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Core Stability Exercises and Hereditary Ataxia (Core-ataxia)

Primary Purpose

Hereditary Ataxia, Spinocerebellar Degenerations, Cerebellar Ataxia

Status
Completed
Phase
Not Applicable
Locations
Spain
Study Type
Interventional
Intervention
Therapeutic core stability exercises
Usual care
Sponsored by
Universitat Internacional de Catalunya
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Hereditary Ataxia focused on measuring ataxia, balance, gait ataxia, activities of daily living, core stability exercises, postural balance

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers
  • Inclusion criteria: suffer a degenerative hereditary ataxia. spinocerebellar ataxia (SCA), Friedreich's ataxia (FRDA), idiopathic sporadic cerebellar ataxia, and specific neurodegenerative disorders in which ataxia is the dominant symptom (e.g. cerebellar variant of multiple systems atrophy (MSA-C). Both sexes and age ≥ 18 years old. •Ability to understand and execute simple instructions.
  • Exclusion Criteria: Concurrent neurologic disorder (e. g. Parkinson's disease) or major orthopedic problem (e. g. amputation) that hamper sitting balance, relevant psychiatric disorders that may prevent from following instructions, Other treatments that could influence the effects of the interventions, Contraindication to physical activity (e.g., heart failure).

Sites / Locations

  • Rosa Cabanas Valdés

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

Core stability exercises group

Control group

Arm Description

30 minutes of core stability exercises program at a light intensity and take a rest breaks if is necessary. They will be instructed in the use of the 4-5 points of the Borg 10 Rating of Perceived Exertion for self-monitoring of exercise intensity. The exercises will performed twice a day for 5 days a week during 5 weeks. A physiotherapist conducted an initial home visit to ensure correct execution of the exercises. He or she will teach the exercises and then the patient will perform them alone in your home. Once a week the physiotherapist will phone the patient and will ask her/him for doubts.

The patients to continue as normal and not change their routine in terms of exercise and physical activity during the period of study.

Outcomes

Primary Outcome Measures

Rate of dynamic sitting balance and trunk coordination
Spanish-version of Trunk Impairment Scale 2.0. Each item will be performed three times and the highest score counts. Otherwise, no practice session allowed. The patient can be corrected between attempts. The tests are verbally explained to the patient and can be demonstrated if needed. There are two subscales: dynamic sitting balance and coordination. The first have 10 items and second 6. The highest possible total score is consequently 16 points, which indicates a good dynamic sitting balance and correct trunk control and sitting coordination. If the patient cannot maintain a sitting position for 10 seconds without back and arm support, with hands on thighs, feet in contact with the ground and knees bent at 90° (starting position), the total score for the scale is 0 points.
Rate of static sitting balance
Sitting section of Scale for the assessment and rating of ataxia (SARA). Patient is asked to sit on an examination bed without support of feet, eyes open and arms outstretched to the front. 0 Normal, no difficulties sitting >10 seconds, 1 Slight difficulties, intermittent sway, 2 Constant sway, but able to sit > 10 s without support, 3 Able to sit for > 10 s only with intermittent support, 4 Unable to sit for >10 s without continuous support
Rate of ataxia severity
Scale for the Assessment and Rating of Ataxia (SARA). The scale is made up of 8 items related to gait, stance, sitting, speech, finger-chase test, nose-finger test, fast alternating

