Management of Constitutional Thinness Through an Adapted Physical Activity Program, Whether or Not Associated With Food Supplementation. Interventional Study Compared to Matched Controls: NUTRILEAN + Study (NUTRILEAN +)
Healthy Normal Weight Women, Constitutionally Lean Women
About this trial
This is an interventional treatment trial for Healthy Normal Weight Women focused on measuring energy metabolism, body composition, physical training, constitutional leanness
Eligibility Criteria
Inclusion Criteria:
Inclusion criteria common to both groups
- Adult women aged 18 to 35, having a stable weight for at least 3 months.
- Body mass index (BMI) ≤ 17.5 kg / m2 (for the "constitutional thinness" group) or 20 kg / m2 ≤ BMI ≤ 25 kg / m2 (for the normal-weighted control group)
- Able to give informed consent to participate in research.
- Affiliation to a Social Security scheme.
Inclusion criteria specific to women with constitutional thinness
- BMI ≤ 17.5 kg / m2
- Weight stable for at least 3 months
- No eating disorder
- No biological markers of undernutrition
- Absence of secondary amenorrhea
Inclusion criteria specific to normo-weighted subjects
- 20 kg / m2 ≤ BMI ≤ 25 kg / m2
- Weight stable for at least 3 months
- No eating disorder
- No biological markers of undernutrition
- Absence of secondary amenorrhea
Exclusion Criteria:
- Pregnant or breastfeeding woman
- Severe progressive disease
- Medical or surgical history judged by the investigator to be incompatible with this study
- Diabetes or any other pathology limiting the application of one or the other trial strategy
- History of cardiovascular and / or neuro-vascular pathology, and / or cardiovascular and / or neuro-vascular risk factors (excluding obesity / overweight)
- Surgical intervention in the previous 3 months
- Taking medications that may interfere with the results of the study
- Regular practice of intense physical activity (more than 3 physical activity sessions per week)
- Regular consumption of tobacco or alcohol
- Special diet
- Abnormal plasma levels of IGF-1, estradiol, free T3, cortisol and leptin (only for the "constitutional thinness" group)
- Persons under guardianship or subjects deprived of their liberty by judicial or administrative decision
- Person in a period of exclusion from another study
- Refusal of participation
Sites / Locations
- Chu Clermont Ferrand
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Experimental
Experimental
Normal weight
constitutionally lean women - Physical training only
constitutionally lean women - Physical training + proteins
the normal weight women will receive the 12-week physical activity intervention and serve as a control group.
women will receive the 12-week physical activity intervention
women will receive the 12-week physical activity intervention in addition to a protein supplementation