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COVID-19 Thrombosis Prevention Trials: Post-hospital Thromboprophylaxis

Primary Purpose

Covid19

Status
Completed
Phase
Phase 3
Locations
United States
Study Type
Interventional
Intervention
Apixaban 2.5 MG
Placebo
Sponsored by
Thomas L. Ortel
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional prevention trial for Covid19

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • • Age ≥ 18 years

    • PCR-positive COVID-19 infection
    • Hospitalized for two or more days

Exclusion Criteria:

  • Pre-existing indication for anticoagulation (e.g., pulmonary embolism or deep vein thrombosis; atrial fibrillation; mechanical cardiac valve)
  • Contraindication to antithrombotic therapy (e.g., known bleeding within the last 30 days requiring emergency room presentation or hospitalization; major surgery within 14 days; ischemic stroke, intracranial bleed or neurosurgery within 3 months.
  • Platelet count < 50,000/mcL
  • Hemoglobin <8 gm/dL
  • Renal insufficiency (eGFR < 30 mL/min/1.73 m2)
  • Pregnancy
  • Prison inmate
  • Life expectancy less than 90 days
  • Unwilling or unable to provide informed consent/unwilling or unable to complete the study protocol
  • Dual antiplatelet therapy that cannot be discontinued
  • Concomitant need for strong inducers/inhibitors of p-gp or CYP3A4

Sites / Locations

  • Valleywise Health Medical Center
  • Dignity Health-St Josephs
  • Central Arkansas Veterans Health Care System
  • University of Arkansas for Medical Sciences
  • Stanford University School of Medicine
  • New Ananda Medical and Urgent Care, Inc.
  • UCSF at Zuckerberg San Francisco General Hospital
  • Mazur and Statner MD PC
  • Torrance Medical Center
  • Centura Health Porter Adventist Hospital
  • Saint Anthony Hospital
  • St. Anthony North Health Campus
  • Baycare Hospital
  • Florida Heart Center
  • University of Florida
  • Mount Sinai Medical Center
  • Tallahassee Memorial HealthCare
  • James A. Haley Veteran's Hospital
  • BayCare Hospital- Winter Haven
  • Emory University
  • Medical College of Georgia/Augusta University
  • Savannah Health Services, LLC DBA Memorial Health University Medical Center
  • Queens Medical Center
  • Hawaii Pacific Health
  • Snake River Research, PLLC
  • University of Illinois at Chicago
  • Cook County Health
  • Rush University Medical Center
  • The University of Chicago Medicine
  • OSF Little Company of Mary
  • Loyola University Medical Center
  • Indiana University Health Bloomington Hospital
  • Lutheran Medical Group
  • Indiana University Health Methodist Hospital
  • Franciscan Health Michigan City
  • Reid Physician Associates
  • Baptist Health Lexington
  • University Medical Center New Orleans
  • Ochsner Clinic Foundation-Baton Rouge
  • Ochsner Clinic Foundation
  • Willis-Knighton Physician Network/Tri-State Medical Clinic
  • Maine Medical Center/Maine Medical Partners Adult Hospital Medicine
  • Pen Bay Medical Center
  • Anne Arundel Medical Center
  • Lifebridge (Sinai Hospital of Baltimore)
  • Adventist HealthCare Shady Grove Medical Center
  • Boston University
  • Lahey Hospital and Medical Center
  • Baystate Medical center
  • Bay Regional Medical Center d/b/a/ McLaren Bay Region
  • Henry Ford Hospital
  • Western Michigan University
  • MidMichigan Medical Center
  • McLaren Macomb
  • Minneapolis VA Health Care System
  • University of Mississippi Medical Center
  • Truman Medical Center
  • Barnes-Jewish Hospital
  • St Louis University
  • Mercury Street Medical Group
  • CHI St Elizabeth Hospital
  • Renown Health
  • Dartmouth Hichcock Medical Center
  • AtlantiCare Regional Medical Center
  • Hope Tower at Jersey Shore University Medical Center
  • Newark Beth Israel Medical Center
  • Capital Health System, Inc.
  • Christus St. Vincent Regional Medical Center
  • Montefiore Medical Center
  • NYU Langone Hospital-Brooklyn
  • Coney Island Hospital
  • Buffalo General Medical Center
  • Mercy Hospital Buffalo
  • Jamaica Hospital Medical Center
  • New York University Langone Health
  • Stony Brook University Hospital
  • Westchester Medical Center
  • University of North Carolina at Chapel Hill
  • Duke Medical Center
  • East Carolina University/Vidant Health
  • Wake Med Hospital
  • Wake Forest Baptist Medical Center
  • Summa Health
  • University of Cincinnati
  • Cleveland Clinic Foundation
  • Ohio State University
  • Kettering Medical Center
  • Ascension St. John Bartlesville
  • Ascension St. John Tulsa
  • Oregon Health and Science University
  • St. Luke's University Health Network
  • Conemaugh Memorial Medical Center
  • Temple University Hospital
  • University of Pittsburgh
  • Tower Health Medical Group
  • Rhode Island Hospital
  • The Miriam Hospital
  • Monument Health Clinical Research
  • Erlanger Health System
  • Vanderbilt University Medical Center
  • Christus St. Elizabeth Hospital
  • Baylor Scott and White Medical Center- College Station
  • University of Texas Southwestern Medical Center
  • Texas Health Harris Methodist
  • University of Texas- Houston, LBJ Hospital
  • UT Houston MHH-SW
  • UTHouston
  • Texas Health Frisco
  • Baylor Scott and White-Round Rock
  • Baylor Scott and White-Temple
  • The Woodlands Center For Respiratory & Sleep Research
  • CHRISTUS Trinity Clinic Pulmonary Medicine
  • The University of Texas Health Science Center at Tyler
  • UT Health East Texas (Tyler)
  • UT Rio Grande Valley
  • MultiCare Institute for Research & Innovation
  • UW Medicine Valley Medical Center
  • Virginia Mason Medical Center
  • CAMC Clinical Trials Center
  • West Virginia University Hospital
  • Blood Center of Wisconsin

