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Subcutaneous Immunoglobulin in De-novo CIDP (SIDEC) (SIDEC)

Primary Purpose

CIDP - Chronic Inflammatory Demyelinating Polyneuropathy

Status
Recruiting
Phase
Phase 4
Locations
Denmark
Study Type
Interventional
Intervention
Immunoglobulin
Sponsored by
University of Aarhus
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for CIDP - Chronic Inflammatory Demyelinating Polyneuropathy focused on measuring Immunoglobulins, Intravenous, Injections, Subcutaneous

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Fulfilling EFNS/PNS criteria for definite, probable or pure motor CIDP.
  • No previous treatment with IVIG or SCIG.
  • Age ≥ 18.
  • ODSS ≥ 2 - either (arm/leg): 1/1, 2/0 or 0/2 at the time of inclusion.

Clinical criteria for typical CIDP

  • Chronically progressive, stepwise, or recurrent symmetric proximal and distal weakness and sensory dysfunction of all extremities, developing over at least 2 months; cranial nerves may be affected.
  • Absent or reduced tendon reflexes in all extremities.

Criteria for pure motor CIDP • Pure motor affection; otherwise as for typical CIDP.

Electrophysiological criteria for CIDP

  1. Motor distal latency prolongation ≥50% above ULN in two nerves (excluding median neuropathy at the wrist from carpal tunnel syndrome), or
  2. Reduction of motor conduction velocity ≥30% below LLN in two nerves, or
  3. Prolongation of F-wave latency ≥30% above ULN in two nerves (≥50% if amplitude of distal negative peak CMAP ≤80% of LLN values), or
  4. Absence of F-waves in two nerves of these nerves have distal negative peak CMAP amplitudes ≥20% of LLN + ≥1 other demyelinating parameter in ≥1 other nerve, or
  5. Partial motor conduction block: ≥50% amplitude reduction of the proximal negative peak CMAP relative to distal, if distal negative peak CMAP >20% of LLN, in two nerves, or in one nerve + ≥1 other demyelinating parameter in ≥1 other nerve, or
  6. Abnormal dispersion (≥30% duration increase between the proximal and distal negative peak CMAP) in ≥2 nerves, or
  7. Distal CMAP duration (interval between onset of the first negative peak an return to baseline of the last negative peak) increase in ≥1 nerve (median ≥6.6 ms, ulnar ≥6.7 ms, peroneal ≥7.6 ms, tibial ≥8.8 ms) + ≥1 other demyelinating parameter in ≥1 other nerve

Electrophysiological criteria for probable CIDP

(a) ≥30% amplitude reduction of the proximal negative peak CMAP relative to distal, excluding the posterior tibial nerve, if distal negative peak CMAP ≥20% of LLN, in two nerves, or in one nerve + ≥1 other demyelinating parameter in ≥1 other nerve

Exclusion Criteria:

  • Other causes of neuropathy
  • Increased risk of thromboembolism
  • Pregnancy (Plasma HCG is tested at inclusion in all fertile women)
  • Breast feeding
  • Malignancy
  • Severe medical disease
  • Other immune modulating treatment than low dose steroid (prednisolon < 25 mg daily) within the last 6 months prior to inclusion
  • Hepatitis B or C or HIV infection (screening at inclusion)
  • Known IgA deficiency
  • Known allergy to consents in PRIVIGEN or HIZENTRA
  • Body weight > 120 kg

After treatment initiation:

  • Pregnancy
  • Serious medical disease that affects treatment or examinations
  • Non-compliance to treatment
  • Initiation of other immune modulating therapy
  • Unacceptable side effects
  • Withdrawal of consent to participate (drop-out)

Sites / Locations

  • Department of Neurology, Aalborg University Hospital
  • Department of Neurology, Aarhus University HospitalRecruiting
  • Department of Neurology, Rigshospitalet, Copenhagen University Hospital
  • Department of Neurology, Odense University Hospital

Arms of the Study

Arm 1

Arm 2

Arm Type

Active Comparator

Active Comparator

Arm Label

Patients treated with immunoglobulin intravenously (IVIG)

Patients treated with immunoglobulin subcutaneously (SCIG)

Arm Description

Immunoglobulin (PRIVIGEN) intravenously 2 g/kg/4week for 26 weeks. After this 60 weeks of reduction every 12 weeks (90%, 75%, 50%, 25% and 0%).

