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Study of WP1220 for the Treatment of Adult Subjects With Cutaneous T-Cell Lymphoma (CTCL)

Primary Purpose

Cutaneous T-Cell Lymphoma/Mycosis Fungoides

Status
Completed
Phase
Phase 1
Locations
Poland
Study Type
Interventional
Intervention
WP1220
Sponsored by
Moleculin Biotech, Inc.
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Cutaneous T-Cell Lymphoma/Mycosis Fungoides

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  1. Age ≥ 18 years at the time of signing informed consent.
  2. Clinical diagnosis of MF.
  3. Stage IA, IB, IIA, IIB, or II MF: T1-T4 with measurable lesions
  4. Previously treatment with at least one standard therapy used to treat Stage IA, IB, IIA, IIB, or III MF.
  5. Measurable skin disease must have at least 2 eligible baseline index lesions with maximum total area ≤ 40 cm2. Eligible lesions must be below the head (face and scalp are excluded) and must not involve the genitalia or anus.
  6. ECOG performance status of 0-2
  7. Subject must read and sign informed consent form and be willing to comply with the instructions, restrictions, nature and procedures of the study.
  8. Willing to avoid tanning devices or exposure of the treated skin to the sun.
  9. Willing to not use cosmetics, including lotions, creams, and moisturizers on the treated lesions.
  10. Willing to use topical steroid on a maximum of 25% of BSA occupied by MF on areas not involved in the clinical trial.
  11. Must have recovered from the effects of surgery requiring general anesthesia and intubation for a minimum of 3 months, and from minor surgery requiring only local anesthetic for a minimum of 2 weeks.
  12. Concomitant disease must be stable and subjects must be on the same dose and schedule of any medications for at least 1 month before screening.
  13. Subjects of both genders who are of childbearing potential including perimenopausal women who are fewer than 2 years from their last menses, must use one of the following effective means of contraceptionL

    • Birth control pills in conjunction with spermicide gel
    • Surgical sterilization
    • Intra uterine device
    • Condom and spermicide gel together
    • Sexual abstinence during study period

The requirements above do not apply to:

  • Postmenopausal women with spontaneous amenorrhea for at least 2 years, or
  • Subjects with bilateral oophoerctomy with or without a hysterectomy and an absence of bleeding for at least 6 months, or
  • Subjects with total hysterectomy and an absence of bleeding for at least 3 months

Exclusion Criteria:

  1. MF with no prior therapy.
  2. Subjects with a diagnosis of stage IV MF at Screening or subsequently observed at Baseline.
  3. Subjects with unusual phenotypes, e.g. lymphomatoid papulosis MF-like type.
  4. Subjects who require immediate treatment for progressive MF.
  5. Subjects treated with at least one of the following methods within 8 weeks prior to

    Baseline:

    • Total body electron beam radiation
    • Investigational drugs or treatments
  6. Subjects treated with at least one of the following methods within 4 weeks prior to

    Baseline:

    • Local radiation therapy
    • UVB therapy
    • PUVA
    • Topical chemotherapy
    • Topical corticosteroids or retinoids
    • Systemic chemotherapeutic agents (excluding low doses of MTX max. 25 mg/wk)
  7. Index lesion treatment with at least one of the following methods within 2 weeks prior to Baseline:

    • Any surgical procedures other than biopsies related to CTCL diagnosis or follow- up
    • Any topical treatment other than bland moisturizers (creams, lotions, emollients, etc)
  8. Skin infections on screening or baseline involving index lesions planned to be treated in the clinical trial.
  9. The presence of any clinically significant laboratory abnormalities at screening including, but not limited to abnormalities of the white blood count, hemoglobin, platelets, serum chemistry (glucose, uric acid, calcium, phosphorus, sodium, potassium, chloride, alkaline phosphatase, albumin and total bilirubin), thyroid stimulating hormone, fT3 and fT4 as determined by the Investigator in conjunction with the Medical Monitor.
  10. Any significant uncontrolled medical disease as evaluated by the Investigator and/or Medical Monitor, chronic or active within the past 6 months, including but not limited to, cardiac disease, seizure disorder, liver disease, renal disease, chronic infection, uncontrolled diabetes, lung disease.
  11. Any prior history or active malignancy other than MF.
  12. Subjects in deep depression.
  13. Subjects who are not mentally capable of understanding the protocol and all procedures.
  14. Subjects who do not agree to have the necessary blood draws and procedures for laboratory tests and evaluations according to protocol.
  15. Known allergy to any active or inactive ointment ingredient.
  16. Pregnant and nursing women.

Sites / Locations

  • Medical University of Gdansk

Arms of the Study

Arm 1

Arm Type

Experimental

Arm Label

10% WP1220 ointment

Arm Description

10% WP1220 ointment topically applied 2x day for 84 days

Outcomes

Primary Outcome Measures

Evaluation of the safety profile of WP1220 applied topically (adverse events)
Safety will be evaluated by reported adverse events

Secondary Outcome Measures

Evaluation of WP1220 applied topically to index lesions via standard measurement scale
Efficacy to be demonstrated through ≥50% improvement in standard assessments of lesions in comparison to baseline.

Full Information

First Posted
March 19, 2019
Last Updated
January 8, 2021
Sponsor
Moleculin Biotech, Inc.
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1. Study Identification

Unique Protocol Identification Number
NCT04702503
Brief Title
Study of WP1220 for the Treatment of Adult Subjects With Cutaneous T-Cell Lymphoma (CTCL)
Official Title
A Phase 1b Study Evaluating the Safety and Efficacy of Topical Administration of WP1220, an Inhibitor of STAT3 Activation, in Adults With Stage I, II, or III Mycosis Fungoides (Cutaneous T-Cell Lymphoma, CTCL)
Study Type
Interventional

2. Study Status

Record Verification Date
January 2021
Overall Recruitment Status
Completed
Study Start Date
March 8, 2019 (Actual)
Primary Completion Date
November 15, 2019 (Actual)
Study Completion Date
November 15, 2020 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Moleculin Biotech, Inc.