Arms of the Study

Arm 1

Arm 2

Arm Type

Active Comparator

Placebo Comparator

Arm Label

Apixaban

Placebo

Arm Description

Drug: Apixaban 2.5 MG Participants will be given study medication at the time of discharge from the hospital. Participants will take Apixaban 2.5 MG twice a day, once in the morning and once in the evening, for 30 days. Participants will be contacted (electronic or telephone) 2 days after starting the study medication and contact will continue up to day 90 after starting study treatment. Follow up will be through electronic and/or telephone contact depending on the participant's preference, compliance, and medication adherence. Participants will be queried for any clinically relevant endpoints, especially major bleeding or a need to seek healthcare attention for any reason. Follow-up will occur from the time of discharge and through the 30 day study period, with contacts 2 days, 10 days, 20 days, and 30 days after discharge. Two additional study contacts will take place 45 days and 90 days after discharge.

Drug: Placebo Participants will be given study medication at the time of discharge from the hospital. Participants will take the Placebo twice a day, once in the morning and once in the evening, for 30 days. Participants will be contacted (electronic or telephone) 2 days after starting the study medication and contact will continue up to day 90 after starting study treatment. Follow up will be through electronic and/or telephone contact depending on the participant's preference, compliance, and medication adherence. Participants will be queried for any clinically relevant endpoints, especially major bleeding or a need to seek healthcare attention for any reason. Follow-up will occur from the time of discharge and through the 30 day study period, with contacts 2 days, 10 days, 20 days, and 30 days after discharge. Two additional study contacts will take place 45 days and 90 days after discharge.

Outcomes

Primary Outcome Measures

Composite outcome of symptomatic deep vein thrombosis, pulmonary embolism, other venous thromboembolism, ischemic stroke, myocardial infarction, other arterial thromboembolism, and all-cause mortality as measured by hospital records.