Immunoglobulin (HIZENTRA) subcutaneously 0.54 g/kg/week for 26 weeks. After this 60 weeks of reduction every 12 weeks (90%, 75%, 50%, 25% and 0%).

Outcomes

Primary Outcome Measures

Change in disability
Evaluated with overall disability sum score (ODSS)

Secondary Outcome Measures

Change in grip strength
Grip strength (JAMAR)
Change in general muscle strength
MRC-score
Change in sensation
INCAT-Sensory Sum Score (ISS)
Change in walking performance
10-meter-walk test (10-MWT)
Change in walking performance and imbalance
6-spot-step test (6-SST)
Change in dexterity
9-hole-peg test (9-HPT)
Change in quality of life
QoL (EQ-5D-5L incl. VAS)
Change in fatigue severity
Fatigue Severity Scale (FSS)
Change in pain severity
Neuropathic Pain Symptom Inventory (NPSI)
Change in disability
Rasch built overall disability scale (RODS)
Change in treatment satisfaction
Life Quality Index (LQI)
Serum samples
Plasma IgG (IgG1, IgG2, IgG3, IgG4) Hematology: hemoglobin, reticulocyte count, haptoglobin, bilirubin, plasma haemoglobin, leukocyte count, thrombocyte count. Inflammatory biomarkers: sCD163 and neurofilament
Fluctuations in the describing parameters (ODSS and RODS) in both groups (SCIG and IVIG) based on measurement at time points for treatment with IVIG
Average value of examinations made at week 0, 4 and 20 (prior to IVIG infusion) Average value of examinations made at week 2, 14 and 26 (2 weeks after IVIG infusion)

Full Information

First Posted
September 9, 2020
Last Updated
October 9, 2020
Sponsor
University of Aarhus
Collaborators
Rigshospitalet, Denmark, Aarhus University Hospital, Odense University Hospital, Aalborg University Hospital
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1. Study Identification

Unique Protocol Identification Number
NCT04589299
Brief Title
Subcutaneous Immunoglobulin in De-novo CIDP (SIDEC)
Acronym
SIDEC
Official Title
Randomized, Parallel Study of Subcutaneous Versus Intravenous Immunoglobulin in Treatment-naïve Patients With Chronic Inflammatory Demyelinating Polyneuropathy
Study Type
Interventional

2. Study Status

Record Verification Date
March 2020
Overall Recruitment Status
Recruiting
Study Start Date
June 4, 2020 (Actual)
Primary Completion Date
December 31, 2025 (Anticipated)
Study Completion Date
December 31, 2025 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
University of Aarhus
Collaborators
Rigshospitalet, Denmark, Aarhus University Hospital, Odense University Hospital, Aalborg University Hospital

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Product Manufactured in and Exported from the U.S.
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
SIDEC - (Subcutaneous Immunoglobulin in De-novo CIDP) ia a study designed as a randomized, parallel study with an open-label extension phase. The aims are to compare the effect of SCIG and IVIG in 60 treatment-naïve CIDP patients, and to detect the lowest effective dosage for maintenance treatment.
Detailed Description
In fase I the patients are followed for 26 weeks on a fixed dose of 0.54 g/kg/week in the SCIG group (total 14 g/kg) and 2 g/kg/4week in the IVIG group (total 14 g/kg). The patients automatically continue in fase II in which treatment is reduced every 12 weeks (90%, 75%, 50%, 25% and 0%) over a course 60 weeks. The patients are evaluated at every visit with overall disability sum score (ODSS), grip strength, medical research council score (MRC-score), INCAT-Sensory Sum Score (ISS), 10-meter-walk test (10-MWT), 6-spot-step test (6-SST), 9-hole-peg test (9-HPT), quality of life (EQ-5D-5L), Fatigue Severity Scale (FSS), Neuropathic Pain Symptom Inventory (NPSI), Rasch built overall disability scale (RODS) and Life Quality Index (LQI) and blood samples.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
CIDP - Chronic Inflammatory Demyelinating Polyneuropathy
Keywords
Immunoglobulins, Intravenous, Injections, Subcutaneous

