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Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics (STAR-OM)

Primary Purpose

Methamphetamine Abuse, Opioid-use Disorder, HIV Seropositivity

Status
Active
Phase
Not Applicable
Locations
Vietnam
Study Type
Interventional
Intervention
High intensity contingency management
Low intensity contingency management
SMS reminders
Matrix only
Matrix + Contingency management
Sponsored by
Hanoi Medical University
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Methamphetamine Abuse focused on measuring methamphetamine use, opioid use disorders, methadone, HIV

Eligibility Criteria

16 Years - undefined (Child, Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • ASSIST scores moderate (4-26) or high-risk (27+) for methamphetamine use;
  • Confirmed methamphetamine use with urine analysis;
  • Willing to provide at least three pieces of contact information;
  • Having a cell phone to receive texts.

Exclusion Criteria:

  • Psychosis or other interfering problems;
  • Cannot understand study procedures as judged by research assistants.

Sites / Locations

  • Hai Ba Trung methadone clinic
  • Long Bien methadone clinic
  • Nam Tu Liem Methadone clinic
  • District 4 Methadone clinic

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm 4

Arm 5

Arm 6

Arm Type

Active Comparator

Active Comparator

Active Comparator

Active Comparator

Active Comparator

Active Comparator

Arm Label

A - High intensity Contingency management + SMS reminders

B - High intensity Contingency management + Matrix only

C - High intensity Contingency management + (Matrix + CM)

D - Low intensity Contingency management + SMS reminders

E - Low intensity Contingency management + Matrix only

F - Low intensity Contingency management + (Matrix+CM)

Arm Description

Participants who respond to the high intensity contingency management (frontline intervention) receive the adaptive intervention of SMS reminders.

Participants who do not respond to the high intensity contingency management are randomized into the Matrix only group.

Participants who do not respond to the high intensity contingency management are randomized into the Matrix plus contingency management group.

Participants who respond to the low intensity contingency management (frontline intervention) receive the adaptive intervention of SMS reminders.

Participants who do not respond to the who intensity contingency management are randomized into the Matrix only group.

Participants who do not respond to the who intensity contingency management are randomized into the Matrix plus contingency management group.

Outcomes

Primary Outcome Measures

Increase in HIV viral suppression for HIV-positive participants
We will conduct quick HIV testing during screening and viral load test at baseline, 12, 24 and 48 weeks after enrolment.
Reduction in HIV risk behaviors for both HIV-positive and HIV-negative participants
Structured questionnaires will collect self-reported data at baseline, 24 and 48 weeks after enrolment
Reduction in methamphetamine use
This outcome is measured by urine test (point abstinence) and self-report (continuous abstinence and longest period). Urine tests will be collected just before enrolment, twice a week during weeks of contingency management, group education and Matrix meetings, once a week during weeks of SMS reminders intervention, twice a week during week 12th, 24th, 48th. Self-reported drug use information is collected at baseline, weeks 12th, 24th and 48th. We use one scale: Amphetamine Cessation Symptoms Assessment (ACSA), score range: 0-64, higher scores mean more severe symptoms.

Secondary Outcome Measures

Adherence to ART if HIV-positive
This information will be collected using the study questionnaire at baseline, weeks 12th, 24th and 48th.
Frequency of HIV testing if HIV-negative
This information will be collected using the study questionnaire at baseline, weeks 12th, 24th and 48th.
Frequency of heroin use
This outcome will be measured by urine drug tests just before enrolment, twice a week during weeks of contingency management, group education and Matrix meetings, once a week during weeks of SMS reminders intervention, twice a week during week 12th, 24th, 48th.
Frequency of opioid overdose
This information will be collected using the study questionnaire at baseline, weeks 12th, 24th and 48th.
Changes in quality of life
This outcome will be measured using the study questionnaire at baseline, weeks 12th, 24th and 48th. We use the EQ-5D-5L scale (the 5-level, 5-dimension instrument developed by EuroQol Group in 2009). The Vietnam values range from -0.515 to 1. Higher scores mean worse quality of life.