Secondary Outcome Measures

The composite outcome of all-cause mortality and the EQ5D index score.
The composite outcome of all-cause mortality and the EQ5D index score.
The composite outcome of symptomatic deep vein thrombosis, pulmonary embolism, other venous thromboembolism, ischemic stroke, myocardial infarction, other arterial thromboembolism, and all-cause mortality as measured by hospital records.
The composite outcome of symptomatic deep vein thrombosis, pulmonary embolism, other venous thromboembolism, ischemic stroke, myocardial infarction, other arterial thromboembolism, and all-cause mortality as measured by hospital records.
New, symptomatic VTE (inclusive of DVT, PE, or other venous thrombosis) for up to 30 days after randomization as measured by hospital records.
New, symptomatic ATE (inclusive of ischemic stroke, MI, or peripheral arterial thromboembolism) for up to 30 days after randomization as measured by hospital records.

Full Information

First Posted
November 30, 2020
Last Updated
November 8, 2022
Sponsor
Thomas L. Ortel
Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
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1. Study Identification

Unique Protocol Identification Number
NCT04650087
Brief Title
COVID-19 Thrombosis Prevention Trials: Post-hospital Thromboprophylaxis
Official Title
COVID-19 Post-hospital Thrombosis Prevention Trial: An Adaptive, Multicenter, Prospective, Randomized Platform Trial Evaluating the Efficacy and Safety of Antithrombotic Strategies in Patients With COVID-19 Following Hospital Discharge
Study Type
Interventional

2. Study Status

Record Verification Date
November 2022
Overall Recruitment Status
Completed
Study Start Date
February 15, 2021 (Actual)
Primary Completion Date
July 24, 2022 (Actual)
Study Completion Date
September 23, 2022 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor-Investigator
Name of the Sponsor
Thomas L. Ortel
Collaborators
National Heart, Lung, and Blood Institute (NHLBI)

4. Oversight

Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
A multicenter, adaptive, randomized platform trial evaluating the efficacy and safety of antithrombotic strategies in patients with COVID-19 following hospital discharge
Detailed Description
This study is an adaptive, prospective, randomized platform trial designed to compare the effectiveness and safety of antithrombotic therapy with no antithrombotic therapy after hospitalization for 48 hours or longer for COVID-19. For Stage 1 of this study, participants will be randomized to either prophylactic anticoagulation or matching placebo for 30 days, and then followed for an additional 60 days after the completion of treatment (total duration of follow-up, 90 days). The primary objective is to determine the most effective and safe antithrombotic strategy to prevent the composite outcome of symptomatic deep vein thrombosis, pulmonary embolism, other venous thromboembolism, ischemic stroke, myocardial infarction, other arterial thromboembolism, and all-cause mortality by 30 days following discharge from the hospital. Biobanking of samples for future biomarker and mechanistic studies will be available for centers able to participate and collect samples from eligible participants. Samples will be collected at the time of enrollment and after the completion of 30 days of therapy