Secondary Outcome Measures

Rate of standing balance
Standing section of Scale for the assessment and rating of ataxia (SARA). Patient is asked to stand (1) in natural position, (2) with feet together in parallel (big toes touching each other) and (3) in tandem (both feet on one line, no space between heel and toe). Proband does not wear shoes, eyes are open. For each condition, three trials are allowed. Best trial is rated. 0 Normal, able to stand in tandem for > 10 seconds 1 Able to stand with feet together without sway, but not in tandem for > 10s, 2 Able to stand with feet together for > 10 s, but only with sway, 3 Able to stand for > 10 s without support in natural, position, but not with feet together, 4 Able to stand for >10 s in natural position only with intermittent support, 5 Able to stand >10 s in natural position only with constant support of one arm, 6 Unable to stand for >10 s even with constant support of one arm.
Rate of gait ability
Gait section of Scale for the assessment and rating of ataxia (SARA). Patient is asked (1) to walk at a safe distance parallel to a wall including a half-turn (turn around to face the opposite direction of gait) and (2) to walk in tandem (heels to toes) without support. Scoring items from 0 to 8: 0 Normal, no difficulties in walking, turning and walking tandem (up to one misstep allowed) and 8 Unable to walk, even supported. Gait speed by 4 meters walking test (meters per second) . The individual walks without assistance for 6 meters, with the time measured for the intermediate 4 meters to allow for acceleration and deceleration.
Rate of balance confidence
Activities-specific Balance Confidence (ABC). Larger typeset should be used for self-administration, while an enlarged version of the rating scale on an index card will facilitate in-person interviews. The ABC is an 11-point scale and ratings should consist of whole numbers (0-100) for each item. Total the ratings (possible range = 0 - 1600) and divide by 16 to get each subject's ABC score. If a subject qualifies his/her response to items #2, #9, #11, #14 or #15 (different ratings for "up" vs. "down" or "onto" vs. "off"), solicit separate ratings and use the lowest confidence of the two (as this will limit the entire activity, for instance the likelihood of using the stairs.) • 80% = high level of physical functioning • 50-80% = moderate level of physical functioning • < 50% = low level of physical, functioning . < 67% = older adults at risk for falling; predictive of future fall.
Rate of lower limb strength
30 seconds sit-to-stand. The 30-second chair stand involves recording the number of stands a person can complete in 30 seconds rather then the amount of time it takes to complete a pre-determined number of repetitions. That way, it is possible to assess a wide variety of ability levels with scores ranging from 0 for those who can not complete 1 stand to greater then 20 for more fit individuals.
Rate of adherence
Adherence to the core stability exercise programme will be determined using exercise diaries, and process evaluation will be conducted via structured interviews with each participant at end of treatment.
Rate of health status
Health status by Euroqol 5 dimensions (EQ-5D). EQ-5D is a visual analogue scale for health ranging from 0 (worst possible) to 100 (best possible).
Rate of gait speed
4 meters walking test (4-MWT)
Rate of quality of life
Quality of life by EQ-5D-5L. The EQ-5D-5L is a self-assessed, health related, quality of life questionnaire. The scale measures quality of life on a 5-component scale including mobility, self-care, usual activities, pain/discomfort, and anxiety/depression

Full Information

First Posted
February 10, 2021
Last Updated
May 2, 2023
Sponsor
Universitat Internacional de Catalunya
Collaborators
Universitat de Lleida
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1. Study Identification

Unique Protocol Identification Number
NCT04750850
Brief Title
Core Stability Exercises and Hereditary Ataxia
Acronym
Core-ataxia
Official Title
The Effectiveness of Core Stability Exercises to Improve Balance and Gait in Hereditary Ataxias. Pilot Study
Study Type
Interventional

2. Study Status

Record Verification Date
May 2023
Overall Recruitment Status
Completed
Study Start Date
May 20, 2021 (Actual)
Primary Completion Date
November 30, 2022 (Actual)
Study Completion Date
January 10, 2023 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Universitat Internacional de Catalunya
Collaborators
Universitat de Lleida

