Methodology for Developing an Occlusal Appliance With CBD Active Carrier (CBD-OCC-APP)

Evaluation of the efficacy of the occlusal appliance with active cannabidiol (CBD) molecules in TMD patients

Occlusal appliance therapies are used in TMD patients. In this research the active CBD molecules will be released from the occlusal appliance during nighttime, in population of patients suffering from TMD. The effectiveness of the myorelaxation (sEMG of mastcatory muscles activity) and analgesic effect( VAS analysis) of occlusal appliance with the CBD molecules will be compared to the traditional acrylic-resin material used so far for occlusal appliance manufacture. The aim of the research is the evaluation of the innovative material effectiveness, used for the production of the occlusal appliance.

Occlusal appliance manufactured with CBD molecules released from material to patients oral cavity during sleep time

Inclusion Criteria: patient agreement to take part in the study RDC/TMD group Ia and Ib Bruxism Index> 3 ( Brux-off polysomnography) Exclusion Criteria: CBD allergy/hypersensitivity/ addiction Therapy with analgesic drugs Therapy with drugs affecting muscle function Fixed or removable dental prosthesis Ongoing orthodontic treatment Other general disorders affecting muscle tension

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