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Covid19

7. Study Design

Primary Purpose
Prevention
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Masking Description
Double Blind
Allocation
Randomized
Enrollment
1219 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Apixaban
Arm Type
Active Comparator
Arm Description
Drug: Apixaban 2.5 MG Participants will be given study medication at the time of discharge from the hospital. Participants will take Apixaban 2.5 MG twice a day, once in the morning and once in the evening, for 30 days. Participants will be contacted (electronic or telephone) 2 days after starting the study medication and contact will continue up to day 90 after starting study treatment. Follow up will be through electronic and/or telephone contact depending on the participant's preference, compliance, and medication adherence. Participants will be queried for any clinically relevant endpoints, especially major bleeding or a need to seek healthcare attention for any reason. Follow-up will occur from the time of discharge and through the 30 day study period, with contacts 2 days, 10 days, 20 days, and 30 days after discharge. Two additional study contacts will take place 45 days and 90 days after discharge.
Arm Title
Placebo
Arm Type
Placebo Comparator
Arm Description
Drug: Placebo Participants will be given study medication at the time of discharge from the hospital. Participants will take the Placebo twice a day, once in the morning and once in the evening, for 30 days. Participants will be contacted (electronic or telephone) 2 days after starting the study medication and contact will continue up to day 90 after starting study treatment. Follow up will be through electronic and/or telephone contact depending on the participant's preference, compliance, and medication adherence. Participants will be queried for any clinically relevant endpoints, especially major bleeding or a need to seek healthcare attention for any reason. Follow-up will occur from the time of discharge and through the 30 day study period, with contacts 2 days, 10 days, 20 days, and 30 days after discharge. Two additional study contacts will take place 45 days and 90 days after discharge.
Intervention Type
Drug
Intervention Name(s)
Apixaban 2.5 MG
Other Intervention Name(s)
Eliquis
Intervention Description
Participants will take Apixaban 2.5 MG twice a day, once in the morning and once in the evening for 30 days. Participants will be contacted (electronic or telephone) 2 days after starting the study medication and will continue up to day 90 after starting study treatment. Followup will occur from the time of discharge through the 30 day study period with contacts at 2 days, 10 days, 20 days and 30 days after discharge. Two additional study contacts will take place 45 days and 90 days after discharge.
Intervention Type
Drug
Intervention Name(s)
Placebo
Intervention Description
Participants will take placebo twice a day, once in the morning and once in the evening for 30 days. Participants will be contacted (electronic or telephone) 2 days after starting the study medication and will continue up to day 90 after starting study treatment. Followup will occur from the time of discharge through the 30 day study period with contacts at 2 days, 10 days, 20 days and 30 days after discharge. Two additional study contacts will take place 45 days and 90 days after discharge.
Primary Outcome Measure Information:
Title
Composite outcome of symptomatic deep vein thrombosis, pulmonary embolism, other venous thromboembolism, ischemic stroke, myocardial infarction, other arterial thromboembolism, and all-cause mortality as measured by hospital records.
Time Frame
30 days after hospital discharge
Secondary Outcome Measure Information:
Title
The composite outcome of all-cause mortality and the EQ5D index score.
Time Frame
30 days after hospital discharge
Title
The composite outcome of all-cause mortality and the EQ5D index score.
Time Frame
90 days after hospital discharge
Title
The composite outcome of symptomatic deep vein thrombosis, pulmonary embolism, other venous thromboembolism, ischemic stroke, myocardial infarction, other arterial thromboembolism, and all-cause mortality as measured by hospital records.
Time Frame
45 days after hospital discharge
Title
The composite outcome of symptomatic deep vein thrombosis, pulmonary embolism, other venous thromboembolism, ischemic stroke, myocardial infarction, other arterial thromboembolism, and all-cause mortality as measured by hospital records.
Time Frame
90 days after hospital discharge
Title
New, symptomatic VTE (inclusive of DVT, PE, or other venous thrombosis) for up to 30 days after randomization as measured by hospital records.
Time Frame
30 days after randomization
Title
New, symptomatic ATE (inclusive of ischemic stroke, MI, or peripheral arterial thromboembolism) for up to 30 days after randomization as measured by hospital records.
Time Frame
30 days after randomization
Other Pre-specified Outcome Measures:
Title
The incidence of all-cause mortality
Time Frame
30 days following discharge from hospital
Title
The incidence of all-cause rehospitalization for up to 90 days after randomization
Time Frame
90 days following discharge from hospital
Title
The individual domains of EQ5D and the EQ5D visual analog scale for 30 and 90 days after randomization
Time Frame
30 and 90 days following discharge from hospital

