Study of Imupret Application in the Technology of Delayed Prescription of Antibiotics in Patients With Acute Tonsillitis
Acute Tonsillitis
About this trial
This is an interventional treatment trial for Acute Tonsillitis focused on measuring Acute tonsillitis, antibiotics, phytotherapy
Eligibility Criteria
Inclusion Criteria:
- Children (males/females), 6 - 12 years old, with severe acute tonsillitis.
- Possibility to initiate therapy within 72 hours since the onset of the disease symptoms.
- Score 4-5 according to McIsaac Scale.
- Patient's and (or) one of his/her parents' willingness and ability to fulfil the requirements of the Study Protocol.
- Signed informed consent of the patient and (or) his/her parents for participation in the study.
Exclusion Criteria:
- Score -1 to 3 according to McIsaac Scale.
Indication for hospitalization, including:
- purulent complications (peritonsillar abscess and others);
- severe general condition.
- Indication for immediate initiation of systemic antibiotic therapy
- patients at risk of developing severe complications, including e.g. clinically relevant concomitant diseases of heart, lungs, kidneys, liver, neuromuscular apparatus, cancer diseases, immunosuppression, diabetes mellitus, cystic fibrosis.
- suspected infectious mononucleosis (by clinical signs);
- use of systemic antibacterial or antifungal agents, systemic glucocorticosteroids, cytostatics, immunomodulatory drugs, "interferons" or interferon derivatives during the last 14 days prior to inclusion;
- presence of haemorrhagic or pronounced necrotic process in oral cavity or pharynx, including the lymphoid ring.
- Intolerability or individual hypersensitivity to any of the study drug ingredients and the reference treatment scheme.
Sites / Locations
- Ivano-Frankivsk National Medical University
Arms of the Study
Arm 1
Arm 2
Experimental
Other
The main group
The comparison group
1. soft diet; 2. Elimination of factors that irritate the mucous membrane of the pharynx (thermal, chemical); 4. Local NSAIDs - benzydamine hydrochloride. 5. Imupret oral drops in the age-related dosage of 6 times per day for 6 days with the subsequent transition to the regime of 15 drops / 3 times in a day according to the patient's condition. 6. Paracetamol as antipyretic, if necessary.
1. soft diet; 2. Elimination of factors that irritate the mucous membrane of the pharynx (thermal, chemical); 4. Local NSAIDs - benzydamine hydrochloride. 5. Paracetamol as antipyretic, if necessary.