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
The hereditary ataxias are a group of genetic disorders characterized by slowly progressive incoordination of gait and balance impairments in sitting and standing. Trunk local stability during gait is lower in patients with degenerative ataxia than that in healthy adult population. Given the fact that drug interventions are rare in degenerative diseases and limited to only specific type of diseases and symptoms, physiotherapy is a major cornerstone in current therapy of ataxic gait. Core stability exercises training could be included as an adjunct to conventional balance training in improving dynamic balance and gait. Due to the nature of the interventions, the study will have a single blind design.
Detailed Description
The hereditary ataxias are a group of genetic disorders characterized by slowly progressive incoordination of gait and often associated with poor coordination of hands, speech, and eye movements. Prevalence of the autosomal dominant cerebellar ataxias (ADCAs) is estimated to be approximately 1-5:100,000 populations. Hereditary ataxia may result from: dysfunction of the cerebellum and its associated system, lesions in the spinal cord and/or peripheral sensory loss. Clinical manifestations of hereditary ataxia are poor coordination of movement and a wide-based, uncoordinated, unsteady gait. Poor coordination of the limbs and of speech (dysarthria) are often present. Ataxia patients perceive impairments in balance, coordination and speech as the symptoms with greatest impact, as well as fatigue. Postural disorders in cerebellar ataxia constitute a major cause of poor balance. Local stability of the trunk during gait in patients with cerebellar degenerative ataxia is lower than that in controls. To compensate for this instability, walkers increase the width of the base of support, take smaller steps and increase the duration of foot contact to the floor, sacrificing swing phase. They progress forward slower, with a lower cadence and preferred walking pace. This lack of stability is in turn correlated with the history of falls. Local stability of the trunk may thus be useful when planning gait and balance rehabilitation in patients with ataxia. Developing core strength is essential for everyday health and well-being, as a strong core protects the spine, reduces back pain, enhances movement patterns, and improves balance, stability and posture. However, while motor training programs have been shown to be beneficial in other neurodegenerative diseases (e.g., Parkinson's disease or stroke, their effectiveness remains controversial in the field of degenerative hereditary ataxias. There's emerging evidence that rehabilitation may improve function, mobility, ataxia and balance in genetic degenerative ataxia. Although these conclusions are based primarily on moderate to low-quality studies, the consistency of positive effects verifies that rehabilitation is beneficial. Intensive rehabilitation (with balance and coordination exercises) improves the patients' functional abilities (level of proof: moderate). Although techniques such as virtual reality, biofeedback, treadmill exercises with supported body weight and torso weighting appear to be of value, their specific efficacy has yet to be characterized. This body of literature is limited by the wide range of underlying conditions studied and methodological weaknesses (small sample sizes, poorly described rehabilitation protocols, etc. The aim of this study is that a program of core stability exercises could improve sitting and standing balance and gait in hereditary ataxia patients. Secondary objectives are activities of daily living, lower limb strength and health status of quality of life. After giving informed consent, participants will be randomly assigned (at a ratio 1:1) to core stability group or control group. Concealed treatment allocation will be performed via opaque envelopes. The study will be carried out in accordance with the principles enunciated in the current version of the Declaration of Helsinki and the requirements of Spanish law and the Spanish regulatory authority.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Hereditary Ataxia, Spinocerebellar Degenerations, Cerebellar Ataxia
Keywords
ataxia, balance, gait ataxia, activities of daily living, core stability exercises, postural balance