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: • Age ≥ 18 years PCR-positive COVID-19 infection Hospitalized for two or more days Exclusion Criteria: Pre-existing indication for anticoagulation (e.g., pulmonary embolism or deep vein thrombosis; atrial fibrillation; mechanical cardiac valve) Contraindication to antithrombotic therapy (e.g., known bleeding within the last 30 days requiring emergency room presentation or hospitalization; major surgery within 14 days; ischemic stroke, intracranial bleed or neurosurgery within 3 months. Platelet count < 50,000/mcL Hemoglobin <8 gm/dL Renal insufficiency (eGFR < 30 mL/min/1.73 m2) Pregnancy Prison inmate Life expectancy less than 90 days Unwilling or unable to provide informed consent/unwilling or unable to complete the study protocol Dual antiplatelet therapy that cannot be discontinued Concomitant need for strong inducers/inhibitors of p-gp or CYP3A4
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Tracy Wang, MD
Organizational Affiliation
Duke University
Official's Role
Principal Investigator
Facility Information:
Facility Name
Valleywise Health Medical Center
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85008
Country
United States
Facility Name
Dignity Health-St Josephs
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85013
Country
United States
Facility Name
Central Arkansas Veterans Health Care System
City
Little Rock
State/Province
Arkansas
ZIP/Postal Code
72205
Country
United States
Facility Name
University of Arkansas for Medical Sciences
City
Little Rock
State/Province
Arkansas
ZIP/Postal Code
72205
Country
United States
Facility Name
Stanford University School of Medicine
City
Palo Alto
State/Province
California
ZIP/Postal Code
94304
Country
United States
Facility Name
New Ananda Medical and Urgent Care, Inc.
City
S. El Monte
State/Province
California
ZIP/Postal Code
91733
Country
United States
Facility Name
UCSF at Zuckerberg San Francisco General Hospital
City
San Francisco
State/Province
California
ZIP/Postal Code
94110
Country
United States
Facility Name
Mazur and Statner MD PC
City
Thousand Oaks
State/Province
California
ZIP/Postal Code
91360
Country
United States
Facility Name
Torrance Medical Center
City
Torrance
State/Province
California
ZIP/Postal Code
90502
Country
United States
Facility Name
Centura Health Porter Adventist Hospital
City
Denver
State/Province
Colorado
ZIP/Postal Code
80210
Country
United States
Facility Name
Saint Anthony Hospital
City
Lakewood
State/Province
Colorado
ZIP/Postal Code
80228
Country
United States
Facility Name
St. Anthony North Health Campus
City
Westminster
State/Province
Colorado
ZIP/Postal Code
80023
Country
United States
Facility Name
Baycare Hospital
City
Clearwater
State/Province
Florida
ZIP/Postal Code
33756
Country
United States
Facility Name
Florida Heart Center
City
Fort Pierce
State/Province
Florida
ZIP/Postal Code
34590
Country
United States
Facility Name
University of Florida
City
Gainesville
State/Province
Florida
ZIP/Postal Code
32610
Country
United States
Facility Name
Mount Sinai Medical Center
City
Miami Beach
State/Province
Florida
ZIP/Postal Code
33140
Country
United States
Facility Name
Tallahassee Memorial HealthCare
City
Tallahassee
State/Province
Florida
ZIP/Postal Code
32308
Country
United States
Facility Name
James A. Haley Veteran's Hospital
City
Tampa
State/Province
Florida
ZIP/Postal Code
33612
Country
United States
Facility Name
BayCare Hospital- Winter Haven
City
Winter Haven
State/Province
Florida
ZIP/Postal Code
33881
Country
United States
Facility Name
Emory University
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30308
Country
United States
Facility Name
Medical College of Georgia/Augusta University
City
Augusta
State/Province
Georgia
ZIP/Postal Code
30912
Country
United States
Facility Name
Savannah Health Services, LLC DBA Memorial Health University Medical Center
City
Savannah
State/Province
Georgia
ZIP/Postal Code
31404
Country
United States
Facility Name
Queens Medical Center
City
Honolulu
State/Province
Hawaii
ZIP/Postal Code
96813
Country
United States
Facility Name
Hawaii Pacific Health
City
Honolulu
