GCF collected.
Time Frame
12 months.
Title
Visual analogue scale (VAS).
Description
VAS scores were used to estimate patient discomfort experienced during test and control treatment by drawing a vertical line on a 100-millimeter standardized horizontal line (0="no pain" and 100="worst pain I can imagine").
Time Frame
12 months.
10. Eligibility
Sex
All
Minimum Age & Unit of Time
30 Years
Maximum Age & Unit of Time
80 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Received supportive periodontal therapy (SPT) every 3-6 months for 2-3 years following periodontal therapy.
Having bilateral non-mobile, fully erupted mandibular first, second or third molars with degree II furcation defects.
PD≥4 mm with bleeding or pus on probing. -
Exclusion Criteria:
Mobile mandibular molars, molars with clinical or radiographic evidence of supra-/subgingival calculus or apical pathology.
Use of systemic antibiotics within 6 months or SPT within 3 months of study.
Any current medical condition affecting periodontal treatment or use of the abrasive air-polishing device.
Subjects with diabetes, cancer, HIV/aids, acute infections, disorders that may compromise wound healing, or pregnant women.
-
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Knut N. Leknes, Professor
Organizational Affiliation
Department of Clinical Dentistry - Periodontics, University of Bergen, NORWAY.
Official's Role
Principal Investigator
12. IPD Sharing Statement
Plan to Share IPD
No
Citations:
PubMed Identifier
9567987
Citation
Wilson TG Jr. Supportive periodontal treatment introduction--definition, extent of need, therapeutic objectives, frequency and efficacy. Periodontol 2000. 1996 Oct;12:11-5. doi: 10.1111/j.1600-0757.1996.tb00074.x. No abstract available.
Results Reference
background
PubMed Identifier
6363463
Citation
Badersten A, Nilveus R, Egelberg J. Effect of nonsurgical periodontal therapy. II. Severely advanced periodontitis. J Clin Periodontol. 1984 Jan;11(1):63-76. doi: 10.1111/j.1600-051x.1984.tb01309.x.
Results Reference
background
PubMed Identifier
1765938
Citation
Zappa U, Smith B, Simona C, Graf H, Case D, Kim W. Root substance removal by scaling and root planing. J Periodontol. 1991 Dec;62(12):750-4. doi: 10.1902/jop.1991.62.12.750.
Results Reference
background
PubMed Identifier
9623897
Citation
Flemmig TF, Petersilka GJ, Mehl A, Hickel R, Klaiber B. Working parameters of a magnetostrictive ultrasonic scaler influencing root substance removal in vitro. J Periodontol. 1998 May;69(5):547-53. doi: 10.1902/jop.1998.69.5.547.
Results Reference
background
PubMed Identifier
3897504
Citation
Lie T, Leknes KN. Evaluation of the effect on root surfaces of air turbine scalers and ultrasonic instrumentation. J Periodontol. 1985 Sep;56(9):522-31. doi: 10.1902/jop.1985.56.9.522.
Results Reference
background
PubMed Identifier
11686828
Citation
Schmidlin PR, Beuchat M, Busslinger A, Lehmann B, Lutz F. Tooth substance loss resulting from mechanical, sonic and ultrasonic root instrumentation assessed by liquid scintillation. J Clin Periodontol. 2001 Nov;28(11):1058-66. doi: 10.1034/j.1600-051x.2001.281111.x.
Results Reference
background
PubMed Identifier
21134232
Citation
Petersilka GJ. Subgingival air-polishing in the treatment of periodontal biofilm infections. Periodontol 2000. 2011 Feb;55(1):124-42. doi: 10.1111/j.1600-0757.2010.00342.x. No abstract available.
Results Reference
background
PubMed Identifier
1820859
Citation
Fischer C, Wennberg A, Fischer RG, Attstrom R. Clinical evaluation of pulp and dentine sensitivity after supragingival and subgingival scaling. Endod Dent Traumatol. 1991 Dec;7(6):259-65. doi: 10.1111/j.1600-9657.1991.tb00214.x.
Results Reference
background
PubMed Identifier
26312087
Citation
Latheef P, Sirajuddin S, Gundapaneni V, Mn K, Apine A. Iatrogenic Damage to the Periodontium Caused by Periodontal Treatment Procedures. Open Dent J. 2015 Jun 26;9:203-7. doi: 10.2174/1874210601509010203. eCollection 2015.
