search
Back to results

A Study to Assess the Efficacy, Safety, and Tolerability of Brensocatib in Participants With Non-Cystic Fibrosis Bronchiectasis (ASPEN)

Primary Purpose

Non-Cystic Fibrosis Bronchiectasis

Status
Active
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Brensocatib 10 mg
Brensocatib 25 mg
Placebo
Sponsored by
Insmed Incorporated
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Non-Cystic Fibrosis Bronchiectasis focused on measuring ASPEN, Brensocatib, INS1007

Eligibility Criteria

12 Years - 85 Years (Child, Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  1. Provide their signed study informed consent to participate.

    a. Adolescent participants must have signed study assent form to participate, and the adolescent's parent or legal guardian must have provided signed informed consent for the adolescent to participate.

  2. Clinical history consistent with non-cystic fibrosis bronchiectasis (NCFBE) (cough, chronic sputum production and/or recurrent respiratory infections) that is confirmed by chest computerized tomography (CT) scan.
  3. At least 2 PEs defined by need for antibiotic prescription by a physician for the signs and symptoms of respiratory infections in the past 12 months before the Screening Visit.

    a. Adolescent participants are required to have at least 1 pulmonary exacerbation in the prior 12 months.

  4. Women must be postmenopausal (defined as no menses for 12 months without an alternative medical cause), surgically sterile, or using highly effective contraception (ie, methods that can achieve a failure rate <1% per year when used consistently and correctly) from Day 1 to at least 90 days after the last dose.
  5. Male participants with female partners of childbearing potential must be using effective contraception from Day 1 to at least 90 days after the last dose.
  6. Male participants with pregnant or non-pregnant women of child-bearing potential partners must use condoms to avoid potential exposure to the embryo/fetus.

Exclusion Criteria:

  1. A primary diagnosis of chronic obstructive pulmonary disease (COPD) or asthma as judged by the Investigator.
  2. Bronchiectasis due to cystic fibrosis.
  3. Current smokers as defined per Centers for Disease Control (CDC).
  4. Known or suspected immunodeficiency disorder, including history of invasive opportunistic infections.
  5. Known history of human immunodeficiency virus (HIV) infection.
  6. Currently being treated for nontuberculous mycobacteria (NTM) lung infection, allergic bronchopulmonary aspergillosis, or tuberculosis (TB).
  7. Active and current symptomatic infection by 2019 corona virus disease (COVID-19).
  8. Inability to follow the procedures of the study (eg, due to language problems or psychological disorders).
  9. Receiving medications or therapy that are prohibited as concomitant medications.
  10. Previously participated in a clinical trial for brensocatib.
  11. Received any live attenuated vaccine within 4 weeks prior to the first administration of brensocatib.
  12. Suffering an exacerbation 4 weeks before Screening or during the Screening period.
  13. Adult participants only: Have compliance issues with completion of electronic diary entries during the Screening Period and in the opinion of the Investigator, compliance is unlikely to improve during the study.
  14. Participated in any other interventional clinical studies within 3 months before Screening Visit.
  15. History of alcohol or drug abuse within 6 months prior to the Screening Visit.
  16. Is the Investigator or any Sub-Investigator, research assistant, pharmacist, study coordinator, other staff or relative thereof directly involved in the conduct of the study.
  17. Known history of hypersensitivity to brensocatib or any of its excipients.

Sites / Locations

  • USA013
  • USA080
  • USA044
  • USA104
  • USA055
  • USA029
  • USA102
  • USA022
  • USA024
  • USA035
  • USA078
  • USA027
  • USA075
  • USA017
  • USA001
  • USA015
  • USA076
  • USA082
  • USA039
  • USA072
  • USA019
  • USA037
  • USA049
  • USA052
  • USA103
  • USA089
  • USA074
  • USA084
  • USA120
  • USA012
  • USA053
  • USA073
  • USA061
  • USA115
  • USA063
  • USA031
  • USA020
  • USA051
  • USA003
  • USA079
  • USA064
  • USA010
  • USA006
  • USA122
  • USA059
  • USA110
  • USA065
  • USA066
  • USA021
  • USA085
  • USA033
  • USA096
  • USA026
  • USA067
  • USA028
  • USA093
  • USA023
  • USA038
  • USA046
  • USA005
  • USA036
  • USA041
  • USA109
  • USA097
  • USA050
  • USA011
  • USA002
  • USA034
  • USA088
  • ARG027
  • ARG021
  • ARG022
  • ARG002
  • ARG001
  • ARG003
  • ARG004
  • ARG006
  • ARG013
  • ARG017
  • ARG009
  • ARG012
  • ARG018
  • ARG026
  • ARG023
  • ARG014
  • ARG010
  • ARG015
  • ARG025
  • ARG005
  • ARG007
  • ARG011
  • ARG019
  • AUS013
  • AUS008
  • AUS007
  • AUS012
  • AUS001
  • AUS010
  • AUS006
  • AUS019
  • AUS011
  • AUS017
  • AUS022
  • AUS009
  • AUS002
  • AUS014
  • AUS020
  • AUS018
  • AUS005
  • AUS021
  • AUS003
  • AUS015
  • AUT002
  • BEL002
  • BEL009
  • BEL004
  • BEL001
  • BEL007
  • BEL003
  • BEL008
  • BRA009
  • BRA005
  • BRA001
  • BRA006
  • BRA003
  • BRA004
  • BRA011
  • BGR011
  • BGR009
  • BGR002
  • BGR005
  • BGR006
  • BGR014
  • BGR015
  • BGR007
  • BGR018
  • BGR019
  • BGR004
  • BGR008
  • BGR017
  • BGR010
  • BGR012
  • BGR013
  • BGR016
  • CAN004
  • CAN002
  • CHL007
  • CHL005
  • CHL010
  • CHL001
  • CHL002
  • CHL008
  • CHL004
  • COL006
  • COL001
  • COL005
  • COL003
  • COL002
  • COL004
  • DNK008
  • DNK001
  • DNK005
  • DNK006
  • DNK003
  • DNK007
  • DNK004
  • DNK002
  • FRA002
  • FRA004
  • FRA011
  • FRA003
  • FRA009
  • FRA010
  • FRA006
  • DEU009
  • DEU025
  • DEU027
  • DEU008
  • DEU005
  • DEU031
  • DEU013
  • DEU016
  • DEU003
  • DEU020
  • DEU002
  • DEU019
  • DEU006
  • DEU011
  • DEU014
  • DEU021
  • DEU015
  • DEU023
  • DEU029
  • GRC003
  • GRC007
  • GRC006
  • HUN005
  • IRL003
  • IRL002
  • IRL001
  • ISR001
  • ISR010
  • ISR008
  • ISR006
  • ISR002
  • ISR009
  • ISR011
  • ISR007
  • ISR003
  • ISR004
  • ITA010
  • ITA008
  • ITA002
  • ITA006
  • ITA012
  • ITA011
  • ITA004
  • ITA003
  • ITA001
  • ITA007
  • ITA009
  • JPN029
  • JPN031
  • JPN027
  • JPN023
  • JPN009
  • JPN020
  • JPN001
  • JPN022
  • JPN028
  • JPN005
  • JPN008
  • JPN011
  • JPN034
  • JPN024
  • JPN013
  • JPN012
  • JPN015
  • JPN007
  • JPN014
  • JPN006
  • JPN017
  • JPN002
  • JPN032
  • JPN019
  • JPN030
  • JPN003
  • JPN004
  • JPN016
  • JPN010
  • JPN018
  • KOR015
  • KOR008
  • KOR007
  • KOR003
  • KOR004
  • KOR012
  • KOR011
  • KOR009
  • KOR013
  • KOR010
  • KOR005
  • LVA002
  • LVA005
  • MYS004
  • MYS001
  • MYS003
  • MYS005
  • MEX007
  • MEX008
  • MEX005
  • MEX004
  • MEX003
  • MEX006
  • MEX001
  • MEX002
  • NLD003
  • NLD001
  • NLD002
  • NLD006
  • NZL006
  • NZL009
  • NZL005
  • NZL001
  • NZL002
  • NZL011
  • NZL003
  • NZL008
  • NZL007
  • NZL010
  • PER005
  • PER001
  • PER003
  • PER002
  • PER006
  • POL012
  • POL005
  • POL006
  • POL016
  • POL015
  • POL017
  • POL018
  • POL008
  • POL011
  • POL010
  • POL007
  • POL001
  • POL014
  • POL009
  • PRT005
  • PRT009
  • PRT006
  • PRT002
  • PRT003
  • SRB001
  • SRB003
  • SRB007
  • SRB014
  • SRB010
  • SVK002
  • SVK003
  • ESP009
  • ESP008
  • ESP013
  • ESP012
  • ESP015
  • ESP011
  • ESP003
  • ESP016
  • ESP001
  • ESP006
  • ESP007
  • ESP002
  • TWN003
  • TWN002
  • TWN001
  • TWN005
  • TWN006
  • TWN007
  • TWN004
  • THA004
  • THA002
  • THA003
  • TUR006
  • TUR010
  • TUR011
  • TUR003
  • TUR008
  • TUR004
  • TUR009
  • TUR005
  • TUR001
  • UKR001
  • UKR007
  • UKR005
  • UKR012
  • UKR009
  • UKR008
  • UKR004
  • UKR003
  • UKR010
  • GBR001
  • GBR015
  • GBR017
  • GBR013
  • GBR016
  • GBR006
  • GBR002
  • GBR007
  • GBR004
  • GBR009
  • GBR008
  • GBR011
  • GBR003
  • GBR012
  • GBR018
  • GBR010

