COVID-19, Chronic Adaptation and Response to Exercise (COVID-CARE)

This is an interventional treatment trial for COVID-19 focused on measuring Aerobic Exercise Training, Physical Function, Physical Activity, Convalescence, SARS-CoV-2 Read More

• INCLUSION CRITERIA:

Screening procedures will be performed as part of this study. In order to be eligible to participate in this study, an individual must meet all of the following criteria:

1. Male or female, aged 18 to 80 years
2. Previous infection with SARS-CoV2, confirmed by laboratory or a healthcare provider-administered test at least 4 weeks prior to enrollment. Participants with a documented positive home antigen test will need confirmation of positive COVID-19 antibodies (positive anti-Nucleocapsid antibody test, OR positive anti-Spike antibody test if unvaccinated at the time of the antibody test) to be considered.

3. Presence of physical limitations or significant fatigue since COVID-19 as demonstrated by:

   1. Total score less than or equal to 19 on the PROMIS short form for physical function or total score greater than or equal to 9 on the PROMIS short form for fatigue, AND
   2. Score greater than or equal to 1 on the Patient Global Rating of Flu Severity and Patient Global Assessment of Interference with Daily Activities
4. Able to read, speak and understand English or Spanish
5. Able to understand and willing to sign a written informed consent document
6. Willing and able to complete study procedures

EXCLUSION CRITERIA:

An individual who meets any of the following criteria will be excluded from participation in this study:

1. Above normal performance (i.e, greater than or equal to 100% predicted) in the 6MWT based on normative data for gender and age (86,87)
2. History or cardiac condition as determined by NIH cardiology to be unsafe for exercise participation (e.g. ischemic heart disease, right- or left-sided heart failure, cor pulmonale or pulmonary hypertension, dilated or hypertrophic cardiomyopathy or non-idiopathic cardiomyopathy)
3. Significant hepatic or renal dysfunction
4. Cancer diagnosis with evidence of metastasis or a life expectancy of less than one year
5. History of stroke resulting in impairments in functional mobility that limits safe participation
6. Active substance abuse including EtOH
7. Severe psychiatric disease, not responsive to treatment or medication
8. History of diabetes and on insulin pump therapy, or uncontrolled diabetes with HbA1c > 9.0%
9. Pregnancy
10. Acceptance onto a lung transplant waiting list
11. Extreme obesity with BMI > 40 kg/m^2
12. On medications that would influence exercise performance such as beta blockers or antiretroviral therapy
13. Ongoing tobacco and/or nicotine product use
14. Enrolled in another interventional clinical research trial
15. Any other medical or health condition(s) that unduly increases the risk of exercise testing or training, affects the normal physiologic response to exercise testing or training, and/or would otherwise interfere with the ability to interpret the data as determined by the PI