Research on Emissions, Air Quality, Climate and Cooking Technologies in Northern Ghana (REACCTING)
Primary Purpose
Inflammation, Growth Retardation
Status
Completed
Phase
Not Applicable
Locations
Study Type
Interventional
Intervention
Philips stove
Gyapa stove
Sponsored by

About this trial
This is an interventional basic science trial for Inflammation
Eligibility Criteria
Inclusion
Individual Participants:
- Classified as "rural"
- Uses biofuel as main cooking fuel source (firewood, animal waste, crop residue/sawdust)
- Uses borehole as main water source (to facilitate social network analysis linking household's knowledge and attitudes toward stoves to experience of social contacts);
- Does not have electricity (to permit possible addition of lighting intervention at a later date);
- Has a woman in household aged 18-55 and at least one child under five (since women and children are the most vulnerable to cookstove smoke and are thus the main focus of our health measures).
Clusters:
- No more than 25% classified as urban
- Accessible year-round (determined by field staff)
- Having at least 10 eligible households (in line with the participant criteria above)
Exclusion:
- Household could not be located
- Household declined to participate
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm Type
No Intervention
Experimental
Experimental
Experimental
Arm Label
Control
Gyapa/Gyapa
Gyapa/Philips
Philips/Philips
Arm Description
Households enrolled in the control arm of the study did not receive either improved cookstove
Households enrolled in the Gyapa/Gyapa arm of the study received two Gyapa stoves for free
Households enrolled in the Gyapa/Philips arm of the study received one Gyapa stove and one Philips stove for free
Households enrolled in the Philips/Philips arm of the study received two Philips stoves for free
Outcomes
Primary Outcome Measures
Health (Biomarkers of inflammation)
Health indicators from blood spot samples (C-Reactive Protein, Sicam, sVCAM, serum amyloid A, Interleukin-1b, Interleukin-6, Interleukin-8, tumor necrosis factor alpha).
Health (Biomarkers of inflammation)
Health indicators from blood spot samples (C-Reactive Protein, Sicam, sVCAM, serum amyloid A, Interleukin-1b, Interleukin-6, Interleukin-8, tumor necrosis factor alpha).
Health (Biomarkers of inflammation)
Health indicators from blood spot samples (C-Reactive Protein, Sicam, sVCAM, serum amyloid A, Interleukin-1b, Interleukin-6, Interleukin-8, tumor necrosis factor alpha).
Health (Biomarkers of inflammation)
Health indicators from blood spot samples (C-Reactive Protein, Sicam, sVCAM, serum amyloid A, Interleukin-1b, Interleukin-6, Interleukin-8, tumor necrosis factor alpha).
Height
Height of participants
Height
Height of participants
Height
Height of participants
Height
Height of participants
Weight
Weight of participants
Weight
Weight of participants
Weight
Weight of participants
Weight
Weight of participants
Mid-arm circumference
Measurement of mid-upper arm circumference of participants
Mid-arm circumference
Measurement of mid-upper arm circumference of participants
Mid-arm circumference
Measurement of mid-upper arm circumference of participants
Mid-arm circumference
Measurement of mid-upper arm circumference of participants
Secondary Outcome Measures
Personal exposure to fine particulate matter (PM2.5)
48 hour integrated personal PM2.5 concentrations from filter measurements
Personal exposure to carbon monoxide (CO)
Daily average and integrated personal CO concentrations
Kitchen area concentrations of carbon monoxide (CO)
Daily average and integrated kitchen area CO concentrations
Kitchen area concentrations of fine particulate matter (PM2.5)
48 hour integrated kitchen area PM2.5 concentrations from filter measurements
Self-reported stove usage
Surveys administered to respondents (primary cooks)
Self-reported stove usage
Surveys administered to respondents (primary cooks)
Self-reported stove usage
Surveys administered to respondents (primary cooks)
Self-reported stove usage
Surveys administered to respondents (primary cooks)
Stove usage as measured by devices
Continuous stove usage indicators as measured by temperature loggers on stoves
Full Information
NCT ID
NCT04633135
First Posted
September 14, 2020
Last Updated
November 11, 2020
Sponsor
University of Colorado, Boulder
Collaborators
Environmental Protection Agency (EPA), U.S. National Science Foundation
1. Study Identification
Unique Protocol Identification Number