State/Province
Hawaii
ZIP/Postal Code
96827
Country
United States
Facility Name
Snake River Research, PLLC
City
Idaho Falls
State/Province
Idaho
ZIP/Postal Code
83404
Country
United States
Facility Name
University of Illinois at Chicago
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60607
Country
United States
Facility Name
Cook County Health
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Facility Name
Rush University Medical Center
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Facility Name
The University of Chicago Medicine
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60637
Country
United States
Facility Name
OSF Little Company of Mary
City
Evergreen Park
State/Province
Illinois
ZIP/Postal Code
60805
Country
United States
Facility Name
Loyola University Medical Center
City
Maywood
State/Province
Illinois
ZIP/Postal Code
60153
Country
United States
Facility Name
Indiana University Health Bloomington Hospital
City
Bloomington
State/Province
Indiana
ZIP/Postal Code
47403
Country
United States
Facility Name
Lutheran Medical Group
City
Fort Wayne
State/Province
Indiana
ZIP/Postal Code
46804
Country
United States
Facility Name
Indiana University Health Methodist Hospital
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46202
Country
United States
Facility Name
Franciscan Health Michigan City
City
Michigan City
State/Province
Indiana
ZIP/Postal Code
46360
Country
United States
Facility Name
Reid Physician Associates
City
Richmond
State/Province
Indiana
ZIP/Postal Code
47374
Country
United States
Facility Name
Baptist Health Lexington
City
Lexington
State/Province
Kentucky
ZIP/Postal Code
40503
Country
United States
Facility Name
University Medical Center New Orleans
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70112
Country
United States
Facility Name
Ochsner Clinic Foundation-Baton Rouge
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70121
Country
United States
Facility Name
Ochsner Clinic Foundation
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70121
Country
United States
Facility Name
Willis-Knighton Physician Network/Tri-State Medical Clinic
City
Shreveport
State/Province
Louisiana
ZIP/Postal Code
71103
Country
United States
Facility Name
Maine Medical Center/Maine Medical Partners Adult Hospital Medicine
City
Portland
State/Province
Maine
ZIP/Postal Code
04102
Country
United States
Facility Name
Pen Bay Medical Center
City
Rockport
State/Province
Maine
ZIP/Postal Code
04856
Country
United States
Facility Name
Anne Arundel Medical Center
City
Annapolis
State/Province
Maryland
ZIP/Postal Code
21401
Country
United States
Facility Name
Lifebridge (Sinai Hospital of Baltimore)
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21215
Country
United States
Facility Name
Adventist HealthCare Shady Grove Medical Center
City
Rockville
State/Province
Maryland
ZIP/Postal Code
20850
Country
United States
Facility Name
Boston University
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02118
Country
United States
Facility Name
Lahey Hospital and Medical Center
City
Burlington
State/Province
Massachusetts
ZIP/Postal Code
01805
Country
United States
Facility Name
Baystate Medical center
City
Springfield
State/Province
Massachusetts
ZIP/Postal Code
01199
Country
United States
Facility Name
Bay Regional Medical Center d/b/a/ McLaren Bay Region
City
Bay City
State/Province
Michigan
ZIP/Postal Code
48708
Country
United States
Facility Name
Henry Ford Hospital
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48202
Country
United States
Facility Name
Western Michigan University
City
Kalamazoo
State/Province
Michigan
ZIP/Postal Code
49008
Country
United States
Facility Name
MidMichigan Medical Center
City
Midland
State/Province
Michigan
ZIP/Postal Code
48670
Country
United States
Facility Name
McLaren Macomb
City
Mount Clemens
State/Province
Michigan
ZIP/Postal Code
48043
Country
United States
Facility Name
Minneapolis VA Health Care System
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55417
Country
United States
Facility Name
University of Mississippi Medical Center
City
Jackson
State/Province
Mississippi
ZIP/Postal Code
39216
