The Role of Micro Nutrient Supplement in Improvement of the Sperm DNA Fragmentation
Infertility, Male
About this trial
This is an interventional treatment trial for Infertility, Male focused on measuring Sperm DNA fragmentation, micronutrient, In vitro fertilization
Eligibility Criteria
Inclusion Criteria:
- Male from infertile couples
Exclusion Criteria:
- Men with acute systemic diseases
- acute urinary tract infection
- hepatic function disorders
- malignant diseases
- retrograde ejaculation
- azoospermia
Sites / Locations
- Hue University of Medicine and Pharmacy, Hue University
Arms of the Study
Arm 1
Arm 2
Experimental
Other
PROFortil group
Vitamin E group
Men with increased sperm DNA fragmentation (>=30%) will be indicated for multi-micronutrient supplement (PROfortil™, twice daily) plus Vitamin E (Enat 400, once per day) in 3 months then checked again post-treatment for DF). The IVF/ICSI cycles will then be analyzed for embryo quality, pregnancy outcomes including biochemical pregnancy rate, clinical pregnancy rate, on-going pregnancy, miscarriage.
Any case with high DNA fragmentation index (DFI >=30%) will be randomized indicated only Vitamin E (Enat 400 once per day) in 3 months then checked again post-treatment for (DFI). The IVF/ICSI cycles will then be analyzed for embryo quality, pregnancy outcomes including biochemical pregnancy rate, clinical pregnancy rate, on-going pregnancy, miscarriage.