Analysis of Conjunctival Changes as Indicators for Ab-interno Gelatin Microstent Implantation Surgery Outcomes (IIT_XEN)
Glaucoma, Glaucoma Open-Angle Primary
About this trial
This is an interventional basic science trial for Glaucoma focused on measuring Gel stent, Trabeculectomy, In vivo confocal microscopy, Conjunctival impression cytology, Anterior segment optical coherence tomography
Eligibility Criteria
Inclusion Criteria:
- Primary open angle glaucoma
- Written informed consent
- Older than 18 years old
Exclusion Criteria:
- Patients that don't fully understand the purpose and the postoperative care
- Severe or end-stage glaucoma
- Patients with prior ocular surgery, excluding uncomplicated phacoemulsification 6 months prior to the inclusion in the study
Sites / Locations
- Hospital Clínic - ICOFRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Gel Stent implantation
Trabeculectomy
XEN gel stent: a clear cornea incision in the inferotemporal quadrant was performed, injecting the XEN 45 device into the superonasal quadrant using an ab interno approach. Approximately 15 min before inserting the implant, 0.1 ml of a MMC solution (0.01%) was injected into the superior conjunctiva. Both stand-alone and combined phaco-glaucoma procedures were used.
Trabeculectomy: the surgical technique is as follows: retro/peribulbar o subtenon's anesthesia, superior corneal traction suture, phacoemulsification through 2.2 with in-the-bag IOL implantation, a fornix-based conjunctival flap, sufficient but not excessive cauterization, application MMC 0,2 mg/ml for 2 minutes under the conjunctiva, then MMC was washed out with 100 ml of saline solution, then a scleral flap (4x3 mm in the trabeculectomy) is dissected. A sclerectomy with punch and peripheral iridectomy were performed, and suture nylon 10/00 sutures was used to place 3 or 4 stiches in the scleral flap