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Experimental

Placebo Comparator

Arm Label

Brensocatib 10 mg

Brensocatib 25 mg

Placebo

Arm Description

Participants will receive brensocatib 10 mg, tablets orally, once daily, for 52 weeks.

Participants will receive brensocatib 25 mg, tablets orally, once daily, for 52 weeks.

Participants will receive a brensocatib-matching placebo, tablets orally, once daily, for 52 weeks.

Outcomes

Primary Outcome Measures

Rate of Adjudicated Pulmonary Exacerbations (PEs)

Secondary Outcome Measures

Time to First Adjudicated Pulmonary Exacerbation (PE)
Percentage of Participants who are Pulmonary Exacerbation (PE) Free
Change From Baseline in Postbronchodilator Forced Expiratory Volume in 1 Second (FEV1)
Rate of Severe Adjudicated Pulmonary Exacerbations (PEs)
Change from Baseline to Week 52 in Quality of Life Questionnaire - Bronchiectasis (QOL-B) Respiratory Symptoms Domain Score in Adult Participants
Number of Participants who Experience at Least one Treatment-Emergent Adverse Events (TEAEs)
Plasma Concentration of Brensocatib at Select Time Points

Full Information

First Posted
October 14, 2020
Last Updated
October 6, 2023
Sponsor
Insmed Incorporated
search

1. Study Identification

Unique Protocol Identification Number
NCT04594369
Brief Title
A Study to Assess the Efficacy, Safety, and Tolerability of Brensocatib in Participants With Non-Cystic Fibrosis Bronchiectasis
Acronym
ASPEN
Official Title
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy, Safety, and Tolerability of Brensocatib Administered Once Daily for 52 Weeks in Subjects With Non-Cystic Fibrosis Bronchiectasis - The ASPEN Study
Study Type
Interventional

2. Study Status

Record Verification Date
October 2023
Overall Recruitment Status
Active, not recruiting
Study Start Date
December 1, 2020 (Actual)
Primary Completion Date
March 22, 2024 (Anticipated)
Study Completion Date
March 22, 2024 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Insmed Incorporated

4. Oversight

Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The primary objective of this study is to evaluate the effect of brensocatib at 10 mg and 25 mg compared with placebo on the rate of pulmonary exacerbations (PEs) over the 52-week treatment period.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Non-Cystic Fibrosis Bronchiectasis
Keywords
ASPEN, Brensocatib, INS1007

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantInvestigator
Allocation
Randomized
Enrollment
1767 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Brensocatib 10 mg
Arm Type
Experimental
Arm Description
Participants will receive brensocatib 10 mg, tablets orally, once daily, for 52 weeks.
Arm Title
Brensocatib 25 mg
Arm Type
Experimental
Arm Description
Participants will receive brensocatib 25 mg, tablets orally, once daily, for 52 weeks.
Arm Title
Placebo
Arm Type
Placebo Comparator
Arm Description
Participants will receive a brensocatib-matching placebo, tablets orally, once daily, for 52 weeks.
Intervention Type
Drug
Intervention Name(s)
Brensocatib 10 mg
Other Intervention Name(s)
INS1007
Intervention Description
Oral tablet.
Intervention Type
Drug
Intervention Name(s)
Brensocatib 25 mg
Other Intervention Name(s)
INS1007
Intervention Description
Oral tablet.
Intervention Type
Drug
Intervention Name(s)
Placebo
Intervention Description
Brensocatib-matching oral tablet.
Primary Outcome Measure Information:
Title
Rate of Adjudicated Pulmonary Exacerbations (PEs)
Time Frame
52 Weeks
Secondary Outcome Measure Information:
Title
Time to First Adjudicated Pulmonary Exacerbation (PE)
Time Frame
52 Weeks
Title
Percentage of Participants who are Pulmonary Exacerbation (PE) Free
Time Frame
52 Weeks
Title
Change From Baseline in Postbronchodilator Forced Expiratory Volume in 1 Second (FEV1)
Time Frame
Baseline, at Week 52
Title
Rate of Severe Adjudicated Pulmonary Exacerbations (PEs)
Time Frame
52 Weeks
Title
Change from Baseline to Week 52 in Quality of Life Questionnaire - Bronchiectasis (QOL-B) Respiratory Symptoms Domain Score in Adult Participants
Time Frame
Baseline to Week 52
Title
Number of Participants who Experience at Least one Treatment-Emergent Adverse Events (TEAEs)
Time Frame
56 Weeks
Title
Plasma Concentration of Brensocatib at Select Time Points
Time Frame
Pre-dose and post-dose at multiple time points up to Week 52

