Familial Risk for Bipolar Disorder and Alcohol Sensitivity (FACS)
Bipolar Disorder, Alcohol Drinking, Alcohol Use Disorder
About this trial
This is an interventional prevention trial for Bipolar Disorder
Eligibility Criteria
Inclusion Criteria:
Inclusion criteria for all participants:
- between 21 and 26 years of age
- having consumed at least 4 (men) or 3 (women) drinks on a single occasion at least twice over the last year
- euthymic at the time of study
Inclusion criteria for familial risk for bipolar disorder (only) participants:
- having at least one parent diagnosed with bipolar disorder type I, confirmed by family history interview
Inclusion criteria for familial risk for both bipolar disorder and alcohol use disorders participants:
- having at least one parent diagnosed with bipolar disorder type I, confirmed by family history interview
- having at least one parent diagnosed with an alcohol use disorder, confirmed by family history interview
Inclusion criteria for familial risk for alcohol use disorders (only) participants:
- having at least one parent diagnosed with an alcohol use disorder, confirmed by family history interview
Exclusion Criteria:
For all subjects exclusion criteria include:
- history of manic episode
- history of psychosis
- history of significant medical illness, particularly if possible changes in cerebral tissue
- full Scale IQ <85
- positive pregnancy test
- history of cannabis use disorder>moderate over past year
- history of AUD>mild over lifetime
- scores > 15 on the alcohol Use Disorders Identification Test (AUDIT; part of phone screen)
- ever being in an abstinence-oriented treatment program for alcohol use
- reporting wanting to quit drinking but not being able to
- any medical, religious, or other reasons for not drinking alcohol
- history of heart attack, heart trouble, high blood pressure, diabetes, or liver disease
- an adverse reaction to alcoholic beverages
- a flushing response (possibly suggesting altered alcohol metabolism)
- reporting never consuming 4 (men) or 3 (women) or more drinks on a single occasion at least twice over the last year
- unwillingness to have a friend or family member drive them home after the alcohol administration sessions
- a past substance use disorder (other than alcohol, cannabis, or nicotine) over the past year
Additional exclusion criteria for familial risk for bipolar disorder participants:
- not taking medications for >4 weeks (i.e. participants must be stable on antidepressant or anti-anxiety medication)
Additional exclusion criteria for healthy comparison subjects also include:
- any prior psychiatric hospitalizations
- lifetime history of a neurodevelopmental disorder, affective disorder, psychotic disorder, eating disorder
- having a parent diagnosed with a mood disorder or AUD
- greater than 1 month of lifetime psychotropic medication
Sites / Locations
- University of Texas at AustinRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
Alcohol
Placebo
Participants will be dosed to a 0.08g% blood alcohol concentration.
Participants will receive a low dose of alcohol (placebo condition).