Genetically-informed Behavioral and Cognitive Interventions for the Management of Tinnitus
Tinnitus
About this trial
This is an interventional treatment trial for Tinnitus
Eligibility Criteria
Inclusion Criteria:
- adult patients with bothersome bilateral non-pulsative tinnitus and hearing loss
Exclusion Criteria:
- no major comorbidities
- no psychiatric history
Sites / Locations
- ENT clinic
Arms of the Study
Arm 1
Arm 2
Experimental
Other
group A genetically informed intervention
group B control
Group A patients are offered a genetically based approach to tinnitus management that includes a genetic test and at least three office based treatment sessions. A rationally-designed personalized management plan based on the genetic results is based on four single nucleotide polymorphisms (SNPs) of the dopamine and serotonin pathways, namely COMT rs4680, HTR2A rs7997012, HTR2A rs6311, and TPH2 rs4570625, that have been associated with behavioral or cognitive responses
In Group B, treatments are offered randomly taking care to offer CBT to equal number of patients as in Group A. In both groups, during the first visit, patients are offered a simple, few-minute tinnitus update and advice, relevant to their educational level and are being suggested that an average of 4 sessions are required over a period of approx. 4 months for making tinnitus noise less or not bothersome