10. Eligibility

Sex
All
Minimum Age & Unit of Time
12 Years
Maximum Age & Unit of Time
85 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Provide their signed study informed consent to participate. a. Adolescent participants must have signed study assent form to participate, and the adolescent's parent or legal guardian must have provided signed informed consent for the adolescent to participate. Clinical history consistent with non-cystic fibrosis bronchiectasis (NCFBE) (cough, chronic sputum production and/or recurrent respiratory infections) that is confirmed by chest computerized tomography (CT) scan. At least 2 PEs defined by need for antibiotic prescription by a physician for the signs and symptoms of respiratory infections in the past 12 months before the Screening Visit. a. Adolescent participants are required to have at least 1 pulmonary exacerbation in the prior 12 months. Women must be postmenopausal (defined as no menses for 12 months without an alternative medical cause), surgically sterile, or using highly effective contraception (ie, methods that can achieve a failure rate <1% per year when used consistently and correctly) from Day 1 to at least 90 days after the last dose. Male participants with female partners of childbearing potential must be using effective contraception from Day 1 to at least 90 days after the last dose. Male participants with pregnant or non-pregnant women of child-bearing potential partners must use condoms to avoid potential exposure to the embryo/fetus. Exclusion Criteria: A primary diagnosis of chronic obstructive pulmonary disease (COPD) or asthma as judged by the Investigator. Bronchiectasis due to cystic fibrosis. Current smokers as defined per Centers for Disease Control (CDC). Known or suspected immunodeficiency disorder, including history of invasive opportunistic infections. Known history of human immunodeficiency virus (HIV) infection. Currently being treated for nontuberculous mycobacteria (NTM) lung infection, allergic bronchopulmonary aspergillosis, or tuberculosis (TB). Active and current symptomatic infection by 2019 corona virus disease (COVID-19). Inability to follow the procedures of the study (eg, due to language problems or psychological disorders). Receiving medications or therapy that are prohibited as concomitant medications. Previously participated in a clinical trial for brensocatib. Received any live attenuated vaccine within 4 weeks prior to the first administration of brensocatib. Suffering an exacerbation 4 weeks before Screening or during the Screening period. Adult participants only: Have compliance issues with completion of electronic diary entries during the Screening Period and in the opinion of the Investigator, compliance is unlikely to improve during the study. Participated in any other interventional clinical studies within 3 months before Screening Visit. History of alcohol or drug abuse within 6 months prior to the Screening Visit. Is the Investigator or any Sub-Investigator, research assistant, pharmacist, study coordinator, other staff or relative thereof directly involved in the conduct of the study. Known history of hypersensitivity to brensocatib or any of its excipients.
Facility Information:
Facility Name
USA013
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35233-1711
Country
United States
Facility Name
USA080
City
Conway
State/Province
Arkansas
ZIP/Postal Code
72032
Country
United States
Facility Name
USA044
City
Little Rock
State/Province
Arkansas
ZIP/Postal Code
72205
Country
United States
Facility Name
USA104
City
Fresno
State/Province
California
ZIP/Postal Code
93702
Country
United States
Facility Name
USA055
City
Los Angeles
State/Province
California
ZIP/Postal Code
90048
Country
United States
Facility Name
USA029
City
Newport Beach
State/Province
California
ZIP/Postal Code
92663
Country
United States
Facility Name
USA102
City
Northridge
State/Province
California
ZIP/Postal Code
91324-3138
Country
United States
Facility Name
USA022
City
Palm Springs
State/Province
California
ZIP/Postal Code
92262
Country
United States
Facility Name
USA024
City
Sacramento
State/Province
California
ZIP/Postal Code
95817-1460
Country
United States
Facility Name
USA035
City
San Diego
State/Province
California
ZIP/Postal Code
92120
Country
United States
Facility Name
USA078
City
Santa Barbara
State/Province
California
ZIP/Postal Code
93105-4353
Country
United States
Facility Name
USA027
City
Ventura
State/Province
California
ZIP/Postal Code
93003
Country
United States
Facility Name
USA075
City
Denver
State/Province
Colorado
ZIP/Postal Code
80206-2761
Country
United States
Facility Name
USA017
City
Farmington
State/Province
Connecticut
ZIP/Postal Code
06030
Country
United States
Facility Name
USA001
City
Washington
State/Province
District of Columbia
ZIP/Postal Code
20007
Country
United States
Facility Name
USA015
City
Clearwater
State/Province
Florida
ZIP/Postal Code
33765
Country
United States
Facility Name
USA076
City
Gainesville
State/Province
Florida
ZIP/Postal Code
32610-0001
Country
United States
Facility Name
USA082
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32224-1865
Country
United States
Facility Name
USA039
City
Kissimmee
State/Province
Florida
ZIP/Postal Code
34746
Country
United States
Facility Name
USA072
City
Leesburg
State/Province
Florida
ZIP/Postal Code
34748-5077
Country
United States
Facility Name
USA019
City
Miami Lakes
State/Province
Florida
ZIP/Postal Code
33014
Country
United States
Facility Name
USA037
City
Miami
State/Province
Florida
ZIP/Postal Code
33126
Country
United States
Facility Name
USA049
City
Naples
State/Province
Florida
ZIP/Postal Code
34102-5444
Country
United States
Facility Name
USA052
City
Orlando
State/Province
Florida
ZIP/Postal Code
32825
Country
United States
Facility Name
USA103
City
Plantation
State/Province
Florida
ZIP/Postal Code
33324
Country
United States
Facility Name
USA089
City
Saint Petersburg
State/Province
Florida
ZIP/Postal Code
33704
Country
United States
Facility Name
USA074
City
Saint Petersburg
State/Province
Florida
ZIP/Postal Code
33707
Country
United States
Facility Name
USA084
City
Sarasota
State/Province
Florida
ZIP/Postal Code
34239-3502
Country
United States
Facility Name
USA120
City
Tampa
State/Province
Florida
ZIP/Postal Code
33606
Country
United States
Facility Name
USA012
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30342