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
Outcomes Assessor
Allocation
Randomized
Enrollment
20 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Core stability exercises group
Arm Type
Experimental
Arm Description
30 minutes of core stability exercises program at a light intensity and take a rest breaks if is necessary. They will be instructed in the use of the 4-5 points of the Borg 10 Rating of Perceived Exertion for self-monitoring of exercise intensity. The exercises will performed twice a day for 5 days a week during 5 weeks. A physiotherapist conducted an initial home visit to ensure correct execution of the exercises. He or she will teach the exercises and then the patient will perform them alone in your home. Once a week the physiotherapist will phone the patient and will ask her/him for doubts.
Arm Title
Control group
Arm Type
Active Comparator
Arm Description
The patients to continue as normal and not change their routine in terms of exercise and physical activity during the period of study.
Intervention Type
Other
Intervention Name(s)
Therapeutic core stability exercises
Other Intervention Name(s)
trunk exercises
Intervention Description
exercises focused on trunk muscle strengthening, proprioception, selective movements of the trunk and pelvis muscle, and coordination, and will be carried out in supine, sitting on a stable surface and sitting on an unstable surface (ball). The exercise involves changes in the position of the body with or without resistance, aiming to improve strength, endurance, proprioception and coordination. Training is determined by the patient's ability to undertake easy exercises and progress to more challenging exercises.
Intervention Type
Other
Intervention Name(s)
Usual care
Other Intervention Name(s)
Conventional physiotherapy
Intervention Description
Usual routine as walking and activities of daily living.
Primary Outcome Measure Information:
Title
Rate of dynamic sitting balance and trunk coordination
Description
Spanish-version of Trunk Impairment Scale 2.0. Each item will be performed three times and the highest score counts. Otherwise, no practice session allowed. The patient can be corrected between attempts. The tests are verbally explained to the patient and can be demonstrated if needed. There are two subscales: dynamic sitting balance and coordination. The first have 10 items and second 6. The highest possible total score is consequently 16 points, which indicates a good dynamic sitting balance and correct trunk control and sitting coordination. If the patient cannot maintain a sitting position for 10 seconds without back and arm support, with hands on thighs, feet in contact with the ground and knees bent at 90° (starting position), the total score for the scale is 0 points.
Time Frame
T1: Baseline, T2: 5 weeks and T3: follow up 5 weeks
Title
Rate of static sitting balance
Description
Sitting section of Scale for the assessment and rating of ataxia (SARA). Patient is asked to sit on an examination bed without support of feet, eyes open and arms outstretched to the front. 0 Normal, no difficulties sitting >10 seconds, 1 Slight difficulties, intermittent sway, 2 Constant sway, but able to sit > 10 s without support, 3 Able to sit for > 10 s only with intermittent support, 4 Unable to sit for >10 s without continuous support
Time Frame
T1: Baseline, T2: 5 weeks and T3: follow up 5 weeks
Title
Rate of ataxia severity
Description
Scale for the Assessment and Rating of Ataxia (SARA). The scale is made up of 8 items related to gait, stance, sitting, speech, finger-chase test, nose-finger test, fast alternating
Time Frame
T1: Baseline, T2: 5 weeks and T3: follow up 5 weeks
Secondary Outcome Measure Information:
Title
Rate of standing balance
Description