NCT04633135
Brief Title
Research on Emissions, Air Quality, Climate and Cooking Technologies in Northern Ghana
Acronym
REACCTING
Official Title
Research on Emissions, Air Quality, Climate and Cooking Technologies in Northern Ghana
Study Type
Interventional
2. Study Status
Record Verification Date
November 2020
Overall Recruitment Status
Completed
Study Start Date
January 1, 2012 (Actual)
Primary Completion Date
December 31, 2016 (Actual)
Study Completion Date
December 31, 2017 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
University of Colorado, Boulder
Collaborators
Environmental Protection Agency (EPA), U.S. National Science Foundation
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No
5. Study Description
Brief Summary
REACCTING (Research on Emissions, Air quality, Climate, and Cooking Technologies in Northern Ghana) is an interdisciplinary randomized cookstove intervention study in the Kassena-Nankana District of Northern Ghana. The study tests two types of biomass burning stoves that have the potential to meet local cooking needs and represent different "rungs" in the cookstove technology ladder: a locally-made, low-tech Gyapa rocket stove and the imported, highly efficient Philips gasifier stove. Intervention households were randomized into four different groups, three of which received different combinations of two improved stoves, while the fourth group serves as a control for the duration of the study. Diverse measurements assess different points along the causal chain linking the intervention to final outcomes of interest. The investigators assess stove use and cooking behavior, cooking emissions, household air pollution and personal exposure, health burden, and local to regional air quality. Integrated analysis and modeling will tackle a range of interdisciplinary science questions, including examining ambient exposures among the regional population, assessing how those exposures might change with different technologies and behaviors, and estimating the comparative impact of local behavior and technological changes versus regional climate variability and change on local air quality and health outcomes.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Inflammation, Growth Retardation
7. Study Design
Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Model Description
There were 4 groups, 3 intervention and 1 control, all operating over the same period.
Masking
None (Open Label)
Allocation
Randomized
Enrollment
200 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Control
Arm Type
No Intervention
Arm Description
Households enrolled in the control arm of the study did not receive either improved cookstove
Arm Title
Gyapa/Gyapa
Arm Type
Experimental
Arm Description
Households enrolled in the Gyapa/Gyapa arm of the study received two Gyapa stoves for free
Arm Title
Gyapa/Philips
Arm Type
Experimental
Arm Description
Households enrolled in the Gyapa/Philips arm of the study received one Gyapa stove and one Philips stove for free
Arm Title
Philips/Philips
Arm Type
Experimental
Arm Description
Households enrolled in the Philips/Philips arm of the study received two Philips stoves for free
Intervention Type
Device
Intervention Name(s)
Philips stove
Other Intervention Name(s)
Gasifier stove
Intervention Description
Philips Smokeless stove HD4012LS
Intervention Type
Device
Intervention Name(s)
Gyapa stove
Other Intervention Name(s)
Rocket stove
Intervention Description
Wood stove made in Ghana
Primary Outcome Measure Information:
Title
Health (Biomarkers of inflammation)
Description
Health indicators from blood spot samples (C-Reactive Protein, Sicam, sVCAM, serum amyloid A, Interleukin-1b, Interleukin-6, Interleukin-8, tumor necrosis factor alpha).
Time Frame
At baseline
Title
Health (Biomarkers of inflammation)
Description
Health indicators from blood spot samples (C-Reactive Protein, Sicam, sVCAM, serum amyloid A, Interleukin-1b, Interleukin-6, Interleukin-8, tumor necrosis factor alpha).
Time Frame
At 6 months
Title
Health (Biomarkers of inflammation)
Description
Health indicators from blood spot samples (C-Reactive Protein, Sicam, sVCAM, serum amyloid A, Interleukin-1b, Interleukin-6, Interleukin-8, tumor necrosis factor alpha).
Time Frame
At 12 months
Title
Health (Biomarkers of inflammation)
Description
Health indicators from blood spot samples (C-Reactive Protein, Sicam, sVCAM, serum amyloid A, Interleukin-1b, Interleukin-6, Interleukin-8, tumor necrosis factor alpha).