Country
United States
Facility Name
Truman Medical Center
City
Kansas City
State/Province
Missouri
ZIP/Postal Code
64108
Country
United States
Facility Name
Barnes-Jewish Hospital
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Facility Name
St Louis University
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Facility Name
Mercury Street Medical Group
City
Butte
State/Province
Montana
ZIP/Postal Code
59701
Country
United States
Facility Name
CHI St Elizabeth Hospital
City
Lincoln
State/Province
Nebraska
ZIP/Postal Code
68510
Country
United States
Facility Name
Renown Health
City
Reno
State/Province
Nevada
ZIP/Postal Code
89502
Country
United States
Facility Name
Dartmouth Hichcock Medical Center
City
Lebanon
State/Province
New Hampshire
ZIP/Postal Code
03756
Country
United States
Facility Name
AtlantiCare Regional Medical Center
City
Atlantic City
State/Province
New Jersey
ZIP/Postal Code
08401
Country
United States
Facility Name
Hope Tower at Jersey Shore University Medical Center
City
Neptune
State/Province
New Jersey
ZIP/Postal Code
07753
Country
United States
Facility Name
Newark Beth Israel Medical Center
City
Newark
State/Province
New Jersey
ZIP/Postal Code
07112
Country
United States
Facility Name
Capital Health System, Inc.
City
Trenton
State/Province
New Jersey
ZIP/Postal Code
08638
Country
United States
Facility Name
Christus St. Vincent Regional Medical Center
City
Santa Fe
State/Province
New Mexico
ZIP/Postal Code
87505
Country
United States
Facility Name
Montefiore Medical Center
City
Bronx
State/Province
New York
ZIP/Postal Code
10467
Country
United States
Facility Name
NYU Langone Hospital-Brooklyn
City
Brooklyn
State/Province
New York
ZIP/Postal Code
111220
Country
United States
Facility Name
Coney Island Hospital
City
Brooklyn
State/Province
New York
ZIP/Postal Code
11235
Country
United States
Facility Name
Buffalo General Medical Center
City
Buffalo
State/Province
New York
ZIP/Postal Code
14203
Country
United States
Facility Name
Mercy Hospital Buffalo
City
Buffalo
State/Province
New York
ZIP/Postal Code
14220
Country
United States
Facility Name
Jamaica Hospital Medical Center
City
Jamaica
State/Province
New York
ZIP/Postal Code
11418
Country
United States
Facility Name
New York University Langone Health
City
New York
State/Province
New York
ZIP/Postal Code
10016
Country
United States
Facility Name
Stony Brook University Hospital
City
Stony Brook
State/Province
New York
ZIP/Postal Code
11794
Country
United States
Facility Name
Westchester Medical Center
City
Valhalla
State/Province
New York
ZIP/Postal Code
10595
Country
United States
Facility Name
University of North Carolina at Chapel Hill
City
Chapel Hill
State/Province
North Carolina
ZIP/Postal Code
27514
Country
United States
Facility Name
Duke Medical Center
City
Durham
State/Province
North Carolina
ZIP/Postal Code
27710
Country
United States
Facility Name
East Carolina University/Vidant Health
City
Greenville
State/Province
North Carolina
ZIP/Postal Code
27858
Country
United States
Facility Name
Wake Med Hospital
City
Raleigh
State/Province
North Carolina
ZIP/Postal Code
27610
Country
United States
Facility Name
Wake Forest Baptist Medical Center
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27157
Country
United States
Facility Name
Summa Health
City
Akron
State/Province
Ohio
ZIP/Postal Code
44304
Country
United States
Facility Name
University of Cincinnati
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45267
Country
United States
Facility Name
Cleveland Clinic Foundation
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44195
Country
United States
Facility Name
Ohio State University
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43210
Country
United States
Facility Name
Kettering Medical Center
City
Kettering
State/Province
Ohio
ZIP/Postal Code
45429
Country
United States
Facility Name
Ascension St. John Bartlesville
City
Tulsa
State/Province
Oklahoma
ZIP/Postal Code
74104
Country
United States
Facility Name
Ascension St. John Tulsa
City
Tulsa
State/Province
Oklahoma
ZIP/Postal Code
74104
Country
United States
Facility Name
Oregon Health and Science University