Standing section of Scale for the assessment and rating of ataxia (SARA). Patient is asked to stand (1) in natural position, (2) with feet together in parallel (big toes touching each other) and (3) in tandem (both feet on one line, no space between heel and toe). Proband does not wear shoes, eyes are open. For each condition, three trials are allowed. Best trial is rated. 0 Normal, able to stand in tandem for > 10 seconds 1 Able to stand with feet together without sway, but not in tandem for > 10s, 2 Able to stand with feet together for > 10 s, but only with sway, 3 Able to stand for > 10 s without support in natural, position, but not with feet together, 4 Able to stand for >10 s in natural position only with intermittent support, 5 Able to stand >10 s in natural position only with constant support of one arm, 6 Unable to stand for >10 s even with constant support of one arm.
Time Frame
T1: Baseline, T2: 5 weeks and T3: follow up 5 weeks
Title
Rate of gait ability
Description
Gait section of Scale for the assessment and rating of ataxia (SARA). Patient is asked (1) to walk at a safe distance parallel to a wall including a half-turn (turn around to face the opposite direction of gait) and (2) to walk in tandem (heels to toes) without support. Scoring items from 0 to 8: 0 Normal, no difficulties in walking, turning and walking tandem (up to one misstep allowed) and 8 Unable to walk, even supported. Gait speed by 4 meters walking test (meters per second) . The individual walks without assistance for 6 meters, with the time measured for the intermediate 4 meters to allow for acceleration and deceleration.
Time Frame
T1: Baseline, T2: 5 weeks and T3: follow up 5 weeks
Title
Rate of balance confidence
Description
Activities-specific Balance Confidence (ABC). Larger typeset should be used for self-administration, while an enlarged version of the rating scale on an index card will facilitate in-person interviews. The ABC is an 11-point scale and ratings should consist of whole numbers (0-100) for each item. Total the ratings (possible range = 0 - 1600) and divide by 16 to get each subject's ABC score. If a subject qualifies his/her response to items #2, #9, #11, #14 or #15 (different ratings for "up" vs. "down" or "onto" vs. "off"), solicit separate ratings and use the lowest confidence of the two (as this will limit the entire activity, for instance the likelihood of using the stairs.) • 80% = high level of physical functioning • 50-80% = moderate level of physical functioning • < 50% = low level of physical, functioning . < 67% = older adults at risk for falling; predictive of future fall.
Time Frame
T1: Baseline, T2: 5 weeks and T3: follow up 5 weeks
Title
Rate of lower limb strength
Description
30 seconds sit-to-stand. The 30-second chair stand involves recording the number of stands a person can complete in 30 seconds rather then the amount of time it takes to complete a pre-determined number of repetitions. That way, it is possible to assess a wide variety of ability levels with scores ranging from 0 for those who can not complete 1 stand to greater then 20 for more fit individuals.
Time Frame
T1: Baseline, T2: 5 weeks and T3: follow up 5 weeks
Title
Rate of adherence
Description
Adherence to the core stability exercise programme will be determined using exercise diaries, and process evaluation will be conducted via structured interviews with each participant at end of treatment.
Time Frame
T2: 5 weeks
Title
Rate of health status
Description
Health status by Euroqol 5 dimensions (EQ-5D). EQ-5D is a visual analogue scale for health ranging from 0 (worst possible) to 100 (best possible).
Time Frame
T1: Baseline, T2: 5 weeks and T3: follow up 5 weeks
Title
Rate of gait speed
Description
4 meters walking test (4-MWT)
Time Frame
T1: Baseline, T2: 5 weeks and T3: follow up 5 weeks
Title
Rate of quality of life
Description
Quality of life by EQ-5D-5L. The EQ-5D-5L is a self-assessed, health related, quality of life questionnaire. The scale measures quality of life on a 5-component scale including mobility, self-care, usual activities, pain/discomfort, and anxiety/depression
Time Frame
T1: Baseline, T2: 5 weeks and T3: follow up 5 weeks