Results Reference
background
PubMed Identifier
23193405
Citation
Lin YH, Gillam DG. The Prevalence of Root Sensitivity following Periodontal Therapy: A Systematic Review. Int J Dent. 2012;2012:407023. doi: 10.1155/2012/407023. Epub 2012 Oct 31.
Results Reference
background
PubMed Identifier
12694431
Citation
Petersilka GJ, Steinmann D, Haberlein I, Heinecke A, Flemmig TF. Subgingival plaque removal in buccal and lingual sites using a novel low abrasive air-polishing powder. J Clin Periodontol. 2003 Apr;30(4):328-33. doi: 10.1034/j.1600-051x.2003.00290.x.
Results Reference
background
PubMed Identifier
20553116
Citation
Petersilka G. Re: "Subgingival plaque removal using a new air-polishing device". Moene R, Decaillet F, Andersen E, Mombelli A. (J Periodontol 2010;81:79-88.). J Periodontol. 2010 Jul;81(7):962-3. doi: 10.1902/jop.2010.100118. No abstract available.
Results Reference
background
PubMed Identifier
21861637
Citation
Flemmig TF, Arushanov D, Daubert D, Rothen M, Mueller G, Leroux BG. Randomized controlled trial assessing efficacy and safety of glycine powder air polishing in moderate-to-deep periodontal pockets. J Periodontol. 2012 Apr;83(4):444-52. doi: 10.1902/jop.2011.110367. Epub 2011 Aug 23.
Results Reference
background
PubMed Identifier
21736599
Citation
Wennstrom JL, Dahlen G, Ramberg P. Subgingival debridement of periodontal pockets by air polishing in comparison with ultrasonic instrumentation during maintenance therapy. J Clin Periodontol. 2011 Sep;38(9):820-7. doi: 10.1111/j.1600-051X.2011.01751.x. Epub 2011 Jul 7.
Results Reference
background
PubMed Identifier
28425827
Citation
Caygur A, Albaba MR, Berberoglu A, Yilmaz HG. Efficacy of glycine powder air-polishing combined with scaling and root planing in the treatment of periodontitis and halitosis: A randomised clinical study. J Int Med Res. 2017 Jun;45(3):1168-1174. doi: 10.1177/0300060517705540. Epub 2017 Apr 20.
Results Reference
background
PubMed Identifier
30311948
Citation
Kruse AB, Akakpo DL, Maamar R, Woelber JP, Al-Ahmad A, Vach K, Ratka-Krueger P. Trehalose powder for subgingival air-polishing during periodontal maintenance therapy: A randomized controlled trial. J Periodontol. 2019 Mar;90(3):263-270. doi: 10.1002/JPER.17-0403. Epub 2018 Nov 9.
Results Reference
background
PubMed Identifier
24078975
Citation
Hagi TT, Hofmanner P, Salvi GE, Ramseier CA, Sculean A. Clinical outcomes following subgingival application of a novel erythritol powder by means of air polishing in supportive periodontal therapy: a randomized, controlled clinical study. Quintessence Int. 2013 Nov-Dec;44(10):753-61. doi: 10.3290/j.qi.a30606.
Results Reference
background
PubMed Identifier
25262675
Citation
Hagi TT, Hofmanner P, Eick S, Donnet M, Salvi GE, Sculean A, Ramseier CA. The effects of erythritol air-polishing powder on microbiologic and clinical outcomes during supportive periodontal therapy: Six-month results of a randomized controlled clinical trial. Quintessence Int. 2015 Jan;46(1):31-41. doi: 10.3290/j.qi.a32817.
Results Reference
background
PubMed Identifier
25041441
Citation
Muller N, Moene R, Cancela JA, Mombelli A. Subgingival air-polishing with erythritol during periodontal maintenance: randomized clinical trial of twelve months. J Clin Periodontol. 2014 Sep;41(9):883-9. doi: 10.1111/jcpe.12289. Epub 2014 Aug 7.
Results Reference
background
PubMed Identifier
29700503
Citation
Ng E, Byun R, Spahr A, Divnic-Resnik T. The efficacy of air polishing devices in supportive periodontal therapy: A systematic review and meta-analysis. Quintessence Int. 2018;49(6):453-467. doi: 10.3290/j.qi.a40341.