Country
United States
Facility Name
USA053
City
Augusta
State/Province
Georgia
ZIP/Postal Code
30912
Country
United States
Facility Name
USA073
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60611-2951
Country
United States
Facility Name
USA061
City
Maywood
State/Province
Illinois
ZIP/Postal Code
60153
Country
United States
Facility Name
USA115
City
Hammond
State/Province
Indiana
ZIP/Postal Code
46324-2213
Country
United States
Facility Name
USA063
City
Iowa City
State/Province
Iowa
ZIP/Postal Code
52242
Country
United States
Facility Name
USA031
City
Kansas City
State/Province
Kansas
ZIP/Postal Code
66160
Country
United States
Facility Name
USA020
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70112
Country
United States
Facility Name
USA051
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70112
Country
United States
Facility Name
USA003
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21224-3057
Country
United States
Facility Name
USA079
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02114
Country
United States
Facility Name
USA064
City
Springfield
State/Province
Massachusetts
ZIP/Postal Code
01199
Country
United States
Facility Name
USA010
City
Rochester
State/Province
Minnesota
ZIP/Postal Code
55905
Country
United States
Facility Name
USA006
City
Chesterfield
State/Province
Missouri
ZIP/Postal Code
63017
Country
United States
Facility Name
USA122
City
Columbia
State/Province
Missouri
ZIP/Postal Code
65212-1000
Country
United States
Facility Name
USA059
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Facility Name
USA110
City
Lincoln
State/Province
Nebraska
ZIP/Postal Code
68510
Country
United States
Facility Name
USA065
City
Toms River
State/Province
New Jersey
ZIP/Postal Code
08755
Country
United States
Facility Name
USA066
City
New Hyde Park
State/Province
New York
ZIP/Postal Code
11042-1102
Country
United States
Facility Name
USA021
City
New York
State/Province
New York
ZIP/Postal Code
10017-6739
Country
United States
Facility Name
USA085
City
New York
State/Province
New York
ZIP/Postal Code
10032-3729
Country
United States
Facility Name
USA033
City
Gastonia
State/Province
North Carolina
ZIP/Postal Code
28054
Country
United States
Facility Name
USA096
City
Huntersville
State/Province
North Carolina
ZIP/Postal Code
28078-5082
Country
United States
Facility Name
USA026
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27103
Country
United States
Facility Name
USA067
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45267
Country
United States
Facility Name
USA028
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44106
Country
United States
Facility Name
USA093
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44195
Country
United States
Facility Name
USA023
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239
Country
United States
Facility Name
USA038
City
DuBois
State/Province
Pennsylvania
ZIP/Postal Code
15801
Country
United States
Facility Name
USA046
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19104
Country
United States
Facility Name
USA005
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29425
Country
United States
Facility Name
USA036
City
Rock Hill
State/Province
South Carolina
ZIP/Postal Code
29732
Country
United States
Facility Name
USA041
City
Franklin
State/Province
Tennessee
ZIP/Postal Code
37067
Country
United States
Facility Name
USA109
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37232-0028
Country
United States
Facility Name
USA097
City
Dallas
State/Province
Texas
ZIP/Postal Code
75246-2081
Country
United States
Facility Name
USA050
City
McKinney
State/Province
Texas
ZIP/Postal Code
75069-8085
Country
United States
Facility Name
USA011
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78258
Country
United States
Facility Name
USA002
City
Tyler
State/Province
Texas
ZIP/Postal Code
75708
Country
United States
Facility Name
USA034
City
Williamsburg
State/Province
Virginia
ZIP/Postal Code
23188
Country
United States
Facility Name
USA088
City
Vancouver
State/Province
Washington
ZIP/Postal Code
98664-1913
Country
United States
Facility Name
ARG027
City
Bahia Blanca
State/Province
Buenos Aires
ZIP/Postal Code
8000
Country
Argentina
Facility Name
ARG021
City
Ciudad Autónoma de Buenos Aires
State/Province
Buenos Aires
ZIP/Postal Code
C1121ABE
Country
Argentina
Facility Name
ARG022
City
Ciudad Autónoma de Buenos Aires
State/Province
Buenos Aires
ZIP/Postal Code
C1122AAK
Country
Argentina
Facility Name
ARG002
City
Ciudad Autónoma de Buenos Aires
State/Province
Buenos Aires
ZIP/Postal Code
C1414AIF
Country
Argentina
Facility Name
ARG001
City
Ciudad Autónoma de Buenos Aires
State/Province
Buenos Aires
ZIP/Postal Code
C1425AZB
Country
Argentina
Facility Name
ARG003
City
Ciudad Autónoma de BuenosAires
State/Province
Buenos Aires
ZIP/Postal Code
C1425BEN
Country
Argentina
Facility Name
ARG004
City
Ciudad Autónoma de BuenosAires
State/Province
Buenos Aires
ZIP/Postal Code
C1426ABP
Country
Argentina
Facility Name
ARG006
City
la Plata
State/Province
Buenos Aires
ZIP/Postal Code
B1902COS
Country
Argentina
Facility Name
ARG013
City
Mar del Plata
State/Province
Buenos Aires
ZIP/Postal Code
B7600FYK
Country
Argentina
Facility Name
ARG017
City
Mar Del Plata
State/Province
Buenos Aires
ZIP/Postal Code
CP 7600
Country
Argentina
Facility Name
ARG009
City
Villa Vatteone
State/Province
Buenos Aires
ZIP/Postal Code
B1853AIK
Country
Argentina
Facility Name
ARG012
City
Ciudad Autónoma de Buenos Aires
State/Province
Ciudad Autónoma De BuenosAires
ZIP/Postal Code
C10227AAP
Country
Argentina
Facility Name
ARG018
City
Ciudad Autónoma de Buenos Aires
State/Province
Ciudad Autónoma De BuenosAires
ZIP/Postal Code
C1060
Country
Argentina
Facility Name
ARG026
City
Recoleta
State/Province
Ciudad Autónoma De BuenosAires
ZIP/Postal Code
C1425EFD
Country
Argentina
Facility Name
ARG023
City
Río Cuarto
State/Province
Córdoba
ZIP/Postal Code
5800
Country
Argentina
Facility Name
ARG014
City
Vistalba
State/Province
Mendoza
ZIP/Postal Code
M5544
Country
Argentina
Facility Name
ARG010
City
Rosario
State/Province
Santa Fe
ZIP/Postal Code
S2000DTC
Country
Argentina
Facility Name
ARG015
City
San Miguel de Tucumán
State/Province
Tucumán
ZIP/Postal Code
4000
Country
Argentina
Facility Name
ARG025
City
San Miguel de Tucumán
State/Province
Tucumán
ZIP/Postal Code
T4000IHE
Country
Argentina
Facility Name
ARG005
City
Córdoba
