Enhanced Secondary Intention Healing vs. Standard Secondary Intention Healing in Mohs Surgical Defects on the Head and Distal Lower Extremities
Wound Heal
About this trial
This is an interventional treatment trial for Wound Heal focused on measuring Mohs surgery, Manuka honey, Secondary intention wound healing
Eligibility Criteria
Inclusion Criteria:
- 18 years of age or older
- Post-operative wounds following Mohs surgery on the head or distal lower extremities
- Single Mohs post-operative defect
- Post-operative wounds greater than 1cm in width
- Depth of defect at least to subcutaneous tissue
- Patients have the ability to provide their own wound care
- Agreeable to regularly scheduled follow-up visits and transmission of photos via HIPAA compliant Vanderbilt University Medical Center Box
- Patients are able to provide informed consent
Exclusion Criteria:
- Under 18 years of age
- Unable to provide informed consent
- Unable to understand oral and written English
- Post-operative wounds not appropriate for secondary intention healing
- Sensitivity or allergy to APIS® biomaterial including collagen and its derivatives, porcine-derived materials or honey
- Immunosuppressed and organ transplant patients
- Post-operative wounds superficial to subcutaneous tissue
Sites / Locations
- Vanderbilt University Medical Center
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Active Comparator
Active Comparator
APIS Biomaterial on the Head
APIS Biomaterial on the Lower Extremities
Standard Secondary Intention Healing on the Head
Standard Secondary Intention Healing on the Lower Extremities
Participants in this group will receive the experimental APIS Biomaterial on the Head. One layer of APIS® will be applied to the post-operative wound covered by petrolatum impregnated gauze, a non-stick Telfa pad, gauze, and Opsite tape. The biomaterial will be reapplied if it is completely absorbed at follow up and the wound depth below the epithelial level.
Participants in this group will receive the experimental APIS Biomaterial on the Lower Extremities. One layer of APIS® will be applied to the post-operative wound covered by petrolatum impregnated gauze, a non-stick Telfa pad, gauze, and Opsite tape. The biomaterial will be reapplied if it is completely absorbed at follow up and the wound depth below the epithelial level.
Participants in this group will receive standard secondary intention wound healing post-operative care on the Head. Post-operative wound will heal via conventional secondary intention. Application of petrolatum impregnated gauze, a non-stick Telfa pad, gauze, and Opsite tape.
Participants in this group will receive standard secondary intention wound healing post-operative care on the Lower Extremities. Post-operative wound will heal via conventional secondary intention. Application of petrolatum impregnated gauze, a non-stick Telfa pad, gauze, and Opsite tape.