Acetated Ringer's Solution Versus Saline in Patients With Septic Shock

The primary aim of this trial is to compare the effect of acetated ringer's solution with that of saline for therapy on the incidence and development of major adverse renal events among septic shock patients. The investigators hypothesize that use of acetated ringer's solution for resuscitation among septic shock patients will reduce the incidence of major adverse kidney events.

Normal saline and Ringer's solutions are the preferred crystalloid fluids administered in early septic shock. However, evidence have associated saline with hyperchloremia and secondary metabolic acidosis, and renal vasoconstriction, increased incidence of acute kidney injury (AKI) and mortality. The primary aim of this trial is to compare the effect of acetated ringer's solution with that of saline for therapy on the incidence and development of major adverse renal events among septic shock patients. The investigators hypothesize that use of acetated ringer's solution for resuscitation among septic shock patients will reduce the incidence of major adverse kidney events.

Inclusion Criteria: Adult patients presenting to the ICU diagnosed as septic shock within 24 hours. Exclusion Criteria: Pregnancy; Likely requirement for immediate hemodialysis or renal replacement therapy; Patients have already received fluids for more than 4 liters; Patient in extremis or death deemed imminent and inevitable.

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