WashIn /WashOut Procedure To Prevent Agitation During Recovery After Inhalational Anesthesia With Sevoflurane (OPERA)
Agitation, Emergence, Postoperative Delirium, Postoperative Cognitive Dysfunction
About this trial
This is an interventional prevention trial for Agitation, Emergence focused on measuring emergence agitation, postoperative agitation, postoperative delirium, postoperative cognitive dysfunction
Eligibility Criteria
Inclusion Criteria:
- Written informed consent from participants
- Age ≥ 18 years
- Planned open abdominal surgery
- General anesthesia
Exclusion Criteria:
- Pregnant patients and breastfeeding patients
- Mental disorders
- Epilepsy, Parkinson disease, Alzheimer, peripheral nerve and neuromuscular junction pathology (amyotrophic lateral sclerosis, Guillain-Barre Syndrome, myasthenia gravis et cet.)
- Use of antidepressants, antipsychotics, sedatives, psychoactive drugs within a month before surgery.
Sites / Locations
- Moscow Scientific Clinical CenterRecruiting
- Clinical hospital №1 of the I.M. Sechenov First Moscow State Medical University (Sechenov University)Recruiting
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Study group
Control group
A group of patients in relation to whom the "Wash In / WashOut" procedure will be applied. In this group we stop the supply of sevoflurane to the first signs of awakening and record the level of sevoflurane , then we resume the supply of sevoflurane to the end-tidal concentration of 1 MAC maintain the anesthesia for 5 min and stop the supply of sevoflurane to the first signs of awakening again, then we resume the supply of sevoflurane to the end-tidal concentration of 1 MAC maintain the anesthesia for 5 min and finally ( the third time) stop supplying sevoflurane and extubate patient after recovery of muscle tone, spontaneous breathing and consciousness.
A group of patients in relation to whom will be applied the traditional method of recovery from anesthesia. In this group during the period of awakening we stop supplying sevoflurane and extubate patient after recovery of muscle tone, spontaneous breathing and consciousness.