Airway Microbiota Based Treatment of Asthma in Preschool Children (AMBT)
Asthma in Children
About this trial
This is an interventional treatment trial for Asthma in Children focused on measuring preschool wheeze, airway microbiota
Eligibility Criteria
Inclusion Criteria:
- physician diagnosed recurrent wheeze(at least 3 episodes of wheezing or at least one course of oral steroids in the last 6 months)
Exclusion Criteria:
- Any congenital heart disease diagnosed by a physician
- Any chronic respiratory condition other than preschool wheeze (bronchopulmonary dysplasia, bronchiolitis obliteran, congenital airway and lung malformations, bronchomalacia, chronic aspiration) diagnosed by a physician
- Received antibiotic last 6 weeks
Sites / Locations
- Children's Hospital of Fudan UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Microbiota and eosinophils phenotype based therapy
Clinical guidelines based therapy
The children will be treated with different protocol(Fluticasone propionate (FP),Azithromycin,or FP+Azithromycin) according to their Blood eosinophils level and airway microbiota pattern for 3 months and follow up for 1 year.
The children will be treated as directed by their paediatrician, the clinical practice is based on the guideline for the diagnosis and optimal management of asthma in children of China 2016 (FP or montelukast for 3 months,or intermittent budesonide inhalation suspension during wheezing episode) and follow up for 1 year.