High Frequency Oscillatory Ventilation Versus High Frequency Jet Ventilation for Congenital Diaphragmatic Hernia
Congenital Diaphragmatic Hernia
About this trial
This is an interventional treatment trial for Congenital Diaphragmatic Hernia
Eligibility Criteria
Inclusion Criteria:
- Admitted to either the University of Utah and/or Primary Children's Hospital NICU within 24 hours of birth
- Requiring mechanical ventilation
- Umbilical arterial line or peripheral arterial line in place
- Obtained signed consent
- Infant is ≤ 24 hours of age
Exclusion Criteria:
Severe anomaly
- Chromosomal abnormalities
- Major congenital anomalies, including cardiac, central nervous system and syndromes
- Post-natal diagnosis > 24 hours of life
- Unable to obtain consent for participation
- Unable to randomize within 24 hours of life
Sites / Locations
- Primary Children's HospitalRecruiting
- University HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Active Comparator
Active Comparator
Active Comparator
High Frequency Jet Ventilation (HFJV) with intrathoracic liver
High Frequency Jet Ventilation (HFJV) without intrathoracic liver
High Frequency Oscillatory Ventilation (HFOV) with intrathoracic liver
High Frequency Oscillatory Ventilation (HFOV) without intrathoracic liver
Babies known to have the presence of the liver in the intrathoracic space will be placed on the HFJV at delivery or as soon as possible after consent. During analysis, these babies will be compared to babies with intrathoracic liver and randomized to high frequency oscillating ventilator.
Babies who do not have any liver in the intrathoracic space will be placed on the HFJV at delivery or as soon as possible after consent. During analysis, these babies will be compared to babies without intrathoracic liver and randomized to high frequency oscillating ventilator.
Babies known to have the presence of the liver in the intrathoracic space will be placed on the HFOV at delivery or as soon as possible after consent. During analysis, these babies will be compared to babies with intrathoracic liver and randomized to HFJV.
Babies who do not have any liver in the intrathoracic space will be placed on the HFOV at delivery or as soon as possible after consent. During analysis, these babies will be compared to babies without intrathoracic liver and randomized to HFJV.