Full Information

First Posted
January 4, 2021
Last Updated
October 10, 2023
Sponsor
Hanoi Medical University
Collaborators
University of California, Los Angeles, University of Medicine and Pharmacy at Ho Chi Minh City
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1. Study Identification

Unique Protocol Identification Number
NCT04706624
Brief Title
Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics
Acronym
STAR-OM
Official Title
Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics
Study Type
Interventional

2. Study Status

Record Verification Date
October 2023
Overall Recruitment Status
Active, not recruiting
Study Start Date
November 2, 2020 (Actual)
Primary Completion Date
June 30, 2024 (Anticipated)
Study Completion Date
March 31, 2025 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Hanoi Medical University
Collaborators
University of California, Los Angeles, University of Medicine and Pharmacy at Ho Chi Minh City

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
The investigators propose to develop and evaluate optimal combinations of evidence-based interventions to improve HIV outcomes and reduce methamphetamine use (hereafter: meth use) among people with opioid use disorder who are in methadone maintenance therapy (MMT) in Vietnam. Over the past decade, the expansion of MMT has contributed to stemming both HIV and opioid epidemics. However, rising meth use threatens these achievements. Evidence-based interventions such as Motivational Enhancement Therapy, Contingency Management, Matrix Model, and SMS reminders are effective in reducing meth use. The study will be conducted in the two largest cities in Vietnam, Hanoi and Ho Chi Minh City (HCMC), where there are the highest number of MMT patients and the highest burden of HIV cases. Building on the pilot work of the research team in Hanoi, through collaborative work with local MMT providers and patients, the investigators will first further refine adapted EBIs to develop adaptive strategies. The adaptive design includes: (1) Two frontline interventions: 6 weeks of contingency management then 6 weeks of weekly group educational sessions and 12 weeks of contingency management; (2) One (short-term) tailoring outcome: urine tests negative with meth metabolites in both week 11 and 12 are considered responsive to frontline interventions; (3) Three alternative interventions: those with positive outcomes will move to 12-week maintenance stage and receive two daily SMS reminders plus one weekly self-monitoring assessment messages. Non-responders will move to 12-week enhanced treatment stage and are randomly assigned to either Matrix group counseling only or Matrix group counseling plus contingency management. The full randomization trial will be conducted with 200 HIV-positive and 400 HIV-negative MMT patients who report moderate- and high-risk meth use on self-screening with ASSIST or have urine positive with meth metabolites. In each location, the study will stratify participants by HIV status before randomizing them to one of two frontline interventions. Primary outcomes - including HIV viral suppression, HIV risk behaviors, and meth use (reported and urine tests) - will be assessed at 12, 24 and 48 weeks. The study team also conducts ethnographic observations and in-depth interviews with MMT clinic managers, clinical staff and MMT patients to explore implementation barriers and facilitators.
Detailed Description
1) To develop adaptive interventions, including two frontline interventions and four adaptive strategies, through collaborative processes (Aim 1): During Month 3 - 9, the investigators refine the EBIs to develop adaptive interventions. 1a) Assessment: The team conducts 4 Focus Group Discussions (FGDs) with MMT patients on local taxonomy and patterns of meth use, trigger situations, motivations for seeking treatment, motivations and barriers for participating in different EBIs, inputs/advice on proposed adaptive design, and barriers and facilitators for retention of participants in each of the adaptive steps. 1b) Decision: The team organizes a workgroup that involves MMT clinical staff, representatives of CBOs working with people who use drugs, social workers working with MMT patients, and MMT patients themselves to review the contents of FGDs in the Assessment step, experiences of pilot intervention in Hanoi, the conceptual and empirical evidence of EBIs to make recommendations on core contents of each EBI. Contingency management is a 12-week or 6-week low-value escalating schedule. Participants give urine twice a week. Matrix group counseling involves twice weekly group sessions that last for about 60 to 90 minutes each. Group counseling focuses on relapse prevention. SMS-text: Participants receive automated, unidirectional, scripted, theory-based and culturally responsive text reminders twice daily plus a weekly self-monitoring assessment messages. The text messages are scripted across: 1) drug use, sexual risk reduction, physical health and HIV care (for HIV+ participants); and, 2) the theoretical construct of cognitive-behavioral therapy including understanding external and internal triggers; relapse prevention and relapse analysis and goal setting. 