Immune Modulation by Enhanced vs Standard Prehabilitation Program Before Major Surgery
Surgery, Immune System and Related Disorders, Preoperative Care
About this trial
This is an interventional supportive care trial for Surgery focused on measuring Personalized program, Physical Activity, Stress-reduction, Cognition, Nutrition, inflammatory, immune response
Eligibility Criteria
Inclusion Criteria:
- Adult patients (≥ 18 years)
- Competent to provide informed consent
- Undergoing major elective surgery under general anesthesia in ≥14 days from enrollment (abdominal, thoracic, plastic and neurosurgeries).
- Fluent in English
Exclusion Criteria:
- Premorbid conditions or orthopedic impairments with contraindications to exercise
- Cognitive disabilities defined as evolutive neurological or neurodegenerative disease
- ASA score 4 or higher or patient under palliative care
- Illiteracy (inability to read the English language).
- Expected length of stay at hospital < 48 hours
- Patient under tutorship or curatorship
- Pregnant or breast-feeding woman
- Absence of informed consent or request to not participate to the study
Sites / Locations
- Stanford UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Personalized prehabilitation
Standard prehabilitation
Patients will participate in a personalized health optimization program combining one-on-one coaching, tailored to each patient's physical, nutritional, well-being and cognitive status baseline. Prehabilitation will last from a minimum of 14 days to a maximum of 42 days before surgery
Patients in the control group will be provided with standard instructions in a hard-copy form specific to prehabilitation before surgery associating physical, nutritional, stress-reduction and cognitive recommendations without any personalized coaching for at least 14 days prior to surgery.