Trial of Famotidine & N-Acetyl Cysteine for Outpatients With COVID-19
Covid19
About this trial
This is an interventional treatment trial for Covid19 focused on measuring outpatient, famotidine, n-acetyl cysteine
Eligibility Criteria
Inclusion Criteria:
- Age > 18
- performance of a SARS-CoV-2 test within 1 day of enrollment, N.B., must be positive to proceed to treatment phase of the trial
Exclusion Criteria:
- All patients under 18
- Known allergy to N-Acetyl Cysteine
- Known allergy to famotidine or other H2-receptor antagonists
- Pregnant or Nursing Mothers
- Laboratory Evidence or History of Renal Impairment (eGFR < 30 mL/min/1.73 m2)
- Taking H2-receptor antagonists, hydroxychloroquine or chloroquine.
- Patient has been admitted to the hospital prior to study enrollment
Sites / Locations
- Prisma Health Baptist Easley Hospital
- Prisma Health Greenville Memorial Hospital
- Prisma Health Greer Memorial Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Arm 7
Arm 8
Arm 9
Arm 10
Arm 11
Arm 12
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Low Dose N-Acetyl Cysteine Alone
Medium Dose N-Acetyl Cysteine
Low Dose N-Acetyl Cysteine and Low Dose Famotidine
High Dose N-Acetyl Cysteine Alone
Medium Dose N-Acetyl Cysteine and Low Dose Famotidine
Low Dose N-Acetyl Cysteine and Medium Dose Famotidine
High Dose N-Acetyl Cysteine and Low Dose Famotidine
Medium Dose N-Acetyl Cysteine and Medium Dose Famotidine
Low Dose N-Acetyl Cysteine and High Dose Famotidine
High Dose N-Acetyl Cysteine and Medium Dose Famotidine
Medium Dose N-Acetyl Cysteine and High Dose Famotidine
High Dose N-Acetyl Cysteine and High Dose Famotidine
N-Acetyl Cysteine 600 mg three times daily
N-Acetyl Cysteine 1,200 mg three times daily
N-Acetyl Cysteine 600 mg three times daily Famotidine 20 mg three times daily
N-Acetyl Cysteine 1,800 mg three times daily
N-Acetyl Cysteine 1,200 mg three times daily Famotidine 20 mg three times daily
N-Acetyl Cysteine 600 mg three times daily Famotidine 40 mg three times daily
N-Acetyl Cysteine 1,800 mg three times daily Famotidine 20 mg three times daily
N-Acetyl Cysteine 1,200 mg three times daily Famotidine 40 mg three times daily
N-Acetyl Cysteine 600 mg three times daily Famotidine 80 mg three times daily
N-Acetyl Cysteine 1,800 mg three times daily Famotidine 40 mg three times daily
N-Acetyl Cysteine 1,200 mg three times daily Famotidine 80 mg three times daily
N-Acetyl Cysteine 1,800 mg three times daily Famotidine 80 mg three times daily