Developing an EEG Paradigm to Study Prediction Error in Anorexia Nervosa
Anorexia Nervosa
About this trial
This is an interventional other trial for Anorexia Nervosa
Eligibility Criteria
Inclusion Criteria:
Healthy Controls
- Females ages 11 - 17 years
- Healthy body weight between 90 and 110 % average body weight.
- Edinburgh Handedness Inventory Revised (EHI-R) LQ* score > +200
- English is primary language spoken
Restricting Type Anorexia Nervosa
- Females ages 11 - 17 years
- Diagnostic criteria. Current diagnosis of AN, including being underweight below 17.5 body mass index (BMI, kg/m2), will have a severe fear of weight gain, body image distortion and absence of the menstrual cycle over three consecutive months (if applicable).
- First 1-2 weeks in treatment at The University of California San Diego Eating Disorders Center for Treatment and Research or Rady Children's Hospital San Diego Medical Behavioral Unit.
- Restricting subtype, that is without binge/purge behaviors
- Edinburgh Handedness Inventory Revised (EHI-R) LQ* score > +200
- English is primary language spoken
Exclusion Criteria:
Healthy Controls
- Current pregnancy or breast feeding within last 3 months
- Illiterate/Blind individuals
- First degree relative with current or past eating disorder
- Current Medications other than BCP or IUD
- Past or present Axis I psychiatric disorder including substance or alcohol use disorder as determined through PI interview and MINI-Kid clinical interview
Major Medical illness (as determined through medical history in bioscreen and PI interview) such as:
Conditions that are life threatening:
- cancer
- heart disease
- stroke
- HIV/AIDS
- Seizure Disorders
Conditions that are life threatening Conditions that cause serious disability without necessarily being life threatening:
- stroke
- closed head or spinal cord injuries
- mental retardation
- congenital malformations.
Conditions that cause significant pain or discomfort that can cause serious interruptions to life activities:
- severe allergies
- migraine
- arthritis
- sickle cell disease
Conditions that require major commitments of time and effort from care-givers for a substantial period of time:
- mobility disorders
- blindness
- Alzheimer's disease and other dementias
- chronic obstructive pulmonary disease
- paraplegia or quadriplegia
- Down's syndrome
- depression
Conditions that may require frequent monitoring:
- diabetes
- conditions requiring anticoagulation treatment
- severe asthma
- severe allergies
- schizophrenia and other psychotic illnesses.
Conditions that predict or are associated with severe consequences:
- hypertension (associated with heart disease)
- depression (associated with suicide)
- diabetes (associated with blindness, kidney failure)
- alcohol and other substance abuse (associated with intentional and unintentional injuries).
- Recent history of suspected substance abuse or a lifetime history of psychostimulant abuse and/or dependence
- Metal implants or braces (as determined through fMRI screening form)
Anorexia Nervosa
- Pregnancy or breast feeding within last 3 months
- Lifetime history of bipolar disorder or psychosis
- Illiterate/Blind individuals
- Use of an anti-psychotic or other dopamine acting medication including stimulants within the past week at time of MRI
- Recent history of substance abuse or dependence (within the last month)
Major Medical illness (as determined through medical history in bioscreen and PI interview) such as:
Conditions that are life threatening:
- cancer
- heart disease
- stroke
- HIV/AIDS
- Seizure Disorders
Conditions that are life threatening Conditions that cause serious disability without necessarily being life threatening:
- stroke
- closed head or spinal cord injuries
- mental retardation
- congenital malformations.
Conditions that cause significant pain or discomfort that can cause serious interruptions to life activities:
- severe allergies
- migraine
- arthritis
- sickle cell disease
Conditions that require major commitments of time and effort from care-givers for a substantial period of time:
- mobility disorders
- blindness
- Alzheimer's disease and other dementias
- chronic obstructive pulmonary disease
- paraplegia or quadriplegia
- Down's syndrome
Conditions that may require frequent monitoring:
- diabetes
- conditions requiring anticoagulation treatment
- severe asthma
- severe allergies
- schizophrenia and other psychotic illnesses.
Conditions that predict or are associated with severe consequences:
- hypertension (associated with heart disease)
- diabetes (associated with blindness, kidney failure)
- alcohol and other substance abuse (associated with intentional and unintentional injuries) within the last month
- Metal implants or braces (as determined through fMRI screening form)
Sites / Locations
- University of California San DiegoRecruiting
Arms of the Study
Arm 1
Arm 2
Other
Other
Anorexia Nervosa Group
Healthy Control Group
Participants with anorexia nervosa
Participants who are considered to be healthy controls