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
Single center, pilot study to evaluate the safety and efficacy topical administration of WP1220 in subjects with Stage I, II or III Mycosis Fungoides (CTCL)

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Cutaneous T-Cell Lymphoma/Mycosis Fungoides

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 1
Interventional Study Model
Single Group Assignment
Masking
None (Open Label)
Allocation
N/A
Enrollment
5 (Actual)

8. Arms, Groups, and Interventions

Arm Title
10% WP1220 ointment
Arm Type
Experimental
Arm Description
10% WP1220 ointment topically applied 2x day for 84 days
Intervention Type
Drug
Intervention Name(s)
WP1220
Intervention Description
Topical administration 2x daily for 84 consecutive days
Primary Outcome Measure Information:
Title
Evaluation of the safety profile of WP1220 applied topically (adverse events)
Description
Safety will be evaluated by reported adverse events
Time Frame
12 weeks (3 28-day cycles)
Secondary Outcome Measure Information:
Title
Evaluation of WP1220 applied topically to index lesions via standard measurement scale
Description
Efficacy to be demonstrated through ≥50% improvement in standard assessments of lesions in comparison to baseline.
Time Frame
12 weeks

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Age ≥ 18 years at the time of signing informed consent. Clinical diagnosis of MF. Stage IA, IB, IIA, IIB, or II MF: T1-T4 with measurable lesions Previously treatment with at least one standard therapy used to treat Stage IA, IB, IIA, IIB, or III MF. Measurable skin disease must have at least 2 eligible baseline index lesions with maximum total area ≤ 40 cm2. Eligible lesions must be below the head (face and scalp are excluded) and must not involve the genitalia or anus. ECOG performance status of 0-2 Subject must read and sign informed consent form and be willing to comply with the instructions, restrictions, nature and procedures of the study. Willing to avoid tanning devices or exposure of the treated skin to the sun. Willing to not use cosmetics, including lotions, creams, and moisturizers on the treated lesions. Willing to use topical steroid on a maximum of 25% of BSA occupied by MF on areas not involved in the clinical trial. Must have recovered from the effects of surgery requiring general anesthesia and intubation for a minimum of 3 months, and from minor surgery requiring only local anesthetic for a minimum of 2 weeks. Concomitant disease must be stable and subjects must be on the same dose and schedule of any medications for at least 1 month before screening. Subjects of both genders who are of childbearing potential including perimenopausal women who are fewer than 2 years from their last menses, must use one of the following effective means of contraceptionL Birth control pills in conjunction with spermicide gel Surgical sterilization Intra uterine device Condom and spermicide gel together Sexual abstinence during study period The requirements above do not apply to: Postmenopausal women with spontaneous amenorrhea for at least 2 years, or Subjects with bilateral oophoerctomy with or without a hysterectomy and an absence of bleeding for at least 6 months, or Subjects with total hysterectomy and an absence of bleeding for at least 3 months Exclusion Criteria: MF with no prior therapy. Subjects with a diagnosis of stage IV MF at Screening or subsequently observed at Baseline. Subjects with unusual phenotypes, e.g. lymphomatoid papulosis MF-like type. Subjects who require immediate treatment for progressive MF. Subjects treated with at least one of the following methods within 8 weeks prior to Baseline: Total body electron beam radiation Investigational drugs or treatments Subjects treated with at least one of the following methods within 4 weeks prior to Baseline: Local radiation therapy UVB therapy PUVA Topical chemotherapy Topical corticosteroids or retinoids Systemic chemotherapeutic agents (excluding low doses of MTX max. 25 mg/wk) Index lesion treatment with at least one of the following methods within 2 weeks prior to Baseline: Any surgical procedures other than biopsies related to CTCL diagnosis or follow- up Any topical treatment other than bland moisturizers (creams, lotions, emollients, etc) Skin infections on screening or baseline involving index lesions planned to be treated in the clinical trial. The presence of any clinically significant laboratory abnormalities at screening including, but not limited to abnormalities of the white blood count, hemoglobin, platelets, serum chemistry (glucose, uric acid, calcium, phosphorus, sodium, potassium, chloride, alkaline phosphatase, albumin and total bilirubin), thyroid stimulating hormone, fT3 and fT4 as determined by the Investigator in conjunction with the Medical Monitor. Any significant uncontrolled medical disease as evaluated by the Investigator and/or Medical Monitor, chronic or active within the past 6 months, including but not limited to, cardiac disease, seizure disorder, liver disease, renal disease, chronic infection, uncontrolled diabetes, lung disease. Any prior history or active malignancy other than MF. Subjects in deep depression. Subjects who are not mentally capable of understanding the protocol and all procedures. Subjects who do not agree to have the necessary blood draws and procedures for laboratory tests and evaluations according to protocol. Known allergy to any active or inactive ointment ingredient. Pregnant and nursing women.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Sandra Silberman, MD, PhD
Organizational Affiliation
Moleculin Biotech, Inc.
Official's Role
Study Director
Facility Information:
Facility Name
Medical University of Gdansk
City
Gdansk
Country
Poland

12. IPD Sharing Statement

Learn more about this trial

Study of WP1220 for the Treatment of Adult Subjects With Cutaneous T-Cell Lymphoma (CTCL)

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