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 4
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
60 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Patients treated with immunoglobulin intravenously (IVIG)
Arm Type
Active Comparator
Arm Description
Immunoglobulin (PRIVIGEN) intravenously 2 g/kg/4week for 26 weeks. After this 60 weeks of reduction every 12 weeks (90%, 75%, 50%, 25% and 0%).
Arm Title
Patients treated with immunoglobulin subcutaneously (SCIG)
Arm Type
Active Comparator
Arm Description
Immunoglobulin (HIZENTRA) subcutaneously 0.54 g/kg/week for 26 weeks. After this 60 weeks of reduction every 12 weeks (90%, 75%, 50%, 25% and 0%).
Intervention Type
Biological
Intervention Name(s)
Immunoglobulin
Intervention Description
Randomization 1:1 to the same total dose of either SCIG or IVIG for 26 weeks of stable dose + 60 weeks of redcution.
Primary Outcome Measure Information:
Title
Change in disability
Description
Evaluated with overall disability sum score (ODSS)
Time Frame
Week 0 to 26
Secondary Outcome Measure Information:
Title
Change in grip strength
Description
Grip strength (JAMAR)
Time Frame
Week 0 to 26
Title
Change in general muscle strength
Description
MRC-score
Time Frame
Week 0 to 26
Title
Change in sensation
Description
INCAT-Sensory Sum Score (ISS)
Time Frame
Week 0 to 26
Title
Change in walking performance
Description
10-meter-walk test (10-MWT)
Time Frame
Week 0 to 26
Title
Change in walking performance and imbalance
Description
6-spot-step test (6-SST)
Time Frame
Week 0 to 26
Title
Change in dexterity
Description
9-hole-peg test (9-HPT)
Time Frame
Week 0 to 26
Title
Change in quality of life
Description
QoL (EQ-5D-5L incl. VAS)
Time Frame
Week 0 to 26
Title
Change in fatigue severity
Description
Fatigue Severity Scale (FSS)
Time Frame
Week 0 to 26
Title
Change in pain severity
Description
Neuropathic Pain Symptom Inventory (NPSI)
Time Frame
Week 0 to 26
Title
Change in disability
Description
Rasch built overall disability scale (RODS)
Time Frame
Week 0 to 26
Title
Change in treatment satisfaction
Description
Life Quality Index (LQI)
Time Frame
Week 2 to 26
Title
Serum samples
Description
Plasma IgG (IgG1, IgG2, IgG3, IgG4) Hematology: hemoglobin, reticulocyte count, haptoglobin, bilirubin, plasma haemoglobin, leukocyte count, thrombocyte count. Inflammatory biomarkers: sCD163 and neurofilament
Time Frame
Week 0 to 26
Title
Fluctuations in the describing parameters (ODSS and RODS) in both groups (SCIG and IVIG) based on measurement at time points for treatment with IVIG
Description
Average value of examinations made at week 0, 4 and 20 (prior to IVIG infusion) Average value of examinations made at week 2, 14 and 26 (2 weeks after IVIG infusion)
Time Frame
Week 0 to 26
Other Pre-specified Outcome Measures:
Title
The lowest dose of IVIG or SCIG reached during the 60 weeks of reduction (Fase II).
Description
Monitored on ODSS and the same secondary parameters as in week 0 to 26
Time Frame
Week 26 to 86

