Prevention of Hand-foot Skin Reaction
Hepatocellular Carcinoma

About this trial
This is an interventional prevention trial for Hepatocellular Carcinoma focused on measuring hand-foot skin reaction, side effect of sorafenib, symptom related to target therapy, efficacy of urea-based cream, symptom management
Eligibility Criteria
Inclusion Criteria:
- HCC by proof of pathology
- Presence of tumor thrombus in the main trunk of the portal vein or the first-order branches of the portal vein with minimal ascetics or with no ascetics by abdominal CT scan
- Child-Pugh liver function class A
- Planning to receive oral sorafenib 400 mg twice per day
- Age of 20 or more years old
- Able to communication in Chinese, Taiwanese or Hakka
Exclusion Criteria:
- Encephalopathy, psychosis, cognition impairment, blindness or hearing impairment
- Allergic history to urea
- Present ulceration, blisters, infective problems on the palms or soles
- Previous surgery, systematic chemotherapy or frequent radial ablation
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Other
Experimental
Active Comparator
Best support care (BSC)
BSC plus moisture cream
10% urea-based cream
Interventions for comparison group (group C) who received BSC alone were (1) informed of potential presentations of HFSR, (2) asked for wearing waterproof gloves before execute household or work with water, (3) provided the method of contacting with healthcare specialists for confirming early diagnosis of HFSR, and (4) asked for self-report when they occurred symptoms of HFSR.
The A group with BCS plus moisturizing cream received the interventions as the comparison group, was given the moisturizing cream (dimethicone, fragrance free, Aveeno, United States) for 9 times and was instructed how to use the cream. The education of usage included (1) using the cream twice a day from 3 days before starting sorafenib and each week post starting sorafenib, (2) scooping out nut-sized cream with a unique spoon each time, (3) gently applied the cream evenly on symmetrical palms below wrists and symmetrical soles below ankles each time, (4) wore unique cotton gloves immediately after the appalment of cream for 30 minutes each time.
The B group with BCS plus 10% urea-based cream had the similar interventions as the A group with BCS plus moisturizing cream except being given the cream container with different component (10% urea; Sipharr, Taiwan). The outlook of the containers with the two kinds of cream was the same. All the cream looks white and grey.