ZIP/Postal Code
X5003DCE
Country
Argentina
Facility Name
ARG007
City
Mendoza
ZIP/Postal Code
M5500CCG
Country
Argentina
Facility Name
ARG011
City
Rosario
ZIP/Postal Code
S2000JKR
Country
Argentina
Facility Name
ARG019
City
Santa Fe
ZIP/Postal Code
3000
Country
Argentina
Facility Name
AUS013
City
Kogarah
State/Province
New South Wales
ZIP/Postal Code
2217
Country
Australia
Facility Name
AUS008
City
New Lambton Heights
State/Province
New South Wales
ZIP/Postal Code
2305
Country
Australia
Facility Name
AUS007
City
Westmead
State/Province
New South Wales
ZIP/Postal Code
2145
Country
Australia
Facility Name
AUS012
City
Cairns North
State/Province
Queensland
ZIP/Postal Code
4870
Country
Australia
Facility Name
AUS001
City
Chermside
State/Province
Queensland
ZIP/Postal Code
4032
Country
Australia
Facility Name
AUS010
City
Greenslopes
State/Province
Queensland
ZIP/Postal Code
4120
Country
Australia
Facility Name
AUS006
City
South Brisbane
State/Province
Queensland
ZIP/Postal Code
4101
Country
Australia
Facility Name
AUS019
City
South Brisbane
State/Province
Queensland
ZIP/Postal Code
4101
Country
Australia
Facility Name
AUS011
City
Adelaide
State/Province
South Australia
ZIP/Postal Code
5000
Country
Australia
Facility Name
AUS017
City
Bedford Park
State/Province
South Australia
ZIP/Postal Code
5042
Country
Australia
Facility Name
AUS022
City
North Adelaide
State/Province
South Australia
ZIP/Postal Code
5006
Country
Australia
Facility Name
AUS009
City
Woodville South
State/Province
South Australia
ZIP/Postal Code
5011
Country
Australia
Facility Name
AUS002
City
Box Hill
State/Province
Victoria
ZIP/Postal Code
3128
Country
Australia
Facility Name
AUS014
City
Clayton
State/Province
Victoria
ZIP/Postal Code
3168
Country
Australia
Facility Name
AUS020
City
Parkville
State/Province
Victoria
ZIP/Postal Code
3052
Country
Australia
Facility Name
AUS018
City
Murdoch
State/Province
Western Australia
ZIP/Postal Code
6150
Country
Australia
Facility Name
AUS005
City
Nedlands
State/Province
Western Australia
ZIP/Postal Code
6009
Country
Australia
Facility Name
AUS021
City
Nedlands
State/Province
Western Australia
ZIP/Postal Code
6009
Country
Australia
Facility Name
AUS003
City
Concord
ZIP/Postal Code
NSW 2139
Country
Australia
Facility Name
AUS015
City
Spearwood
ZIP/Postal Code
6163
Country
Australia
Facility Name
AUT002
City
Linz
ZIP/Postal Code
4021
Country
Austria
Facility Name
BEL002
City
Gent
State/Province
Oost-Vlaanderen
ZIP/Postal Code
9000
Country
Belgium
Facility Name
BEL009
City
Gent
State/Province
Oost-Vlaanderen
ZIP/Postal Code
9000
Country
Belgium
Facility Name
BEL004
City
Roeselare
State/Province
West-Vlaanderen
ZIP/Postal Code
8800
Country
Belgium
Facility Name
BEL001
City
Leuven
ZIP/Postal Code
3000
Country
Belgium
Facility Name
BEL007
City
Liège
ZIP/Postal Code
4000
Country
Belgium
Facility Name
BEL003
City
Mechelen
ZIP/Postal Code
2800
Country
Belgium
Facility Name
BEL008
City
Sint-Niklaas
ZIP/Postal Code
9100
Country
Belgium
Facility Name
BRA009
City
Passo Fundo
State/Province
Rio Grande Do Sul
ZIP/Postal Code
99010-120
Country
Brazil
Facility Name
BRA005
City
Porto Alegre
State/Province
Rio Grande Do Sul
ZIP/Postal Code
90035-074
Country
Brazil
Facility Name
BRA001
City
Blumenau
State/Province
Santa Catarina
ZIP/Postal Code
89030-240
Country
Brazil
Facility Name
BRA006
City
Santo André
State/Province
São Paulo
ZIP/Postal Code
09090-790
Country
Brazil
Facility Name
BRA003
City
Botucatu
ZIP/Postal Code
18618-686
Country
Brazil
Facility Name
BRA004
City
São Bernardo do Campo
ZIP/Postal Code
09715-090
Country
Brazil
Facility Name
BRA011
City
São Paulo
ZIP/Postal Code
05403-000
Country
Brazil
Facility Name
BGR011
City
Sofia
State/Province
Sofia-Grad
ZIP/Postal Code
1336
Country
Bulgaria
Facility Name
BGR009
City
Sofia
State/Province
Sofia-Grad
ZIP/Postal Code
1510
Country
Bulgaria
Facility Name
BGR002
City
Sofia
State/Province
Sofia-Grad
ZIP/Postal Code
1680
Country
Bulgaria
Facility Name
BGR005
City
Blagoevgrad
ZIP/Postal Code
2700
Country
Bulgaria
Facility Name
BGR006
City
Gabrovo
ZIP/Postal Code
5300
Country
Bulgaria
Facility Name
BGR014
City
Kozloduy
ZIP/Postal Code
3320
Country
Bulgaria
Facility Name
BGR015
City
Lovech
ZIP/Postal Code
5500
Country
Bulgaria
Facility Name
BGR007
City
Montana
ZIP/Postal Code
3400
Country
Bulgaria
Facility Name
BGR018
City
Pazardzhik
ZIP/Postal Code
4400
Country
Bulgaria
Facility Name
BGR019
City
Pleven
ZIP/Postal Code
5800
Country
Bulgaria
Facility Name
BGR004
City
Plovdiv
ZIP/Postal Code
4023
Country
Bulgaria
Facility Name
BGR008
City
Ruse
ZIP/Postal Code
7002
Country
Bulgaria
Facility Name
BGR017
City
Sliven
ZIP/Postal Code
8800
Country
Bulgaria
Facility Name
BGR010
City
Sofia
ZIP/Postal Code
1233
Country
Bulgaria
Facility Name
BGR012
City
Veliko Tarnovo
ZIP/Postal Code
5000
Country
Bulgaria
Facility Name
BGR013
City
Vidin
ZIP/Postal Code
3700
Country
Bulgaria
Facility Name
BGR016
City
Vratsa
ZIP/Postal Code
3000
Country
Bulgaria
Facility Name
CAN004
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5T 3A9
Country
Canada
Facility Name
CAN002
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H2X 0A9
Country
Canada
Facility Name
CHL007
City
Valdivia
State/Province
Los Ríos
ZIP/Postal Code
5110683
Country
Chile
Facility Name
CHL005
City
Curicó
State/Province
Maule
ZIP/Postal Code
3440000
Country
Chile
Facility Name
CHL010
City
Talca
State/Province
Maule
ZIP/Postal Code
3481349
Country
Chile
Facility Name
CHL001
City
Providencia
State/Province
Región-MetropolitanadeSantiago
ZIP/Postal Code
7500000
Country
Chile
Facility Name
CHL002
City
Providencia
State/Province
Región-MetropolitanadeSantiago
ZIP/Postal Code
7500000
Country
Chile
Facility Name
CHL008
City
Providencia
State/Province
Región-MetropolitanadeSantiago
ZIP/Postal Code
7500587
Country
Chile
Facility Name
CHL004
City
Quillota
ZIP/Postal Code
2260000
Country
Chile
Facility Name
COL006
City
Zipaquira
State/Province
Cundinamarca
ZIP/Postal Code
250252
Country
Colombia
Facility Name
COL001
City
Bogotá
State/Province
Distrito Capital De Bogotá
ZIP/Postal Code
111211
Country
Colombia
Facility Name
COL005
City
Floridablanca
State/Province
Santander
ZIP/Postal Code
681004
Country
Colombia
Facility Name
COL003
City
Cali
State/Province
Valle Del Cauca
ZIP/Postal Code
760026
Country
Colombia
Facility Name
COL002
City
Bogota DC
ZIP/Postal Code
110131
Country
Colombia
Facility Name
COL004
City