Results Reference
background
PubMed Identifier
23890177
Citation
Hashino E, Kuboniwa M, Alghamdi SA, Yamaguchi M, Yamamoto R, Cho H, Amano A. Erythritol alters microstructure and metabolomic profiles of biofilm composed of Streptococcus gordonii and Porphyromonas gingivalis. Mol Oral Microbiol. 2013 Dec;28(6):435-51. doi: 10.1111/omi.12037. Epub 2013 Jul 29.
Results Reference
background
PubMed Identifier
26407817
Citation
Bunaes DF, Lie SA, Enersen M, Aastrom AN, Mustafa K, Leknes KN. Site-specific treatment outcome in smokers following non-surgical and surgical periodontal therapy. J Clin Periodontol. 2015 Oct;42(10):933-42. doi: 10.1111/jcpe.12462. Epub 2015 Oct 28.
Results Reference
background
PubMed Identifier
5315729
Citation
Muhlemann HR, Son S. Gingival sulcus bleeding--a leading symptom in initial gingivitis. Helv Odontol Acta. 1971 Oct;15(2):107-13. No abstract available.
Results Reference
background
PubMed Identifier
4500182
Citation
O'Leary TJ, Drake RB, Naylor JE. The plaque control record. J Periodontol. 1972 Jan;43(1):38. doi: 10.1902/jop.1972.43.1.38. No abstract available.
Results Reference
background
PubMed Identifier
1058213
Citation
Hamp SE, Nyman S, Lindhe J. Periodontal treatment of multirooted teeth. Results after 5 years. J Clin Periodontol. 1975 Aug;2(3):126-35. doi: 10.1111/j.1600-051x.1975.tb01734.x.
Results Reference
background
PubMed Identifier
26662482
Citation
Barros SP, Williams R, Offenbacher S, Morelli T. Gingival crevicular fluid as a source of biomarkers for periodontitis. Periodontol 2000. 2016 Feb;70(1):53-64. doi: 10.1111/prd.12107.
Results Reference
background
PubMed Identifier
23879704
Citation
Belibasakis GN, Schmidlin PR, Sahrmann P. Molecular microbiological evaluation of subgingival biofilm sampling by paper point and curette. APMIS. 2014 Apr;122(4):347-52. doi: 10.1111/apm.12151. Epub 2013 Jul 24.
Results Reference
background
PubMed Identifier
15491460
Citation
Socransky SS, Haffajee AD, Smith C, Martin L, Haffajee JA, Uzel NG, Goodson JM. Use of checkerboard DNA-DNA hybridization to study complex microbial ecosystems. Oral Microbiol Immunol. 2004 Dec;19(6):352-62. doi: 10.1111/j.1399-302x.2004.00168.x.
Results Reference
background
PubMed Identifier
7833043
Citation
Socransky SS, Smith C, Martin L, Paster BJ, Dewhirst FE, Levin AE. "Checkerboard" DNA-DNA hybridization. Biotechniques. 1994 Oct;17(4):788-92.
Results Reference
background
PubMed Identifier
9495612
Citation
Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL Jr. Microbial complexes in subgingival plaque. J Clin Periodontol. 1998 Feb;25(2):134-44. doi: 10.1111/j.1600-051x.1998.tb02419.x.
Results Reference
background
PubMed Identifier
2197679
Citation
Wewers ME, Lowe NK. A critical review of visual analogue scales in the measurement of clinical phenomena. Res Nurs Health. 1990 Aug;13(4):227-36. doi: 10.1002/nur.4770130405.
Results Reference
background
PubMed Identifier
22694321
Citation
Krohn-Dale I, Boe OE, Enersen M, Leknes KN. Er:YAG laser in the treatment of periodontal sites with recurring chronic inflammation: a 12-month randomized, controlled clinical trial. J Clin Periodontol. 2012 Aug;39(8):745-52. doi: 10.1111/j.1600-051X.2012.01912.x. Epub 2012 Jun 13.
Results Reference
background
PubMed Identifier
2262586
Citation
Hujoel PP, Loesche WJ. Efficiency of split-mouth designs. J Clin Periodontol. 1990 Nov;17(10):722-8. doi: 10.1111/j.1600-051x.1990.tb01060.x.
