High Flow Nasal Cannula (HFNC) Initiation Flow Rate Study
Bronchiolitis
About this trial
This is an interventional treatment trial for Bronchiolitis focused on measuring Bronchiolitis, HFNC, High Flow Nasal Cannula, Infants
Eligibility Criteria
Inclusion Criteria:
- Patients less than 12 months of age
- Clinical signs of moderate to severe bronchiolitis defined by American Academy of Pediatrics
- Requires ICU level of care by clinicians' discretion
- Requiring HFNC support
Exclusion Criteria:
- Infants who required immediate need for respiratory support such as non-invasive positive pressure ventilation (NIPPV) or invasive ventilation
- Congenital heart disease,
- Immunocompromised state
- Upper airway obstruction
- Chronic lung disease
- Bronchopulmonary dysplasia,
- Home oxygen therapy requirement
- Acute trauma patients
- Baseline craniofacial malformations
- Admitted to the neonatal or cardiac ICUs
- Patients who are admitted to the floor
Sites / Locations
- Children's Health - Children's Medical Center
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Experimental
Arm 1, HFNC 1 L/kg/min
Arm 2, HFNC 1.5 L/kg/min
Arm 3, HFNC 2 L/kg/min
The infant that is randomized to the HFNC therapy arm 1 will be placed on high flow at 1 L/kg/min (up to a maximum of 20 L/min) on fraction of inspired oxygen (FiO2) of 21 %. They will remain on FiO2 of 21% for a minimum of 10 minutes while monitoring SpO2. If oxygen saturation (SpO2) is <90%, FiO2 will be slowly increased to maintain SpO2 ≥ 90 %.
The infant that is randomized to the HFNC therapy arm 2 will be placed on high flow at 1.5 L/kg/min (up to a maximum of 20 L/min) on fraction of inspired oxygen (FiO2) of 21 %. They will remain on FiO2 of 21% for a minimum of 10 minutes while monitoring SpO2. If SpO2 is <90%, FiO2 will be slowly increased to maintain SpO2 ≥ 90 %.
The infant that is randomized to the HFNC therapy arm 3 will be placed on high flow at 2 L/kg/min (up to a maximum of 20 L/min) on fraction of inspired oxygen (FiO2) of 21 %. They will remain on FiO2 of 21% for a minimum of 10 minutes while monitoring SpO2. If SpO2 is <90%, FiO2 will be slowly increased to maintain SpO2 ≥ 90 %.