Santiago de Cali
ZIP/Postal Code
076001
Country
Colombia
Facility Name
DNK008
City
Copenhagen O
State/Province
Capital
ZIP/Postal Code
2100
Country
Denmark
Facility Name
DNK001
City
Hvidovre
State/Province
Capital
ZIP/Postal Code
DK-2650
Country
Denmark
Facility Name
DNK005
City
Odense C
State/Province
South Denmark
ZIP/Postal Code
5000
Country
Denmark
Facility Name
DNK006
City
Vejle
State/Province
South Denmark
ZIP/Postal Code
7100
Country
Denmark
Facility Name
DNK003
City
Aalborg
ZIP/Postal Code
9000
Country
Denmark
Facility Name
DNK007
City
Aarhus
ZIP/Postal Code
DK-8200
Country
Denmark
Facility Name
DNK004
City
Hellerup
ZIP/Postal Code
2900
Country
Denmark
Facility Name
DNK002
City
Roskilde
ZIP/Postal Code
4000
Country
Denmark
Facility Name
FRA002
City
Strasbourg
State/Province
Bas-Rhin
ZIP/Postal Code
67091
Country
France
Facility Name
FRA004
City
Amiens cedex 1
ZIP/Postal Code
80054
Country
France
Facility Name
FRA011
City
Creteil
ZIP/Postal Code
94010
Country
France
Facility Name
FRA003
City
Nantes
ZIP/Postal Code
44093
Country
France
Facility Name
FRA009
City
Nice
ZIP/Postal Code
6002
Country
France
Facility Name
FRA010
City
Paris
ZIP/Postal Code
75014
Country
France
Facility Name
FRA006
City
Toulouse
ZIP/Postal Code
31400
Country
France
Facility Name
DEU009
City
Heidelberg
State/Province
Baden-Württemberg
ZIP/Postal Code
69126
Country
Germany
Facility Name
DEU025
City
München
State/Province
Bayern
ZIP/Postal Code
80336
Country
Germany
Facility Name
DEU027
City
Potsdam
State/Province
Brandenburg
ZIP/Postal Code
14467
Country
Germany
Facility Name
DEU008
City
Frankfurt am Main
State/Province
Hessen
ZIP/Postal Code
60590
Country
Germany
Facility Name
DEU005
City
Marburg
State/Province
Hessen
ZIP/Postal Code
35037
Country
Germany
Facility Name
DEU031
City
Hannover
State/Province
Niedersachsen
ZIP/Postal Code
30625
Country
Germany
Facility Name
DEU013
City
Essen
State/Province
Nordrhein-Westfalen
ZIP/Postal Code
45239
Country
Germany
Facility Name
DEU016
City
Halle
State/Province
Sachsen-Anhalt
ZIP/Postal Code
06120
Country
Germany
Facility Name
DEU003
City
Leipzig
State/Province
Sachsen
ZIP/Postal Code
04347
Country
Germany
Facility Name
DEU020
City
Geesthacht
State/Province
Schleswig-Holstein
ZIP/Postal Code
21502
Country
Germany
Facility Name
DEU002
City
Berlin
ZIP/Postal Code
10717
Country
Germany
Facility Name
DEU019
City
Berlin
ZIP/Postal Code
10961
Country
Germany
Facility Name
DEU006
City
Berlin
ZIP/Postal Code
13125
Country
Germany
Facility Name
DEU011
City
Berlin
ZIP/Postal Code
13353
Country
Germany
Facility Name
DEU014
City
Dresden
ZIP/Postal Code
01307
Country
Germany
Facility Name
DEU021
City
Frankfurt
ZIP/Postal Code
60389
Country
Germany
Facility Name
DEU015
City
Hannover
ZIP/Postal Code
30625
Country
Germany
Facility Name
DEU023
City
Mainz
ZIP/Postal Code
55128
Country
Germany
Facility Name
DEU029
City
Muenster
ZIP/Postal Code
48149
Country
Germany
Facility Name
GRC003
City
Alexandroupoli
State/Province
Evros
ZIP/Postal Code
681 00
Country
Greece
Facility Name
GRC007
City
Herakleion
ZIP/Postal Code
71110
Country
Greece
Facility Name
GRC006
City
Thessaloniki
ZIP/Postal Code
57010
Country
Greece
Facility Name
HUN005
City
Tatabánya
State/Province
Komárom-Esztergom
ZIP/Postal Code
2800
Country
Hungary
Facility Name
IRL003
City
Dublin
ZIP/Postal Code
15
Country
Ireland
Facility Name
IRL002
City
Dublin
ZIP/Postal Code
Dublin 8
Country
Ireland
Facility Name
IRL001
City
Limerick
ZIP/Postal Code
V94 F858
Country
Ireland
Facility Name
ISR001
City
Ashkelon
ZIP/Postal Code
78278
Country
Israel
Facility Name
ISR010
City
Beer Sheva
ZIP/Postal Code
84101
Country
Israel
Facility Name
ISR008
City
Haifa
ZIP/Postal Code
34362
Country
Israel
Facility Name
ISR006
City
Jerusalem
ZIP/Postal Code
91031
Country
Israel
Facility Name
ISR002
City
Jerusalem
ZIP/Postal Code
91120
Country
Israel
Facility Name
ISR009
City
Kefar-Sava
ZIP/Postal Code
44281
Country
Israel
Facility Name
ISR011
City
Petach Tikva
ZIP/Postal Code
49100
Country
Israel
Facility Name
ISR007
City
Ramat Gan
ZIP/Postal Code
52621
Country
Israel
Facility Name
ISR003
City
Rehovot
ZIP/Postal Code
76100
Country
Israel
Facility Name
ISR004
City
Zerifin
ZIP/Postal Code
70300
Country
Israel
Facility Name
ITA010
City
Bologna
State/Province
Emilia-Romagna
ZIP/Postal Code
40138
Country
Italy
Facility Name
ITA008
City
Ferrara
State/Province
Emilia-Romagna
ZIP/Postal Code
44124
Country
Italy
Facility Name
ITA002
City
Reggio Emilia
State/Province
Emilia-Romagna
ZIP/Postal Code
42100
Country
Italy
Facility Name
ITA006
City
Milano
State/Province
Lombardia
ZIP/Postal Code
20122
Country
Italy
Facility Name
ITA012
City
Milano
State/Province
Lombardia
ZIP/Postal Code
20122
Country
Italy
Facility Name
ITA011
City
Rozzano
State/Province
Lombardia
ZIP/Postal Code
20089
Country
Italy
Facility Name
ITA004
City
Siena
State/Province
Toscana
ZIP/Postal Code
53100
Country
Italy
Facility Name
ITA003
City
Milano
ZIP/Postal Code
20157
Country
Italy
Facility Name
ITA001
City
Palermo
ZIP/Postal Code
90127
Country
Italy
Facility Name
ITA007
City
Pavia
ZIP/Postal Code
27100
Country
Italy
Facility Name
ITA009
City
Roma
ZIP/Postal Code
00168
Country
Italy
Facility Name
JPN029
City
Toyoake
State/Province
Aiti
ZIP/Postal Code
470-1192
Country
Japan
Facility Name
JPN031
City
Toon-Shi
State/Province
Ehime
ZIP/Postal Code
791-0203
Country
Japan
Facility Name
JPN027
City
Fukuoka-Shi
State/Province
Hukuoka
ZIP/Postal Code
815-0032
Country
Japan
Facility Name
JPN023
City
Iizuka-Shi
State/Province
Hukuoka
ZIP/Postal Code
820-0018
Country
Japan
Facility Name
JPN009
City
Kobe-City
State/Province
Hyôgo
ZIP/Postal Code
650-0047
Country
Japan
Facility Name
JPN020
City
Kasama-Shi
State/Province
Ibaraki
ZIP/Postal Code
309-1703
Country
Japan
Facility Name
JPN001
City
Naka-gun
State/Province
Ibaraki
ZIP/Postal Code
319-1113
Country
Japan
Facility Name
JPN022
City
Takamatsu-Shi
State/Province
Kagawa
ZIP/Postal Code
761-8073
Country
Japan
Facility Name
JPN028
City
Yokohama-Shi Konan-Ku
State/Province
Kanagawa
ZIP/Postal Code
234-0054
Country
Japan
Facility Name
JPN005
City
Koshi shi
State/Province
Kumamoto
ZIP/Postal Code
861-1196
Country
Japan
Facility Name
JPN008
City
Matsusaka-shi
State/Province
Mie
ZIP/Postal Code
515-8544
Country
Japan
Facility Name
JPN011
City
Tsu
State/Province
Mie
ZIP/Postal Code
514-1101
Country
Japan
Facility Name
JPN034
City
Sendai-shi
State/Province
