Comparative Study of Dietary and Immunological Management of Refractory Epilepsy in Children
Refractory Epilepsy
About this trial
This is an interventional treatment trial for Refractory Epilepsy
Eligibility Criteria
Inclusion Criteria:
- 1-Age 1 month up to 17 years 2-Both male and female 3-Epileptic patient on two tolerated and appropriately chosen and used antiepilptic drugs with no response
Exclusion Criteria:
1-Neonate 2-Epieptic patient on monotherapy 3-Conditions mimic epilepsy 4-Pseudo refractioness 5-Absolute contraindications for the use of diet therapy include carnitine deficiency (primary), carnitine palmitoyltransferase (CPT) I OR II deficiency, carnitine translocase deficiency, β-oxidation defects, pyruvate carboxylase deficiency, and porphyria 6-Contraindication for Rituximab:
- Hypersensitivity to any component, murine proteins. b. Heart failure c. Active infection
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Active Comparator
Active Comparator
Active Comparator
RITUXIMAB
KETOGENIC DIET
TRACE ELEMENTS
CORTICOSTEROID
rituximab INTRAVENOUS 750MG/m2 every 2 weeks for 2 doses
The common element of these different approaches is variable reduction in the amount of carbohydrate with appropriate increase in fat. Diets that produce a state of ketosis are referred to as ''ketogenic"
. Essential trace elements that include zinc, copper, magnesium, and selenium
corticosteroid pulse therapy 30 mg /kg /day for 5 days monthly for 6 month