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239
Country
United States
Facility Name
St. Luke's University Health Network
City
Easton
State/Province
Pennsylvania
ZIP/Postal Code
18045
Country
United States
Facility Name
Conemaugh Memorial Medical Center
City
Johnstown
State/Province
Pennsylvania
ZIP/Postal Code
15905
Country
United States
Facility Name
Temple University Hospital
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19140
Country
United States
Facility Name
University of Pittsburgh
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15213
Country
United States
Facility Name
Tower Health Medical Group
City
West Reading
State/Province
Pennsylvania
ZIP/Postal Code
19611
Country
United States
Facility Name
Rhode Island Hospital
City
Providence
State/Province
Rhode Island
ZIP/Postal Code
02903
Country
United States
Facility Name
The Miriam Hospital
City
Providence
State/Province
Rhode Island
ZIP/Postal Code
02906
Country
United States
Facility Name
Monument Health Clinical Research
City
Rapid City
State/Province
South Dakota
ZIP/Postal Code
57701
Country
United States
Facility Name
Erlanger Health System
City
Chattanooga
State/Province
Tennessee
ZIP/Postal Code
37403
Country
United States
Facility Name
Vanderbilt University Medical Center
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37232
Country
United States
Facility Name
Christus St. Elizabeth Hospital
City
Beaumont
State/Province
Texas
ZIP/Postal Code
77702
Country
United States
Facility Name
Baylor Scott and White Medical Center- College Station
City
College Station
State/Province
Texas
ZIP/Postal Code
77845
Country
United States
Facility Name
University of Texas Southwestern Medical Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75390
Country
United States
Facility Name
Texas Health Harris Methodist
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76104
Country
United States
Facility Name
University of Texas- Houston, LBJ Hospital
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
UT Houston MHH-SW
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
UTHouston
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Texas Health Frisco
City
Plano
State/Province
Texas
ZIP/Postal Code
75024
Country
United States
Facility Name
Baylor Scott and White-Round Rock
City
Round Rock
State/Province
Texas
ZIP/Postal Code
78665
Country
United States
Facility Name
Baylor Scott and White-Temple
City
Temple
State/Province
Texas
ZIP/Postal Code
76508
Country
United States
Facility Name
The Woodlands Center For Respiratory & Sleep Research
City
The Woodlands
State/Province
Texas
ZIP/Postal Code
77380
Country
United States
Facility Name
CHRISTUS Trinity Clinic Pulmonary Medicine
City
Tyler
State/Province
Texas
ZIP/Postal Code
75701
Country
United States
Facility Name
The University of Texas Health Science Center at Tyler
City
Tyler
State/Province
Texas
ZIP/Postal Code
75708
Country
United States
Facility Name
UT Health East Texas (Tyler)
City
Tyler
State/Province
Texas
ZIP/Postal Code
75708
Country
United States
Facility Name
UT Rio Grande Valley
City
Weslaco
State/Province
Texas
ZIP/Postal Code
78596
Country
United States
Facility Name
MultiCare Institute for Research & Innovation
City
Puyallup
State/Province
Washington
ZIP/Postal Code
98372
Country
United States
Facility Name
UW Medicine Valley Medical Center
City
Renton
State/Province
Washington
ZIP/Postal Code
98055
Country
United States
Facility Name
Virginia Mason Medical Center
City
Seattle
State/Province
Washington
ZIP/Postal Code
98101
Country
United States
Facility Name
CAMC Clinical Trials Center
City
Charleston
State/Province
West Virginia
ZIP/Postal Code
25304
Country
United States
Facility Name
West Virginia University Hospital
City
Morgantown
State/Province
West Virginia
ZIP/Postal Code
26506
Country
United States
Facility Name
Blood Center of Wisconsin
City
Milwaukee
State/Province
Wisconsin
ZIP/Postal Code
53226
Country
United States

12. IPD Sharing Statement

Plan to Share IPD
No

Learn more about this trial

COVID-19 Thrombosis Prevention Trials: Post-hospital Thromboprophylaxis

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