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion criteria: suffer a degenerative hereditary ataxia. spinocerebellar ataxia (SCA), Friedreich's ataxia (FRDA), idiopathic sporadic cerebellar ataxia, and specific neurodegenerative disorders in which ataxia is the dominant symptom (e.g. cerebellar variant of multiple systems atrophy (MSA-C). Both sexes and age ≥ 18 years old. •Ability to understand and execute simple instructions. Exclusion Criteria: Concurrent neurologic disorder (e. g. Parkinson's disease) or major orthopedic problem (e. g. amputation) that hamper sitting balance, relevant psychiatric disorders that may prevent from following instructions, Other treatments that could influence the effects of the interventions, Contraindication to physical activity (e.g., heart failure).
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Rosa C Cabanas-Valdés, PhD
Organizational Affiliation
Universitat Internacional de Catalunya
Official's Role
Principal Investigator
Facility Information:
Facility Name
Rosa Cabanas Valdés
City
Cardedeu
State/Province
Barcelona
ZIP/Postal Code
08440
Country
Spain

12. IPD Sharing Statement

Plan to Share IPD
No
Citations:
PubMed Identifier
32211513
Citation
Chen DH, Latimer C, Yagi M, Ndugga-Kabuye MK, Heigham E, Jayadev S, Meabon JS, Gomez CM, Keene CD, Cook DG, Raskind WH, Bird TD. Heterozygous STUB1 missense variants cause ataxia, cognitive decline, and STUB1 mislocalization. Neurol Genet. 2020 Feb 10;6(2):1-13. doi: 10.1212/NXG.0000000000000397. eCollection 2020 Apr.
Results Reference
background
PubMed Identifier
24603320
Citation
Ruano L, Melo C, Silva MC, Coutinho P. The global epidemiology of hereditary ataxia and spastic paraplegia: a systematic review of prevalence studies. Neuroepidemiology. 2014;42(3):174-83. doi: 10.1159/000358801. Epub 2014 Mar 5.
Results Reference
background
Citation
OVERTON, Caroline E.; O'BRIEN, Kate. Guidelines on the Diagnosis and Management of Miscarriage. Early Pregnancy, 2017, 129.
Results Reference
background
PubMed Identifier
24582474
Citation
Marquer A, Barbieri G, Perennou D. The assessment and treatment of postural disorders in cerebellar ataxia: a systematic review. Ann Phys Rehabil Med. 2014 Mar;57(2):67-78. doi: 10.1016/j.rehab.2014.01.002. Epub 2014 Feb 6.
Results Reference
background
PubMed Identifier
26811155
Citation
Chini G, Ranavolo A, Draicchio F, Casali C, Conte C, Martino G, Leonardi L, Padua L, Coppola G, Pierelli F, Serrao M. Local Stability of the Trunk in Patients with Degenerative Cerebellar Ataxia During Walking. Cerebellum. 2017 Feb;16(1):26-33. doi: 10.1007/s12311-016-0760-6.
Results Reference
background
PubMed Identifier
27792020
Citation
Park J, Gong J, Yim J. Effects of a sitting boxing program on upper limb function, balance, gait, and quality of life in stroke patients. NeuroRehabilitation. 2017;40(1):77-86. doi: 10.3233/NRE-161392.
Results Reference
background
PubMed Identifier
26922850
Citation
Cabanas-Valdes R, Urrutia G, Bagur-Calafat C, Caballero-Gomez FM, German-Romero A, Girabent-Farres M. Validation of the Spanish version of the Trunk Impairment Scale Version 2.0 (TIS 2.0) to assess dynamic sitting balance and coordination in post-stroke adult patients. Top Stroke Rehabil. 2016 Aug;23(4):225-32. doi: 10.1080/10749357.2016.1151662. Epub 2016 Mar 11.
Results Reference
background
PubMed Identifier
27821673
Citation
Haruyama K, Kawakami M, Otsuka T. Effect of Core Stability Training on Trunk Function, Standing Balance, and Mobility in Stroke Patients. Neurorehabil Neural Repair. 2017 Mar;31(3):240-249. doi: 10.1177/1545968316675431. Epub 2016 Nov 9.
Results Reference
background
PubMed Identifier
32349543
Citation
Cabrera-Martos I, Jimenez-Martin AT, Lopez-Lopez L, Rodriguez-Torres J, Ortiz-Rubio A, Valenza MC. Effects of a core stabilization training program on balance ability in persons with Parkinson's disease: a randomized controlled trial. Clin Rehabil. 2020 Jun;34(6):764-772. doi: 10.1177/0269215520918631. Epub 2020 Apr 29.
Results Reference
background
PubMed Identifier
26451007
Citation
Cabanas-Valdes R, Bagur-Calafat C, Girabent-Farres M, Caballero-Gomez FM, Hernandez-Valino M, Urrutia Cuchi G. The effect of additional core stability exercises on improving dynamic sitting balance and trunk control for subacute stroke patients: a randomized controlled trial. Clin Rehabil. 2016 Oct;30(10):1024-1033. doi: 10.1177/0269215515609414. Epub 2015 Oct 8.