1c) Administration: At the end of the Decision step, the workgroup put together a framework for the adaptive design that include different interventions, sequence, decision rule and contents of interventions. This framework is presented and discussed in a second round of FGDs with target populations in each city. 2) Pilot implementation of adaptive interventions (Aim 1): During Month 3 - 9, the study team chooses one MMT clinic in each city for piloting the adaptive design. The pilot implementation, which lasts 12 weeks, aims to identify issues that need to be addressed before the full implementation. The pilot recruits 40 meth-using MMT patients (20 from each city, at least 10 HIV positive) and over-recruits women. Inclusion criteria for the pilot sample include: 1) 16 years old or older; 2) score of 4-26 (moderate risk) or 27+ (high risk) on ASSIST regarding meth use OR urine screen positive for metabolite of meth; 4) having a cell phone able to receive texts; (5) and willing to participate in treatment. These participants are excluded from the full implementation. 2a) Pilot Monitoring and Evaluation: The study team in each city monitors the overall operation of the pilot to ensure that interventions are carried out as planned. For each intervention session, a Master Behavioral Counselor and an ethnographer observe the implementation regarding content integrity, flow, location, message clarity, interventionist-participant interaction, participant attendance, engagement, and responsiveness. Second, after each phase of intervention implementation (self-screening, frontline interventions, decision stage, maintenance, enhanced treatment), a FGD is organized for all intervention facilitators and another with patients to understand their experiences and to gather feedback regarding potential modifications. 2b) Intervention modification and assessment finalization: The evaluation data helps to identify factors that may affect implementation and outcomes. Modifications to intervention characteristics to ensure the relevance of the intervention for target settings and populations are completed at this stage. This phase gives an opportunity to finalize the recruitment and retention strategies as well as assessment tools. 3) Full implementation of SMART design to compare effectiveness of two frontline interventions and four adaptive strategies (Aim 1) 3a) Selection of clinical settings to become intervention sites: Criteria for selecting clinics are established. Existing statistics are viewed and clinics that meet criteria are shortlisted. 20 MMT clinics are selected randomly from the shortlisted candidates (10 from Hanoi, 10 from HCMC). 3b) Intervention facilitator recruitment and training: The intervention team in each city includes one Master Behavioral Counselor with Master-level training in clinical psychology and two intervention coaches with bachelor degrees in social work, psychology or public health to support and ensure quality of implementation of the EBIs by MMT clinical staff. Both Master Counselor and intervention coaches are also facilitators for Matrix group counseling where MMT clinical staff will not be able to carry out themselves. Once MMT clinics are selected, managers of these clinics nominate a physician, two counselors and one nurse to participate in the study as intervention facilitators. Before the start of intervention, all intervention staff at MMT clinics (1) receive didactic training on the theory behind the approach; (2) pass a knowledge test to evaluate their grasp of the concepts within and behind the approach; (3) watch a video of a Master Behavioral Counselor conducting intervention sessions and discuss the details of the session, and (4) conduct at least two pilot EBIs, which are recorded and observed by the HMU/UMP intervention team and the PIs. All subsequent interventions are audio recorded and coded to ensure the presence of essential elements of the intervention. Intervention staffs who have lower levels of intervention integrity or who have significant drift are provided detailed feedback and supervision. 3c) Participant recruitment and randomization: The 20 selected clinics are randomly assigned into 5 clusters (4 clusters of 4 clinics from the same city and 1 cluster of 4 clinics from two cities). In each cluster, CBO members and health care staff distribute flyers and CBO members working in each MMT clinic approach patients when patients come daily for their MMT dosages to invite them to participate in self-screening with tablet-based ASSIST as well as urine drug test and Quick HIV tests. Once agreed, CBO assist with self-screening processes. Individuals who participate in self-screening give verbal agreement to participate and receive compensation for their time. Those with low-risk scores and urine negative with meth metabolites are offered a Brief Intervention by trained CBO members. Those with reactive Quick HIV tests are referred to HIV care facilities if these participants have not done so. Recruiting participants for adaptive interventions: CBO members invite those who are at moderate-risk and high-risk