Olfactory Training for Olfactory Dysfunction After Coronavirus Disease - 19 (COVID-19)
Covid19, SARS-CoV Infection, Olfactory Disorder
About this trial
This is an interventional treatment trial for Covid19
Eligibility Criteria
Inclusion Criteria:
- Confirmed diagnosis of COVID-19 by Real Time Polymerase chain-reaction for SARS-CoV-2 or serological tests for SARS-CoV-2 antigens.\
- Olfactory dysfunction confirmed by Connecticut Chemosensory Clinical Research Test (CCCRC-T).
Exclusion Criteria:
- Smokers
- Individuals with diagnosed rhinitis
- Individuals with diagnosed Neurological diseases
- Individuals submitted to brain surgery
- Previous historic of hyposmia and/ or anosmia
- Pregnancy
- Allergy to any of the substances present in the olfactory test kit
- Individuals who are undergoing another treatment for olfactory dysfunction
Sites / Locations
- Unidade de Ensino E Assistência Em Fisioterapia E Terapia Ocupacional
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
No Intervention
No Intervention
Experimental Group 1: Essences Oils
Experimental Group 2: Clinical follow-up
Control Group
The individuals of this group are 150 individuals with olfactory disorder related to COVID-19 that will be submitted to clinical exams, olfactory test and MRI imaging, after that, participants will undergo an olfactory training with essences oils. Each participant in this group will receive a kit with four 30 ml bottles, each containing a circular piece of watercolor paper soaked in one of the four essences oils (rose, eucalyptus, lemon and cloves) used in olfactory training, a manual to make the olfactory training at home and a self-assessment diary which should be filled weekly. Each participant of this group will use the training kit for three months, the olfactory training consists of inhaling each of the substances for 30 seconds, with an interval of 30 seconds between them, twice a day, upon waking up and before bed, the participants will be reassessed with CCCRT after each month of training. The results of this group will be compared with the other groups.
The individuals of this group are 150 individuals with olfactory disorder related to COVID-19. that will be submitted to clinical exams, olfactory test and MRI imaging, after three months they will be reassessed.
The individuals of this group are 50 healthy individuals, without previous COVID-19 infection, that will be submitted to clinical exams, olfactory test, MRI imaging and the participants will be tested for the ability to identification of the essence oils utilized by Experimental group 1.