Jump: MR Simulation For Radiation Therapy Master Protocol (JUMP)
Prostate Cancer, Recurrent Adenocarcinoma, Liver Cancer
About this trial
This is an interventional treatment trial for Prostate Cancer focused on measuring Prostate Cancer, Recurrent Adenocarcinoma, Liver Cancer, Head and Neck Cancer
Eligibility Criteria
Inclusion Criteria:
- Participants must have a confirmed malignancy requiring radiation therapy.
- Age: 18 years or older
- ECOG performance status ≤2 (Karnofsky ≥60%, see Appendix A)
- Ability to understand and the willingness to sign a written informed consent document.
- Disease-specific eligibility criteria will be specified in the appropriate subprotocol.
Exclusion Criteria:
- For MRI involving contrast, history of allergic reactions attributed to gadoliniumbased IV contrast. Note: If patient will not receive contrast, this is not applicable
- Participants who cannot undergo an MRI
- Disease-specific exclusion criteria will be specified in the appropriate subprotocol
Sites / Locations
- Brigham and Women HospitalRecruiting
- Dana Farber Cancer InstituteRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Experimental
Phase I MRI Simulation
Phase II MR Simulation Protocol: Track A
Phase II MR Simulation Protocol: Track B
This research study involves a screening period to determine eligibility. - Radiation mapping to define the target for radiation.acquiring MR data at the specified timepoint in a patient's care plan and ability to identify the radiation target and develop a radiation therapy plan on the MR data.
MR-only Radiation Therapy Simulation MRI-simulation and synthetic CT to plan treatment
Adjusted Margin or / Dose Painted RT Based on Imaging of MR Simulator (e.g. biological imaging or higher resolution imaging)