scores for meth or have urine positive with meth metabolites to participate in the study. Those who express interest and provide contact information are referred to research assistants (RA) who then makes appointment to screen for eligibility. At each clinic, RA conduct a brief survey and collect urine sample to confirm recent meth use. The study over-recruits women as the majority of MMT patients in Vietnam are men. The study aims to recruit 200 HIV+ and 400 HIV-. Those who sign informed consent are enrolled in baseline assessment and electronically fingerprinted to create unique ID. Participants receive compensation for their participation in baseline assessment. Eligible participants at each clinic are first stratified by HIV status, and then randomized to low vs. high intensity frontline interventions. 4) Cost-effectiveness analysis of interventions (Aim 2) 4a) The cost-effectiveness analysis has two goals: 1) to determine whether any additional improvement in outcomes associated with interventions of different intensity and expense is worth the additional cost; and 2) to provide guidance to the Vietnam Ministry of Health on the cost of scaling-up and implementing the interventions. This analysis measures the increment in cost between contrasted interventions divided by the increment in outcomes. Effectiveness of each intervention for HIV+ and HIV- groups is measured by the estimated outcome probabilities for each outcome of interest, as in Aim 1. 4b) Costs are assessed from the point of view of the public health agency. The second analysis will include social costs. Implementation costs are calculated based on costs for each arm incurred by health care providers, including costs of implementing the intervention, mental health and drug treatment services used. An activity-based costing approach is used to estimate the cost of fielding the interventions in 20 MMT clinics. A template is used to collect data on salaries for personnel and consultants, physical resources, clinical supplies and miscellaneous charges that are required to deliver each intervention type. Data is collected from participants on medical visits and involvement with the criminal justice system. These differences are costed out using local pricing data. Per capita costs for each intervention are calculated by dividing the total cost for each site/arm by the number of participants in each arm at that site. 5) Ethnographic evaluation to identify the structural, provider, and patient-level factors that influence adoption and scale-up of interventions in MMT clinics. (Aim 3). 5a) Ethnographic interviews: Two ethnographic researchers conduct pre-post intervention in-depth interviews with 12 individuals in each cluster of clinics. Participants include MMT manager, MMT clinical staff, CBO members and patients who participate in interventions. In each cluster, at least 6 patients are selected. In-depth ethnographic interviews with these individuals take place immediately before enrollment and immediately after maintenance or enhanced treatments end. With CBO and MMT staff, pre-intervention interviews explore experiences with current work; experiences with meth users, expectations of whether and how the interventions would work. Post-intervention interviews explore actual experiences with delivering interventions as well as perceived barriers and facilitators for adoption and scale-up. With participants: first interviews explore family of origin, childhood and coming of age; histories of sexual and affective relations; histories of drug use and patterns of meth use; current social support; broader life goals; motivations to participate in the study, and expectations of how the interventions would work. Second interviews explore actual experiences and outcomes as well as motivations to stay in the interventions. The Consolidated Framework for Implementation Research is used in all interviews to probe participant perceptions of the characteristics of the STAR-OM interventions, of outer settings, inner settings, provider characteristics and the implementation process. 5b) Ethnographic Observation: Two kinds of observations take place. The first, carried out with in-depth interviews of participants who consent to participate in this additional form of data collection, involves having two ethnographers spend time with them to observe activities such as individual meetings, group activities and other daily activities in the clinical and/or community settings. The second element of observation involve Master Counselors to observe randomly selected sessions of interventions in CM and CBT period and keep a logbook of SMS messages that are sent out to each participant in the study. A checklist is used to assess the fidelity of interventions contents and delivery. Master Counselors also assess other contextual information that is useful to determine whether interventions are effectively delivered. All observation periods are recorded with detailed field notes.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Methamphetamine Abuse, Opioid-use Disorder, HIV Seropositivity
Keywords
methamphetamine use, opioid use disorders, methadone, HIV

