Treating Primary Progressive Aphasia (PPA) Using tDCS
Primary Progressive Aphasia
About this trial
This is an interventional treatment trial for Primary Progressive Aphasia focused on measuring non-invasive brain stimulation, transcranial direct current stimulation (tDCS), speech therapy
Eligibility Criteria
Inclusion Criteria:
- Presence of aphasia attributable to the semantic variant (svPPA) or non- fluent/agrammatic variant (naPPA) of Primary Progressive Aphasia.
- Must be a native English speaker
Exclusion Criteria:
- History of seizures or unexplained loss of consciousness
- Subjects with metallic objects in the face or head other than dental apparatus such as braces, fillings, and implants.
- Subjects with Pacemakers or ICDs.
- Subjects with previous craniotomy or any breach in the skull
- Subjects with a history of other neurological disorder (stroke, TBI, Parkinson)
- Subjects with a history of small vessel disease
Sites / Locations
- University of PennsylvaniaRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Sham Comparator
tDCS + CILT
Sham tDCS + CILT
Participants will undergo 10 daily sessions (Monday-Friday, x2 weeks) of tDCS for 20 minutes using a montage in which an anode (1.5 mA) is placed over F7 (left frontotemporal lobe) and the cathode will be place on O1 (left occipital) using the 10-20 EEG mapping system. Subjects will participate in a modified constraint-induced language therapy.
Participants will undergo 10 daily sessions (Monday-Friday, x2 weeks) of sham tDCS for 20 minutes using a montage in which an anode is placed of F7 and cathose is placed over O1. Subjects will participate in a modified constraint-induced language therapy,