Camrelizumab Combined With Apatinib and Capecitabine in Patients With Advanced Unresectable Biliary Tract Cancer.

This is an interventional treatment trial for Biliary Tract Cancer focused on measuring Capecitabine, Targeted Molecular Therapy, Biliary Tract Cancer Read More

Inclusion Criteria:

• Aged 18-70 years old, both genders.
• Conform to the histological or cytological confirmation of biliary tract carcinoma，including gallbladder cancers and cholangiocarcinomas.
• Patients have advanced unresectable biliary tract carcinoma, including recurrence or metastasis of BTC after radical resection.
• Patientss who have not received any prior PD-1 inhibitor and Apatinib therapy.
• Patients must have at least 1 lesion that is measurable using RECIST v1.1 criteria.
• Eastern Cooperative Oncology Group Performance Status of 0 or 1within one week before enrollment.
• Life expectancy greater than 3 months.
• Patient must have adequate organ function defined by the study-specified laboratory tests.
• Patient must use acceptable form of birth control while on study.
• Ability to understand and willingness to sign a written informed consent document.

Exclusion Criteria:

• Patients with known history of allogeneic organ transplantation or allogeneic hematopoietic stem cell transplantation or planned transplantation.
• Patients with other malignant tumor in the past 5 years (except cured skin basal cell carcinoma and cervical carcinoma).
• History of esophageal variceal bleeding, hepatic encephalopathy, massive ascites and abdominal infection.
• Concurrent medical condition requiring the use of immunosuppressive medications, or immunosuppressive doses of systemic or absorbable topical corticosteroids. Doses > 10 mg/day prednisone or equivalent are prohibited within 14 days before study drug administration.
• Known history of hypersensitivity to any components of the camrelizumab, apatinib and Capecitabine formulation, or other antibody formulation.
• Patients who may receive live vaccine during the study, or previous had vaccination within 4 weeks.
• Known or occurrence of central nervous system (CNS) metastases or hepatic encephalopathy.
• Peripheral neuropathy> Grade 1.
• Patients with any active autoimmune disease or history of autoimmune disease.
• History of immunodeficiency or human immunodeficiency virus (HIV) infection.
• Clinically significant cardiovascular and cerebrovascular diseases, including but not limited to severe acute myocardial infarction within 6 months before enrollment, unstable or severe angina, or coronary artery bypass surgery, Congestive heart failure (New York heart association (NYHA) class > 2), ventricular arrhythmia which need medical intervention.
• Hypertension and unable to be controlled within normal level following treatment of anti-hypertension agents (within 3 months): systolic blood pressure > 140 mmHg, diastolic blood pressure > 90 mmHg.
• Coagulation abnormalities (INR>1.5 or APTT>1.5×ULN), with bleeding tendency or are receiving thrombolytic or anticoagulant therapy.
• History of hereditary or acquired bleeding and thrombotic tendency, such as hemophilia, coagulopathy, thrombocytopenia, hypersplenism, etc.
• Patients with obvious cough blood or hemoptysis volume of half teaspoon (2.5 ml) or more within 2 months before entering the study.
• Have significant clinically significant bleeding symptoms or have a clear bleeding tendency within 3 months before entering the study, such as gastrointestinal bleeding, hemorrhagic gastric ulcer, fecal occult blood++ and above at baseline, or vasculitis, etc.
• Previous Arterial/venous thrombosis events within 6 months.
• Required for long-term anticoagulant therapy with warfarin or heparin, or long-term antiplatelet therapy (aspirin ≥300 mg/day or clopidogrel ≥75 mg/day).
• Severe infection within 4 weeks before the first medication (e.g. need for intravenous antibiotics, antifungal or antiviral drugs), or active infection or an unexplained fever > 38.5°C during screening visits or on the first scheduled day of dosing.
• Participated in any other drug clinical study within 4 weeks before the first administration, or no more than 5 half lives from the last administration.
• Known history of psychotropic drug abuse or drug abuse.
• Pregnant and lactating women. Any other medical, psychiatric, or social condition deemed by the investigator to be likely to interfere with a subject's rights, safety, welfare, or ability to sign informed consent, cooperate, and participate in the study or would interfere with the interpretation of the results.