Nicotinamide to Prevent Delirium
Delirium Confusional State
About this trial
This is an interventional prevention trial for Delirium Confusional State
Eligibility Criteria
Inclusion Criteria:
- Older than 65 years old.
- Newly admitted due to suspected coronavirus disease (COVID-19) under study.
- To have less than 24 hours from the hospitalization at the moment of randomization.
- Able to take medicine orally.
- Signed an informed consent.
Exclusion Criteria:
- An expected stay or life expectancy of less than 48 hours.
- Severe liver dysfunction or Lewy body disease.
- Syndromes associated with alcohol dependency and drug abuse.
- Psychotic or bipolar disorders receiving treatment with antipsychotics.
- Delirious at admission Patients.
- Documented viral infections.
Sites / Locations
- Hospital Clínico Universidad de Chile
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Nicotinamide
Control
Patients who meet the inclusion / exclusion criteria will be randomly assigned to the experimental group:They will continue to receive standard prevention measures: Detection of delirium, education of health care team and the patient's family, sleep hygiene plan, early mobilization, resolve sensory impairments, and delivery of information of temporal-spatial reorientation in continuously. Study medication will be managed by nurses and administered daily at 7 a.m. This regimen will be continued up to 7 days after admission. The dosage of nicotinamide will be 1,5 gr per day.
Patients who meet the inclusion / exclusion criteria will be randomly assigned to the Control group: They will continue to receive the standard prevention measures: delirium detection, treatment health team education and the patient's family, sleep hygiene plan, early mobilization, resolve sensorial deterioration, and delivery of information of temporal-spatial reorientation in a continuous manner. Study medication will be managed by nurses and administered daily at 7 a.m. (in these case placebo tablets). This regimen will be continued up to 7 days after admission.