Antibiotics as Adjuncts to Periodontal Therapy:Pharmacokinetic Considerations and Dosing Strategies (AMA)
Periodontal Diseases, Antibiotics, Pharmacokinetics
About this trial
This is an interventional treatment trial for Periodontal Diseases
Eligibility Criteria
Inclusion Criteria:
- Informed Consent as documented by signature
- Aged 18-80 years old with need of periodontal treatment associated with adjunctive antibiotic therapy
- Presence of at least 30% of the teeth in the mouth with PD>6mm and BOP
Exclusion Criteria:
- Persons with systemic illnesses (uncontrolled diabetes mellitus, cancer, human immunodeficiency virus, bone metabolic diseases or disorders that compromise wound healing, radiation, or immunosuppressive therapy)
- Pregnancy or lactation
- Persons who had taken AB within the previous 2 months
- Persons who are taking nonsteroidal anti-inflammatory drugs
- Persons who have a confirmed or suspected intolerance to 5-nitroimidazole derivatives or amoxicillin or macrolides
- Previous periodontal therapy the last 1 year
- Known or suspected non-compliance, drug or alcohol abuse
- Inability to follow due to language problems, psychological disorders, dementia, etc. of the participant
- Participants not willing to attend regular dental maintenance visits and follow-up evaluations
- Participation in another study with investigational drug within the 30 days preceding and during the present study
Sites / Locations
- University of Geneva, University Clinics of Dental MedicineRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Active Comparator
Amoxicilline and Metronidazole for 7 days
Amoxicilline and Metronidazole for 3 days
Azithromycine for 3 days
Drug: AMOXICILLINE Sandoz cpr pell 500mg, Sandoz Pharmaceuticals AG + FLAGYL cpr pell 500mg, Sanofi-Aventis ( Suisse) SA, 3/d for 7 days Systemic antibiotics after sub gingival mechanical debridement
Drug: AMOXICILLINE Sandoz cpr pell 500mg, Sandoz Pharmaceuticals AG + FLAGYL cpr pell 500mg, Sanofi-Aventis ( Suisse) SA, 3/d for 3 days Systemic antibiotics after sub gingival mechanical debridement
Drug: AZITHROMYCIN Pfizer cpr pell 500mg, Pfizer PFE Switzerland GmbH 1/d 500mg for 3 days Systemic antibiotics after sub gingival mechanical debridement