Results Reference
background
PubMed Identifier
1430289
Citation
Hujoel PP, DeRouen TA. Validity issues in split-mouth trials. J Clin Periodontol. 1992 Oct;19(9 Pt 1):625-7. doi: 10.1111/j.1600-051x.1992.tb01709.x.
Results Reference
background
PubMed Identifier
9645400
Citation
Hujoel PP. Design and analysis issues in split mouth clinical trials. Community Dent Oral Epidemiol. 1998 Apr;26(2):85-6. doi: 10.1111/j.1600-0528.1998.tb01932.x. No abstract available.
Results Reference
background
PubMed Identifier
9118268
Citation
Cobb CM. Non-surgical pocket therapy: mechanical. Ann Periodontol. 1996 Nov;1(1):443-90. doi: 10.1902/annals.1996.1.1.443. No abstract available.
Results Reference
background
PubMed Identifier
283222
Citation
Bower RC. Furcation morphology relative to periodontal treatment. Furcation entrance architecture. J Periodontol. 1979 Jan;50(1):23-7. doi: 10.1902/jop.1979.50.1.23.
Results Reference
background
PubMed Identifier
288913
Citation
Bower RC. Furcation morphology relative to periodontal treatment. Furcation root surface anatomy. J Periodontol. 1979 Jul;50(7):366-74. doi: 10.1902/jop.1979.50.7.366. No abstract available.
Results Reference
background
PubMed Identifier
12710749
Citation
Petersilka GJ, Tunkel J, Barakos K, Heinecke A, Haberlein I, Flemmig TF. Subgingival plaque removal at interdental sites using a low-abrasive air polishing powder. J Periodontol. 2003 Mar;74(3):307-11. doi: 10.1902/jop.2003.74.3.307.
Results Reference
background
PubMed Identifier
14717858
Citation
Armitage GC. Analysis of gingival crevice fluid and risk of progression of periodontitis. Periodontol 2000. 2004;34:109-19. doi: 10.1046/j.0906-6713.2002.003427.x. No abstract available.
Results Reference
background
PubMed Identifier
29574763
Citation
Tsang YC, Corbet EF, Jin LJ. Subgingival glycine powder air-polishing as an additional approach to nonsurgical periodontal therapy in subjects with untreated chronic periodontitis. J Periodontal Res. 2018 Jun;53(3):440-445. doi: 10.1111/jre.12532. Epub 2018 Mar 25.
Results Reference
background
PubMed Identifier
28306142
Citation
Bunaes DF, Mustafa M, Mohamed HG, Lie SA, Leknes KN. The effect of smoking on inflammatory and bone remodeling markers in gingival crevicular fluid and subgingival microbiota following periodontal therapy. J Periodontal Res. 2017 Aug;52(4):713-724. doi: 10.1111/jre.12438. Epub 2017 Mar 17.
Results Reference
background
PubMed Identifier
26121365
Citation
Hagi TT, Klemensberger S, Bereiter R, Nietzsche S, Cosgarea R, Flury S, Lussi A, Sculean A, Eick S. A Biofilm Pocket Model to Evaluate Different Non-Surgical Periodontal Treatment Modalities in Terms of Biofilm Removal and Reformation, Surface Alterations and Attachment of Periodontal Ligament Fibroblasts. PLoS One. 2015 Jun 29;10(6):e0131056. doi: 10.1371/journal.pone.0131056. eCollection 2015.
Results Reference
background
PubMed Identifier
2201705
Citation
Antczak-Bouckoms AA, Tulloch JF, Berkey CS. Split-mouth and cross-over designs in dental research. J Clin Periodontol. 1990 Aug;17(7 Pt 1):446-53. doi: 10.1111/j.1600-051x.1990.tb02343.x.
Results Reference
background
PubMed Identifier
33478480
Citation
Ulvik IM, Saethre T, Bunaes DF, Lie SA, Enersen M, Leknes KN. A 12-month randomized controlled trial evaluating erythritol air-polishing versus curette/ultrasonic debridement of mandibular furcations in supportive periodontal therapy. BMC Oral Health. 2021 Jan 21;21(1):38. doi: 10.1186/s12903-021-01397-3.
Results Reference
derived
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Air-polishing or Conventional Treatment
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