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Fulfilling EFNS/PNS criteria for definite, probable or pure motor CIDP. No previous treatment with IVIG or SCIG. Age ≥ 18. ODSS ≥ 2 - either (arm/leg): 1/1, 2/0 or 0/2 at the time of inclusion. Clinical criteria for typical CIDP Chronically progressive, stepwise, or recurrent symmetric proximal and distal weakness and sensory dysfunction of all extremities, developing over at least 2 months; cranial nerves may be affected. Absent or reduced tendon reflexes in all extremities. Criteria for pure motor CIDP • Pure motor affection; otherwise as for typical CIDP. Electrophysiological criteria for CIDP Motor distal latency prolongation ≥50% above ULN in two nerves (excluding median neuropathy at the wrist from carpal tunnel syndrome), or Reduction of motor conduction velocity ≥30% below LLN in two nerves, or Prolongation of F-wave latency ≥30% above ULN in two nerves (≥50% if amplitude of distal negative peak CMAP ≤80% of LLN values), or Absence of F-waves in two nerves of these nerves have distal negative peak CMAP amplitudes ≥20% of LLN + ≥1 other demyelinating parameter in ≥1 other nerve, or Partial motor conduction block: ≥50% amplitude reduction of the proximal negative peak CMAP relative to distal, if distal negative peak CMAP >20% of LLN, in two nerves, or in one nerve + ≥1 other demyelinating parameter in ≥1 other nerve, or Abnormal dispersion (≥30% duration increase between the proximal and distal negative peak CMAP) in ≥2 nerves, or Distal CMAP duration (interval between onset of the first negative peak an return to baseline of the last negative peak) increase in ≥1 nerve (median ≥6.6 ms, ulnar ≥6.7 ms, peroneal ≥7.6 ms, tibial ≥8.8 ms) + ≥1 other demyelinating parameter in ≥1 other nerve Electrophysiological criteria for probable CIDP (a) ≥30% amplitude reduction of the proximal negative peak CMAP relative to distal, excluding the posterior tibial nerve, if distal negative peak CMAP ≥20% of LLN, in two nerves, or in one nerve + ≥1 other demyelinating parameter in ≥1 other nerve Exclusion Criteria: Other causes of neuropathy Increased risk of thromboembolism Pregnancy (Plasma HCG is tested at inclusion in all fertile women) Breast feeding Malignancy Severe medical disease Other immune modulating treatment than low dose steroid (prednisolon < 25 mg daily) within the last 6 months prior to inclusion Hepatitis B or C or HIV infection (screening at inclusion) Known IgA deficiency Known allergy to consents in PRIVIGEN or HIZENTRA Body weight > 120 kg After treatment initiation: Pregnancy Serious medical disease that affects treatment or examinations Non-compliance to treatment Initiation of other immune modulating therapy Unacceptable side effects Withdrawal of consent to participate (drop-out)
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Lars Markvardsen, MD, PhD
Phone
+45 20231903
Email
larsmark@rm.dk
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Henning Andersen, MD,DMSc,PhD
Organizational Affiliation
Aarhus University, Aarhus University Hospital
Official's Role
Principal Investigator
Facility Information:
Facility Name
Department of Neurology, Aalborg University Hospital
City
Aalborg
ZIP/Postal Code
9000
Country
Denmark
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Izabella Obál, Md, PhD
Phone
9766 2200
Email
i.obal@rn.dk
Facility Name
Department of Neurology, Aarhus University Hospital
City
Aarhus C
ZIP/Postal Code
8000
Country
Denmark
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Henning Andersen, DMSc
Email
hennande@rm.dk
First Name & Middle Initial & Last Name & Degree
Lars Markvardsen, MD
Phone
+45 7846 3337
Email
larsmark@rm.dk
First Name & Middle Initial & Last Name & Degree
Lars Markvardsen, MD
First Name & Middle Initial & Last Name & Degree
Henning Andersen, DMSc
Facility Name
Department of Neurology, Rigshospitalet, Copenhagen University Hospital
City
Copenhagen
ZIP/Postal Code
2100
Country
Denmark
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tina D Jeppesen, MD,DMSc,PhD
Email
tina.dysgaard.jeppesen@regionh.dk
First Name & Middle Initial & Last Name & Degree
Tina D Jeppesen, MD,DMSc,PhD
Facility Name
Department of Neurology, Odense University Hospital
City
Odense
ZIP/Postal Code
5000
Country
Denmark
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Søren Sindrup, MD, DMSc
Phone
+45 6541 2485
Email
soeren.sindrup@rsyd.dk

12. IPD Sharing Statement

Plan to Share IPD
No

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Subcutaneous Immunoglobulin in De-novo CIDP (SIDEC)

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