Time Frame
At 18 months
Title
Height
Description
Height of participants
Time Frame
At baseline
Title
Height
Description
Height of participants
Time Frame
At 6 months
Title
Height
Description
Height of participants
Time Frame
At 12 months
Title
Height
Description
Height of participants
Time Frame
At 18 months
Title
Weight
Description
Weight of participants
Time Frame
At baseline
Title
Weight
Description
Weight of participants
Time Frame
At 6 months
Title
Weight
Description
Weight of participants
Time Frame
At 12 months
Title
Weight
Description
Weight of participants
Time Frame
At 18 months
Title
Mid-arm circumference
Description
Measurement of mid-upper arm circumference of participants
Time Frame
At baseline
Title
Mid-arm circumference
Description
Measurement of mid-upper arm circumference of participants
Time Frame
At 6 months
Title
Mid-arm circumference
Description
Measurement of mid-upper arm circumference of participants
Time Frame
At 12 months
Title
Mid-arm circumference
Description
Measurement of mid-upper arm circumference of participants
Time Frame
At 18 months
Secondary Outcome Measure Information:
Title
Personal exposure to fine particulate matter (PM2.5)
Description
48 hour integrated personal PM2.5 concentrations from filter measurements
Time Frame
48 hour deployment periods
Title
Personal exposure to carbon monoxide (CO)
Description
Daily average and integrated personal CO concentrations
Time Frame
48 hour deployment periods
Title
Kitchen area concentrations of carbon monoxide (CO)
Description
Daily average and integrated kitchen area CO concentrations
Time Frame
48 hour deployment periods
Title
Kitchen area concentrations of fine particulate matter (PM2.5)
Description
48 hour integrated kitchen area PM2.5 concentrations from filter measurements
Time Frame
48 hour deployment periods
Title
Self-reported stove usage
Description
Surveys administered to respondents (primary cooks)
Time Frame
At baseline
Title
Self-reported stove usage
Description
Surveys administered to respondents (primary cooks)
Time Frame
At 6 months
Title
Self-reported stove usage
Description
Surveys administered to respondents (primary cooks)
Time Frame
At 12 months
Title
Self-reported stove usage
Description
Surveys administered to respondents (primary cooks)
Time Frame
At 18 months
Title
Stove usage as measured by devices
Description
Continuous stove usage indicators as measured by temperature loggers on stoves
Time Frame
Throughout data collection period, approximately 2 years.
10. Eligibility
Sex
All
Gender Based
Yes
Minimum Age & Unit of Time
0 Years
Maximum Age & Unit of Time
55 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion
Individual Participants:
Classified as "rural"
Uses biofuel as main cooking fuel source (firewood, animal waste, crop residue/sawdust)
Uses borehole as main water source (to facilitate social network analysis linking household's knowledge and attitudes toward stoves to experience of social contacts);
Does not have electricity (to permit possible addition of lighting intervention at a later date);
Has a woman in household aged 18-55 and at least one child under five (since women and children are the most vulnerable to cookstove smoke and are thus the main focus of our health measures).
Clusters:
No more than 25% classified as urban
Accessible year-round (determined by field staff)
Having at least 10 eligible households (in line with the participant criteria above)
Exclusion:
Household could not be located
Household declined to participate
12. IPD Sharing Statement
Plan to Share IPD
No
IPD Sharing Plan Description
De-identified data are available upon request.
Citations:
PubMed Identifier
25885780
Citation
Dickinson KL, Kanyomse E, Piedrahita R, Coffey E, Rivera IJ, Adoctor J, Alirigia R, Muvandimwe D, Dove M, Dukic V, Hayden MH, Diaz-Sanchez D, Abisiba AV, Anaseba D, Hagar Y, Masson N, Monaghan A, Titiati A, Steinhoff DF, Hsu YY, Kaspar R, Brooks B, Hodgson A, Hannigan M, Oduro AR, Wiedinmyer C. Research on Emissions, Air quality, Climate, and Cooking Technologies in Northern Ghana (REACCTING): study rationale and protocol. BMC Public Health. 2015 Feb 12;15:126. doi: 10.1186/s12889-015-1414-1.
Results Reference
background
PubMed Identifier
34863138
Citation
Abdo M, Kanyomse E, Alirigia R, Coffey ER, Piedrahita R, Diaz-Sanchez D, Hagar Y, Naumenko DJ, Wiedinmyer C, Hannigan MP, Oduro AR, Dickinson KL. Health impacts of a randomized biomass cookstove intervention in northern Ghana. BMC Public Health. 2021 Dec 4;21(1):2211. doi: 10.1186/s12889-021-12164-y.
Results Reference
derived
Learn more about this trial
Research on Emissions, Air Quality, Climate and Cooking Technologies in Northern Ghana
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