Miyagi
ZIP/Postal Code
980-0873
Country
Japan
Facility Name
JPN024
City
Sendai-shi
State/Province
Miyagi
ZIP/Postal Code
984-8560
Country
Japan
Facility Name
JPN013
City
Nagasaki-Shi
State/Province
Nagasaki
ZIP/Postal Code
852-8501
Country
Japan
Facility Name
JPN012
City
Chuo-ku
State/Province
Niigata
ZIP/Postal Code
951-8510
Country
Japan
Facility Name
JPN015
City
Matsue
State/Province
Simane
ZIP/Postal Code
690-8556
Country
Japan
Facility Name
JPN007
City
Kiyose
State/Province
Tokyo
ZIP/Postal Code
204-8522
Country
Japan
Facility Name
JPN014
City
Ota-Ku
State/Province
Tokyo
ZIP/Postal Code
143-8541
Country
Japan
Facility Name
JPN006
City
Shinagawa-ku
State/Province
Tokyo
ZIP/Postal Code
140-8522
Country
Japan
Facility Name
JPN017
City
Shinagawa-ku
State/Province
Tokyo
ZIP/Postal Code
141-8625
Country
Japan
Facility Name
JPN002
City
Shinjuku-ku
State/Province
Tokyo
ZIP/Postal Code
160-8582
Country
Japan
Facility Name
JPN032
City
Shinjuku-ku
State/Province
Tokyo
ZIP/Postal Code
1628655
Country
Japan
Facility Name
JPN019
City
Shimonoseki-Shi
State/Province
Yamaguti
ZIP/Postal Code
750-0041
Country
Japan
Facility Name
JPN030
City
Fukuoka-shi
ZIP/Postal Code
8408571
Country
Japan
Facility Name
JPN003
City
Hamamatsu-Shi
ZIP/Postal Code
434-8511
Country
Japan
Facility Name
JPN004
City
Kita Kyushu-shi
ZIP/Postal Code
807-8556
Country
Japan
Facility Name
JPN016
City
Matsue-shi
ZIP/Postal Code
690-8504
Country
Japan
Facility Name
JPN010
City
Meguro-ku
ZIP/Postal Code
152-0021
Country
Japan
Facility Name
JPN018
City
Toyonaka-shi
ZIP/Postal Code
560-8552
Country
Japan
Facility Name
KOR015
City
Ansan-si
State/Province
Gyeonggido
ZIP/Postal Code
15355
Country
Korea, Republic of
Facility Name
KOR008
City
Bucheon-si
State/Province
Gyeonggido
ZIP/Postal Code
14584
Country
Korea, Republic of
Facility Name
KOR007
City
Seongnam-si
State/Province
Gyeonggido
ZIP/Postal Code
13620
Country
Korea, Republic of
Facility Name
KOR003
City
Seoul
State/Province
Seoul Teugbyeolsi
ZIP/Postal Code
05030
Country
Korea, Republic of
Facility Name
KOR004
City
Incheon
ZIP/Postal Code
21431
Country
Korea, Republic of
Facility Name
KOR012
City
Seoul
ZIP/Postal Code
02447
Country
Korea, Republic of
Facility Name
KOR011
City
Seoul
ZIP/Postal Code
02841
Country
Korea, Republic of
Facility Name
KOR009
City
Seoul
ZIP/Postal Code
03312
Country
Korea, Republic of
Facility Name
KOR013
City
Seoul
ZIP/Postal Code
03722
Country
Korea, Republic of
Facility Name
KOR010
City
Seoul
ZIP/Postal Code
06273
Country
Korea, Republic of
Facility Name
KOR005
City
Seoul
ZIP/Postal Code
06591
Country
Korea, Republic of
Facility Name
LVA002
City
Daugavpils
State/Province
Daugavpils Aprinkis
ZIP/Postal Code
LV-5401
Country
Latvia
Facility Name
LVA005
City
Jurmala
ZIP/Postal Code
LV-2015
Country
Latvia
Facility Name
MYS004
City
Kuantan
State/Province
Pahang
ZIP/Postal Code
25100
Country
Malaysia
Facility Name
MYS001
City
Kuala Lumpur
State/Province
WilayahPersekutuan KualaLumpur
ZIP/Postal Code
50603
Country
Malaysia
Facility Name
MYS003
City
Kota Bahru
ZIP/Postal Code
16150
Country
Malaysia
Facility Name
MYS005
City
Kuala Lumpur
ZIP/Postal Code
50590
Country
Malaysia
Facility Name
MEX007
City
Guadalajara
State/Province
Jalisco
ZIP/Postal Code
44160
Country
Mexico
Facility Name
MEX008
City
Guadalajara
State/Province
Jalisco
ZIP/Postal Code
44160
Country
Mexico
Facility Name
MEX005
City
Guadalajara
State/Province
Jalisco
ZIP/Postal Code
44220
Country
Mexico
Facility Name
MEX004
City
Guadalajara
State/Province
Jalisco
ZIP/Postal Code
44700
Country
Mexico
Facility Name
MEX003
City
Monterrey
State/Province
Nuevo León
ZIP/Postal Code
64460
Country
Mexico
Facility Name
MEX006
City
Durango
ZIP/Postal Code
34080
Country
Mexico
Facility Name
MEX001
City
Monterrey
ZIP/Postal Code
64718
Country
Mexico
Facility Name
MEX002
City
Oaxaca
ZIP/Postal Code
68000
Country
Mexico
Facility Name
NLD003
City
Arnhem
State/Province
Gelderland
ZIP/Postal Code
6815 AD
Country
Netherlands
Facility Name
NLD001
City
Alkmaar
State/Province
Noord-Holland
ZIP/Postal Code
1815 JD
Country
Netherlands
Facility Name
NLD002
City
Amsterdam
State/Province
Noord-Holland
ZIP/Postal Code
1105 AZ
Country
Netherlands
Facility Name
NLD006
City
Rotterdam
ZIP/Postal Code
3015 GD
Country
Netherlands
Facility Name
NZL006
City
Otahuhu
State/Province
Auckland
ZIP/Postal Code
1640
Country
New Zealand
Facility Name
NZL009
City
Hastings
State/Province
Hawkes's Bay
ZIP/Postal Code
4122
Country
New Zealand
Facility Name
NZL005
City
Christchurch
State/Province
South Island
ZIP/Postal Code
8011
Country
New Zealand
Facility Name
NZL001
City
Dunedin
State/Province
South Island
ZIP/Postal Code
9001
Country
New Zealand
Facility Name
NZL002
City
Hamilton
State/Province
Waikato
ZIP/Postal Code
3204
Country
New Zealand
Facility Name
NZL011
City
Paraparaumu
State/Province
Wellington
ZIP/Postal Code
5032
Country
New Zealand
Facility Name
NZL003
City
Auckland
ZIP/Postal Code
1051
Country
New Zealand
Facility Name
NZL008
City
Auckland
ZIP/Postal Code
1051
Country
New Zealand
Facility Name
NZL007
City
Tauranga
ZIP/Postal Code
3110
Country
New Zealand
Facility Name
NZL010
City
Wellington
ZIP/Postal Code
6021
Country
New Zealand
Facility Name
PER005
City
Chancay
ZIP/Postal Code
15131
Country
Peru
Facility Name
PER001
City
Lima
ZIP/Postal Code
15001
Country
Peru
Facility Name
PER003
City
Lima
ZIP/Postal Code
15036
Country
Peru
Facility Name
PER002
City
Lima
ZIP/Postal Code
15084
Country
Peru
Facility Name
PER006
City
Piura
ZIP/Postal Code
20001
Country
Peru
Facility Name
POL012
City
Ostrowiec Swietokrzyski
State/Province
Swietokrzyskie
ZIP/Postal Code
27-400
Country
Poland
Facility Name
POL005
City
Bialystok
ZIP/Postal Code
15-044
Country
Poland
Facility Name
POL006
City
Bielsko Biala
ZIP/Postal Code
43-300
Country
Poland
Facility Name
POL016
City
Katowice
ZIP/Postal Code
40-081
Country
Poland
Facility Name
POL015
City
Kielce
ZIP/Postal Code
25-751
Country
Poland
Facility Name
POL017
City
Krakow
ZIP/Postal Code
30-510
Country
Poland
Facility Name
POL018
City
Ksawerow
ZIP/Postal Code
95-054
Country
Poland
Facility Name
POL008
City
Rabka-Zdroj
ZIP/Postal Code
34-700
Country
Poland
Facility Name
POL011
City
Rzeszów
ZIP/Postal Code
35-051
Country
Poland
Facility Name
POL010
City
Siedlce
ZIP/Postal Code
08-110
Country
Poland
Facility Name
POL007
City
Sosnowiec
ZIP/Postal Code
41-208
Country
Poland
Facility Name
POL001