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Sequential Assignment
Model Description
Two frontline interventions: contingency management (CM) throughout 12 weeks (high intensity CM); and CM in 6 weeks followed by 6 weeks of weekly group educational sessions (low intensity CM); Consecutive urine tests negative with methamphetamine at week 11 and week 12 (two urine tests per week) are considered as responsive to frontline interventions; any positive with one of the urine tests during week 11 and 12 or failure to provide urine are considered non-responsive; Three treatment alternatives: Responders to frontline interventions will receive two daily automatic unidirectional scripted SMS reminder plus one weekly self-monitoring assessment message over 12 weeks (maintenance treatment); non-responders will be randomized to either Matrix group counseling alone or Matrix group counseling with CM over 12 weeks.
Masking
None (Open Label)
Allocation
Randomized
Enrollment
640 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
A - High intensity Contingency management + SMS reminders
Arm Type
Active Comparator
Arm Description
Participants who respond to the high intensity contingency management (frontline intervention) receive the adaptive intervention of SMS reminders.
Arm Title
B - High intensity Contingency management + Matrix only
Arm Type
Active Comparator
Arm Description
Participants who do not respond to the high intensity contingency management are randomized into the Matrix only group.
Arm Title
C - High intensity Contingency management + (Matrix + CM)
Arm Type
Active Comparator
Arm Description
Participants who do not respond to the high intensity contingency management are randomized into the Matrix plus contingency management group.
Arm Title
D - Low intensity Contingency management + SMS reminders
Arm Type
Active Comparator
Arm Description
Participants who respond to the low intensity contingency management (frontline intervention) receive the adaptive intervention of SMS reminders.
Arm Title
E - Low intensity Contingency management + Matrix only
Arm Type
Active Comparator
Arm Description
Participants who do not respond to the who intensity contingency management are randomized into the Matrix only group.
Arm Title
F - Low intensity Contingency management + (Matrix+CM)
Arm Type
Active Comparator
Arm Description
Participants who do not respond to the who intensity contingency management are randomized into the Matrix plus contingency management group.
Intervention Type
Behavioral
Intervention Name(s)
High intensity contingency management
Intervention Description
Participants receive 12 weeks of contingency management.
Intervention Type
Behavioral
Intervention Name(s)
Low intensity contingency management
Intervention Description
Participants receive 6 weeks of contingency management and 6 weeks of group education.
Intervention Type
Behavioral
Intervention Name(s)
SMS reminders
Intervention Description
Participants receive two daily SMS reminders plus one weekly self-monitoring assessment.
Intervention Type
Behavioral
Intervention Name(s)
Matrix only
Intervention Description
Participants attend 12 weekly Matrix group counseling sessions.
Intervention Type
Behavioral
Intervention Name(s)
Matrix + Contingency management
Intervention Description
Participants attend 12 weekly Matrix group counseling sessions plus 12 weeks of contingency management.
Primary Outcome Measure Information:
Title
Increase in HIV viral suppression for HIV-positive participants
Description
We will conduct quick HIV testing during screening and viral load test at baseline, 12, 24 and 48 weeks after enrolment.
Time Frame
48 weeks
Title
Reduction in HIV risk behaviors for both HIV-positive and HIV-negative participants
Description
Structured questionnaires will collect self-reported data at baseline, 24 and 48 weeks after enrolment
Time Frame
48 weeks
Title
Reduction in methamphetamine use
Description
This outcome is measured by urine test (point abstinence) and self-report (continuous abstinence and longest period). Urine tests will be collected just before enrolment, twice a week during weeks of contingency management, group education and Matrix meetings, once a week during weeks of SMS reminders intervention, twice a week during week 12th, 24th, 48th. Self-reported drug use information is collected at baseline, weeks 12th, 24th and 48th. We use one scale: Amphetamine Cessation Symptoms Assessment (ACSA), score range: 0-64, higher scores mean more severe symptoms.
Time Frame
48 weeks
Secondary Outcome Measure Information:
Title
Adherence to ART if HIV-positive
Description
This information will be collected using the study questionnaire at baseline, weeks 12th, 24th and 48th.
Time Frame
48 weeks
Title
Frequency of HIV testing if HIV-negative
Description
This information will be collected using the study questionnaire at baseline, weeks 12th, 24th and 48th.
Time Frame
48 weeks
Title
Frequency of heroin use
Description
This outcome will be measured by urine drug tests just before enrolment, twice a week during weeks of contingency management, group education and Matrix meetings, once a week during weeks of SMS reminders intervention, twice a week during week 12th, 24th, 48th.
Time Frame
48 weeks
Title
Frequency of opioid overdose
Description
This information will be collected using the study questionnaire at baseline, weeks 12th, 24th and 48th.
Time Frame
48 weeks
Title
Changes in quality of life
Description
This outcome will be measured using the study questionnaire at baseline, weeks 12th, 24th and 48th. We use the EQ-5D-5L scale (the 5-level, 5-dimension instrument developed by EuroQol Group in 2009). The Vietnam values range from -0.515 to 1. Higher scores mean worse quality of life.
Time Frame
48 weeks

10. Eligibility

Sex
All
Minimum Age & Unit of Time
16 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: ASSIST scores from 10+ for methamphetamine use OR Confirmed methamphetamine use with urine analysis; Willing to provide at least three pieces of contact information; Having a cell phone to receive texts. Exclusion Criteria: Psychosis or other interfering problems; Cannot understand study procedures as judged by research assistants.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Le Minh Giang, PhD
Organizational Affiliation
Hanoi Medical University
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Steve Shoptaw, PhD
Organizational Affiliation
University of California, Los Angeles, Department of Family Medicine
Official's Role
Principal Investigator
Facility Information:
Facility Name
Hai Ba Trung methadone clinic
City
Hanoi
ZIP/Postal Code
100000
Country
Vietnam
Facility Name
Long Bien methadone clinic
City
Hanoi
ZIP/Postal Code
100000
Country
Vietnam
Facility Name
Nam Tu Liem Methadone clinic
City
Hanoi
ZIP/Postal Code
100000
Country
Vietnam
Facility Name
District 4 Methadone clinic
City
Ho Chi Minh City
ZIP/Postal Code
728000
Country
Vietnam

12. IPD Sharing Statement

Plan to Share IPD
Yes
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