Visual-OLfactory Training in Participants With COVID-19 Resultant Loss of Smell (VOLT)
Anosmia, Covid19, Ageusia
About this trial
This is an interventional treatment trial for Anosmia focused on measuring Anosmia, Loss of Smell, Loss of Taste, Hyposmia, Ageusia, Covid-19, SARS-CoV-2
Eligibility Criteria
Inclusion Criteria:
- Subjective or clinically diagnosed olfactory dysfunction of 3 months duration or longer initially diagnosed within 2 weeks of a COVID-19 infection
Exclusion Criteria:
- Diagnosed olfactory dysfunction due to head trauma
- Chronic rhinosinusitis
- Congenital olfactory dysfunction
- Nasal polyps
- Neurodegenerative disorders (for example, Alzheimer or Parkinson Disease)
- Pre-Assessment UPSIT score ≥34 for males and ≥35 for females
- Pregnant
- Inability to read, write, and understand English
- Inability to perform home olfactory training (for example, due to limited access to internet)
- Residence outside of the the United States of America
- Previously conducting smell training
Sites / Locations
- Washington University School of Medicine in Saint Louis
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Experimental
Experimental
Experimental
Unimodal Olfactory Training with Conventional Odors
Unimodal Olfactory Training with Patient-Preferred Odors
Bimodal Visual, Olfactory Training with Conventional Odors
Bimodal Visual, Olfactory Training with Patient-Preferred Odors
Participants will undergo smell training without a visual component, and train using 4 pre-determined scents: rose, lemon, eucalyptus, and clove.
Participants will undergo smell training without a visual component, and undergo an odor selection process in which they choose four scents to train with that they identify as important. A total of 24 scents will be included for patients to select from, including: Lemon, Orange, Grapefruit, Lime, Eucalyptus, Peppermint, Spearmint, Tea Tree, Rose, Lavender, Jasmine, Geranium, Frankincense, Cedarwood, Juniper, Sandalwood, Black Pepper, Oregano, Rosemary, Clove, Vanilla, Coffee, Cinnamon, Nutmeg.
Participants will undergo smell training while simultaneously focusing on a picture of the odor, and train using 4 pre-determined scents: rose, lemon, eucalyptus, and clove.
Participants will undergo smell training while simultaneously focusing on a picture of the odor, and undergo an odor selection process in which they choose four scents to train with that they identify as important. A total of 24 scents will be included for patients to select from, including: Lemon, Orange, Grapefruit, Lime, Eucalyptus, Peppermint, Spearmint, Tea Tree, Rose, Lavender, Jasmine, Geranium, Frankincense, Cedarwood, Juniper, Sandalwood, Black Pepper, Oregano, Rosemary, Clove, Vanilla, Coffee, Cinnamon, Nutmeg.