City
Sucha Beskidzka
ZIP/Postal Code
34-200
Country
Poland
Facility Name
POL014
City
Szczecin
ZIP/Postal Code
70-111
Country
Poland
Facility Name
POL009
City
Tarnow
ZIP/Postal Code
33-100
Country
Poland
Facility Name
PRT005
City
Aveiro
ZIP/Postal Code
3814-501
Country
Portugal
Facility Name
PRT009
City
Braga
ZIP/Postal Code
4710-243
Country
Portugal
Facility Name
PRT006
City
Guarda
ZIP/Postal Code
6300-858
Country
Portugal
Facility Name
PRT002
City
Guimaraes
ZIP/Postal Code
4835-044
Country
Portugal
Facility Name
PRT003
City
Lisboa
ZIP/Postal Code
1649-035
Country
Portugal
Facility Name
SRB001
City
Belgrade
ZIP/Postal Code
11000
Country
Serbia
Facility Name
SRB003
City
Belgrade
ZIP/Postal Code
11000
Country
Serbia
Facility Name
SRB007
City
Nis
ZIP/Postal Code
18000
Country
Serbia
Facility Name
SRB014
City
Sombor
ZIP/Postal Code
25000
Country
Serbia
Facility Name
SRB010
City
Uzice
ZIP/Postal Code
31000
Country
Serbia
Facility Name
SVK002
City
Bardejov
ZIP/Postal Code
085 01
Country
Slovakia
Facility Name
SVK003
City
Spisská Nová Ves
ZIP/Postal Code
052 01
Country
Slovakia
Facility Name
ESP009
City
Santiago de Compostela
State/Province
A Coruña
ZIP/Postal Code
15706
Country
Spain
Facility Name
ESP008
City
Oviedo
State/Province
Asturias
ZIP/Postal Code
33011
Country
Spain
Facility Name
ESP013
City
Badalona
State/Province
Barcelona
ZIP/Postal Code
08036
Country
Spain
Facility Name
ESP012
City
Santander
State/Province
Cantabria
ZIP/Postal Code
39008
Country
Spain
Facility Name
ESP015
City
Pozuelo de Alarcon
State/Province
Madrid
ZIP/Postal Code
28223
Country
Spain
Facility Name
ESP011
City
Pamplona
State/Province
Navarra
ZIP/Postal Code
31008
Country
Spain
Facility Name
ESP003
City
Barcelona
ZIP/Postal Code
08035
Country
Spain
Facility Name
ESP016
City
Barcelona
ZIP/Postal Code
8036
Country
Spain
Facility Name
ESP001
City
Girona
ZIP/Postal Code
17007
Country
Spain
Facility Name
ESP006
City
L´Hospitalet de Llobregat
ZIP/Postal Code
08907
Country
Spain
Facility Name
ESP007
City
Madrid
ZIP/Postal Code
28007
Country
Spain
Facility Name
ESP002
City
Madrid
Country
Spain
Facility Name
TWN003
City
Kaohsiung City
ZIP/Postal Code
80756
Country
Taiwan
Facility Name
TWN002
City
Kaohsiung
ZIP/Postal Code
82544
Country
Taiwan
Facility Name
TWN001
City
Kaohsiung
ZIP/Postal Code
833
Country
Taiwan
Facility Name
TWN005
City
New Taipei City
ZIP/Postal Code
22060
Country
Taiwan
Facility Name
TWN006
City
Taipei City
ZIP/Postal Code
11490
Country
Taiwan
Facility Name
TWN007
City
Taipei
ZIP/Postal Code
10002
Country
Taiwan
Facility Name
TWN004
City
Taipei
ZIP/Postal Code
11217
Country
Taiwan
Facility Name
THA004
City
Nakhonnayok
State/Province
Nakhon Nayok
ZIP/Postal Code
26120
Country
Thailand
Facility Name
THA002
City
Muang
State/Province
Nonthaburi
ZIP/Postal Code
11000
Country
Thailand
Facility Name
THA003
City
Khon Kaen
ZIP/Postal Code
40002
Country
Thailand
Facility Name
TUR006
City
Atakum
State/Province
Samsun
ZIP/Postal Code
55270
Country
Turkey
Facility Name
TUR010
City
Ankara
ZIP/Postal Code
6010
Country
Turkey
Facility Name
TUR011
City
Ankara
ZIP/Postal Code
6340
Country
Turkey
Facility Name
TUR003
City
Canakkale
ZIP/Postal Code
17110
Country
Turkey
Facility Name
TUR008
City
Izmir
ZIP/Postal Code
35100
Country
Turkey
Facility Name
TUR004
City
Izmir
ZIP/Postal Code
35110
Country
Turkey
Facility Name
TUR009
City
Kocaeli
ZIP/Postal Code
41380
Country
Turkey
Facility Name
TUR005
City
Konya
ZIP/Postal Code
42075
Country
Turkey
Facility Name
TUR001
City
Mersin
ZIP/Postal Code
33079
Country
Turkey
Facility Name
UKR001
City
Kharkiv
State/Province
Kharkivs'ka Oblast
ZIP/Postal Code
61124
Country
Ukraine
Facility Name
UKR007
City
Kherson
State/Province
Khersons'ka Oblast
ZIP/Postal Code
73003
Country
Ukraine
Facility Name
UKR005
City
Poltava
State/Province
Poltavs'ka Oblast
ZIP/Postal Code
36010
Country
Ukraine
Facility Name
UKR012
City
Dnipro
ZIP/Postal Code
49102
Country
Ukraine
Facility Name
UKR009
City
Ivano-Frankivsk
ZIP/Postal Code
76018
Country
Ukraine
Facility Name
UKR008
City
Kyiv
ZIP/Postal Code
01033
Country
Ukraine
Facility Name
UKR004
City
Kyiv
ZIP/Postal Code
03038
Country
Ukraine
Facility Name
UKR003
City
Odesa
ZIP/Postal Code
65025
Country
Ukraine
Facility Name
UKR010
City
Vinnytsia
ZIP/Postal Code
21018
Country
Ukraine
Facility Name
GBR001
City
Cambridge
State/Province
Cambridgeshire
ZIP/Postal Code
CB23 3RE
Country
United Kingdom
Facility Name
GBR015
City
Exeter
State/Province
Devon
ZIP/Postal Code
EX2 5DW
Country
United Kingdom
Facility Name
GBR017
City
Norwich
State/Province
Norfolk
ZIP/Postal Code
NR4 7UY
Country
United Kingdom
Facility Name
GBR013
City
Llandough, Penarth
State/Province
Vale Of Glamorgan, The
ZIP/Postal Code
CF64 2XX
Country
United Kingdom
Facility Name
GBR016
City
Bradford
State/Province
Yorkshire
ZIP/Postal Code
BD9 6RJ
Country
United Kingdom
Facility Name
GBR006
City
Birmingham
ZIP/Postal Code
B9 5SS
Country
United Kingdom
Facility Name
GBR002
City
Chertsey
ZIP/Postal Code
KT16 0PZ
Country
United Kingdom
Facility Name
GBR007
City
Dundee
ZIP/Postal Code
DDI 9SY
Country
United Kingdom
Facility Name
GBR004
City
Liverpool
ZIP/Postal Code
L14 3PE
Country
United Kingdom
Facility Name
GBR009
City
London
ZIP/Postal Code
SW3 6NP
Country
United Kingdom
Facility Name
GBR008
City
Manchester
ZIP/Postal Code
M23 9LT
Country
United Kingdom
Facility Name
GBR011
City
Manchester
ZIP/Postal Code
M8 5RB
Country
United Kingdom
Facility Name
GBR003
City
Newcastle upon Tyne
ZIP/Postal Code
NE7 7DN
Country
United Kingdom
Facility Name
GBR012
City
Salford
ZIP/Postal Code
M6 8HD
Country
United Kingdom
Facility Name
GBR018
City
Southampton
ZIP/Postal Code
SO16 6YD
Country
United Kingdom
Facility Name
GBR010
City
Swansea
ZIP/Postal Code
SA6 6NL
Country
United Kingdom

12. IPD Sharing Statement

Plan to Share IPD
No
Citations:
PubMed Identifier
35976570
Citation
Chalmers JD, Usansky H, Rubino CM, Teper A, Fernandez C, Zou J, Mange KC. Pharmacokinetic/Pharmacodynamic Evaluation of the Dipeptidyl Peptidase 1 Inhibitor Brensocatib for Non-cystic Fibrosis Bronchiectasis. Clin Pharmacokinet. 2022 Oct;61(10):1457-1469. doi: 10.1007/s40262-022-01147-w. Epub 2022 Jul 25.
Results Reference
derived

Learn more about this trial

A Study to Assess the Efficacy, Safety, and Tolerability of Brensocatib in Participants With Non-Cystic Fibrosis Bronchiectasis

We'll reach out to this number within 24 hrs