Effect of Vitamin D Supplementation in Live Birth Rate of in Vitro Fertilization Outcome
Infertility
About this trial
This is an interventional treatment trial for Infertility
Eligibility Criteria
Inclusion Criteria:
- Infertile women undergoing IVF
- Aged between 18 and 43 years old, inclusive, at the time of signing informed consent
- Having given voluntary written informed consent
Exclusion Criteria:
- Already taking vitamin D
- Undergoing preimplantation genetic testing
- Use of donor oocytes or donor embryos
- Presence of hydrosalpinx not corrected surgically
- Active tuberculosis/ receiving therapy for tuberculosis
- History of any medical condition or medications that may predispose to vitamin D sensitivity, altered vitamin D metabolism and/or hypercalcemia, including history of renal/ureteral stones, parathyroid disease, renal or liver failure, current use of anticonvulsants, current use of steroid
- Allergy to vitamin D
- Abnormal serum calcium values
Sites / Locations
- Kwong Wah HospitalRecruiting
- Queen Mary Hospital, University of Hong KongRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
Vitamin D
Placebo
Vitamin D 50,000IU per week for 4 weeks from recruitment, followed by 50,000IU per week every 2 weeks throughout the IVF cycle. Subjects to stop own supplements and folic acid will be provided. If pregnant and fetal viability confirmed at 6 weeks gestation, switch to Materna until delivery. If not pregnant, to continue vitamin D 50,000IU once every 2 weeks until 6 months from recruitment. The rest of the IVF, embryo transfer procedure and antenatal care will be the same as usual practice.
Placebo tablets identical to the active drug for 4 weeks from recruitment, followed by placebo tablets once every 2 weeks throughout the IVF cycle. Subjects to stop own supplements and folic acid will be provided. If pregnant and fetal viability confirmed at 6 weeks gestation, switch to Materna until delivery. If not pregnant, to continue placebo tablets once every 2 weeks until 6 months from recruitment. The rest of the IVF, embryo transfer procedure and antenatal care will be the same as usual practice.