Results Reference
background
PubMed Identifier
24877117
Citation
Synofzik M, Ilg W. Motor training in degenerative spinocerebellar disease: ataxia-specific improvements by intensive physiotherapy and exergames. Biomed Res Int. 2014;2014:583507. doi: 10.1155/2014/583507. Epub 2014 Apr 27.
Results Reference
background
PubMed Identifier
32583055
Citation
He M, Zhang HN, Tang ZC, Gao SG. Balance and coordination training for patients with genetic degenerative ataxia: a systematic review. J Neurol. 2021 Oct;268(10):3690-3705. doi: 10.1007/s00415-020-09938-6. Epub 2020 Jun 24.
Results Reference
background
PubMed Identifier
28595509
Citation
Milne SC, Corben LA, Georgiou-Karistianis N, Delatycki MB, Yiu EM. Rehabilitation for Individuals With Genetic Degenerative Ataxia: A Systematic Review. Neurorehabil Neural Repair. 2017 Jul;31(7):609-622. doi: 10.1177/1545968317712469. Epub 2017 Jun 9.
Results Reference
background
Citation
Seco, C. J., et al. Improvements in quality of life in individuals with friedreich's ataxia after participation in a 5-year program of physical activity: an observational study pre-post test design, and two years follow-up. Int J Neurorehabil, 2014, 1.3: 129
Results Reference
background
PubMed Identifier
25668777
Citation
Chang YJ, Chou CC, Huang WT, Lu CS, Wong AM, Hsu MJ. Cycling regimen induces spinal circuitry plasticity and improves leg muscle coordination in individuals with spinocerebellar ataxia. Arch Phys Med Rehabil. 2015 Jun;96(6):1006-13. doi: 10.1016/j.apmr.2015.01.021. Epub 2015 Feb 7.
Results Reference
background
PubMed Identifier
22140200
Citation
Miyai I, Ito M, Hattori N, Mihara M, Hatakenaka M, Yagura H, Sobue G, Nishizawa M; Cerebellar Ataxia Rehabilitation Trialists Collaboration. Cerebellar ataxia rehabilitation trial in degenerative cerebellar diseases. Neurorehabil Neural Repair. 2012 Jun;26(5):515-22. doi: 10.1177/1545968311425918. Epub 2011 Dec 2.
Results Reference
background
PubMed Identifier
25082955
Citation
Bunn LM, Marsden JF, Giunti P, Day BL. Training balance with opto-kinetic stimuli in the home: a randomized controlled feasibility study in people with pure cerebellar disease. Clin Rehabil. 2015 Feb;29(2):143-53. doi: 10.1177/0269215514539336. Epub 2014 Jul 31.
Results Reference
background
PubMed Identifier
30958572
Citation
Velazquez-Perez L, Rodriguez-Diaz JC, Rodriguez-Labrada R, Medrano-Montero J, Aguilera Cruz AB, Reynaldo-Cejas L, Gongora-Marrero M, Estupinan-Rodriguez A, Vazquez-Mojena Y, Torres-Vega R. Neurorehabilitation Improves the Motor Features in Prodromal SCA2: A Randomized, Controlled Trial. Mov Disord. 2019 Jul;34(7):1060-1068. doi: 10.1002/mds.27676. Epub 2019 Apr 8.
Results Reference
background
PubMed Identifier
30132999
Citation
Rodriguez-Diaz JC, Velazquez-Perez L, Rodriguez Labrada R, Aguilera Rodriguez R, Laffita Perez D, Canales Ochoa N, Medrano Montero J, Estupinan Rodriguez A, Osorio Borjas M, Gongora Marrero M, Reynaldo Cejas L, Gonzalez Zaldivar Y, Almaguer Gotay D. Neurorehabilitation therapy in spinocerebellar ataxia type 2: A 24-week, rater-blinded, randomized, controlled trial. Mov Disord. 2018 Sep;33(9):1481-1487. doi: 10.1002/mds.27437. Epub 2018 Aug 22.
Results Reference
background
Citation
Tabbassum, Khan Neha, et al. Core stability training with conventional balance training improves dynamic balance in progressive degenerative cerebellar ataxia. Indian Journal of Physiotherapy and Occupational Therapy, 2013, 7.1: 136.
Results Reference
background
PubMed Identifier
16769946
Citation
Schmitz-Hubsch T, du Montcel ST, Baliko L, Berciano J, Boesch S, Depondt C, Giunti P, Globas C, Infante J, Kang JS, Kremer B, Mariotti C, Melegh B, Pandolfo M, Rakowicz M, Ribai P, Rola R, Schols L, Szymanski S, van de Warrenburg BP, Durr A, Klockgether T, Fancellu R. Scale for the assessment and rating of ataxia: development of a new clinical scale. Neurology. 2006 Jun 13;66(11):1717-20. doi: 10.1212/01.wnl.0000219042.60538.92. Erratum In: Neurology. 2006 Jul 25;67(2):299. Fancellu, Roberto [added].
Results Reference
background

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Core Stability Exercises and Hereditary Ataxia

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