Emergency Echocardiography in Sepsis (GENESIS)
Sepsis, Echocardiography, Organ Dysfunction Syndrome Sepsis
About this trial
This is an interventional treatment trial for Sepsis focused on measuring Sepsis, Echocardiography, Haemodynamic, Emergency Medicine
Eligibility Criteria
Inclusion Criteria:
- Patients admitted to the ED
- Age ≥ 18 years and affiliation to Social Security
- With sepsis (Sepsis-3 definition):
Clinically suspected or documented acute infection
AND a quick score Sequential Organ Failure Assessment (qSOFA) ≥ 2 points with:
- Systolic blood pressure ≤ 100 mmHg (1 point) requiring fluid loading
- AND encephalopathy (1 point) OR respiratory rate ≥ 22 cpm (1 point) AND a systolic blood pressure ≤ 100 mmHg after 500 mL of crystalloid vascular filling - Informed consent
Exclusion Criteria:
- Decision to limit care or moribund status
- Pregnancy or breast feeding
- Subject under juridical protection.
Sites / Locations
- CH d'AlbiRecruiting
- Bordeaux university hospitalRecruiting
- CH d'Eaubonne - Montmorency
- Grenoble university hospitalRecruiting
- Hopital de VersaillesRecruiting
- Limgoes university hospitalRecruiting
- Hospices civils de LyonRecruiting
- Nantes university hospitalRecruiting
- Nice university hospitalRecruiting
- Hopital lariboisièreRecruiting
- Poitiers university hospitalRecruiting
- La réunion university hospitalRecruiting
- Toulouse university hospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Other
Intervention arm
Control arm
Assessment using an early transthoracic echocardiography (after 500 mL of fluids) to identify the hemodynamic profile responsible for the acute circulatory failure associated with sepsis / septic shock and to guide ongoing treatment (therapeutic algorithm) and monitor its efficacy and tolerance.
Conventional management according to current standards of care based on SSC recommendations, including a standardized fluid resuscitation of 30 mL/kg.